Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

Eilam, Yahav; Khattib, Hamdan; Pintel, Noam; Avni, Dorit

doi:10.1002/gch2.202200177

Cited by 101Seaweed-derived Bioactive CompoundsProtein Hydrolysis and Bioactive PeptidesAlgal biology and biofuel production

Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

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Eilam, Yahav, Khattib, Hamdan, Pintel, Noam, Avni, Dorit·2023·Global Challenges

DOI 10.1002/gch2.202200177PMC PMC10190620

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Abstract

Dietary proteins derived from animal sources, although containing well‐balanced profiles of essential amino acids, have considerable environmental and adverse health effects associated with the intake of some animal protein‐based products. Consuming foods based on animal proteins carries a higher risk of developing non‐communicable diseases such as cancer, heart disease, non‐alcoholic fatty liver disease (NAFLD), and inflammatory bowel disease (IBD). Moreover, dietary protein consumption is increasing due to population growth, posing a supply challenge. There is, therefore, growing interest in discovering novel alternative protein sources. In this context, microalgae have been recognized as strategic crops that can provide a sustainable source of protein. Compared to conventional high‐protein crops, using microalgal biomass for protein production presents several advantages in food and feed in terms of productivity, sustainability, and nutritional value. Moreover, microalgae positively impact the environment by not exploiting land or causing water pollution. Many studies have revealed the potential of microalgae as an alternative protein source with the added value of positive effects on human health due to their anti‐inflammatory, antioxidant, and anti‐cancer properties. The main emphasis of this review is on the potential health‐promoting applications of microalgae‐based proteins, peptides, and bioactive substances for IBD and NAFLD.

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Peptides from Limnospira platensis suppress inflammatory marker expression in endothelial cells, promoting a healthier vascular environment.
“Notably, peptides from Limnospira platensis have been shown to suppress inflammatory marker expression in endothelial cells, promoting a healthier vascular environment [72].”
From Navigating the potential of algal peptides: health effects, market applications, and scientific challenges (2026) · cites this paper as [72]
In “Microalga-Based Proteins and Peptides” (page unavailable), the review reports that peptides from Spirulina maxima suppressed cytokine generation by endothelial cells. It discusses peptides from Spirulina platensis separately, but does not attribute this endothelial-cell effect to them. The claimed vascular benefit is an inference rather than a reported outcome. (LLM, conf=0.88)
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Designing the Future of Food: Challenges to Innovation in Microalgae‐Derived Blue Protein Systems
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From Microalgal Biomass to Products: Downstream Processing Technology Gaps and the Road to Commercial Diversification
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Food and Feed Preparation Using Algae
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Nannochloropsis biomass alleviates high fat diet induced cardiac and hepatic metabolic disturbances in mice
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Identification and biofunctionality profiling of peptides from Arthrospira platensis and Tetraselmis chuii: In silico predictions and in vitro validation
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Benefits of the use of microalgae on nutrition and health of monogastrics
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Evidence of use of microalgae on glycemic control and glucose metabolism
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Phage therapy as a sustainable strategy to promote microalgal health
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The Potential Role of Microalgal Antioxidant Molecules on the Microbiota–Gut Axis in Inflammatory Bowel Diseases
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Microalgae as an innovative feed ingredient in monogastric nutrition
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Hepatoprotective effects of pentadecanoic acid-rich microalgae Melosira nummuloides in a high-fat diet-induced mouse model of non-alcoholic fatty liver disease
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Processing Techniques for Algae-Based Foods: Preserving Nutritional Quality and Flavor
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Differential metabolites facilitate metabolic dysfunction-associated fatty liver disease malignancy via immune evasion and M2-polarized macrophages
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Alternative Proteins
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Microalgal Biomass for Food Security: Current Status and Future Perspectives
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Microalgae as a sustainable source of protein and food ingredients
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Self-citation
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Edible proteins and bioactive peptides from microalgae
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Authors: Eilam, Y., Khattib, H., Pintel, N., & Avni, D.
Affiliations: Migal - Galilee Technology Center (IL)
Corresponding author: Avni, Dorit
ORCID: Avni, Dorit
Venue: Global Challenges
Publisher: Wiley
Published: 2023-04-25
Volume: 7
Issue: 5
Pages: 2200177-2200177
ISSN: 2056-6646 (ISSN-L)
DOI: 10.1002/gch2.202200177
PMC: PMC10190620
OpenAlex: W4366983651
Cited by: 101
References: 267
Citations by year: 2026: 25 · 2025: 39 · 2024: 32 · 2023: 5
FWCI: 2.55
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Global Challenges (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: European Commission (101000501, HORIZON2020)
Topics: Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Keywords: microalgae, alternative protein sources, gut health, liver health, non-alcoholic fatty liver disease, inflammatory bowel disease, anti-inflammatory peptides, bioactive compounds, antioxidant activity, anticancer properties, animal protein alternatives, sustainable protein production, functional food ingredients

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Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

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