MicroRNAs: the fine-tuners of Toll-like receptor signalling

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834

NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses

Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317

Mammalian microRNAs predominantly act to decrease target mRNA levels

Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822

A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing

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The impact of microRNAs on protein output

Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592

B lymphocytes secrete antigen-presenting vesicles.

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Widespread changes in protein synthesis induced by microRNAs

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MicroRNA-155 is induced during the macrophage inflammatory response

O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610731104 · Cited by 1,866

Requirement of bic/microRNA-155 for Normal Immune Function

Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833

Toll-like Receptors and the Control of Immunity

Fitzgerald, K. A., & Kagan, J. C. (2020) · Cell · doi:10.1016/j.cell.2020.02.041 · Cited by 2,168

Diversity, Mechanisms, and Significance of Macrophage Plasticity

Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199

microRNA Regulation of Inflammatory Responses

O'Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 843

MicroRNAs as regulatory elements in immune system logic

Mehta, A., & Baltimore, D. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.40 · Cited by 704

NLRP3 inflammasome activity is negatively controlled by miR-223

Bauernfeind, F., Rieger, A., Schildberg, F. A., Knolle, P. A., Schmid-Burgk, J. L., & Hornung, V. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201516 · Cited by 544

MicroRNA-146a: A Dominant, Negative Regulator of the Innate Immune Response

Saba, R., Sorensen, D. L., & Booth, S. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00578 · Cited by 427

Dissecting negative regulation of Toll-like receptor signaling

Kondo, T., Kawai, T., & Akira, S. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.05.002 · Cited by 419

Malt1-induced cleavage of regnase-1 in CD4(+) helper T cells regulates immune activation

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MicroRNA-125b Potentiates Macrophage Activation

Chaudhuri, A. A., So, A. Y.-L., Sinha, N., Gibson, W. S. J., Taganov, K. D., O’Connell, R. M., & Baltimore, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102001 · Cited by 327

Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers

Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumour immunity

Baer, C., Squadrito, M. L., Laoui, D., Thompson, D., Hansen, S. K., Kiialainen, A., Hoves, S., Ries, C. H., Ooi, C.-H., & De Palma, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3371 · Cited by 259

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

He, X., Jing, Z., & Cheng, G. (2014) · BioMed Research International · doi:10.1155/2014/945169 · Cited by 238

IL-10–induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes

Rossato, M., Curtale, G., Tamassia, N., Castellucci, M., Mori, L., Gasperini, S., Mariotti, B., De Luca, M., Mirolo, M., Cassatella, M. A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209100109 · Cited by 215

MicroRNA 21 Is a Homeostatic Regulator of Macrophage Polarization and Prevents Prostaglandin E2-Mediated M2 Generation

Wang, Z., Brandt, S., Medeiros, A., Wang, S., Wu, H., Dent, A., & Serezani, C. H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0115855 · Cited by 169

Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia

Freilich, R. W., Woodbury, M. E., & Ikezu, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079416 · Cited by 160

MiR-9 promotes microglial activation by targeting MCPIP1

Yao, H., Ma, R., Yang, L., Hu, G., Chen, X., Duan, M., Kook, Y., Niu, F., Liao, K., Fu, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms5386 · Cited by 158

Danger‐associated molecular patterns ( DAMPs ) in acute lung injury

Tolle, L. B., & Standiford, T. J. (2013) · The Journal of Pathology · doi:10.1002/path.4124 · Cited by 157

Circulating inflammatory miRNA signature in response to different doses of aerobic exercise

de Gonzalo-Calvo, D., Dávalos, A., Montero, A., García-González, Á., Tyshkovska, I., González-Medina, A., Soares, S. M. A., Martínez-Camblor, P., Casas-Agustench, P., Rabadán, M., et al. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00077.2015 · Cited by 150

Immune Dysregulation in Children With Down Syndrome

Huggard, D., Doherty, D. G., & Molloy, E. J. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00073 · Cited by 144

MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4

Tserel, L., Runnel, T., Kisand, K., Pihlap, M., Bakhoff, L., Kolde, R., Peterson, H., Vilo, J., Peterson, P., & Rebane, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.213561 · Cited by 136

Chronic Alcohol-Induced microRNA-155 Contributes to Neuroinflammation in a TLR4-Dependent Manner in Mice

Lippai, D., Bala, S., Csak, T., Kurt-Jones, E. A., & Szabo, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070945 · Cited by 129

MicroRNA-92a Negatively Regulates Toll-like Receptor (TLR)-triggered Inflammatory Response in Macrophages by Targeting MKK4 Kinase

Lai, L., Song, Y., Liu, Y., Chen, Q., Han, Q., Chen, W., Pan, T., Zhang, Y., Cao, X., & Wang, Q. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.445429 · Cited by 126

The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids

Agudo, J., Ruzo, A., Tung, N., Salmon, H., Leboeuf, M., Hashimoto, D., Becker, C., Garrett-Sinha, L.-A., Baccarini, A., Merad, M., et al. (2014) · Nature Immunology · doi:10.1038/ni.2767 · Cited by 122

Control of cytokine mRNA expression by RNA-binding proteins and microRNAs

Palanisamy, V., Jakymiw, A., Van Tubergen, E. A., D’Silva, N. J., & Kirkwood, K. L. (2012) · Journal of Dental Research · doi:10.1177/0022034512437372 · Cited by 117

Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages

Cobos Jiménez, V., Bradley, E. J., Willemsen, A. M., van Kampen, A. H. C., Baas, F., & Kootstra, N. A. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00140.2013 · Cited by 103

A Role for microRNA-155 Modulation in the Anti-HIV-1 Effects of Toll-Like Receptor 3 Stimulation in Macrophages

Swaminathan, G., Rossi, F., Sierra, L.-J., Gupta, A., Navas-Martín, S., & Martín-García, J. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002937 · Cited by 103

Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription

Alasoo, K., Martinez, F. O., Hale, C., Gordon, S., Powrie, F., Dougan, G., Mukhopadhyay, S., & Gaffney, D. J. (2015) · Scientific Reports · doi:10.1038/srep12524 · Cited by 102

The Role of Ets2 Transcription Factor in the Induction of MicroRNA-155 (miR-155) by Lipopolysaccharide and Its Targeting by Interleukin-10

Quinn, S. R., Mangan, N. E., Caffrey, B. E., Gantier, M. P., Williams, B. R. G., Hertzog, P. J., McCoy, C. E., & O'Neill, L. A. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522730 · Cited by 100

Gut microbiota: a source of novel tools to reduce the risk of human disease?

Collado, M. C., Rautava, S., Isolauri, E., & Salminen, S. (2015) · Pediatric Research · doi:10.1038/pr.2014.173 · Cited by 93

New Perspectives in MicroRNA Regulation of Innate Immunity

Gantier, M. P. (2010) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2010.0037 · Cited by 82

The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation

Kong, H., Yin, F., He, F., Omran, A., Li, L., Wu, T., Wang, Y., & Peng, J. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0574-x · Cited by 81

Type I IFN Inhibits Innate IL-10 Production in Macrophages through Histone Deacetylase 11 by Downregulating MicroRNA-145

Lin, L., Hou, J., Ma, F., Wang, P., Liu, X., Li, N., Wang, J., Wang, Q., & Cao, X. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203450 · Cited by 73

MicroRNA-33 regulates the innate immune response via ATP binding cassette transporter-mediated remodeling of membrane microdomains

Lai, L., Azzam, K. M., Lin, W.-C., Rai, P., Lowe, J. M., Gabor, K. A., Madenspacher, J. H., Aloor, J. J., Parks, J. S., Näär, A. M., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.723056 · Cited by 67

Presenilin 2 influences miR146 level and activity in microglia

Jayadev, S., Case, A., Alajajian, B., Eastman, A. J., Möller, T., & Garden, G. A. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12400 · Cited by 62

Expression of microRNAs miR21, miR146a, and miR155 in tuberous sclerosis complex cortical tubers and their regulation in human astrocytes and SEGA‐derived cell cultures

van Scheppingen, J., Iyer, A. M., Prabowo, A. S., Mühlebner, A., Anink, J. J., Scholl, T., Feucht, M., Jansen, F. E., Spliet, W. G., Krsek, P., et al. (2016) · Glia · doi:10.1002/glia.22983 · Cited by 60

Development of microglia‐targeting adeno‐associated viral vectors as tools to study microglial behavior in vivo

Okada, Y., Hosoi, N., Matsuzaki, Y., Fukai, Y., Hiraga, A., Nakai, J., Nitta, K., Shinohara, Y., Konno, A., & Hirai, H. (2022) · Communications Biology · doi:10.1038/s42003-022-04200-3 · Cited by 58

miR-155 Dysregulation and Therapeutic Intervention in Multiple Sclerosis

McCoy, C. E. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-981-10-5987-2_5 · Cited by 46

MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection

Johnston, D. G. W., Kearney, J., Zasłona, Z., Williams, M. A., O'Neill, L. A. J., & Corr, S. C. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00201 · Cited by 44

MicroRNA-146a Provides Feedback Regulation of Lyme Arthritis but Not Carditis during Infection with Borrelia burgdorferi

Lochhead, R. B., Ma, Y., Zachary, J. F., Baltimore, D., Zhao, J. L., Weis, J. H., O'Connell, R. M., & Weis, J. J. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004212 · Cited by 42

Melatonin and Leishmania amazonensis Infection Altered miR-294, miR-30e, and miR-302d Impacting on Tnf, Mcp-1, and Nos2 Expression

Fernandes, J. C. R., Aoki, J. I., Maia Acuña, S., Zampieri, R. A., Markus, R. P., Floeter-Winter, L. M., & Muxel, S. M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00060 · Cited by 41

MicroRNAs: a symphony orchestrating evolution and disease dynamics

Quah, S., Subramanian, G., Tan, J. S. L., Utami, K. H., & Sampath, P. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.07.004 · Cited by 31

Activation of Toll‐like receptors alters the micro RNA expression profile of keratinocytes

Meisgen, F., Xu Landén, N., Bouez, C., Zuccolo, M., Gueniche, A., Ståhle, M., Sonkoly, E., Breton, L., & Pivarcsi, A. (2014) · Experimental Dermatology · doi:10.1111/exd.12361 · Cited by 26

miRNA-Mediated Priming of Macrophage M1 Differentiation Differs in Gram-Positive and Gram-Negative Settings

Riechert, G., Maucher, D., Schmidt, B., & Schumann, J. (2022) · Genes · doi:10.3390/genes13020211 · Cited by 10