Cited by 1,376Immune Response and InflammationMitochondrial Function and PathologyInflammasome and immune disorders

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Mitochondria in innate immune responses

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West, A. Phillip, Shadel, Gerald S., Ghosh, Sankar·2011·Nature Reviews Immunology

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Abstract

The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.

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Authors: West, A. P., Shadel, G. S., & Ghosh, S.
Affiliations: Yale University (US)
Columbia University (US)
Corresponding author: Ghosh, Sankar
ORCID: West, A. Phillip
Shadel, Gerald S.
Ghosh, Sankar
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-05-20
Volume: 11
Issue: 6
Pages: 389-402
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2975
PMC: PMC4281487
OpenAlex: W2033448006
Cited by: 1,376
References: 103
Citations by year: 2026: 119 · 2025: 78 · 2024: 103 · 2023: 97 · 2022: 102 · 2021: 129 · 2020: 101 · 2019: 83 · 2018: 85 · 2017: 109 · 2016: 95 · 2015: 97 · 2014: 75 · 2013: 46 · 2012: 44
FWCI: 5.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R37 AI33443, R37AI033443)
National Institute of Environmental Health Sciences (ES‑011)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: mitochondria, innate immunity, antiviral signaling, reactive oxygen species, antibacterial immunity, sterile inflammation, programmed cell death, cellular metabolism
MeSH terms: Animals, Bacterial Infections, Humans, Immunity, Innate, Mitochondria, Virus Diseases, Signal Transduction, Reactive Oxygen Species, Models, Immunological, Mitochondrial Proteins

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