Mitochondria in innate immune responses

How mitochondria produce reactive oxygen species

Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Circulating mitochondrial DAMPs cause inflammatory responses to injury

Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329

NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125

Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

ROS Are Good

Mittler, R. (2017) · Trends in Plant Science · doi:10.1016/j.tplants.2016.08.002 · Cited by 3,499

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature · doi:10.1038/nature14156 · Cited by 1,975

The multifaceted contributions of mitochondria to cellular metabolism

Spinelli, J. B., & Haigis, M. C. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0124-1 · Cited by 1,935

Mitochondrial ROS Signaling in Organismal Homeostasis

Shadel, G. S., & Horvath, T. L. (2015) · Cell · doi:10.1016/j.cell.2015.10.001 · Cited by 1,353

Mitochondria are required for antigen-specific t cell activation through reactive oxygen species signaling

Sena, L. A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D. A., Wang, C.-R., Schumacker, P. T., Licht, J. D., Perlman, H., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.10.020 · Cited by 1,338

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

Dunn, J. D., Álvarez, L., Zhang, X., & Soldati, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.09.005 · Cited by 1,233

Mitochondrial DNA in innate immune responses and inflammatory pathology

West, A. P., & Shadel, G. S. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.21 · Cited by 1,115

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960

Mitochondrial Dysfunction and Signaling in Chronic Liver Diseases

Mansouri, A., Gattolliat, C., & Asselah, T. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.083 · Cited by 839

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

Pernas, L. F., & Scorrano, L. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105011 · Cited by 845

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

Li, X., Fang, P., Mai, J., Choi, E. T., Wang, H., & Yang, X. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-19 · Cited by 860

Zinc and its role in immunity and inflammation

Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798

Mitochondrial disorders as windows into an ancient organelle

Vafai, S. B., & Mootha, V. K. (2012) · Nature · doi:10.1038/nature11707 · Cited by 733

Reactive Oxygen Species-Related Nanoparticle Toxicity in the Biomedical Field

Yu, Z., Li, Q., Wang, J., Yu, Y., Wang, Y., Zhou, Q., & Li, P. (2020) · Nanoscale Research Letters · doi:10.1186/s11671-020-03344-7 · Cited by 728

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Shpilka, T., & Haynes, C. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.110 · Cited by 742

The metabolic roots of senescence: mechanisms and opportunities for intervention

Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00483-8 · Cited by 691

Mitochondria and Mitochondrial ROS in Cancer: Novel Targets for Anticancer Therapy

Yang, Y., Karakhanova, S., Hartwig, W., D’Haese, J. G., Philippov, P. P., Werner, J., & Bazhin, A. V. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25349 · Cited by 687

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633

Mitochondria in health, disease, and aging

Harrington, J. S., Ryter, S. W., Plataki, M. E., Price, D. R., & Choi, A. M. K. (2023) · Physiological Reviews · doi:10.1152/physrev.00058.2021 · Cited by 641

Role of Reactive Oxygen Species (ROS) in Therapeutics and Drug Resistance in Cancer and Bacteria

Allimuthu, D. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01243 · Cited by 587

Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STING pathway

Kim, J., Kim, H., & Chung, J. H. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-00965-7 · Cited by 594

Mitochondria as signaling organelles

Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576

Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions

Yin, J., Huang, L., Wu, L., Li, J., James, T. D., & Lin, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00645b · Cited by 551

Mitochondrial Control of Cellular Life, Stress, and Death

Galluzzi, L., Kepp, O., Trojel‐Hansen, C., & Kroemer, G. (2012) · Circulation Research · doi:10.1161/circresaha.112.268946 · Cited by 568

Mitochondrial quality control in kidney injury and repair

Tang, C., Cai, J., Yin, X., Weinberg, J. M., Venkatachalam, M. A., & Dong, Z. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-00369-0 · Cited by 524

Monogenic Mitochondrial Disorders

Koopman, W. J. H., Willems, P. H. G. M., & Smeitink, J. A. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1012478 · Cited by 527

Mitochondrial DNA copy number variation across human cancers

Reznik, E., Miller, M. L., Şenbabaoğlu, Y., Riaz, N., Sarungbam, J., Tickoo, S. K., Al‐Ahmadie, H. A., Lee, W., Seshan, V., Hakimi, A. A., et al. (2016) · eLife · doi:10.7554/elife.10769 · Cited by 530

Inflammaging: disturbed interplay between autophagy and inflammasomes

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2012) · Aging · doi:10.18632/aging.100444 · Cited by 453

Selective autophagy of intracellular organelles: Recent research advances

Li, W., He, P., Huang, Y., Li, Y.-F., Lu, J., Li, M., Kurihara, H., Luo, Z., Meng, T., Onishi, M., et al. (2020) · Theranostics · doi:10.7150/thno.49860 · Cited by 523

Reactive Oxygen Species in the Immune System

Yang, Y., Bazhin, A. V., Werner, J., & Karakhanova, S. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2012.755176 · Cited by 523

Bats as ‘special’ reservoirs for emerging zoonotic pathogens

Brook, C. E., & Dobson, A. P. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2014.12.004 · Cited by 537

The role of mitochondria in NLRP3 inflammasome activation

Liu, Q., Zhang, D., Hu, D., Zhou, X., & Zhou, Y. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.09.010 · Cited by 475

Mitochondria and cell signalling

Tait, S. W. G., & Green, D. R. (2012) · Journal of Cell Science · doi:10.1242/jcs.099234 · Cited by 453

Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6

Tyrrell, D. J., & Goldstein, D. R. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0431-7 · Cited by 447

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

Koopman, W. J. H., Nijtmans, L. G. J., Dieteren, C. E. J., Roestenberg, P., Valsecchi, F., Smeitink, J. A. M., & Willems, P. H. G. M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2743 · Cited by 411

Mitochondria in innate immune signaling

Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410

TRPM2 links oxidative stress to NLRP3 inflammasome activation

Zhong, Z., Zhai, Y., Liang, S., Mori, Y., Han, R., Sutterwala, F. S., & Qiao, L. (2013) · Nature Communications · doi:10.1038/ncomms2608 · Cited by 374

Mitochondrial Dynamics at the Interface of Immune Cell Metabolism and Function

Rambold, A. S., & Pearce, E. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.006 · Cited by 357

Mitochondrial DNA Release in Innate Immune Signaling

Newman, L. E., & Shadel, G. S. (2023) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-032620-104401 · Cited by 349

Metabolic regulation of inflammation

Gaber, T., Strehl, C., & Buttgereit, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.37 · Cited by 320

Psychological Stress and Mitochondria: A Conceptual Framework

Picard, M. A., & McEwen, B. S. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000544 · Cited by 328

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Fecher, C., Trovò, L., Müller, S. A., Snaidero, N., Wettmarshausen, J., Heink, S., Ortiz, O., Wagner, I., Kühn, R., Hartmann, J., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0479-z · Cited by 330

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense

Garaude, J., Acín-Pérez, R., Martínez-Cano, S., Enamorado, M., Ugolini, M., Nistal-Villán, E., Hervás-Stubbs, S., Pelegrín, P., Sander, L. E., Enríquez, J. A., et al. (2016) · Nature Immunology · doi:10.1038/ni.3509 · Cited by 313

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

Bai, J., Cervantes, C., Liu, J., He, S., Zhou, H., Zhang, B., Cai, H., Yin, D., Hu, D., Li, Z., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708744114 · Cited by 317

Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

Salminen, A., Ojala, J. O., Kaarniranta, K., & Kauppinen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0962-0 · Cited by 308

Ischaemia-reperfusion injury: a major protagonist in kidney transplantation

Ponticelli, C. E. (2013) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gft488 · Cited by 295

Hepatitis C virus triggers mitochondrial fission and attenuates apoptosis to promote viral persistence

Kim, S., Syed, G. H., Khan, M. A., Chiu, W.-W., Sohail, M. A., Gish, R. G., & Siddiqui, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321114111 · Cited by 293

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

van Horssen, J., van Schaik, P. E. M., & Witte, M. E. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.06.050 · Cited by 298

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration

Kerur, N., Fukuda, S., Banerjee, D., Kim, Y., Fu, D., Apicella, I., Varshney, A., Yasuma, R., Fowler, B. J., Baghdasaryan, E., et al. (2017) · Nature Medicine · doi:10.1038/nm.4450 · Cited by 290

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

Aviello, G., & Knaus, U. G. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13428 · Cited by 284

Fluorescent Probe HKSOX-1 for Imaging and Detection of Endogenous Superoxide in Live Cells and In Vivo

Hu, J. J., Wong, N.-K., Ye, S., Chen, X., Lu, M.-Y., Zhao, A. Q., Guo, Y., Chun‐Hang, A., Leung, A. Y. H., Shen, J., et al. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b01881 · Cited by 282

Immunoresponsive Gene 1 Augments Bactericidal Activity of Macrophage-Lineage Cells by Regulating β-Oxidation-Dependent Mitochondrial ROS Production

Hall, C. J., Boyle, R. H., Astin, J. W., Flores, M. V., Oehlers, S. H., Sanderson, L. E., Ellett, F., Lieschke, G. J., Crosier, K. E., & Crosier, P. S. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.018 · Cited by 266

Mitochondrial Quality Control as a Therapeutic Target

Suliman, H. B., & Piantadosi, C. A. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.011502 · Cited by 267

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis

Wang, P., Geng, J., Gao, J., Zhao, H., Li, J., Shi, Y., Yang, B., Chen, X., Linghu, Y., Sun, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08680-6 · Cited by 268

Mitochondrial dysfunction in inflammatory bowel disease

Novak, E. A., & Mollen, K. P. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00062 · Cited by 275

Red fluorescent genetically encoded indicator for intracellular hydrogen peroxide

Ermakova, Y. G., Bilan, D. S., Matlashov, M. E., Mishina, N. M., Markvicheva, K. N., Subach, O. M., Subach, F. V., Bogeski, I., Hoth, M., Enikolopov, G., et al. (2014) · Nature Communications · doi:10.1038/ncomms6222 · Cited by 270

Control and dysregulation of redox signalling in the gastrointestinal tract

Campbell, E. L., & Colgan, S. P. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0079-5 · Cited by 267

Listeria hijacks host mitophagy through a novel mitophagy receptor to evade killing

Zhang, Y., Yao, Y., Qiu, X., Wang, G., Hu, Z., Chen, S., Wu, Z., Yuan, N., Gao, H., Wang, J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0324-2 · Cited by 267

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases

Dela Cruz, C. S., & Kang, M.-J. (2018) · Mitochondrion · doi:10.1016/j.mito.2017.12.001 · Cited by 255

The neuroprotective effects of glucagon-like peptide 1 in Alzheimer’s and Parkinson’s disease: An in-depth review

Reich, N., & Hölscher, C. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.970925 · Cited by 248

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S.-I., Mihara, K., & Koshiba, T. (2014) · Nature Communications · doi:10.1038/ncomms5713 · Cited by 257

Orchestrating the interferon antiviral response through the mitochondrial antiviral signaling (MAVS) adapter

Belgnaoui, S. M., Paz, S., & Hiscott, J. B. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.08.001 · Cited by 241

Legionella pneumophila Modulates Mitochondrial Dynamics to Trigger Metabolic Repurposing of Infected Macrophages

Escoll, P., Song, O., Viana, F., Steiner, B., Lagache, T., Olivo‐Marín, J., Impens, F., Brodin, P. M., Hilbi, H., & Buchrieser, C. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.07.020 · Cited by 252

Reactive oxygen species trigger Parkin/PINK1 pathway–dependent mitophagy by inducing mitochondrial recruitment of Parkin

Xiao, B., Goh, J. Y., Xiao, L., Xian, H., Lim, K., & Liou, Y. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.787739 · Cited by 242

Metabolic features of the cell danger response

Naviaux, R. K. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.08.006 · Cited by 243

Molecular Mechanisms of mtDNA-Mediated Inflammation

Gaetano, A. D., Solodka, K., Zanini, G., Selleri, V., Mattioli, A. V., Nasi, M., & Pinti, M. (2021) · Cells · doi:10.3390/cells10112898 · Cited by 241

Platelet microvesicles in health and disease

Melki, I., Tessandier, N., Zufferey, A., & Boilard, É. (2017) · Platelets · doi:10.1080/09537104.2016.1265924 · Cited by 232

The Role of Mitochondria in Inflammation: From Cancer to Neurodegenerative Disorders

Missiroli, S., Genovese, I., Perrone, M., Vezzani, B., Vitto, V. A. M., & Giorgi, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9030740 · Cited by 235

The Role of Taurine in Mitochondria Health: More Than Just an Antioxidant

Jong, C. J., Sandal, P., & Schaffer, S. W. (2021) · Molecules · doi:10.3390/molecules26164913 · Cited by 241

The role of autophagy in viral infections

Chen, T., Tu, S., Ding, L., Jin, M., Chen, H., & Zhou, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00899-2 · Cited by 235

NADPH oxidases and ROS signaling in the gastrointestinal tract

Aviello, G., & Knaus, U. G. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0021-8 · Cited by 235

Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles

Yang, E.-J., Kim, S.-J., Kim, J. S., & Choi, I. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.016 · Cited by 218

BMPR2 Preserves Mitochondrial Function and DNA during Reoxygenation to Promote Endothelial Cell Survival and Reverse Pulmonary Hypertension

Diebold, I., Hennigs, J. K., Miyagawa, K., Li, C. G., Nickel, N. P., Kaschwich, M., Cao, A., Wang, L., Reddy, S., Chen, P.-I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.03.010 · Cited by 217

Israeli Acute Paralysis Virus: Epidemiology, Pathogenesis and Implications for Honey Bee Health

Chen, Y. P., Pettis, J. S., Corona, M., Chen, W. P., Li, C., Spivak, M. S., Visscher, P. K., DeGrandi‐Hoffman, G., Boncristiani, H., Zhao, Y., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004261 · Cited by 217

Danger Signals Activating the Immune Response after Trauma

Hirsiger, S., Simmen, H., Werner, C. M. L., Wanner, G. A., & Rittirsch, D. (2012) · Mediators of Inflammation · doi:10.1155/2012/315941 · Cited by 216

CLEC5A is critical for dengue virus–induced inflammasome activation in human macrophages

Wu, M., Chen, S.-T., Yang, A., Lin, W., Lin, Y., Chen, N., Tsai, I.-S., Li, L., & Hsieh, S.-L. E. (2012) · Blood · doi:10.1182/blood-2012-05-430090 · Cited by 218

Aging - Oxidative stress, antioxidants and computational modeling

Warraich, U.-E.-A., Hussain, F., & Kayani, H. U. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04107 · Cited by 222

Space-Selective Chemodynamic Therapy of CuFe5O8 Nanocubes for Implant-Related Infections

Guo, G., Zhang, H., Shen, H., Zhu, C., He, R., Tang, J. L., Wang, Y., Jiang, X., Wang, J., Bu, W., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c05255 · Cited by 210

Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

Cheng, A. N., Cheng, L.-C., Kuo, C., Lo, Y. K., Chou, H.-Y., Chen, C., Wang, Y., Chuang, T., Cheng, S., & Lee, A. Y. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001372 · Cited by 210

Myxomatosis in Australia and Europe: A model for emerging infectious diseases

Kerr, P. J. (2012) · Antiviral Research · doi:10.1016/j.antiviral.2012.01.009 · Cited by 217

Mitochondrial dysfunction as a trigger of innate immune responses and inflammation

West, A. P. (2017) · Toxicology · doi:10.1016/j.tox.2017.07.016 · Cited by 206

Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy

Jiang, Y., Krantz, S., Qin, X., Li, S., Gunasekara, H., Kim, Y.-M., Zimnicka, A. M., Bae, M., Ma, K., Tóth, P. T., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102304 · Cited by 198

Mitochondria: hub of injury responses in the developing brain

Hagberg, H., Mallard, C. E., Rousset, C. I., & Thornton, C. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70261-8 · Cited by 199

Mitochondrial dynamics and viral infections: A close nexus

Khan, M. A., Syed, G. H., Kim, S., & Siddiqui, A. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.12.040 · Cited by 195

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity

Tur, J., Pereira‐Lopes, S., Vico, T., Marín, E., Muñoz, J. P., Hernández‐Álvarez, M. I., Cardona, P.-J., Antonio Zorzano, A., Lloberas, J., & Celada, A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108079 · Cited by 198

The Role of Maternal Immune Activation in the Pathogenesis of Autism: A Review of the Evidence, Proposed Mechanisms and Implications for Treatment

Zawadzka, A., Cieślik, M., & Adamczyk, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111516 · Cited by 197

Visualization of Mitochondrial Viscosity in Inflammation, Fatty Liver, and Cancer Living Mice by a Robust Fluorescent Probe

Yin, J., Peng, M., & Lin, W. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b01293 · Cited by 189

Sex differences in inflammation, redox biology, mitochondria and autoimmunity

Di Florio, D. N., Sin, J., Coronado, M. J., Atwal, P. S., & Fairweather, D. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101482 · Cited by 185

The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway

Hu, Q., Ren, J., Li, G., Wu, J., Wu, X., Wang, G., Gu, G., Ren, H., Hong, Z., & Li, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0436-x · Cited by 183

Mass extinctions, biodiversity and mitochondrial function: are bats ‘special’ as reservoirs for emerging viruses?

Wang, L., Walker, P. J., & Poon, L. L. M. (2011) · Current Opinion in Virology · doi:10.1016/j.coviro.2011.10.013 · Cited by 193

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes

Hess, C., & Kemper, C. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.003 · Cited by 182

Viral strategies for triggering and manipulating mitophagy

Zhang, L., Qin, Y., & Chen, M. (2018) · Autophagy · doi:10.1080/15548627.2018.1466014 · Cited by 175

The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent

Wiens, K. E., & Ernst, J. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005809 · Cited by 176

Antioxidative nanomaterials and biomedical applications

Liu, Y., & Shi, J. (2019) · Nano Today · doi:10.1016/j.nantod.2019.05.008 · Cited by 174

Toxoplasma Effector MAF1 Mediates Recruitment of Host Mitochondria and Impacts the Host Response

Pernas, L. F., Adomako‐Ankomah, Y., Shastri, A. J., Ewald, S. E., Treeck, M., Boyle, J. P., & Boothroyd, J. C. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001845 · Cited by 183

Mitochondrial function, ornamentation, and immunocompetence

Koch, R. E., Josefson, C. C., & Hill, G. E. (2016) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12291 · Cited by 176

Molecular regulation of neuroinflammation in glaucoma: Current knowledge and the ongoing search for new treatment targets

Tezel, G. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100998 · Cited by 175

Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model

Naviaux, R. K., Zolkipli‐Cunningham, Z., Wang, L., Nakayama, T., Naviaux, J. C., Le, T., Schuchbauer, M. A., Rogač, M., Tang, Q., Dugan, L. L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057380 · Cited by 171

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1β and IL-18 and Arrests CKD

Szeto, H. H., Liu, S., Soong, Y., Seshan, S. V., Cohen‐Gould, L., Manichev, V., Feldman, L. C., & Gustafsson, T. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016070761 · Cited by 171

Mitochondria as Molecular Platforms Integrating Multiple Innate Immune Signalings

Monlun, M., Hyernard, C., Blanco, P., Lartigue, L., & Faustin, B. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.10.028 · Cited by 88

Mitochondria, Oxidative Stress and Innate Immunity

Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315

Mitochondria in innate immune signaling

Banoth, B., & Cassel, S. L. (2018) · Translational Research · doi:10.1016/j.trsl.2018.07.014 · Cited by 410

Mitochondrial reactive zones in antiviral innate immunity

Yasukawa, K., & Koshiba, T. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129839 · Cited by 19

Mitochondria as a centrally positioned hub in the innate immune response

Sandhir, R., Halder, A., & Sunkaria, A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.020 · Cited by 135