Cited by 1,376Immune Response and InflammationMitochondrial Function and PathologyInflammasome and immune disorders

The DOI matches its Crossref record; 102 of the 103 references it cites were found in a registry or an index.

Mitochondria in innate immune responses

Open access

West, A. Phillip, Shadel, Gerald S., Ghosh, Sankar·2011·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri2975

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442

Flagged first, then by citations

Show all 103 references

1 of the 103 references couldn’t be matched to a known paper.

Sorted by citations

Items 101–200 of 1,000

Increased Drp1 promotes autophagy and ESCC progression by mtDNA stress mediated cGAS-STING pathway
Li, Y., Chen, H., Yang, Q., Wan, L., Zhao, J., Wu, Y., Wang, J., Yang, Y., Niu, M., Liu, H., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02262-z · Cited by 175
Mitochondrial DNA in the regulation of innate immune responses
Fang, C., Wei, X., & Wei, Y. (2015) · Protein & Cell · doi:10.1007/s13238-015-0222-9 · Cited by 174
Advances in the understanding of mitochondrial DNA as a pathogenic factor in inflammatory diseases
Boyapati, R. K., Tamborska, A., Dorward, D. A., & Ho, G. (2017) · F1000Research · doi:10.12688/f1000research.10397.1 · Cited by 170
Oxidative Stress Response in Pseudomonas aeruginosa
Nizer, W. S. D. C., Inkovskiy, V., Versey, Z., Strempel, N., Cassol, E., & Overhage, J. (2021) · Pathogens · doi:10.3390/pathogens10091187 · Cited by 179
Positive and purifying selection in mitochondrial genomes of a bird with mitonuclear discordance
Morales, H. E., Pavlova, A., Joseph, L., & Sunnucks, P. (2015) · Molecular Ecology · doi:10.1111/mec.13203 · Cited by 169
Defective mitochondrial fission augments NLRP3 inflammasome activation
Park, S., Won, J.-H., Hwang, I., Hong, S., Lee, H. K., & Yu, J. (2015) · Scientific Reports · doi:10.1038/srep15489 · Cited by 169
Short‐Chain Fatty Acids Induce Pro‐Inflammatory Cytokine Production Alone and in Combination with Toll‐Like Receptor Ligands
Mirmonsef, P., Zariffard, M. R., Gilbert, D. Z., Makinde, H. M., LANDAY, A. L., & Spear, G. T. (2011) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2011.01089.x · Cited by 165
Mitochondrial pathology: stress signals from the energy factory
Raimundo, N. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.005 · Cited by 165
Mitochondrial DNA in extracellular vesicles declines with age
Lazo, S., Hooten, N. N., Green, J., Eitan, E., Mode, N. A., Liu, Q., Zonderman, A. B., Ezike, N., Mattson, M. P., Ghosh, P., et al. (2020) · Aging Cell · doi:10.1111/acel.13283 · Cited by 163
Mitochondrial DNA as an inflammatory mediator in cardiovascular diseases
Nakayama, H., & Otsu, K. (2018) · Biochemical Journal · doi:10.1042/bcj20170714 · Cited by 160
Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy
Escoll, P., Mondino, S., Rolando, M., & Buchrieser, C. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2015.1 · Cited by 168
Mitochondrial STAT3 exacerbates LPS-induced sepsis by driving CPT1a-mediated fatty acid oxidation
Li, R., Li, X., Zhao, J., Meng, F., Yao, C., Bao, E.-S., Sun, N., Chen, X., Cheng, W., Hua, H. M., et al. (2021) · Theranostics · doi:10.7150/thno.63751 · Cited by 159
Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells
Szczęsny, B., Marcatti, M., Ahmad, A., Montalbano, M., Brunyánszki, A., Bibli, S., Papapetropoulos, A., & Szabó, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-19216-1 · Cited by 155
Roles of reactive oxygen species in cell signaling pathways and immune responses to viral infections
Li, Z., Xu, X., Leng, X., He, M., Wang, J., Cheng, S., & Wu, H. (2016) · Archives of Virology · doi:10.1007/s00705-016-3130-2 · Cited by 154
Mitochondrial cristae architecture protects against mtDNA release and inflammation
He, B., Yu, H., Liu, S., Wan, H., Fu, S., Liu, S., Yang, J. J., Zhang, Z., Huang, H., Li, Q., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111774 · Cited by 157
Histone Deacetylase 3 Couples Mitochondria to Drive IL-1β-Dependent Inflammation by Configuring Fatty Acid Oxidation
Chi, Z., Chen, S., Xu, T., Zhen, W., Yu, W., Jiang, D., Guo, X., Wang, Z., Zhang, K., Li, M., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.08.015 · Cited by 156
Mitochondrial DNA drives noncanonical inflammation activation via cGAS–STING signaling pathway in retinal microvascular endothelial cells
Guo, Y., Gu, R., Gan, D., Hu, F., Li, G., & Xu, G. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00637-3 · Cited by 155
Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability
Gao, Z., Li, Y., Wang, F., Huang, T., Fan, K.-Q., Zhang, Y., Zhong, J.-Y., Cao, Q., Tong, C., Jia, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01919-0 · Cited by 149
Mitochondrial DNA stress signalling protects the nuclear genome
Wu, Z., Oeck, S., West, A. P., Mangalhara, K. C., Sainz, A. G., Newman, L. E., Zhang, X.-O., Wu, L., Yan, Q., Bosenberg, M., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0150-8 · Cited by 147
Self-citation
Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling
Kang, Y. J., Bang, B., Han, K. H., Hong, L., Shim, E.-J., Ma, J., Lerner, R. A., & Otsuka, M. (2015) · Nature Communications · doi:10.1038/ncomms9371 · Cited by 146
Macroautophagy in CNS health and disease
Griffey, C. J., & Yamamoto, A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00588-3 · Cited by 147
Mitochondrial Dysfunction and Immune Activation are Detectable in Early Alzheimer's Disease Blood
Lunnon, K., Ibrahim, Z. M., Proitsi, P., Lourdusamy, A., Newhouse, S., Sattlecker, M., Furney, S. J., Saleem, M., Soininen, H. S., Kłoszewska, I., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111592 · Cited by 145
Molecular Mechanisms Responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide
Maitra, U., Deng, H., Glaros, T., Baker, B., Capelluto, D. G. S., Li, Z., & Li, L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200857 · Cited by 151
TiO2 nanoparticles cause mitochondrial dysfunction, activate inflammatory responses, and attenuate phagocytosis in macrophages: A proteomic and metabolomic insight
Chen, Q., Wang, N., Zhu, M., Lu, J., Zhong, H., Xue, X., Guo, S., Li, M., Wei, X., Tao, Y., et al. (2017) · Redox Biology · doi:10.1016/j.redox.2017.12.011 · Cited by 143
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
Yang, L., Youngblood, H. A., Wu, C., & Zhang, Q. (2020) · Translational Neurodegeneration · doi:10.1186/s40035-020-00197-z · Cited by 147
Fatty acid oxidation is dispensable for human macrophage IL-4-induced polarization
Namgaladze, D., & Brüne, B. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.06.007 · Cited by 142
The mitochondrial unfolded protein response: Signaling from the powerhouse
Qureshi, M. A., Haynes, C. M., & Pellegrino, M. W. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.791061 · Cited by 149
ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders
Gambardella, S., Limanaqi, F., Ferese, R., Biagioni, F., Campopiano, R., Centonze, D., & Fornai, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01064 · Cited by 141
Sequential Actions of SIRT1-RELB-SIRT3 Coordinate Nuclear-Mitochondrial Communication during Immunometabolic Adaptation to Acute Inflammation and Sepsis
Liu, T. F., Vachharajani, V., Millet, P., Bharadwaj, M. S., Molina, A. J. A., & McCall, C. E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.566349 · Cited by 145
Nanocatalytic Innate Immunity Activation by Mitochondrial DNA Oxidative Damage for Tumor‐Specific Therapy
Jiang, H., Guo, Y., Wei, C., Hu, P., & Shi, J. (2021) · Advanced Materials · doi:10.1002/adma.202008065 · Cited by 141
Precise modulation and use of reactive oxygen species for immunotherapy
Li, X., Gao, J., Wu, C., Wang, C., Zhang, R., He, J., Xia, Z. J., Joshi, N., Karp, J. M., & Kuai, R. (2024) · Science Advances · doi:10.1126/sciadv.adl0479 · Cited by 140
Oxidative Shielding or Oxidative Stress?
Naviaux, R. K. (2012) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.192120 · Cited by 141
Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins
Yu, C.-Y., Liang, J., Li, J., Lee, Y.-L., Chang, B.-L., Su, C.-I., Huang, W.-J., Lai, M. M. C., & Lin, Y. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005350 · Cited by 138
Mitochondria as a centrally positioned hub in the innate immune response
Sandhir, R., Halder, A., & Sunkaria, A. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.020 · Cited by 135
Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay
Lionaki, E., Markaki, M., Palikaras, K., & Tavernarakis, N. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.04.010 · Cited by 137
Isolated Mitochondria Transfer Improves Neuronal Differentiation of Schizophrenia-Derived Induced Pluripotent Stem Cells and Rescues Deficits in a Rat Model of the Disorder
Robicsek, O., Ene, H. M., Karry, R., Ytzhaki, O., Asor, E., McPhie, D. L., Cohen, B. M., Ben-Yehuda, R., Weiner, I., & Ben‐Shachar, D. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx077 · Cited by 135
Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock
Riché, F. C., Gayat, É., Barthélémy, R., Dorze, M. L., Matéo, J., & Payen, D. M. (2015) · Critical Care · doi:10.1186/s13054-015-1144-x · Cited by 134
Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
Moreno‐Altamirano, M. M. B., Kolstoe, S. E., & Sánchez-García, F. J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00095 · Cited by 136
Crosstalk between mitochondrial (dys)function and mitochondrial abundance
Michel, S., Wanet, A., Pauw, A. D., Rommelaere, G., Arnould, T., & Renard, P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.23021 · Cited by 138
Mitochondrial-mediated antiviral immunity
Koshiba, T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.03.005 · Cited by 134
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Lei, Y., Martinez, C. G., Torres-Odio, S., Bell, S. L., Birdwell, C. E., Bryant, J. D., Tong, C. W.-C., Watson, R. O., West, L. C., & West, A. P. (2021) · Science Advances · doi:10.1126/sciadv.abe7548 · Cited by 132
Self-citation
TRIM14 is a mitochondrial adaptor that facilitates retinoic acid-inducible gene-I–like receptor-mediated innate immune response
Zhou, Z. L., Jia, X., Xue, Q., Dou, Z., Ma, Y., Zhao, Z., Jiang, Z., He, B., Jin, Q., & Wang, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316941111 · Cited by 130
Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks
Anderson, A. J., Jackson, T. D., Stroud, D. A., & Stojanovski, D. (2019) · Open Biology · doi:10.1098/rsob.190126 · Cited by 138
Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS
Wang, Y., Yuan, S., Jia, X., Ge, Y., Ling, T., Nie, M., Lan, X., Chen, S., & Xu, A. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0416-0 · Cited by 131
Mitochondria-targeted paraquat and metformin mediate ROS production to induce multiple pathways of retrograde signaling: A dose-dependent phenomenon
Chowdhury, A. R., Zielonka, J., Kalyanaraman, B., Hartley, R. C., Murphy, M. P., & Avadhani, N. G. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101606 · Cited by 129
Mitophagy-related regulated cell death: molecular mechanisms and disease implications
Yang, M., Wei, X., Yi, X., & Jiang, D. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06804-5 · Cited by 132
Maintenance of redox homeostasis by hypoxia-inducible factors
Samanta, D., & Semenza, G. L. (2017) · Redox Biology · doi:10.1016/j.redox.2017.05.022 · Cited by 127
“ROS signaling plays a critical role in cells of the innate and adaptive immune systems [8,9].”
Background
Cellular Respiration: The Nexus of Stress, Condition, and Ornamentation
Hill, G. E. (2014) · Integrative and Comparative Biology · doi:10.1093/icb/icu029 · Cited by 130
The role of Nox2-derived ROS in the development of cognitive impairment after sepsis
Hernandes, M. S., d’Avila, J. C., Trevelin, S. C., Reis, P. A., Kinjo, É. R., Lopes, L. R., Castro-Faria-Neto, H. C., Cunha, F. Q., Britto, L. R. G., & Bozza, F. A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-36 · Cited by 129
IFN-β-induced reactive oxygen species and mitochondrial damage contribute to muscle impairment and inflammation maintenance in dermatomyositis
Meyer, A., LAVERNY, G., Allenbach, Y., Grelet, É., Ueberschlag-Pitiot, V., Echaniz‐Laguna, A., Lannes, B., Alsaleh, G., Charles, A. L., Singh, F., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1731-9 · Cited by 127
Biomarkers of mitochondrial dysfunction in autism spectrum disorder: A systematic review and meta-analysis
Frye, R. E., Rincon, N., McCarty, P. J., Brister, D., Scheck, A. C., & Rossignol, D. A. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106520 · Cited by 132
Design of Activatable NIR-II Molecular Probe for In Vivo Elucidation of Disease-Related Viscosity Variations
Dou, K., Huang, W., Xiang, Y., Li, S., & Liu, Z. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c00634 · Cited by 126
Platelets release mitochondrial antigens in systemic lupus erythematosus
Melki, I., Allaeys, I., Tessandier, N., Lévesque, T., Cloutier, N., Laroche, A., Vernoux, N., Becker, Y., Benk-Fortin, H., Zufferey, A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aav5928 · Cited by 125
Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction
Pollara, J., Edwards, R. W., Lin, L., Bendersky, V. A., & Brennan, T. V. (2018) · JCI Insight · doi:10.1172/jci.insight.121622 · Cited by 125
Cuproptotic nanoinducer-driven proteotoxic stress potentiates cancer immunotherapy by activating the mtDNA–cGAS–STING signaling
Yu, X., Li, B., Yan, J., Li, W., Tian, H., Wang, G., Zhou, S., & Dai, Y. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122512 · Cited by 125
Lipoprotein lipase maintains microglial innate immunity in obesity.
Gao, Y., Vidal-Itriago, A., Kalsbeek, M. J., Layritz, C., García-Cáceres, C., Tom, R. Z., Eichmann, T. O., Vaz, F. M., Houtkooper, R. H., van der Wel, N., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.008 · Cited by 123
Regulation of RIG-I-like receptor signaling by host and viral proteins
Chiang, J. J., Davis-Gardner, M. E., & Gack, M. U. (2014) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2014.06.005 · Cited by 122
Mitochondrial Dysfunction in Lung Pathogenesis
Piantadosi, C. A., & Suliman, H. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034322 · Cited by 124
Post-COVID-19 Syndrome
Pierce, J. D., Shen, Q., Cintron, S. A., & Hiebert, J. B. (2021) · Nursing Research · doi:10.1097/nnr.0000000000000565 · Cited by 122
Failure of innate and adaptive immune responses in controlling hepatitis C virus infection
Thimme, R., Binder, M., & Bartenschlager, R. F. W. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00319.x · Cited by 128
Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling
Cox, C. S., McKay, S. E., Holmbeck, M. A., Christian, B. E., Scortea, A. C., Tsay, A. J., Newman, L. E., & Shadel, G. S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.011 · Cited by 121
Self-citation
The Role of the NLRP3 Inflammasome in Fibrosis
Artlett, C. M. (2012) · The Open Rheumatology Journal · doi:10.2174/1874312901206010080 · Cited by 122
Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease
Fairley, L. H., Wong, J. H., & Barron, A. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.624538 · Cited by 120
The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model
Dare, A. J., Logan, A., Prime, T. A., Rogatti, S., Goddard, M., Bolton, E. M., Bradley, J. A., Pettigrew, G. J., Murphy, M. P., & Saeb-Parsy, K. (2015) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2015.05.007 · Cited by 119
Structure–Property Correlations of Reactive Oxygen Species-Responsive and Hydrogen Peroxide-Eliminating Materials with Anti-Oxidant and Anti-Inflammatory Activities
Zhang, Q., Zhang, F., Chen, Y., Dou, Y., Tao, H., Zhang, D., Wang, R., Li, X., & Zhang, J. (2017) · Chemistry of Materials · doi:10.1021/acs.chemmater.7b02412 · Cited by 118
3D melatonin nerve scaffold reduces oxidative stress and inflammation and increases autophagy in peripheral nerve regeneration
Qian, Y., Han, Q., Zhao, X., Song, J., Cheng, Y. G., Fang, Z., Ouyang, Y., Yuan, W., & Fan, C. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12516 · Cited by 117
RNA helicase DDX3: at the crossroad of viral replication and antiviral immunity
Valiente‐Echeverría, F., Hermoso, M. A., & Soto‐Rifo, R. (2015) · Reviews in Medical Virology · doi:10.1002/rmv.1845 · Cited by 119
Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss
Kalinec, G. M., Lomberk, G. A., Urrutia, R. A., & Kalinec, F. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00192 · Cited by 117
The Yeast Retrograde Response as a Model of Intracellular Signaling of Mitochondrial Dysfunction
Jazwinski, S. M., & Kriete, A. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00139 · Cited by 119
Role of Metabolic Reprogramming in Pulmonary Innate Immunity and Its Impact on Lung Diseases
Michaeloudes, C., Bhavsar, P. K., Mumby, S. E., Xu, B., Hui, C., Chung, K. F., & Adcock, I. M. (2019) · Journal of Innate Immunity · doi:10.1159/000504344 · Cited by 115
The sensing of mitochondrial DAMPs by non-immune cells
Rodríguez‐Nuevo, A., & Antonio Zorzano, A. (2019) · Cell Stress · doi:10.15698/cst2019.06.190 · Cited by 119
Role of Mitochondria in Viral Infections
Elesela, S., & Lukacs, N. W. (2021) · Life · doi:10.3390/life11030232 · Cited by 113
Reactive Oxygen Species: The 2-Edged Sword of Osteoarthritis
Ding, L., Wang, W., & Xie, G. (2012) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3182579dc6 · Cited by 114
Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial
Naviaux, R. K., Curtis, B., Li, K., Naviaux, J. C., Bright, A. T., Reiner, G., Westerfield, M., Goh, S., Alaynick, W. A., Wang, L., et al. (2017) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.424 · Cited by 113
Formation and repair of oxidative damage in the mitochondrial DNA
Müftüoğlu, M., Mori, M. P., & de Souza-Pinto, N. C. (2014) · Mitochondrion · doi:10.1016/j.mito.2014.03.007 · Cited by 118
Immunologically augmented cancer treatment using modern radiotherapy
Durante, M., Reppingen, N., & Held, K. D. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.05.007 · Cited by 113
Oxidative responses and fungal infection biology
Warris, A., & Ballou, E. R. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.03.004 · Cited by 114
MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
Ho, G., Aird, R. E., Liu, B., Boyapati, R. K., Kennedy, N. A., Dorward, D. A., Noble, C. L., Shimizu, T., Carter, R. N., Chew, E., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.31 · Cited by 113
Innate immunity and tolerance toward mitochondria
Rongvaux, A. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.10.007 · Cited by 115
Effect of Resin-based and Bioceramic Root Canal Sealers on Postoperative Pain: A Split-mouth Randomized Controlled Trial
Graunaitė, I., Skučaitė, N., Lodienė, G., Agentiene, I., & Mačhiulskienė, V. (2018) · Journal of Endodontics · doi:10.1016/j.joen.2018.02.010 · Cited by 109
NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies
Balistreri, C. R., Candore, G., Accardi, G., Colonna‐Romano, G., & Lio, D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-24 · Cited by 111
Mitochondria: In the Cross Fire of SARS-CoV-2 and Immunity
Burtscher, J., Cappellano, G., Omori, A., Koshiba, T., & Millet, G. P. (2020) · iScience · doi:10.1016/j.isci.2020.101631 · Cited by 110
Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularization
Dong, X., Wu, P., Yan, L., Liu, K., Wei, W., Cheng, Q., Liang, X., Chen, Y., & Dai, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121288 · Cited by 107
Pathophysiology of autism spectrum disorders: Revisiting gastrointestinal involvement and immune imbalance
Samsam, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.9942 · Cited by 113
MAVS Promotes Inflammasome Activation by Targeting ASC for K63-Linked Ubiquitination via the E3 Ligase TRAF3
Guan, K., Wei, C., Zheng, Z., Song, T., Wu, F., Zhang, Y., Cao, Y., Ma, S., Chen, W., Xu, Q., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402851 · Cited by 111
The role of mitochondrial ROS in antibacterial immunity
Pinegin, B. V., Vorobjeva, N. V., Pashenkov, M. V., & Chernyak, B. V. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26117 · Cited by 108
Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape
Salminen, A., Haapasalo, A., Kauppinen, A., Kaarniranta, K., Soininen, H. S., & Hiltunen, M. O. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.05.001 · Cited by 107
Immunometabolism in Tuberculosis
Shi, L., Eugenín, E. A., & Subbian, S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00150 · Cited by 108
Mitochondrial function and abnormalities implicated in the pathogenesis of ASD
Castora, F. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.12.015 · Cited by 107
Degraded Mitochondrial DNA is a Newly Identified Subtype of the Damage Associated Molecular Pattern (DAMP) Family and Possible Trigger of Neurodegeneration
Mathew, A. J., Lindsley, T. A., Sheridan, A., Bhoiwala, D. L., Hushmendy, S. F., Yager, E. J., Ruggiero, E. A., & Crawford, D. R. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120145 · Cited by 111
Vibrio cholerae T3SS Effector VopE Modulates Mitochondrial Dynamics and Innate Immune Signaling by Targeting Miro GTPases
Suzuki, M., Danilchanka, O., & Mekalanos, J. J. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.09.015 · Cited by 106
Co-delivery of Dihydroartemisinin and Pyropheophorbide-Iron Elicits Ferroptosis to Potentiate Cancer Immunotherapy
Han, W., Duan, X., Ni, K., Li, Y., Chan, C., & Lin, W. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121315 · Cited by 103
MitochondriaPreprint
Chandel, N. S. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a040543 · Cited by 109
Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio)
Liang, X., Adamovský, O., Souders, C. L., & Martyniuk, C. J. (2018) · Environmental Pollution · doi:10.1016/j.envpol.2018.10.130 · Cited by 102
Mitochondrial Fission Mediates Endothelial Inflammation
Forrester, S. J., Preston, K. J., Cooper, H. A., Boyer, M. J., Escoto, K. M., Poltronetti, A. J., Elliott, K. J., Kuroda, R., Miyao, M., Sesaki, H., et al. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14686 · Cited by 104
Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing Viscosity in Drug-Induced Cells and a Fatty Liver Mouse Model
Wu, Y., Yin, C., Zhang, W., Zhang, Y., & Huo, F. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c05288 · Cited by 102
The Cumulus Cell Layer Protects the Bovine Maturing Oocyte Against Fatty Acid-Induced Lipotoxicity1
Lolicato, F., Brouwers, J. F. H. M., van de Lest, C. H. A., Wubbolts, R., Aardema, H., Priore, P., Roelen, B. A. J., Helms, J. B., & Gadella, B. M. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.114.120634 · Cited by 102
Does PGC1α/FNDC5/BDNF Elicit the Beneficial Effects of Exercise on Neurodegenerative Disorders?
Jodeiri Farshbaf, M., Ghaedi, K., Megraw, T. L., Curtiss, J., Shirani Faradonbeh, M., Vaziri, P., & Nasr-Esfahani, M. H. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8370-x · Cited by 101
Mitofusins deficiency elicits mitochondrial metabolic reprogramming to pluripotency
Son, M. J., Kwon, Y., Son, M.-Y., Seol, B., Choi, H.-S., Ryu, S.-W., Choi, C., & Cho, Y. S. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.43 · Cited by 99
Free radical as a double-edged sword in disease: Deriving strategic opportunities for nanotherapeutics
Zhu, L., Luo, M., Zhang, Y., Fang, F., Li, M., An, F., Zhao, D., & Zhang, J. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214875 · Cited by 100

Authors: West, A. P., Shadel, G. S., & Ghosh, S.
Affiliations: Yale University (US)
Columbia University (US)
Corresponding author: Ghosh, Sankar
ORCID: West, A. Phillip
Shadel, Gerald S.
Ghosh, Sankar
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-05-20
Volume: 11
Issue: 6
Pages: 389-402
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2975
PMC: PMC4281487
OpenAlex: W2033448006
Cited by: 1,376
References: 103
Citations by year: 2026: 119 · 2025: 78 · 2024: 103 · 2023: 97 · 2022: 102 · 2021: 129 · 2020: 101 · 2019: 83 · 2018: 85 · 2017: 109 · 2016: 95 · 2015: 97 · 2014: 75 · 2013: 46 · 2012: 44
FWCI: 5.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (R37 AI33443, R37AI033443)
National Institute of Environmental Health Sciences (ES‑011)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords: mitochondria, innate immunity, antiviral signaling, reactive oxygen species, antibacterial immunity, sterile inflammation, programmed cell death, cellular metabolism
MeSH terms: Animals, Bacterial Infections, Humans, Immunity, Innate, Mitochondria, Virus Diseases, Signal Transduction, Reactive Oxygen Species, Models, Immunological, Mitochondrial Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mitochondria in innate immune responses

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks