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Mitochondria in innate immune responses
Open accessAbstract
The innate immune system has a key role in the mammalian immune response. Recent research has demonstrated that mitochondria participate in a broad range of innate immune pathways, functioning as signalling platforms and contributing to effector responses. In addition to regulating antiviral signalling, mounting evidence suggests that mitochondria facilitate antibacterial immunity by generating reactive oxygen species and contribute to innate immune activation following cellular damage and stress. Therefore, in addition to their well-appreciated roles in cellular metabolism and programmed cell death, mitochondria appear to function as centrally positioned hubs in the innate immune system. Here, we review the emerging knowledge about the roles of mitochondria in innate immunity.
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“Cardiolipin, N-formylated peptides, mtDNA, ATP and reactive oxygen species are known mitochondrial damage-associated molecular patterns (9, 28–30).”
From Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA (2019) · cites this paper as [29]
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“Mitochondria and their components (e.g. N-formylated peptides and mtDNA) are recognized as damage-associated molecular patterns (DAMPs), which activate the innate immune system and elicit an inflammatory response6,21–23.”
From Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations (2019) · cites this paper as [22]
In the citing paper
“The enzyme family of NADPH oxidases (Nox) [13,83] and the respiratory electron transport chain (ETC) of mitochondria [84,85,86] are the two major sources of ROS in many eukaryotic cells.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [84]
In the citing paper
“Complex I produces O2●− into the mitochondrial matrix where it is dismutated by SOD2 to H2O2 [67,84,85,86].”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [84]
In the citing paper
“Mitochondria-derived ROS (mtROS) are mainly produced by complexes I and III as O2●−.”
From Functions of ROS in Macrophages and Antimicrobial Immunity (2021) · cites this paper as [84]
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Cites
How mitochondria produce reactive oxygen species
Murphy, M. P. (2009) · Biochemical Journal · doi:10.1042/bj20081386 · Cited by 8,207
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., & Hauser, C. J. (2010) · Nature · doi:10.1038/nature08780 · Cited by 3,812
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051
Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442
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Items 501–600 of 1,000
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Bao, X., Kolli, D., Ren, J., Liu, T., Garofalo, R. P., & Casola, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062568 · Cited by 40
Intracellular Redox State as Target for Anti-Influenza Therapy: Are Antioxidants Always Effective?
Sgarbanti, R., Amatore, D., Celestino, I., Marcocci, M. E., Fraternale, A., Ciriolo, M. R., Magnani, M., Saladino, R., Garaci, E., Palamara, A. T., et al. (2014) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026614666141203125211 · Cited by 40
Zhong, J., Xu, C., Gabbay‐Benziv, R., Lin, X., & Yang, P. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.030 · Cited by 40
Zheng, J., Wang, C., Chang, M. R., Devarkar, S. C., Schweibenz, B., Crynen, G. C., Garcia-Ordoñez, R. D., Pascal, B. D., Novick, S. J., Patel, S. S., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07780-z · Cited by 40
Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration?
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Mitochondrial DNA: A Key Regulator of Anti-Microbial Innate Immunity
Kausar, S., Yang, L., Abbas, M. N., Hu, X., Zhao, Y., Zhu, Y., & Cui, H. (2020) · Genes · doi:10.3390/genes11010086 · Cited by 40
Zhou, L., Yao, M., Tian, Z., Song, Y.-J., Sun, Y., Ye, J., Li, G., Sng, K. S., Xu, L., Cui, X., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.014 · Cited by 40
Salminen, T. S., & Vale, P. F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00521 · Cited by 46
Cheng, J., Zhang, J., Yang, J., Yi, B., Liu, G., Zhou, M., Kastelic, J. P., Han, B., & Gao, J. (2021) · Veterinary Research · doi:10.1186/s13567-021-00898-x · Cited by 40
Ahmadi, H., Csabai, T. J., Görgey, É., Rashidiani, S., Parhizkar, F., & Maleki, L. A. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113065 · Cited by 43
IFN-ε protects primary macrophages against HIV infection
Tasker, C., Subbian, S., Gao, P., Couret, J., Levine, C., Ghanny, S., Soteropoulos, P., Zhao, X., Landau, N. R., Lu, W., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.88255 · Cited by 42
The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target
Yang, S., & Yang, X. (2025) · Immunity Inflammation and Disease · doi:10.1002/iid3.70301 · Cited by 40
Ability of Escherichia coli to produce hemolysis leads to a greater pathogenic effect on human sperm
Boguen, R. E., Treulen, F., Uribe, P., & Villegas, J. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.01.044 · Cited by 39
Schmoch, T., Uhle, F., Siegler, B. H., Fleming, T., Morgenstern, J., Nawroth, P. P., Weigand, M. A., & Brenner, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030657 · Cited by 39
Jie, C., Luo, Z., Chen, H., Wang, M., Yan, C., Mao, Z., Xiao, G., Kurihara, H., Li, Y.-F., & He, R. (2017) · Oncotarget · doi:10.18632/oncotarget.22350 · Cited by 40
Immunometabolism in the pathogenesis of systemic lupus erythematosus
Zhang, C., Wang, H., Yin, L., Mao, Y., & Zhou, W. (2020) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2020.100046 · Cited by 41
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Mostowy, S., & Cossart, P. (2012) · Advances in immunology · doi:10.1016/b978-0-12-394590-7.00007-5 · Cited by 40
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Martins, I. (2014) · Journal of Molecular and Genetic Medicine · doi:10.4172/1747-0862.1000162 · Cited by 38
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Lu, C., & MacDougall, M. J. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00118 · Cited by 38
Silva, J., Aivio, S., Knobel, P. A., Bailey, L. J., Casali, A., Vinaixa, M., Garcı́a-Cao, I., Coyaud, É., Jourdain, A. A., Pérez-Ferreros, P., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-017-0016-9 · Cited by 43
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Kim, Y., Kumar, A., Chang, C., & Pyaram, K. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700567 · Cited by 39
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Guo, W., Chen, Z., Li, Z., Huang, H., Ren, Y., Zhao, B., Li, G., & Hu, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.136428 · Cited by 38
Tomar, D., Prajapati, P., Lavie, J., Singh, K., Sripada, L., Bhatelia, K., Roy, M., Singh, R. K., Bénard, G., & Singh, R. K. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.10.425 · Cited by 39
Kim, S.-J., Kim, M., Park, D., Chung, H. J., Kim, C., Yoon, J., & Kim, H. J. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.04.011 · Cited by 38
Rehman, A., Kumari, R., Kamthan, A., Tiwari, R. R., Srivastava, R. K., van der Westhuizen, F. H., & Mishra, P. K. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.12.083 · Cited by 37
Zhu, M., Lv, J., Wang, W., Guo, R., Zhong, C., Antia, A., Zeng, Q., Li, J., Liu, Q., Zhou, J., et al. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002039 · Cited by 39
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Ding, L., & Liu, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160510870 · Cited by 37
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Chen, S., Sheng, C., Liu, D., Yao, C., Gao, S., Song, L., Jiang, W., Li, J., & Huang, W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203143 · Cited by 37
Blank, M. L., Xia, J., Morcos, M. M., Sun, M., Cantrell, P. S., Liu, Y., Zeng, X., Powell, C. J., Yates, N. A., Boulanger, M. J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2013336118 · Cited by 38
Zhang, Y., Wang, S., Wang, X., Zan, Q., Yu, X. Q., Fan, L., & Dong, C. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03335-2 · Cited by 38
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Li, B., Wan, Z., Wang, Z., Zuo, J., Xu, Y., Han, X., Phouthapane, V., & Miao, J. (2020) · Cells · doi:10.3390/cells9020494 · Cited by 36
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Giulivi, C., Napoli, E., Schwartzer, J. J., Careaga, M., & Ashwood, P. (2013) · Mediators of Inflammation · doi:10.1155/2013/609602 · Cited by 36
Peterson, B. F., & Scharf, M. E. (2016) · BMC Genomics · doi:10.1186/s12864-016-3126-z · Cited by 36
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Li, H., Yang, X., Song, Y., Zhu, Q., Liao, Z., Liang, Y., Guo, J., Wan, B., & Bao, D. (2023) · Veterinary Microbiology · doi:10.1016/j.vetmic.2023.109673 · Cited by 35
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Tailor, A., Faulkner, L., Naisbitt, D. J., & Park, B. K. (2015) · Human & Experimental Toxicology · doi:10.1177/0960327115606529 · Cited by 35
Sivapathasuntharam, C., Hayes, M. J., Shinhmar, H., Kam, J. H., Sivaprasad, S., & Jeffery, G. (2019) · Scientific Reports · doi:10.1038/s41598-018-37673-6 · Cited by 35
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Rahman, M. A., Akter, S., Ohsaki, E., & Ueda, K. (2020) · Viruses · doi:10.3390/v12020175 · Cited by 35
Mohamud, Y., Li, B., Bahreyni, A., & Luo, H. (2023) · Viruses · doi:10.3390/v15020351 · Cited by 37
Mitochondrial metabolism, reactive oxygen species, and macrophage function-fishing for insights
Hall, C. J., Sanderson, L. E., Crosier, K. E., & Crosier, P. S. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1186-6 · Cited by 37
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Jain, M., & Chandel, N. S. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201307-1380cp · Cited by 35
Caicedo, A., Zambrano, K., Sanon, S., & Gavilanes, A. W. D. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.02.006 · Cited by 34
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Zhang, M., Zhang, Y., Peng, J., Huang, Y., Gong, Z., Lu, H., Han, L., & Wang, D. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113012 · Cited by 34
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Wang, J.-T., Xu, X., Alontaga, A. Y., Chen, Y., & Liu, Y. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.037 · Cited by 36
Sasaki, O., Yoshizumi, T., Kuboyama, M., Ishihara, T., Suzuki, E., Kawabata, S.-I., & Koshiba, T. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.01.010 · Cited by 34
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Napoli, E., Song, G., Schneider, A., Hagerman, R. J., Eldeeb, M. A. A. A., Azarang, A., Tassone, F., & Giulivi, C. (2016) · The FASEB Journal · doi:10.1096/fj.201600315r · Cited by 34
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Khan, S., Raj, D., Jaiswal, K., & Lahiri, A. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.05.005 · Cited by 35
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Weis, S., & Velthuis, A. J. W. T. (2021) · Viruses · doi:10.3390/v13050780 · Cited by 34
Valdés-Aguayo, J. J., Veloz, I. G., Badillo-Almaraz, J. I., Bernal‐Silva, S., Martínez-Vázquez, M. C., Juárez-Alcalá, V., Vargas-Rodríguez, J. R., Gaeta-Velasco, M. L., González-Fuentes, C., Ávila-Carrasco, L., et al. (2021) · Medicina · doi:10.3390/medicina57090928 · Cited by 37
Fu, P., Epshtein, Y., Ramchandran, R., Mascarenhas, J. B., Cress, A. E., Jacobson, J. R., Garcia, J. G. N., & Natarajan, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-97006-y · Cited by 34
Bioactive compounds for neuropathic pain: An update on preclinical studies and future perspectives
Shen, C., Castro, L. F., Fang, C.-Y., Castro, M., Sherali, S., White, S., Wang, R., & Neugebauer, V. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108979 · Cited by 34
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Dobson, G. P., Morris, J. L., & Letson, H. L. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.990903 · Cited by 34
MicroRNAs: New therapeutic targets for intestinal barrier dysfunction
Zhang, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i19.5818 · Cited by 34
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Gao, F., Zhao, Y., Shi, X., Qiao, D., Pei, C., & Kong, X. (2024) · Reviews in Aquaculture · doi:10.1111/raq.12895 · Cited by 34
Waseem, M., Imtiaz, A., Alexander, A., Graham, L. V. D., & Contreras-Galindo, R. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102812 · Cited by 35
Deng, X., Zhang, Z., Ren, T., & Chen, L. (2025) · Cancer Nanotechnology · doi:10.1186/s12645-025-00342-1 · Cited by 34
Lubkin, D. T., Bishawi, M. M., Barbas, A. S., Brennan, T. V., & Kirk, A. D. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003381 · Cited by 34
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Couret, J., & Chang, T. L.-Y. (2016) · PubMed · Cited by 33
Akshay, K., Jerry, J. J., Palanivelu, A., & Teja, D. K. V. (2022) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.59034 · Cited by 33
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Wedam, R., Greer, Y. E., Wisniewski, D. J., Weltz, S., Kundu, M., Voeller, D. M., & Lipkowitz, S. (2023) · Cancers · doi:10.3390/cancers15071936 · Cited by 36
Han, J., Zhang, L., Yang, S., Wang, J., & Tan, D. (2013) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-013-1173-6 · Cited by 33
Mitochondria regulate DNA damage and genomic instability induced by high LET radiation
Zhang, B., Davidson, M. M., & Hei, T. K. (2014) · Life Sciences in Space Research · doi:10.1016/j.lssr.2014.02.006 · Cited by 33
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Numan, M., Brown, J. P., & Michou, L. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120202289 · Cited by 34
Tan, J., Zhang, F., Liang, F., Wang, Y., Li, Z., Yang, H. J., & Liu, X. (2014) · PubMed Central · Cited by 33
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Williams, J., Holmes, R. P., Assimos, D. G., & Mitchell, T. (2016) · Urology · doi:10.1016/j.urology.2016.03.004 · Cited by 33
Peng, Y., Mei, S., Qi, X., Tang, R. N., Yang, W., Feng, J., Zhou, Y., Huang, X., Qian, G., Xing, S., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01426-z · Cited by 32
Hwang, K. Y., & Choi, Y. B. (2015) · Journal of Virology · doi:10.1128/jvi.01903-15 · Cited by 32
Engineered Nanoparticles for Effective Redox Signaling During Angiogenic and Antiangiogenic Therapy
Nethi, S. K., Barui, A. K., Mukherjee, S., & Patra, C. R. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7383 · Cited by 32
Metcalfe, N. B., Bellman, J., Bize, P., Blier, P. U., Crespel, A., Dawson, N. J., Dunn, R. E., Halsey, L. G., Hood, W. R., Hopkins, M., et al. (2023) · BioEssays · doi:10.1002/bies.202300026 · Cited by 38
Innate immune cells and bacterial infection in zebrafish
Astin, J. W., Keerthisinghe, P., Du, L. Y., Sanderson, L. E., Crosier, K. E., Crosier, P. S., & Hall, C. J. (2016) · Methods in cell biology · doi:10.1016/bs.mcb.2016.08.002 · Cited by 33
Byappanahalli, A. M., Omoniyi, V., Hooten, N. N., Smith, J. T., Mode, N. A., Ezike, N., Zonderman, A. B., & Evans, M. K. (2023) · iScience · doi:10.1016/j.isci.2023.108724 · Cited by 31
Yuan, S., Che, Y., Wang, Z., Xing, K., Xie, X., & Chen, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04763-7 · Cited by 31
Brennan, T. V., Rendell, V. R., & Yang, Y. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00101 · Cited by 31
Stefano, G. B., & Kream, R. M. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01117-z · Cited by 31
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Pei, G., & Dorhoi, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136714 · Cited by 32
Noll, D., Leon, F., Brandt, D. Y. C., Pistorius, P. A., Bohec, C. L., Bonadonna, F., Trathan, P. N., Barbosa, A., Rey, A. R., Dantas, G. P. D. M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-07562-0 · Cited by 36
Ma, D., George, C. X., Nomburg, J., Pfaller, C. K., Cattaneo, R., & Samuel, C. E. (2017) · Journal of Virology · doi:10.1128/jvi.01726-17 · Cited by 31
New insights into Nod-like receptors (NLRs) in liver diseases.
Xu, T., Du, Y. Z., Xiu-bin, F., Chen, H., Zhou, D., Wang, Y., & Zhang, L. (2018) · PubMed Central · Cited by 31
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Metadata
- Authors
- West, A. P., Shadel, G. S., & Ghosh, S.
- Affiliations
- Yale University (US)
- Columbia University (US)
- Corresponding author
- Ghosh, Sankar
- Venue
- Nature Reviews Immunology
- Published
- 2011-05-20
- Volume
- 11
- Issue
- 6
- Pages
- 389-402
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4281487
- OpenAlex
- W2033448006
- Cited by
- 1,376
- References
- 103
- Citations by year
- 2026: 119 · 2025: 78 · 2024: 103 · 2023: 97 · 2022: 102 · 2021: 129 · 2020: 101 · 2019: 83 · 2018: 85 · 2017: 109 · 2016: 95 · 2015: 97 · 2014: 75 · 2013: 46 · 2012: 44
- FWCI
- 5.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R37 AI33443, R37AI033443)
- National Institute of Environmental Health Sciences (ES‑011)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- mitochondria, innate immunity, antiviral signaling, reactive oxygen species, antibacterial immunity, sterile inflammation, programmed cell death, cellular metabolism
- MeSH terms
- Animals, Bacterial Infections, Humans, Immunity, Innate, Mitochondria, Virus Diseases, Signal Transduction, Reactive Oxygen Species, Models, Immunological, Mitochondrial Proteins
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