Mitochondria in innate immune responses

How mitochondria produce reactive oxygen species

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A role for mitochondria in nlrp3 inflammasome activation

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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NOX enzymes and the biology of reactive oxygen

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Sterile inflammation: sensing and reacting to damage

Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

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How dying cells alert the immune system to danger

Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737

Tlr signalling augments macrophage bactericidal activity through mitochondrial ros

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

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Translocation of Proteins into Mitochondria

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Functions and dysfunctions of mitochondrial dynamics

Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369

Mitochondrial Oxidative Stress: Implications for Cell Death

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Innate immunity to virus infection

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Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

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NF-κB and the immune response

Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178

Phospholipid synthesis in a membrane fraction associated with mitochondria.

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Phagocytosis of Microbes: Complexity in Action

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011

The Inflammatory Response to Cell Death

Rock, K. L., & Kono, H. (2007) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151456 · Cited by 979

Mitochondrial Fusion and Fission in Mammals

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ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity

Li, X.-D., Sun, L., Seth, R. B., Pineda, G., & Chen, Z. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508531102 · Cited by 842

Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

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Viral evasion and subversion of pattern-recognition receptor signalling

Bowie, A., & Unterholzner, L. (2008) · Nature reviews. Immunology · doi:10.1038/nri2436 · Cited by 763

Recognition and Signaling by Toll-Like Receptors

West, A. P., Koblansky, A. A., & Ghosh, S. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.115827 · Cited by 736

LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

Satoh, T., Kato, H., Kumagai, Y., Yoneyama, M., Sato, S., Matsushita, K., Tsujimura, T., Fujita, T., Akira, S., & Takeuchi, O. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912986107 · Cited by 722

Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol

Han, D., Antunes, F., Canali, R., Rettori, D., & Cadenas, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210269200 · Cited by 711

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

Iyer, S. S., Pulskens, W. P., Sadler, J. J., Butter, L. M., Teske, G. J., Ulland, T. K., Eisenbarth, S. C., Florquin, S., Flavell, R. A., Leemans, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908698106 · Cited by 691

Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors

Giguère, V. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0017 · Cited by 604

NLRX1 is a regulator of mitochondrial antiviral immunity

Moore, C. B., Bergstralh, D. T., Duncan, J. A., Lei, Y. L., Morrison, T. E., Zimmermann, A. G., Accavitti-Loper, M. A., Madden, V. J., Sun, L., Ye, Z., et al. (2008) · Nature · doi:10.1038/nature06501 · Cited by 599

Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling

Tal, M. C., Sasai, M., Lee, H. K., Yordy, B., Shadel, G. S., & Iwasaki, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807694106 · Cited by 595

The Atg5–Atg12 conjugate associates with innate antiviral immune responses

Jounai, N., Takeshita, F., Kobiyama, K., Sakaue-Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704014104 · Cited by 581

Mitochondrial-nuclear communications

Ryan, M. T., & Hoogenraad, N. J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052305.091720 · Cited by 575

Myeloid C-type lectins in innate immunity

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Endogenously oxidized mitochondrial DNA induces in vivo and in vitro inflammatory responses

Collins, L. V., Hajizadeh, S., Holme, E., Jonsson, I., & Tarkowski, A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0703328 · Cited by 504

Antiviral innate immunity pathways

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MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

Jin, L., Waterman, P. M., Jonscher, K. R., Short, C. M., Reisdorph, N. A., & Cambier, J. C. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00640-08 · Cited by 451

Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif

Saha, S. K., Pietras, E. M., He, J. Q., Kang, J. R., Liu, S.-Y., Oganesyan, G., Shahangian, A., Zarnegar, B. J., Shiba, T. L., Wang, Y., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601220 · Cited by 423

Mammalian Mitochondrial Complex I: Biogenesis, Regulation, and Reactive Oxygen Species Generation

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Structural and functional link between the mitochondrial network and the endoplasmic reticulum

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Viral RNA Replication in Association with Cellular Membranes

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MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

Zhang, Q., Itagaki, K., & Hauser, C. J. (2010) · Shock · doi:10.1097/shk.0b013e3181cd8c08 · Cited by 361

Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation

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PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

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Initiation and Beyond: Multiple Functions of the Human Mitochondrial Transcription Machinery

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ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

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NLRX1 is a mitochondrial NOD‐like receptor that amplifies NF‐κB and JNK pathways by inducing reactive oxygen species production

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Disruption of innate immunity due to mitochondrial targeting of a picornaviral protease precursor

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Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils.

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Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

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Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

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TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

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Complex I Binding by a Virally Encoded RNA Regulates Mitochondria-Induced Cell Death

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Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling

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Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

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Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

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The Hepatitis B Virus X Protein Disrupts Innate Immunity by Downregulating Mitochondrial Antiviral Signaling Protein

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The Caspase-1 Inflammasome: A Pilot of Innate Immune Responses

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The NLRP3 inflammasome: A sensor of immune danger signals

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Human mitochondria-derivedN-formylated peptides are novel agonists equally active on FPR and FPRL1, whileListeria monocytogenes-derived peptides preferentially activate FPR

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Nuclear receptor ERRα and coactivator PGC-1β are effectors of IFN-γ-induced host defensePreprint

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Dissociation of a MAVS/IPS-1/VISA/Cardif-IKKε Molecular Complex from the Mitochondrial Outer Membrane by Hepatitis C Virus NS3-4A Proteolytic Cleavage

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An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

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Human nlrp3 inflammasome activation is nox1-4 independent

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Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assemblyPreprint

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Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages

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Virus-Infection or 5′ppp-RNA Activates Antiviral Signal through Redistribution of IPS-1 Mediated by MFN1

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Activation of host pattern recognition receptors by viruses

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The Multiligand-Binding Protein gC1qR, Putative C1q Receptor, Is a Mitochondrial Protein

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Tom70 mediates activation of interferon regulatory factor 3 on mitochondria

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Syk‐coupled C‐type lectin receptors that mediate cellular activation via single tyrosine based activation motifs

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The N-formyl peptide receptors and the anaphylatoxin C5a receptors: An overview

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Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria

Xu, L., Xiao, N., Liu, F., Ren, H., & Gu, J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811029106 · Cited by 159

Positioning mitochondrial plasticity within cellular signaling cascades

Soubannier, V., & McBride, H. M. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.07.008 · Cited by 146

Requirement of NOX2 and Reactive Oxygen Species for Efficient RIG-I-Mediated Antiviral Response through Regulation of MAVS Expression

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MAVS Self-Association Mediates Antiviral Innate Immune Signaling

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Persistent Nuclear Factor-κB Activation in Ucp2-/- Mice Leads to Enhanced Nitric Oxide and Inflammatory Cytokine Production

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Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages

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GB Virus B Disrupts RIG-I Signaling by NS3/4A-Mediated Cleavage of the Adaptor Protein MAVS

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Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1

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The uncoupling protein 2 modulates the cytokine balance in innate immunity☆

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Mitochondria and viruses

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Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors

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The role of mitochondria in cellular defense against microbial infection

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Negative Regulation of MAVS-Mediated Innate Immune Response by PSMA7

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Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain

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Hsp90 Regulates Activation of Interferon Regulatory Factor 3 and TBK-1 Stabilization in Sendai Virus-infected Cells

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