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Studying the mononuclear phagocyte system in the molecular age

Chow, Andrew, Brown, Brian D., Merad, Miriam·2011·Nature Reviews Immunology
DOI 10.1038/nri3087
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Abstract

The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells. Tissue phagocytes share several cell surface markers, phagocytic capability and myeloid classification; however, the factors that regulate the differentiation, homeostasis and function of macrophages and dendritic cells remain largely unknown. The purpose of this manuscript is to review the tools that are currently available and those that are under development to study the origin and function of mononuclear phagocytes.

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Research works printed but not linked: 114

  1. Fogg, D. K. et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311, 83–87 (2006). This study was the first to characterize a dedicated macrophage and DC progenitor. · DOI
  2. Onai, N. et al. Identification of clonogenic common Flt3+M-CSFR+ plasmacytoid and conventional dendritic cell progenitors in mouse bone marrow. Nature Immunol. 8, 1207–1216 (2007). · DOI
  3. Naik, S. H. et al. Development of plasmacytoid and conventional dendritic cell subtypes from single precursor cells derived in vitro and in vivo. Nature Immunol. 8, 1217–1226 (2007). References 3 and 4 were the first characterizations of a DC-restricted progenitor (termed the CDP) that gives rise to classical DCs and plasmacytoid DCs. · DOI
  4. Liu, K. et al. In vivo analysis of dendritic cell development and homeostasis. Science 324, 392–397 (2009). This was the first characterization of pre-DCs and how they are related to MDPs and CDPs. · DOI
  5. Reizis, B., Bunin, A., Ghosh, H. S., Lewis, K. L. & Sisirak, V. Plasmacytoid dendritic cells: recent progress and open questions. Annu. Rev. Immunol. 29, 163–183 (2011). · DOI
  6. Ingersoll, M. A., Platt, A. M., Potteaux, S. & Randolph, G. J. Monocyte trafficking in acute and chronic inflammation. Trends Immunol. 10 Jun 2011 (doi:10.1016/j.it.2011.05.001). · DOI
  7. Chow, A. et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J. Exp. Med. 208, 261–271 (2011). · DOI
  8. Iannacone, M. et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465, 1079–1083 (2010). · DOI
  9. Ginhoux, F. et al. The origin and development of nonlymphoid tissue CD103+ DCs. J. Exp. Med. 206, 3115–3130 (2009). · DOI
  10. Bogunovic, M. et al. Origin of the lamina propria dendritic cell network. Immunity 31, 513–525 (2009). · DOI
  11. Edelson, B. T. et al. Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells. J. Exp. Med. 207, 823–836 (2010). This was the first report that BATF3 is a crucial transcription factor for both CD8α+ and CD103+ DCs, a basis for the future classification of DC subsets. · DOI
  12. Hashimoto, D., Miller, J. & Merad, M. Characterizing DC and macrophage heterogeneity in vivo. Immunity 35, 323–335 (2011). · DOI
  13. Merad, M. & Manz, M. G. Dendritic cell homeostasis. Blood 113, 3418–3427 (2009). · DOI · Paper page
  14. van Rooijen, N. & van Kesteren-Hendrikx, E. Clodronate liposomes: perspectives in research and therapeutics. J. Liposome Res. 12, 81–94 (2002). · DOI
  15. Sudo, T. et al. Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene 11, 2469–2476 (1995).
  16. MacDonald, K. P. et al. An antibody against the colony-stimulating factor 1 receptor depletes the resident subset of monocytes and tissue- and tumor-associated macrophages but does not inhibit inflammation. Blood 116, 3955–3963 (2010). · DOI
  17. Hashimoto, D. et al. Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. J. Exp. Med. 208, 1069–1082 (2011). · DOI
  18. Irvine, K. M. et al. A CSF-1 receptor kinase inhibitor targets effector functions and inhibits pro-inflammatory cytokine production from murine macrophage populations. FASEB J. 20, 1921–1923 (2006). · DOI
  19. Ohno, H. et al. A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol. Cancer Ther. 5, 2634–2643 (2006). · DOI
  20. Conway, J. G. et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc. Natl Acad. Sci. USA 102, 16078–16083 (2005). · DOI
  21. Burns, C. J. & Wilks, A. F. c-FMS inhibitors: a patent review. Expert Opin. Ther. Pat. 21, 147–165 (2011). · DOI
  22. Zhang, Y. et al. APCs in the liver and spleen recruit activated allogeneic CD8+ T cells to elicit hepatic graft-versus-host disease. J. Immunol. 169, 7111–7118 (2002). · DOI
  23. McGill, J., Van Rooijen, N. & Legge, K. L. Protective influenza-specific CD8 T cell responses require interactions with dendritic cells in the lungs. J. Exp. Med. 205, 1635–1646 (2008). · DOI
  24. Traeger, T. et al. Selective depletion of alveolar macrophages in polymicrobial sepsis increases lung injury, bacterial load and mortality but does not affect cytokine release. Respiration 77, 203–213 (2009). · DOI
  25. Qualls, J. E., Kaplan, A. M., van Rooijen, N. & Cohen, D. A. Suppression of experimental colitis by intestinal mononuclear phagocytes. J. Leukoc. Biol. 80, 802–815 (2006). · DOI
  26. Bennett, C. L. & Clausen, B. E. DC ablation in mice: promises, pitfalls, and challenges. Trends Immunol. 28, 525–531 (2007). · DOI
  27. Duffield, J. S. et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J. Clin. Invest. 115, 56–65 (2005). · DOI · Paper page
  28. Stoneman, V. et al. Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ. Res. 100, 884–893 (2007). · DOI · Paper page
  29. Cailhier, J. F. et al. Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation. Am. J. Respir. Crit. Care Med. 173, 540–547 (2006). · DOI
  30. Cailhier, J. F. et al. Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J. Immunol. 174, 2336–2342 (2005). · DOI
  31. Saxena, V., Ondr, J. K., Magnusen, A. F., Munn, D. H. & Katz, J. D. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J. Immunol. 179, 5041–5053 (2007). · DOI
  32. Devey, L. et al. Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol. Ther. 17, 65–72 (2009). · DOI
  33. Fallowfield, J. A. et al. Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J. Immunol. 178, 5288–5295 (2007). · DOI · Paper page
  34. Duffield, J. S. et al. Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am. J. Pathol. 167, 1207–1219 (2005). · DOI
  35. Henderson, N. C. et al. Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am. J. Pathol. 172, 288–298 (2008). · DOI · Paper page
  36. Lin, S. L., Castano, A. P., Nowlin, B. T., Lupher, M. L. & Duffield, J. S. Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations. J. Immunol. 183, 6733–6743 (2009). · DOI
  37. Machida, Y. et al. Renal fibrosis in murine obstructive nephropathy is attenuated by depletion of monocyte lineage, not dendritic cells. J. Pharmacol. Sci. 114, 464–473 (2010). · DOI
  38. Qi, F. et al. Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation. Transplantation 86, 1267–1274 (2008). · DOI
  39. Chua, A. C. L., Hodson, L. J., Moldenhauer, L. M., Robertson, S. A. & Ingman, W. V. Dual roles for macrophages in ovarian cycle-associated development and remodelling of the mammary gland epithelium. Development 137, 4229–4238 (2010). · DOI
  40. Jasper, M. J. et al. Macrophage-derived LIF and IL1B regulate α(1,2)fucosyltransferase 2 (Fut2) expression in mouse uterine epithelial cells during early pregnancy. Biol. Reprod. 84, 179–188 (2011). · DOI
  41. Withers, S. B. et al. Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat. Arterioscler. Thromb. Vasc. Biol. 31, 908–913 (2011). · DOI
  42. Burnett, S. H. et al. Development of peritoneal adhesions in macrophage depleted mice. J. Surg. Res. 131, 296–301 (2006). · DOI
  43. Miyake, Y. et al. Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J. Clin. Invest. 117, 2268–2278 (2007). · DOI
  44. Asano, K. et al. CD169-positive macrophages dominate antitumor immunity by crosspresenting dead cell-associated antigens. Immunity 34, 85–95 (2011). · DOI
  45. Jung, S. et al. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17, 211–220 (2002). · DOI
  46. Bar-On, L. & Jung, S. Defining dendritic cells by conditional and constitutive cell ablation. Immunol. Rev. 234, 76–89 (2010). · DOI
  47. Sapoznikov, A. et al. Organ-dependent in vivo priming of naive CD4+, but not CD8+, T cells by plasmacytoid dendritic cells. J. Exp. Med. 204, 1923–1933 (2007). · DOI
  48. Plaks, V. et al. Uterine DCs are crucial for decidua formation during embryo implantation in mice. J. Clin. Invest. 118, 3954–3965 (2008).
  49. Lucas, M., Schachterle, W., Oberle, K., Aichele, P. & Diefenbach, A. Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26, 503–517 (2007). · DOI
  50. Hochweller, K., Striegler, J., Hammerling, G. J. & Garbi, N. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur. J. Immunol. 38, 2776–2783 (2008). · DOI
  51. Kissenpfennig, A. et al. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22, 643–654 (2005). · DOI
  52. Bennett, C. L. et al. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169, 569–576 (2005). · DOI
  53. Nagao, K. et al. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc. Natl Acad. Sci. USA 106, 3312–3317 (2009). · DOI
  54. Ginhoux, F. et al. Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J. Exp. Med. 204, 3133–3146 (2007). · DOI
  55. Bursch, L. S. et al. Identification of a novel population of Langerin+ dendritic cells. J. Exp. Med. 204, 3147–3156 (2007). · DOI
  56. Farrand, K. J. et al. Langerin+ CD8α+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J. Immunol. 183, 7732–7742 (2009). · DOI
  57. GeurtsvanKessel, C. H. et al. Clearance of influenza virus from the lung depends on migratory langerin+CD11b− but not plasmacytoid dendritic cells. J. Exp. Med. 205, 1621–1634 (2008). · DOI
  58. Birnberg, T. et al. Lack of conventional dendritic cells is compatible with normal development and T cell homeostasis, but causes myeloid proliferative syndrome. Immunity 29, 986–997 (2008). · DOI
  59. Ohnmacht, C. et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J. Exp. Med. 206, 549–559 (2009). · DOI
  60. Teichmann, L. L. et al. Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity 33, 967–978 (2010). · DOI
  61. Christopher, M. J., Rao, M., Liu, F., Woloszynek, J. R. & Link, D. C. Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice. J. Exp. Med. 208, 251–260 (2011). · DOI
  62. Kuipers, H., Schnorfeil, F. M., Fehling, H. J., Bartels, H. & Brocker, T. Dicer-dependent microRNAs control maturation, function, and maintenance of Langerhans cells in vivo. J. Immunol. 185, 400–409 (2010). · DOI
  63. Buch, T. et al. A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration. Nature Methods 2, 419–426 (2005). · DOI
  64. Brockschnieder, D., Pechmann, Y., Sonnenberg-Riethmacher, E. & Riethmacher, D. An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 44, 322–327 (2006). · DOI
  65. Voehringer, D., Liang, H. E. & Locksley, R. M. Homeostasis and effector function of lymphopenia-induced “memory-like” T cells in constitutively T cell-depleted mice. J. Immunol. 180, 4742–4753 (2008). · DOI
  66. Faust, N., Varas, F., Kelly, L. M., Heck, S. & Graf, T. Insertion of enhanced green fluorescent protein into the lysozyme gene creates mice with green fluorescent granulocytes and macrophages. Blood 96, 719–726 (2000). · DOI
  67. Sasmono, R. T. et al. A macrophage colony-stimulating factor receptor–green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse. Blood 101, 1155–1163 (2003). · DOI · Paper page
  68. Jung, S. et al. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106–4114 (2000). · DOI · Paper page
  69. Boes, M. et al. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature 418, 983–988 (2002). · DOI
  70. Lindquist, R. L. et al. Visualizing dendritic cell networks in vivo. Nature Immunol. 5, 1243–1250 (2004). · DOI
  71. Hume, D. A. Applications of myeloid-specific promoters in transgenic mice support in vivo imaging and functional genomics but do not support the concept of distinct macrophage and dendritic cell lineages or roles in immunity. J. Leukoc. Biol. 89, 525–538 (2011). · DOI
  72. MacDonald, K. P. et al. The colony-stimulating factor 1 receptor is expressed on dendritic cells during differentiation and regulates their expansion. J. Immunol. 175, 1399–1405 (2005). · DOI
  73. Sasmono, R. T. et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leukoc. Biol. 82, 111–123 (2007). · DOI
  74. Helft, J., Ginhoux, F., Bogunovic, M. & Merad, M. Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunol. Rev. 234, 55–75 (2010). · DOI
  75. Mempel, T. R., Scimone, M. L., Mora, J. R. & von Andrian, U. H. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr. Opin. Immunol. 16, 406–417 (2004). · DOI
  76. Samokhvalov, I. M., Samokhvalova, N. I. & Nishikawa, S. Cell tracing shows the contribution of the yolk sac to adult haematopoiesis. Nature 446, 1056–1061 (2007). This was the first published technique for the fate mapping of yolk sac-derived haematopoietic cells in adult mice. · DOI
  77. Brown, B. D. & Naldini, L. Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications. Nature Rev. Genet. 10, 578–585 (2009). · DOI · Paper page
  78. Brown, B. D. et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state. Nature Biotech. 25, 1457–1467 (2007). · DOI
  79. Gentner, B. et al. Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. Sci. Transl. Med. 2, 58ra84 (2010). · DOI
  80. Paul, P. et al. A genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell 145, 268–283 (2011). · DOI
  81. Root, D. E., Hacohen, N., Hahn, W. C., Lander, E. S. & Sabatini, D. M. Genome-scale loss-of-function screening with a lentiviral RNAi library. Nature Methods 3, 715–719 (2006). · DOI
  82. Premsrirut, P. K. et al. A rapid and scalable system for studying gene function in mice using conditional RNA interference. Cell 145, 145–158 (2011). · DOI · Paper page
  83. Mestas, J. & Hughes, C. C. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172, 2731–2738 (2004). · DOI · Paper page
  84. Willinger, T., Rongvaux, A., Strowig, T., Manz, M. G. & Flavell, R. A. Improving human hemato-lymphoid-system mice by cytokine knock-in gene replacement. Trends Immunol. 32, 321–327 (2011). · DOI
  85. Rathinam, C. et al. Efficient differentiation and function of human macrophages in humanized CSF-1 mice. Blood 118, 3119–3128 (2011). This paper demonstrated remarkable improvement in engraftment of human myeloid cells when human CSF1 was knocked into Rag2−/−Il2rg−/− recipient mice. · DOI
  86. Strowig, T. et al. Transgenic expression of human signal regulatory protein α in Rag2−/−γc−/− mice improves engraftment of human hematopoietic cells in humanized mice. Proc. Natl Acad. Sci. USA 108, 13218–13223 (2011). This paper demonstrated remarkable improvement in engraftment of human haematopoietic cells when human SIRPA was genetically engineered into Rag2−/−Il2rg−/− recipient mice. · DOI
  87. Lugo-Villarino, G. et al. Identification of dendritic antigen-presenting cells in the zebrafish. Proc. Natl Acad. Sci. USA 107, 15850–15855 (2010). This was the first report to characterize a DC population in zebrafish. · DOI
  88. Wittamer, V., Bertrand, J. Y., Gutschow, P. W. & Traver, D. Characterization of the mononuclear phagocyte system in zebrafish. Blood 117, 7126–7135 (2011). · DOI
  89. Jenkins, S. J. et al. Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science 332, 1284–1288 (2011). This was the first publication to show that, in the context of nematode challenge, macrophages at the site of infection are derived from local populations, rather than from recruited blood precursors. · DOI
  90. Merad, M. et al. Langerhans cells renew in the skin throughout life under steady-state conditions. Nature Immunol. 3, 1135–1141 (2002). · DOI
  91. Li, J., Chen, K., Zhu, L. & Pollard, J. W. Conditional deletion of the colony stimulating factor-1 receptor (c-fms proto-oncogene) in mice. Genesis 44, 328–335 (2006). · DOI
  92. Varol, C. et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204, 171–180 (2007). · DOI · Paper page
  93. Dorner, B. G. et al. Selective expression of the chemokine receptor XCR1 on cross-presenting dendritic cells determines cooperation with CD8+ T cells. Immunity 31, 823–833 (2009). · DOI
  94. Sunderkotter, C. et al. Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172, 4410–4417 (2004). · DOI · Paper page
  95. Engel, D. R. et al. CCR2 mediates homeostatic and inflammatory release of Gr1high monocytes from the bone marrow, but is dispensable for bladder infiltration in bacterial urinary tract infection. J. Immunol. 181, 5579–5586 (2008). · DOI
  96. Kolaczkowska, E. et al. Resident peritoneal leukocytes are important sources of MMP-9 during zymosan peritonitis: superior contribution of macrophages over mast cells. Immunol. Lett. 113, 99–106 (2007). · DOI
  97. Leendertse, M. et al. Peritoneal macrophages are important for the early containment of Enterococcus faecium peritonitis in mice. Innate Immun. 15, 3–12 (2009). · DOI
  98. van Rooijen, N., Kors, N. & Kraal, G. Macrophage subset repopulation in the spleen: differential kinetics after liposome-mediated elimination. J. Leukoc. Biol. 45, 97–104 (1989). · DOI
  99. Nikolic, T., Geutskens, S. B., van Rooijen, N., Drexhage, H. A. & Leenen, P. J. Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion study. Lab. Invest. 85, 487–501 (2005). · DOI
  100. Probst, H. C. et al. Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells. Clin. Exp. Immunol. 141, 398–404 (2005). · DOI
  101. Hickman-Davis, J. M., Michalek, S. M., Gibbs-Erwin, J. & Lindsey, J. R. Depletion of alveolar macrophages exacerbates respiratory mycoplasmosis in mycoplasma-resistant C57BL mice but not mycoplasma-susceptible C3H mice. Infect. Immun. 65, 2278–2282 (1997). · DOI
  102. Leemans, J. C. et al. Depletion of alveolar macrophages exerts protective effects in pulmonary tuberculosis in mice. J. Immunol. 166, 4604–4611 (2001). · DOI
  103. Zhang-Hoover, J., Sutton, A., van Rooijen, N. & Stein-Streilein, J. A critical role for alveolar macrophages in elicitation of pulmonary immune fibrosis. Immunology 101, 501–511 (2000). · DOI
  104. Bem, R. A. et al. Depletion of resident alveolar macrophages does not prevent Fas-mediated lung injury in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, L314–L325 (2008). · DOI
  105. Sitia, G. et al. Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog. 7, e1002061 (2011). · DOI
  106. Zhao, A. et al. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology 135, 217–225 (2008). · DOI
  107. Carmichael, M. D. et al. Role of brain macrophages on IL-1β and fatigue following eccentric exercise-induced muscle damage. Brain Behav. Immun. 24, 564–568 (2010). · DOI
  108. Steel, C. D. et al. Distinct macrophage subpopulations regulate viral encephalitis but not viral clearance in the CNS. J. Neuroimmunol. 226, 81–92 (2010). · DOI
  109. Tang, H. et al. The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling. Nature Immunol. 11, 608–617 (2010). · DOI
  110. King, I. L., Kroenke, M. A. & Segal, B. M. GM-CSF-dependent, CD103+ dermal dendritic cells play a critical role in Th effector cell differentiation after subcutaneous immunization. J. Exp. Med. 207, 953–961 (2010). · DOI
  111. van Rijt, L. S. et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J. Exp. Med. 201, 981–991 (2005). · DOI
  112. Plitas, G. et al. Dendritic cells are required for effective cross-presentation in the murine liver. Hepatology 47, 1343–1351 (2008). · DOI
  113. Vallon-Eberhard, A., Landsman, L., Yogev, N., Verrier, B. & Jung, S. Transepithelial pathogen uptake into the small intestinal lamina propria. J. Immunol. 176, 2465–2469 (2006). · DOI
  114. Kurimoto, I., van Rooijen, N., Dijkstra, C. D. & Streilein, J. W. Role of phagocytic macrophages in induction of contact hypersensitivity and tolerance by hapten applied to normal and ultraviolet B-irradiated skin. Immunology 83, 281–287 (1994).

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Metadata

Authors
Chow, A., Brown, B. D., & Merad, M.
Venue
Nature Reviews Immunology
Publisher
Springer Science and Business Media LLC
Published
2011-10-25
Volume
11
Issue
11
Pages
788-798
ISSN
  • 1474-1733
  • 1474-1741
DOI
10.1038/nri3087
Cited by
279
References
17
Language
en
Licence
www.springer.com/tdm (tdm)

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