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Membrane budding and scission by the ESCRT machinery: it's all in the neck
Open accessAbstract
The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds. ESCRT-III cleaves the bud necks from their cytosolic faces. ESCRT-III-mediated membrane neck cleavage is crucial for many processes, including the biogenesis of multivesicular bodies, viral budding, cytokinesis and, probably, autophagy. Recent studies of ultrastructures induced by ESCRT-III overexpression in cells and the in vitro reconstitution of the budding and scission reactions have led to breakthroughs in understanding these remarkable membrane reactions.
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Metadata
- Authors
- Hurley, J. H., & Hanson, P. I.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2010-06-30
- Volume
- 11
- Issue
- 8
- Pages
- 556-566
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1980798766
- Cited by
- 755
- References
- 13
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- green
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