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CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
Open accessAbstract
The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response to a wide variety of signals, yet target gene transcription is only increased in a subset of cases. Recent studies indicate that CREB functions in concert with a family of latent cytoplasmic co-activators called cAMP-regulated transcriptional co-activators (CRTCs), which are activated through dephosphorylation. A dual requirement for CREB phosphorylation and CRTC dephosphorylation is likely to explain how these activator–co-activator cognates discriminate between different stimuli. Following their activation, CREB and CRTCs mediate the effects of fasting and feeding signals on the expression of metabolic programmes in insulin-sensitive tissues.
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Cites
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases
Ogryzko, V. V., Schiltz, R. L., Russanova, V., Howard, B. H., & Nakatani, Y. (1996) · Cell · doi:10.1016/s0092-8674(00)82001-2 · Cited by 2,952
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587
Self-citationCyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Gonzalez, G. A., & Montminy, M. R. (1989) · Cell · doi:10.1016/0092-8674(89)90013-5 · Cited by 2,464
Self-citationCREB: A Stimulus-Induced Transcription Factor Activated by A Diverse Array of Extracellular Signals
Shaywitz, A. J., & Greenberg, M. E. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.821 · Cited by 2,134
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
Self-citationThe Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950
Self-citationThe CBP co-activator is a histone acetyltransferase
Bannister, A. J., & Kouzarides, T. (1996) · Nature · doi:10.1038/384641a0 · Cited by 1,805
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
CREB: a Ca 2+ -Regulated Transcription Factor Phosphorylated by Calmodulin-Dependent Kinases
Sheng, M., Thompson, M. A., & Greenberg, M. E. (1991) · Science · doi:10.1126/science.1646483 · Cited by 1,488
Nuclear protein CBP is a coactivator for the transcription factor CREB
Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1
Herzig, S., Long, F., Jhala, U. S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., et al. (2001) · Nature · doi:10.1038/35093131 · Cited by 1,440
Self-citationIdentification of a cyclic-AMP-responsive element within the rat somatostatin gene.
Montminy, M. R., Sevarino, K. A., Wagner, J. A., Mandel, G., & Goodman, R. H. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.18.6682 · Cited by 1,385
Self-citationCahill, G. F. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111258 · Cited by 1,319
Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase
Xing, J., Ginty, D. D., & Greenberg, M. E. (1996) · Science · doi:10.1126/science.273.5277.959 · Cited by 1,248
Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., & Viollet, B. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40671 · Cited by 1,181
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
Koo, S.-H., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P., et al. (2005) · Nature · doi:10.1038/nature03967 · Cited by 995
Self-citationDeak, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4426 · Cited by 993
Zhang, X., Odom, D. T., Koo, S.-H., Conkright, M. D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501076102 · Cited by 992
Self-citationCantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., & Auwerx, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.006 · Cited by 921
Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · cited 1×
“In addition to being regulated by the effects of fasting and feeding hormones, hepatic gluconeogenesis is subject to regulation by the circadian clock, which coordinates hepatic metabolism with changes in the external environmen”
Diabetes, Obesity, and the Brain
Schwartz, M. W., & Porte, D. (2005) · Science · doi:10.1126/science.1104344 · Cited by 841
A cyclic AMP- and phorbol ester-inducible DNA element
Comb, M., Birnberg, N. C., Seasholtz, A., Herbert, E., & Goodman, H. M. (1986) · Nature · doi:10.1038/323353a0 · Cited by 741
Sun, P., Enslen, H., Myung, P. S., & Maurer, R. A. (1994) · Genes & Development · doi:10.1101/gad.8.21.2527 · Cited by 734
Radhakrishnan, I., Pérez-Alvarado, G. C., Parker, D., Dyson, H. J., Montminy, M. R., & Wright, P. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80463-8 · Cited by 728
Self-citationActivation of cAMP and mitogen responsive genes relies on a common nuclear factor
Arias, J., Alberts, A. S., Brindle, P., Claret, F. X., Smeal, T., Karin, M., Feramisco, J., & Montminy, M. (1994) · Nature · doi:10.1038/370226a0 · Cited by 725
Self-citationImpey, S., McCorkle, S. R., Cha-Molstad, H., Dwyer, J. M., Yochum, G. S., Boss, J. M., McWeeney, S., Dunn, J. J., Mandel, G., & Goodman, R. H. (2004) · Cell · doi:10.1016/j.cell.2004.10.032 · Cited by 694
The CREB Coactivator TORC2 Functions as a Calcium- and cAMP-Sensitive Coincidence Detector
Screaton, R. A., Conkright, M. D., Katoh, Y., Best, J. L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, J. R., Takemori, H., et al. (2004) · Cell · doi:10.1016/j.cell.2004.09.015 · Cited by 648
Self-citationFGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.
Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P., & Comb, M. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00840.x · Cited by 637
Daitoku, H., Hatta, M., Matsuzaki, H., Aratani, S., Ohshima, T., Miyagishi, M., Nakajima, T., & Fukamizu, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400593101 · Cited by 602
Conkright, M. D., Canettieri, G., Screaton, R., Guzman, E., Miraglia, L., Hogenesch, J. B., & Montminy, M. (2003) · Molecular Cell · doi:10.1016/j.molcel.2003.08.013 · Cited by 602
Self-citationLundblad, J. R., Kwok, R. P. S., Laurance, M. E., Harter, M. L., & Goodman, R. H. (1995) · Nature · doi:10.1038/374085a0 · Cited by 588
Ramirez-Carrozzi, V. R., Braas, D., Bhatt, D. M., Cheng, C. S., Hong, C., Doty, K. R., Black, J. C., Hoffmann, A., Carey, M., & Smale, S. T. (2009) · Cell · doi:10.1016/j.cell.2009.04.020 · Cited by 575
Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis
Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567
Self-citationIguchi-Ariga, S. M., & Schaffner, W. (1989) · Genes & Development · doi:10.1101/gad.3.5.612 · Cited by 559
Dash, P. K., Karl, K. A., Colicos, M. A., Prywes, R., & Kandel, E. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.5061 · Cited by 551
cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2
Jhala, U. S., Canettieri, G., Screaton, R. A., Kulkarni, R. N., Krajewski, S., Reed, J., Walker, J., Lin, X., White, M., & Montminy, M. (2003) · Genes & Development · doi:10.1101/gad.1097103 · Cited by 543
Self-citationAhn, S., Olive, M., Aggarwal, S., Krylov, D., Ginty, D. D., & Vinson, C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.967 · Cited by 503
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjaer, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., III, J. Y., et al. (2008) · Nature · doi:10.1038/nature07349 · Cited by 484
Self-citationHe, L., Sabet, A., Djedjos, S., Miller, R., Sun, X., Hussain, M. A., Radovick, S., & Wondisford, F. E. (2009) · Cell · doi:10.1016/j.cell.2009.03.016 · Cited by 481
Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S., & Montminy, M. (1992) · Cell · doi:10.1016/0092-8674(92)90537-m · Cited by 457
Self-citationHagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., & Montminy, M. R. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.8.4852 · Cited by 453
Self-citationParker, D., Ferreri, K., Nakajima, T., Lamorte, V. J., Evans, R., Koerber, S. C., Hoeger, C., & Montminy, M. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.694 · Cited by 408
Self-citationInsulin modulates gluconeogenesis by inhibition of the coactivator TORC2
Dentin, R., Liu, Y., Koo, S.-H., Hedrick, S., Vargas, T., Heredia, J., Yates, J., & Montminy, M. (2007) · Nature · doi:10.1038/nature06128 · Cited by 400
Self-citationShort, J. M., Wynshaw-Boris, A., Short, H. P., & Hanson, R. W. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67574-x · Cited by 397
Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB
Mair, W., Morantte, I., Rodrigues, A. P. C., Manning, G., Montminy, M., Shaw, R. J., & Dillin, A. (2011) · Nature · doi:10.1038/nature09706 · Cited by 393
Self-citationShimohata, T., Nakajima, T., Yamada, M., Uchida, C., Onodera, O., Naruse, S., Kimura, T., Koide, R., Nozaki, K., Sano, Y., et al. (2000) · Nature Genetics · doi:10.1038/79139 · Cited by 393
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
Imai, S.-I., & Guarente, L. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.02.003 · Cited by 390
Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L., Meltzer, J., Garza, D., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1932773100 · Cited by 367
NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism
Pei, L., Waki, H., Vaitheesvaran, B., Wilpitz, D. C., Kurland, I. J., & Tontonoz, P. (2006) · Nature Medicine · doi:10.1038/nm1471 · Cited by 321
Hepatic Glucose Sensing via the CREB Coactivator CRTC2
Dentin, R., Hedrick, S., Xie, J., Yates, J., & Montminy, M. (2008) · Science · doi:10.1126/science.1151363 · Cited by 319
Self-citationWadzinski, B. E., Wheat, W. H., Jaspers, S., Peruski, L. F., Lickteig, R. L., Johnson, G. L., & Klemm, D. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.5.2822 · Cited by 303
Selective Inhibition of NFAT Activation by a Peptide Spanning the Calcineurin Targeting Site of NFAT
Aramburu, J., García-Cózar, F., Raghavan, A., Okamura, H., Rao, A., & Hogan, P. G. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80063-5 · Cited by 300
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
Wang, Y., Vera, L., Fischer, W. H., & Montminy, M. (2009) · Nature · doi:10.1038/nature08111 · Cited by 297
Self-citationWu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P. S., Bare, O., Labow, M., Spiegelman, B., & Stevenson, S. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606714103 · Cited by 291
Bonni, A., Ginty, D. D., Dudek, H., & Greenberg, M. E. (1995) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1995.1015 · Cited by 290
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
Berdeaux, R., Goebel, N., Banaszynski, L., Takemori, H., Wandless, T., Shelton, G. D., & Montminy, M. (2007) · Nature Medicine · doi:10.1038/nm1573 · Cited by 266
Self-citationConkright, M. D., Guzmán, E., Flechner, L., Su, A. I., Hogenesch, J. B., & Montminy, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00134-5 · Cited by 250
Self-citationA Nitric Oxide Signaling Pathway Controls CREB-Mediated Gene Expression in Neurons
Riccio, A., Alvania, R. S., Lonze, B. E., Ramanan, N., Kim, T., Huang, Y., Dawson, T. M., Snyder, S. H., & Ginty, D. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.12.006 · Cited by 240
Bittinger, M. A., McWhinnie, E., Meltzer, J., Iourgenko, V., Latario, B., Liu, X., Chen, C. H., Song, C., Garza, D., & Labow, M. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.002 · Cited by 229
Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism
(1980) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1980.239.4.e277 · Cited by 222
CREB is activated by UVC through a p38/HOG-1-dependent protein kinase
Iordanov, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1009 · Cited by 210
Identification of small-molecule antagonists that inhibit an activator:coactivator interaction
Best, J. L., Amezcua, C. A., Mayr, B., Flechner, L., Murawsky, C. M., Emerson, B., Zor, T., Gardner, K. H., & Montminy, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406374101 · Cited by 207
Self-citationAdaptor-mediated Recruitment of RNA Polymerase II to a Signal-dependent Activator
Kee, B. L., Arias, J., & Montminy, M. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2373 · Cited by 203
Self-citationRegulation of Transcription by AMP-activated Protein Kinase
Yang, W., Hong, Y. H., Shen, X.-Q., Frankowski, C., Camp, H. S., & Leff, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100316200 · Cited by 200
The Creb1 coactivator Crtc1 is required for energy balance and fertility
Altarejos, J. Y., Goebel, N., Conkright, M. D., Inoue, H., Xie, J., Arias, C. M., Sawchenko, P. E., & Montminy, M. (2008) · Nature Medicine · doi:10.1038/nm.1866 · Cited by 199
Self-citationRegulation of Hepatic Gluconeogenesis by an ER-Bound Transcription Factor, CREBH
Lee, M.-W., Chanda, D., Yang, J., Oh, H., Kim, S. S., Yoon, Y.-S., Hong, S., Park, K.-G., Lee, I.-K., Choi, C. S., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.016 · Cited by 194
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
Kasper, L. H., Boussouar, F., Ney, P. A., Jackson, C. W., Rehg, J., van Deursen, J. M., & Brindle, P. K. (2002) · Nature · doi:10.1038/nature01062 · Cited by 193
The cAMP-regulated transcription factor CREB interactswith a component of the TFIID complex.
Ferreri, K., Gill, G., & Montminy, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1210 · Cited by 193
Self-citationAdipocyte CREB Promotes Insulin Resistance in Obesity
Qi, L., Saberi, M., Zmuda, E., Wang, Y., Altarejos, J., Zhang, X., Dentin, R., Hedrick, S., Bandyopadhyay, G., Hai, T., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.01.006 · Cited by 190
Self-citationAttenuation of a phosphorylation-dependent activator by an HDAC–PP1 complex
Canettieri, G., Morantte, I., Guzmán, E., Asahara, H., Herzig, S., Anderson, S. D., Yates, J. R., & Montminy, M. (2003) · Nature Structural & Molecular Biology · doi:10.1038/nsb895 · Cited by 188
Self-citationFoxOs Function Synergistically to Promote Glucose Production
Haeusler, R. A., Kaestner, K. H., & Accili, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.175851 · Cited by 186
Brindle, P., Linke, S., & Montminy, M. (1993) · Nature · doi:10.1038/364821a0 · Cited by 173
Self-citationCooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J. R., & Montminy, M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601715 · Cited by 172
Self-citationTargeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
Wang, Y., Inoue, H., Ravnskjaer, K., Viste, K., Miller, N., Liu, Y., Hedrick, S., Vera, L., & Montminy, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914897107 · Cited by 167
Self-citationQuinn, P. G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85293-6 · Cited by 166
Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation
Cardinaux, J.-R., Notis, J. C., Zhang, Q., Vo, N., Craig, J. C., Fass, D. M., Brennan, R. G., & Goodman, R. H. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1546-1552.2000 · Cited by 162
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding protein
Zhou, X., Shibusawa, N., Naik, K., Porras, D., Temple, K. A., Ou, H., Kaihara, K. A., Roe, M. W., Brady, M., & Wondisford, F. E. (2004) · Nature Medicine · doi:10.1038/nm1050 · Cited by 160
Parker, D., Jhala, U. S., Radhakrishnan, I., Yaffe, M. B., Reyes, C., Shulman, A. I., Cantley, L. C., Wright, P. E., & Montminy, M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80279-8 · Cited by 158
Self-citationCRTC3 links catecholamine signalling to energy balance
Song, Y., Altarejos, J. Y., Goodarzi, M. O., Inoue, H., Guo, X., Berdeaux, R., Kim, J., Goode, J., Igata, M., Paz, J. C., et al. (2010) · Nature · doi:10.1038/nature09564 · Cited by 155
Self-citationMultiple protein kinase A-regulated events are required for transcriptional induction by cAMP.
Brindle, P. K., Nakajima, T., & Montminy, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10521 · Cited by 144
Self-citationSaluja, D., Vassallo, M. F., & Tanese, N. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.10.5734 · Cited by 133
Veerababu, G., Tang, J., Hoffman, R. T., Daniels, M. C., Hebert, L. F., Crook, E. D., Cooksey, R. C., & McClain, D. A. (2000) · Diabetes · doi:10.2337/diabetes.49.12.2070 · Cited by 128
Ramsey, K. M., Marcheva, B., Kohsaka, A., & Bass, J. T. (2007) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.27.061406.093546 · Cited by 121
Glucose controls CREB activity in islet cells via regulated phosphorylation of TORC2
Jansson, D., Ng, A. C.-H., Fu, A., Depatie, C., Azzabi, M. A., & Screaton, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800796105 · Cited by 119
Phosphorylation of p300 at Serine 89 by Protein Kinase C
Yuan, L. W., & Gambee, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007832200 · Cited by 119
A coactivator trap identifies NONO (p54 nrb ) as a component of the cAMP-signaling pathway
Amelio, A. L., Miraglia, L. J., Conkright, J. J., Mercer, B. A., Batalov, S., Cavett, V. J., Orth, A. P., Caldwell-Busby, J., Hogenesch, J. B., & Conkright, M. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707999105 · Cited by 115
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation
Kasper, L. H., Lerach, S., Wang, J., Wu, S., Jeevan, T., & Brindle, P. K. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.235 · Cited by 115
Erion, D. M., Ignatova, I. D., Yonemitsu, S., Nagai, Y., Chatterjee, P., Weismann, D., Hsiao, J. J., Zhang, D., Iwasaki, T., Stark, R., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.10.007 · Cited by 111
The Insulin-Regulated CREB Coactivator TORC Promotes Stress Resistance in Drosophila
Wang, B., Goode, J., Best, J. L., Meltzer, J., Schilman, P. E., Chen, J., Garza, D., Thomas, J. B., & Montminy, M. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.02.010 · Cited by 110
Self-citationKim, T. K., Kim, T. H., & Maniatis, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12191 · Cited by 109
Hepatic energy state is regulated by glucagon receptor signaling in mice
Berglund, E. D., Lee, R. S., Lustig, D. G., Lynes, S. E., Donahue, E. P., Camacho, R. C., Meredith, M. E., Magnuson, M. A., Charron, M. J., & Wasserman, D. H. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38650 · Cited by 108
Michael, L. F., Asahara, H., Shulman, A. I., Kraus, W. L., & Montminy, M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1596-1603.2000 · Cited by 104
Self-citationDirect regulation of CREB transcriptional activity by ATM in response to genotoxic stress
Shi, Y., Venkataraman, S., Dodson, G. E., Mabb, A. M., LeBlanc, S. E., & Tibbetts, R. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307718101 · Cited by 101
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Metadata
- Authors
- Altarejos, J. Y., & Montminy, M.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2011-02-23
- Volume
- 12
- Issue
- 3
- Pages
- 141-151
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2019010829
- Cited by
- 1,040
- References
- 114
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.