Transcranial magnetic stimulation and synaptic plasticity: Experimental framework and human models

Thickbroom, Gary W.

doi:10.1007/s00221-007-0991-3

Cited by 326Transcranial Magnetic Stimulation StudiesNeuroscience and Neuropharmacology ResearchNeurological disorders and treatments

Transcranial magnetic stimulation and synaptic plasticity: Experimental framework and human models

Thickbroom, Gary W.·2007·Experimental Brain Research

DOI 10.1007/s00221-007-0991-3

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Abstract

Interest in the therapeutic potential of non-invasive human brain stimulation has been boosted by an improved understanding of the mechanisms of synaptic plasticity and the stimulus protocols that can induce plasticity in experimental preparations. A range of transcranial magnetic stimulation (TMS) protocols are available that have the potential to mimic these experimental protocols in the human. Repetitive TMS emulates aspects of activity-dependent plasticity, and theta-burst refinements may be able to take into account excitatory and inhibitory networks, paired associative stimulation can extend network considerations to incorporate sensorimotor integration, inhibitory networks may be targeted with short-interval paired stimulation and finally even the precision of spike-timing dependent plasticity may be accessible through I-(indirect)wave dynamics. This review will provide a synthesis of current concepts of activity- and time-dependent plasticity and their homeostatic regulation based on experimental studies, and relate these concepts to the promising range of TMS interventions that are available to target human brain plasticity.

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Transcranial magnetic stimulation as a tool to induce and explore plasticity in humans
Suppa, A., Asci, F., & Guerra, A. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00005-9 · Cited by 36 · see citing works
Biophysical modeling of neural plasticity induced by transcranial magnetic stimulation
Wilson, M. T., Fulcher, B., Fung, P. K., Robinson, P. A., Fornito, A., & Rogasch, N. C. (2018) · Clinical Neurophysiology · doi:10.1016/j.clinph.2018.03.018 · Cited by 64 · see citing works
Probing the Plasticity of the Brain with TMS
Rothwell, J. C. (2007) · Springer eBooks · doi:10.1007/978-4-431-30962-8_42

Authors: Thickbroom, G. W.
Affiliations: The University of Western Australia (AU)
Corresponding author: Thickbroom, Gary W.
Venue: Experimental Brain Research
Publisher: Springer Science and Business Media LLC
Published: 2007-06-12
Volume: 180
Issue: 4
Pages: 583-593
ISSN: 0014-4819 (ISSN-L)
1432-1106
DOI: 10.1007/s00221-007-0991-3
OpenAlex: W2064656928
Cited by: 326
References: 84
Citations by year: 2026: 12 · 2025: 14 · 2024: 4 · 2023: 13 · 2022: 10 · 2021: 23 · 2020: 19 · 2019: 11 · 2018: 15 · 2017: 17 · 2016: 22 · 2015: 22 · 2014: 24 · 2013: 33 · 2012: 23
FWCI: 1.24
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Experimental Brain Research (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics: Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords: transcranial magnetic stimulation, synaptic plasticity, repetitive TMS, theta burst stimulation, paired associative stimulation, spike-timing-dependent plasticity, activity-dependent plasticity, homeostatic regulation, non-invasive brain stimulation, inhibitory networks, sensorimotor integration
MeSH terms: Action Potentials, Animals, Brain, Humans, Models, Neurological, Nerve Net, Neural Inhibition, Synaptic Transmission, Neuronal Plasticity, Synapses, Transcranial Magnetic Stimulation

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Transcranial magnetic stimulation and synaptic plasticity: Experimental framework and human models

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