Cited by 877Regulation of Appetite and ObesityGrowth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormones

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The many faces of insulin-like peptide signalling in the brain

Fernandez, Ana M., Torres-Alemán, Ignacio·2012·Nature reviews. Neuroscience

DOI 10.1038/nrn3209

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Abstract

Central and peripheral insulin-like peptides (ILPs), which include insulin, insulin-like growth factor 1 (IGF1) and IGF2, exert many effects in the brain. Through their actions on brain growth and differentiation, ILPs contribute to building circuitries that subserve metabolic and behavioural adaptation to internal and external cues of energy availability. In the adult brain each ILP has distinct effects, but together their actions ultimately regulate energy homeostasis - they affect nutrient sensing and regulate neuronal plasticity to modulate adaptive behaviours involved in food seeking, including high-level cognitive operations such as spatial memory. In essence, the multifaceted activity of ILPs in the brain may be viewed as a system organization involved in the control of energy allocation.

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Authors: Fernandez, A. M., & Torres-Alemán, I.
Affiliations: Instituto Cajal (ES)
ORCID: Fernandez, Ana M.
Venue: Nature reviews. Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2012-03-20
Volume: 13
Issue: 4
Pages: 225-239
ISSN: 1471-003X (ISSN-L)
1471-0048
DOI: 10.1038/nrn3209
OpenAlex: W2067443877
Cited by: 872
References: 187
Citations by year: 2026: 21 · 2025: 43 · 2024: 40 · 2023: 62 · 2022: 67 · 2021: 66 · 2020: 47 · 2019: 52 · 2018: 47 · 2017: 91 · 2016: 99 · 2015: 81 · 2014: 65 · 2013: 67 · 2012: 22
FWCI: 8.45
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Neuroscience (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: insulin-like peptides, insulin, insulin-like growth factor I, insulin-like growth factor II, brain, energy homeostasis, nutrient sensing, neuroplasticity, brain development, food seeking, spatial memory, energy allocation
MeSH terms: Animals, Brain, Cognition, Energy Metabolism, Insulin, Insulin-Like Growth Factor I, Insulin-Like Growth Factor II, Neuronal Plasticity, Neurons

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The many faces of insulin-like peptide signalling in the brain

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