The many faces of insulin-like peptide signalling in the brain

Glial and neuronal control of brain blood flow

Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511

Central nervous system control of food intake and body weight

Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503

Role of insulin-like growth factors in embryonic and postnatal growth

Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463

Regulation of neuronal survival by the serine-threonine protein kinase Akt

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120

Cellular Actions of the Insulin-Like Growth Factor Binding Proteins

Firth, S. M., & Baxter, R. C. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0033 · Cited by 1,739

The self-tuning neuron: synaptic scaling of excitatory synapses

Turrigiano, G. G. (2008) · Cell · doi:10.1016/j.cell.2008.10.008 · Cited by 1,533

Cell death and control of cell survival in the oligodendrocyte lineage

Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial

Craft, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.233 · Cited by 1,253

Emissive Synthetic Cofactors: A Highly Responsive NAD + Analogue Reveals Biomolecular Recognition Features

Feldmann, J., Li, Y., & Tor, Y. (2019) · Chemistry - A European Journal · doi:10.1002/chem.201805520 · Cited by 16

Edem1 activity in the fat body regulates insulin signalling and metabolic homeostasis in Drosophila

Pathak, H., & Varghese, J. (2021) · Life Science Alliance · doi:10.26508/lsa.202101079 · Cited by 16

Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway

Zhai, Q., Zeng, Y., Gu, Y., Li, Z., Zhang, T., Yuan, B., Wang, T., Yan, J., Qin, H., Yang, L., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104267 · Cited by 19

Exercise Intervention for Alzheimer’s Disease: Unraveling Neurobiological Mechanisms and Assessing Effects

Ren, J., & Xiao, H. (2023) · Life · doi:10.3390/life13122285 · Cited by 17

Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target

Potenzieri, A., Uccella, S., Preiti, D., Pisoni, M., Rosati, S., Lavarello, C., Bartolucci, M., Debellis, D., Catalano, F., Petretto, A., et al. (2024) · Science Advances · doi:10.1126/sciadv.adk8123 · Cited by 16

Modulation of endoplasmic reticulum chaperone GRP78 by high glucose in hippocampus of streptozotocin-induced diabetic mice and C6 astrocytic cells

Wong, D. P. K., Chu, J. M. T., Hung, V., Lee, K. M., Cheng, C. H. K., Yung, K. K. L., & Yue, K. K. M. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2013.09.010 · Cited by 17

Developmental drift as a mechanism for aging: lessons from nematodes

Lezzerini, M., Smith, R. L., & Budovskaya, Y. V. (2013) · Biogerontology · doi:10.1007/s10522-013-9462-3 · Cited by 16

Integrating insulin-like growth factor 1 and sex hormones into neuroprotection: Implications for diabetes

Huffman, J. N., Hoffmann, C., & Taylor, G. T. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i2.45 · Cited by 16

Reduction in IGF1 mRNA in the Human Subependymal Zone During Aging

Weissleder, C., Barry, G., Fung, S. J., Wong, M. W. K., Double, K. L., Webster, M. J., & Weickert, C. S. (2018) · Aging and Disease · doi:10.14336/ad.2018.0317 · Cited by 16

Low-dose intranasal insulin improves cognitive function and suppresses the development of epilepsy

Peng, S., Yang, J., Wang, Y., Yang, F., Tang, F., Hou, C., Yu, J., Wang, X., & Jiang, G. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146474 · Cited by 16

Another Example of Conditioned Taste Aversion: Case of Snails

中井, 純., Totani, Y., Hatakeyama, D., Dyakonova, V. E., & Ito, E. (2020) · Biology · doi:10.3390/biology9120422 · Cited by 16

Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders

Fischer, I., Shohat, S., Levy, G., Bar, E., Trangle, S. S., Efrati, S., & Barak, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911077 · Cited by 17

The guardian: metabolic and tumour‐suppressive effects of SIRT6

Lerrer, B., & Cohen, H. Y. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.332 · Cited by 16

Effects of dietary leucine supplementation on the hepatic mitochondrial biogenesis and energy metabolism in normal birth weight and intrauterine growth-retarded weanling piglets

Su, W., Xu, W. H., Zhang, H., Ying, Z., Zhou, L., Zhang, L., & Wang, T. (2017) · Nutrition Research and Practice · doi:10.4162/nrp.2017.11.2.121 · Cited by 19

The insulin-like growth factor-1 system in the adult mammalian brain and its implications in central maternal adaptation

Dobolyi, Á., & Lékó, A. H. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.12.002 · Cited by 17

Repression of an activity-dependent autocrine insulin signal is required for sensory neuron development in C. elegans

Horowitz, L. B., Brandt, J. P., & Ringstad, N. (2019) · Development · doi:10.1242/dev.182873 · Cited by 16

Insulin-Dependent Maturation of Newly Generated Olfactory Sensory Neurons after Injury

Kuboki, A., Kikuta, S., Otori, N., Kojima, H., Matsumoto, I., Reisert, J., & Yamasoba, T. (2021) · eNeuro · doi:10.1523/eneuro.0168-21.2021 · Cited by 16

Neural Influences on Tumor Progression Within the Central Nervous System

Lv, W., & Wang, Y. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70097 · Cited by 15

Cardiometabolic health, menopausal estrogen therapy and the brain: How effects of estrogens diverge in healthy and unhealthy preclinical models of aging

Daniel, J. M., Lindsey, S. H., Mostany, R., Schrader, L. A., & Zsombok, A. (2023) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2023.101068 · Cited by 19

Effect of Comorbidities on Ten-Year Survival in Patients with Dementia

Buawangpong, N., Pinyopornpanish, K., Phinyo, P., Jiraporncharoen, W., Angkurawaranon, C., & Soontornpun, A. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221259 · Cited by 15

LTK and ALK promote neuronal polarity and cortical migration by inhibiting IGF1R activity

Christova, T. Y., Ho, S. K., Liu, Y., Gill, M. K., & Attisano, L. (2023) · EMBO Reports · doi:10.15252/embr.202356937 · Cited by 13

Potentialities of IGF-1 for regulating oxidative stress in neuroinflammation and neurodegeneration: theoretical review

Herrera, M. L., Champarini, L. G., Oliveros, A. L., Bellini, M. J., & Hereñú, C. B. (2024) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2024.00093 · Cited by 15

The growth factors cascade and the dendrito-/synapto-genesis versus cell survival in adult hippocampal neurogenesis: The chicken or the egg

Pérez‐Domper, P., Gradari, S., & Trejo, J. L. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.06.001 · Cited by 15

Selective manipulation of aging: a novel strategy for the treatment of neurodegenerative disorders

Cohen, E., Moll, L., & Elami, T. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.13917 · Cited by 15

IGF-1 in autosomal dominant cerebellar ataxia - open-label trial

Sanz‐Gallego, I., Garrido, F. J. R. D. R., Pulido, I., Torres‐Alemán, I., & Arpa, J. (2014) · Cerebellum & Ataxias · doi:10.1186/s40673-014-0013-8 · Cited by 15

Patients with Alzheimer’s Disease Have Increased Levels of Insulin-like Growth Factor-I in Serum but not in Cerebrospinal Fluid

Horváth, A., Salman, Z., Quinlan, P. S., Wallin, A., & Svensson, J. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190921 · Cited by 15

dTBC1D7 regulates systemic growth independently of TSC through insulin signaling

Ren, S., Huang, Z., Jiang, Y., & Wang, T. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201706027 · Cited by 15

Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1

Chen, Y., Bang, S., Park, S.-H., Shi, H., & Kim, S. F. (2015) · Biochemical Journal · doi:10.1042/bj20141487 · Cited by 15

IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei

Fuentes‐Santamaría, V., Alvarado, J. C., la Rosa, L. R., Murillo‐Cuesta, S., Contreras, J., Juiz, J. M., & Varela‐Nieto, I. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0934-2 · Cited by 15

Age and Its Association with Low Insulin and High Amyloid-β Peptides in Blood

Li, H., Zhu, H., Wallack, M., Mwamburi, M., Abdul‐Hay, S. O., Leissring, M. A., & Qiu, W. Q. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150428 · Cited by 14

A Putative Mechanism of Age-Related Synaptic Dysfunction Based on the Impact of IGF-1 Receptor Signaling on Synaptic CaMKIIα Phosphorylation

Ogundele, O. M., Pardo, J., Francis, J., Goya, R. G., & Lee, C. C. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00035 · Cited by 16

Neurotrophic Factors and Their Receptors Are Altered by the Mere Partial IGF-1 Deficiency

Castilla‐Cortázar, I., Iturrieta-Zuazo, I., García‐Magariño, M., Puche, J. E., Martín‐Estal, I., Aguirre, G. A., Femat‐Roldán, G., Cantú-Martínez, L., & Muñoz, Ú. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.01.041 · Cited by 14

Recombinant Human Growth Hormone Activates Neuroprotective Growth Factors in Hypoxic Brain Injury in Neonatal Mice

Jung, S., Terörde, K., Dörr, H., & Trollmann, R. (2021) · Endocrinology · doi:10.1210/endocr/bqab008 · Cited by 14

Protective Effect of Insulin in Mouse Nasal Mucus Against Olfactory Epithelium Injury

Kikuta, S., Kuboki, A., & Yamasoba, T. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.803769 · Cited by 14

Therapeutic potential of blackberry extract in the preventing memory deficits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia

de Mello, J. E., Luduvico, K. P., dos Santos, A., Teixeira, F. C., Cardoso, J. D. S., Soares, M. S. P., Cunico, W. J., Vizzotto, M., Stefanello, F. M., & Spanevello, R. M. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01175-w · Cited by 14

Different impacts of acylated and non-acylated long-acting insulin analogs on neural functions in vitro and in vivo

Tsuneki, H., Yoshida, H., Endo, K., Mori, N., Hosoh, S., Tsuda, M., Wada, T., & Sasaoka, T. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.032 · Cited by 14

Very Early Exercise Rehabilitation After Intracerebral Hemorrhage Promotes Inflammation in the Brain

Tamakoshi, K., Maeda, M., Nakamura, S., & Murohashi, N. (2021) · Neurorehabilitation and neural repair · doi:10.1177/15459683211006337 · Cited by 14

Humic Acid Increases Amyloid β-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells

Li, H., Lu, F., Hung, H., Liu, G., Lai, T., & Lin, C. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160510426 · Cited by 14

Erratum to: IGF-1 deficiency causes atrophic changes associated with upregulation of VGluT1 and downregulation of MEF2 transcription factors in the mouse cochlear nuclei

Fuentes‐Santamaría, V., Alvarado, J. C., la Rosa, L. R., Murillo‐Cuesta, S., Contreras, J., Juiz, J. M., & Varela‐Nieto, I. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0945-z · Cited by 14

Unreported intrinsic disorder in proteins: Building connections to the literature on IDPs

Uversky, V. N. (2014) · Intrinsically Disordered Proteins · doi:10.4161/21690693.2014.970499 · Cited by 16

Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice

Cao, Y., Liu, B., Xu, W., Wang, L., Shi, F.-X., Li, N., Lei, Y., Wang, J., Tian, Q., & Zhou, X. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.06.002 · Cited by 12

Sirtuin 1 Promotes Hyperoxia-Induced Lung Epithelial Cell Death Independent of NF-E2–Related Factor 2 Activation

Potteti, H. R., Rajasekaran, S., Rajamohan, S. B., Tamatam, C. R., Reddy, N. M., & Reddy, S. P. (2015) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0056oc · Cited by 13

Screening the Impact of Sirtuin Inhibitors on Inflammatory and Innate Immune Responses of Macrophages and in a Mouse Model of Endotoxic Shock

Ciarlo, E., & Roger, T. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3667-0_21 · Cited by 13

Short-Term Diet Induced Changes in the Central and Circulating IGF Systems Are Sex Specific

Guerra-Cantera, S., Frago, L. M., Díaz, F., Ros, P., Jiménez‐Hernáiz, M., Freire‐Regatillo, A., Barrios, V., Argente, J., & Chowen, J. A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00513 · Cited by 13

Reorganization of motor cortex and impairment of motor performance induced by hindlimb unloading are partially reversed by cortical IGF-1 administration

Mysoet, J., Canu, M., Gillet, C., Fourneau, J., Garnier, C., Bastide, B., & Dupont, E. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.10.005 · Cited by 13

Increased plasma trimethylamine- N -oxide levels are associated with mild cognitive impairment in high cardiovascular risk elderly population

Buawangpong, N., Pinyopornpanish, K., Phrommintikul, A., Chindapan, N., Devahastin, S., Chattipakorn, N., & Chattipakorn, S. C. (2022) · Food & Function · doi:10.1039/d2fo02021a · Cited by 12

Microglia-Astrocyte Crosstalk in Post-Stroke Neuroinflammation: Mechanisms and Therapeutic Strategies

Shang, T., Kuang, B., Shang, Y., & Zou, W. (2025) · Current Neuropharmacology · doi:10.2174/011570159x350639250403072430 · Cited by 12

From Youthful Vigor to Aging Decline: Unravelling the Intrinsic and Extrinsic Determinants of Hippocampal Neural Stem Cell Aging

Peinado, P. J., & Urbach, A. (2023) · Cells · doi:10.3390/cells12162086 · Cited by 13

Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice

Folgueira, C., Beiroa, D., Gonzalez-Rellan, M. J., Porteiro, B., Milbank, E., Castelao, C., García-Palacios, M., Casanueva, F. F., López, M., Diéguez, C., et al. (2019) · Nutrients · doi:10.3390/nu11040752 · Cited by 12

Drosophila insulin-like peptides regulate concentration-dependent changes of appetite to different carbohydrates

Semaniuk, U. V., Gospodaryov, D. V., Mishchanyn, K., Storey, K. B., & Lushchak, O. V. (2021) · Zoology · doi:10.1016/j.zool.2021.125927 · Cited by 14

Association Between Retinopathy of Prematurity in Very-Low-Birth-Weight Infants and Neurodevelopmental Impairment

Han, G., Lim, D. H., Kang, D., CHO, J., Güallar, E., Chang, Y. S., Chung, T.-Y., Kim, S. J., & Park, W. S. (2022) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2022.08.010 · Cited by 12

Disturbance of suprachiasmatic nucleus function improves cardiac repair after myocardial infarction by IGF2-mediated macrophage transition

Hao, K., Zhai, Q., Gu, Y., Chen, Y.-Q., Wang, Y., Liu, R., Yan, S.-P., Wang, Y., Shi, Y., Lei, W., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01059-w · Cited by 12

Decreased IDE and IGF2 expression but increased Aβ40 in the cerebral cortex of mouse pups by early life lead exposure

Li, N., Yang, G., Wang, Y., Qiao, M., Zhang, P., Shao, J., & Yang, G. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.01.004 · Cited by 12

Major depressive disorder and accelerated aging from a peripheral IGF-1 overexpression perspective

Levada, O. A., & Troyan, A. S. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.109610 · Cited by 12

A radioligand binding assay for the insulin-like growth factor 2 receptor

Potalitsyn, P., Selicharová, I., Sršeň, K., Radosavljević, J., Marek, A., Nováková, K., Jiráček, J., & Žáková, L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238393 · Cited by 12

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Bleeker, J. C., & Houtkooper, R. H. (2016) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-016-9939-8 · Cited by 11

Experience-regulated molecular mechanisms in cortical GABAergic interneurons: from cellular functions to control over circuit plasticity

Spiegel, I. (2020) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2020.11.013 · Cited by 12

Constant light exposure in early life induces m6A-mediated inhibition of IGF gene family in the chicken

Yang, Y., Xu, P., Liu, J., Zhao, M., Cong, W., Han, W., Wang, D., & Zhao, R. (2022) · Journal of Animal Science · doi:10.1093/jas/skac199 · Cited by 11

Increased motor neuron resilience by small molecule compounds that regulate IGF-II expression

Osborn, T. M., Beagan, J. A., & Ole Isacson, A. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.11.002 · Cited by 12

Therapeutic effects of Wharton’s jelly-derived Mesenchymal Stromal Cells on behaviors, EEG changes and IGF-1 in rat model of the Parkinson’s disease

Jalali, M. S., Saki, G., Farbood, Y., Azandeh, S., Mansouri, E., Dehcheshmeh, M. G., & Sarkaki, A. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101921 · Cited by 11

Exogenous insulin-like growth factor 1 attenuates sevoflurane anesthesia-induced cognitive dysfunction in aged rats

Xie, L. H., Fang, Q., Wei, X., Zhou, L., & Wang, S. (2021) · Journal of Neurophysiology · doi:10.1152/jn.00124.2021 · Cited by 11

Reduced Insulin-Like Growth Factor-I Effects in the Basal Forebrain of Aging Mouse

Zegarra-Valdivia, J. A., Chaves‐Coira, I., de Sevilla, M. E. F., Martinez‐Rachadell, L., Esparza, J., Torres‐Alemán, I., & Núñez, Á. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.682388 · Cited by 11

Interactions of Glutamate and Gamma Amino Butyric Acid with the insulin-like growth factor system in traumatic brain injury (TBI) and/or cardiovascular accidents (CVA or stroke): A systematic review

Morales, T. I., Stearns‐Yoder, K. A., Hoffberg, A. S., Khan, T. K., Wortzel, H. S., & Brenner, L. A. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09037 · Cited by 11

Impaired spatial navigation and age‐dependent hippocampal synaptic dysfunction are associated with chronic inflammatory response in db/db mice

Al‐Onaizi, M., Al-Sarraf, A. J., Braysh, K., Kazem, F., Al‐Hussaini, H., Rao, M. S. R., Kilarkaje, N., & ElAli, A. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15835 · Cited by 11

Identification of diagnostic biomarkers in Alzheimer’s disease by integrated bioinformatic analysis and machine learning strategies

Jin, B., Cheng, X., Fei, G., Sang, S., & Zhong, C. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1169620 · Cited by 11

The Role of Insulin-like Growth Factor I in Mechanisms of Resilience and Vulnerability to Sporadic Alzheimer’s Disease

Zegarra-Valdivia, J. A., Pignatelli, J., Núñez, Á., & Torres‐Alemán, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216440 · Cited by 11

White Matter Loss in a Mouse Model of Periventricular Leukomalacia Is Rescued by Trophic Factors

Monteros, A. E. D. L., Barajas, S., Arrazola, A., Taniguchi, A., Zhao, P. M., Bokhoor, P., Holley, S. M., Dejarme, D., Chu, B. C., Cepeda, C., et al. (2013) · Brain Sciences · doi:10.3390/brainsci3041461 · Cited by 11

Divergent and convergent roles for insulin-like peptides in the worm, fly and mammalian nervous systems

Lau, H. E., & Chalasani, S. H. (2014) · Invertebrate Neuroscience · doi:10.1007/s10158-013-0166-9 · Cited by 11

Role of phospholipases D1 and 2 in astroglial proliferation: effects of specific inhibitors and genetic deletion

Burkhardt, U. E., Beyer, S., & Klein, J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.05.004 · Cited by 11

Temporal-logic analysis of microglial phenotypic conversion with exposure to amyloid-β

Anastasio, T. J. (2014) · Molecular BioSystems · doi:10.1039/c4mb00457d · Cited by 11

Insulin Growth Factor-I Promotes Functional Recovery After a Focal Lesion in the Dentate Gyrus

Liquitaya-Montiel, A. J., Aguilar‐Arredondo, A., Arias, C., & Zepeda, A. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311201070818 · Cited by 11

Sex frailty differences in ageing mice: Neuropathologies and therapeutic projections

Herrera, M. L., Basmadjian, O. M., Lockhart, E. F., Dolcetti, F. J. C., Hereñú, C. B., & Bellini, M. J. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14703 · Cited by 11

Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson’s Disease

Ghanta, M. K., Elango, P., & Bhaskar, L. V. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200217114658 · Cited by 11

Compromised IGF signaling causes caspase-6 activation in Huntington disease

Skotte, N. H., Pouladi, M. A., Ehrnhoefer, D. E., Huynh, K., Qiu, X., Nielsen, S. M. B., Nielsen, T. T., Nørremølle, A., & Hayden, M. R. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113396 · Cited by 11

Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities

Páníková, T., Mitrová, K., Halamová, T., Mrzílková, K., Pícha, J., Chrudinová, M., Kurochka, A. S., Selicharová, I., Žáková, L., & Jiráček, J. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c01388 · Cited by 11

Nanoparticle-Mediated Nose-to-Brain Delivery for Ischemic Stroke Therapy: Preclinical Insights

Park, J., & Riew, T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111447 · Cited by 10

Research Progress of Nanocarriers for the Treatment of Alzheimer's Disease

Liu, X., Yuan, M., Li, L., Zhang, J., Huang, X. P., Du, J., Tu, Z., & Wu, H. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612829666221216114912 · Cited by 10

Blocking insulin-like growth factor 1 receptor signaling pathway inhibits neuromuscular junction regeneration after botulinum toxin-A treatment

Ishihara, H., Otani, Y., Tanaka, K., Miyajima, H., Ngo, H. X., & Fujitani, M. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06128-w · Cited by 11

Insulin-Like Growth Factor 1 Has the Potential to Be Used as a Diagnostic Tool and Treatment Target for Autism Spectrum Disorders

Shen, J., Liu, L., Yang, Y., Zhou, M., Xu, S., Zhang, W., & Zhang, C. (2024) · Cureus · doi:10.7759/cureus.65393 · Cited by 13

Insulin-like Growth Factor 1 Impact on Alzheimer’s Disease: Role in Inflammation, Stress, and Cognition

Zegarra-Valdivia, J. A., Arana‐Nombera, H. A., Perez‐Fernandez, L. A., Casimiro‐Arana, M. D. R., Gallegos‐Manayay, V. N., Oliva‐Piscoya, M. D. R., Alamo‐Medina, R. E., Abanto‐Saldaña, E. S., Ordinola, M. C. C., Paredes-Manrique, C., et al. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47040233 · Cited by 12

The Relationship Between Systemic Inflammatory Index and Other Inflammatory Markers with Clinical Severity of the Disease in Patients with Parkinson’s Disease

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Diabetes and associated cognitive disorders: Role of the Hypothalamic-Pituitary Adrenal axis

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Mechanistic perspectives of calorie restriction on vascular homeostasis

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Decreased Serum IGF-1/IGFBP-3 Molar Ratio is Associated with Executive Function Behaviors in Type 2 Diabetic Patients with Mild Cognitive Impairment

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LIF–IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum

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Age‐dependent alterations to paraventricular nucleus insulin‐like growth factor 1 receptor as a possible link between sympathoexcitation and inflammation

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Oxygen-sensitive regulation and neuroprotective effects of growth hormone-dependent growth factors during early postnatal development

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IGF-1 and IGF-1R modulate the effects of IL-4 on retinal ganglion cells survival: The involvement of M1 muscarinic receptor

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Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration

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Aminergic and peptidergic modulation of insulin-producing cells in DrosophilaPreprint

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Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior

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Choroid plexus extracellular vesicle transport of blood-borne insulin-like growth factor 1 to the hippocampus of the immature brain

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Tortuous Paths of Insulin Signaling and Mitochondria in Alzheimer’s Disease

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Functional Network Mapping Reveals State-Dependent Response to IGF1 Treatment in Rett Syndrome

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A Tau-Driven Adverse Outcome Pathway Blueprint Toward Memory Loss in Sporadic (Late-Onset) Alzheimer’s Disease with Plausible Molecular Initiating Event Plug-Ins for Environmental Neurotoxicants

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Estrogen receptors mediate the antidepressant effects of aerobic exercise: A possible new mechanism

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Alterations in tyrosine kinase receptor (Trk) expression induced by insulin-like growth factor-1 in cultured dorsal root ganglion neurons

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Epigenetic factors Polycomb (Pc) and Suppressor of zeste (Su(z)2) negatively regulate longevity in Drosophila melanogaster

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Igf1R/InsR function is required for axon extension and corpus callosum formation

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Insulin-like growth factors in the brain and their potential clinical implications

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Insulin-Like Growth Factor Receptors in the Brain

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