Obesity-associated biomarkers and executive function in children
Open accessAbstract
There is a growing focus on links between obesity and cognitive decline in adulthood, including Alzheimer's disease. It is also increasingly recognized that obesity in youth is associated with poorer cognitive function, specifically executive functioning skills such as inhibitory control and working memory, which are critical for academic achievement. Emerging literature provides evidence for possible biological mechanisms driven by obesity; obesity-associated biomarkers such as adipokines, obesity-associated inflammatory cytokines, and obesity-associated gut hormones have been associated with learning, memory, and general cognitive function. To date, examination of obesity-associated biology with brain function has primarily occurred in animal models. The few studies examining such biologically mediated pathways in adult humans have corroborated the animal data, but this body of work has gone relatively unrecognized by the pediatric literature. Despite the fact that differences in these biomarkers have been found in association with obesity in children, the possibility that obesity-related biology could affect brain development in children has not been actively considered. We review obesity-associated biomarkers that have shown associations with neurocognitive skills, specifically executive functioning skills, which have far-reaching implications for child development. Understanding such gut-brain associations early in the lifespan may yield unique intervention implications.
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Poor executive functioning is associated with consumption of palatable food, leading to inflammation and metabolic changes promoting weight gain.
“It is established that poor executive functioning is associated with consumption of palatable food, leading to inflammation and metabolic changes promoting weight gain [161,162,163].”
From Food Addiction and Psychosocial Adversity: Biological Embedding, Contextual Factors, and Public Health Implications (2020) · cites this paper as [161]
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МЕДИКО-СОЦІАЛЬНЕ ОБҐРУНТУВАННЯ МОДЕЛІ УПРАВЛІННЯ ЯКІСТЮ ЖИТТЯ ДІТЕЙ З ОЖИРІННЯМ
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- Authors
- Miller, A. L., Lee, H. J., & Lumeng, J. C.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Miller, Alison L.
- Venue
- Pediatric Research
- Published
- 2014-10-13
- Volume
- 77
- Issue
- 1-2
- Pages
- 143-147
- ISSN
- 0031-3998 (ISSN-L)
- 1530-0447
- PMC
- PMC4416088
- OpenAlex
- W1979336020
- Cited by
- 122
- References
- 84
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 5 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 10 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 7 · 2015: 4
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Pediatric Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (RC1DK086376, R21DK090718, P30DK092926, P30DK020572, P30DK089503)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- childhood obesity, executive function, adipokines, inflammatory cytokines, gastrointestinal hormones, gut-brain axis, brain development, inhibitory control, working memory, cognitive decline, Alzheimer's disease, academic performance
- MeSH terms
- Brain, Child, Child Development, Humans, Obesity, Biomarkers, Cytokines, Leptin, Adipokines, Executive Function
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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