Cited by 123Adipokines, Inflammation, and Metabolic DiseasesObesity, Physical Activity, DietRegulation of Appetite and Obesity

Obesity-associated biomarkers and executive function in children

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Miller, Alison L., Lee, Hannah J., Lumeng, Julie C.·2015·Pediatric Research

Abstract

There is a growing focus on links between obesity and cognitive decline in adulthood, including Alzheimer's disease. It is also increasingly recognized that obesity in youth is associated with poorer cognitive function, specifically executive functioning skills such as inhibitory control and working memory, which are critical for academic achievement. Emerging literature provides evidence for possible biological mechanisms driven by obesity; obesity-associated biomarkers such as adipokines, obesity-associated inflammatory cytokines, and obesity-associated gut hormones have been associated with learning, memory, and general cognitive function. To date, examination of obesity-associated biology with brain function has primarily occurred in animal models. The few studies examining such biologically mediated pathways in adult humans have corroborated the animal data, but this body of work has gone relatively unrecognized by the pediatric literature. Despite the fact that differences in these biomarkers have been found in association with obesity in children, the possibility that obesity-related biology could affect brain development in children has not been actively considered. We review obesity-associated biomarkers that have shown associations with neurocognitive skills, specifically executive functioning skills, which have far-reaching implications for child development. Understanding such gut-brain associations early in the lifespan may yield unique intervention implications.

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  1. [15]Diano S Farr SA Benoit SC McNay EC da Silva I Horvath B Gaskin FS Nonaka N Jaeger LB Banks WA Morley JE Pinto S Sherwin RS Xu L Yamada KA Sleeman MW Tschop MH Horvath TL Ghrelin controls hippocampal spine synapse density and memory performance Nature Neuroscience 2006 9 381 388 16491079
  2. [36]Morrison CD Leptin signaling in the brain: A link between nutrition and cognition? Biochimica et Biophysica Acta 2009 1792 401 408 19130879 PMC2670357

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Authors
Miller, A. L., Lee, H. J., & Lumeng, J. C.
Affiliations
University of Michigan (US)
Corresponding author
Miller, Alison L.
Venue
Pediatric Research
Published
2014-10-13
Volume
77
Issue
1-2
Pages
143-147
ISSN
  • 0031-3998 (ISSN-L)
  • 1530-0447
OpenAlex
W1979336020
Cited by
122
References
84
Citations by year
2026: 2 · 2025: 8 · 2024: 5 · 2023: 13 · 2022: 14 · 2021: 13 · 2020: 10 · 2019: 17 · 2018: 17 · 2017: 12 · 2016: 7 · 2015: 4
FWCI
1.02
Type
journal article
Language
en
Open access
Locations
  • Pediatric Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (RC1DK086376, R21DK090718, P30DK092926, P30DK020572, P30DK089503)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
childhood obesity, executive function, adipokines, inflammatory cytokines, gastrointestinal hormones, gut-brain axis, brain development, inhibitory control, working memory, cognitive decline, Alzheimer's disease, academic performance
MeSH terms
Brain, Child, Child Development, Humans, Obesity, Biomarkers, Cytokines, Leptin, Adipokines, Executive Function

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