Cited by 110Gut microbiota and healthGastrointestinal motility and disordersAnimal Nutrition and Physiology

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Healthy hosts rule within: ecological forces shaping the gut microbiota

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Byndloss, Mariana X., Pernitzsch, Sandy R., Bäumler, Andreas J.·2018·Mucosal Immunology

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Abstract

A balanced gut microbiota is important for human health, but the mechanisms that maintain homeostasis are incompletely understood. Recent insights suggest the host plays a key role in shaping its gut microbiota to be beneficial. While host control in the small intestine curbs bacterial numbers to avoid competition for simple sugars and amino acids, the host limits oxygen availability in the large intestine to obtain microbial fermentation products from fiber. Epithelial cells are major players in imposing ecological control mechanisms, which involves the release of antimicrobial peptides by small-intestinal Paneth cells and maintenance of luminal anaerobiosis by epithelial hypoxia in the colon. Harnessing these epithelial control mechanisms for therapeutic means could provide a novel lynchpin for strategies to remediate dysbiosis.

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Authors: Byndloss, M. X., Pernitzsch, S. R., & Bäumler, A. J.
Affiliations: University of California, Davis (US)
Corresponding author: Bäumler, Andreas J.
ORCID: Byndloss, Mariana X.
Pernitzsch, Sandy R.
Bäumler, Andreas J.
Venue: Mucosal Immunology
Publisher: Elsevier BV
Published: 2018-09
Volume: 11
Issue: 5
Pages: 1299-1305
ISSN: 1933-0219 (ISSN-L)
DOI: 10.1038/s41385-018-0010-y
OpenAlex: W2800529903
Cited by: 109
References: 106
Citations by year: 2026: 4 · 2025: 11 · 2024: 17 · 2023: 13 · 2022: 8 · 2021: 20 · 2020: 16 · 2019: 16 · 2018: 4
FWCI: 1.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1244 d)
Locations: Mucosal Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: gut microbiota, host-microbe interactions, microbial homeostasis, Paneth cells, antimicrobial peptides, dietary fiber fermentation, small intestine, large intestine, dysbiosis
MeSH terms: Gastrointestinal Microbiome, Host Microbial Interactions, Animals, Ecology, Epithelial Cells, Homeostasis, Humans, Intestinal Mucosa, Intestines, Microbiota

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Healthy hosts rule within: ecological forces shaping the gut microbiota

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