Examination of faecal Bifidobacterium populations in breast- and formula-fed infants during the first 18 months of life
Abstract
Bifidobacteria in the infant faecal microbiota have been the focus of much interest, especially during the exclusive milk-feeding period and in relation to the fortification of infant formulae to better mimic breast milk. However, longitudinal studies examining the diversity and dynamics of the Bifidobacterium population of infants are lacking, particularly in relation to the effects of weaning. Using a polyphasic strategy, the Bifidobacterium populations of breast- and formula-fed infants were examined during the first 18 months of life.Bifidobacterium-specific denaturing gradient gel electrophoresis demonstrated that breast-fed infants harboured greater diversity than formula-fed infants and the diversity of the infants'Bifidobacterium populations increased with weaning. Twenty-seven distinctive banding profiles were observed from ∼1100 infant isolates using ribosomal intergenic spacer analysis, 14 biotypes of which were confirmed to be members of the genus Bifidobacterium. Two profiles (H,Bifidobacterium longum subsp.infantis; and I,Bifidobacterium bifidum) were common culturable biotypes, seen in 9/10 infants, while profile E (Bifidobacterium breve) was common among breast-fed infants. Overall, inter- and intra-individual differences were observed in the Bifidobacterium populations of infants between 1 and 18 months of age, although weaning was associated with increased diversity of the infant Bifidobacterium populations. Breast-fed infants generally harboured a more complex Bifidobacterium microbiota than formula-fed infants.
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Breast-fed infants generally harbor a more complex and numerous Bifidobacterium microbiota than formula-fed infants.
“In fact it has been reported that breast-fed infants generally harbor a more complex and numerous Bifidobacterium microbiota than formula-fed infants (19, 20).”
From Bifidobacteria and Their Health-Promoting Effects (2017) · cites this paper as [20]
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- Authors
- Roger, L. C., Costabile, A., Holland, D. T., Hoyles, L., & McCartney, A. L.
- Affiliations
- University of Reading (GB)
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2010-11-01
- Volume
- 156
- Issue
- 11
- Pages
- 3329-3341
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2101219158
- Cited by
- 291
- References
- 45
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 18 · 2023: 12 · 2022: 14 · 2021: 24 · 2020: 24 · 2019: 16 · 2018: 20 · 2017: 26 · 2016: 25 · 2015: 29 · 2014: 21 · 2013: 17 · 2012: 18
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microbiology (publishedVersion)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (submittedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- Bifidobacterium, infant gut microbiota, breastfeeding, infant formula, weaning, microbial diversity, Bifidobacterium longum subsp. infantis, Bifidobacterium bifidum, Bifidobacterium breve, polyphasic identification, RISA, denaturing gradient gel electrophoresis
- MeSH terms
- Bifidobacterium, Breast Feeding, DNA, Bacterial, Feces, Humans, Infant, Longitudinal Studies, Species Specificity, Weaning, DNA, Ribosomal Spacer, Infant Formula, Biodiversity, Denaturing Gradient Gel Electrophoresis
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