The first isolate of Candida auris in China: clinical and biological aspects
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The emerging human fungal pathogen Candida auris has been recognized as a multidrug resistant species and is associated with high mortality. This fungus was first described in Japan in 2009 and has been reported in at least 18 countries on five continents. In this study, we report the first isolate of C. auris from the bronchoalveolar lavage fluid (BALF) of a hospitalized woman in China. Interestingly, this isolate is susceptible to all tested antifungals including amphotericin B, fluconazole, and caspofungin. Copper sulfate (CuSO4) also has a potent inhibitory effect on the growth of this fungus. Under different culture conditions, C. auris exhibits multiple morphological phenotypes including round-to-ovoid, elongated, and pseudohyphal-like forms. High concentrations of sodium chloride induce the formation of a pseudohyphal-like form. We further demonstrate that C. auris is much less virulent than Candida albicans in both mouse systemic and invertebrate Galleria mellonella models.
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Only one study has reported filamentous growth in C. auris to date, and that growth occurred under conditions of high salt concentrations.
“Only one study has reported filamentous growth in C. auris to date, and that growth occurred under conditions of high salt concentrations (31).”
From Genetic Analysis of <i>Candida auris</i> Implicates Hsp90 in Morphogenesis and Azole Tolerance and Cdr1 in Azole Resistance (2019) · cites this paper as [31]
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Self-citation
- Authors
- Wang, X., Bing, J., Zheng, Q., Zhang, F., Liu, J., Yue, H., Tao, L., Du, H., Wang, Y., Wang, H., & Huang, G.
- Affiliations
- Peking University (CN)
- Chinese Academy of Sciences (CN)
- State Key Laboratory of Mycology, Institute of MicrobiologyChinese Academy of Sciences
- Fudan University (CN)
- Corresponding author
- Wang, Hui
- Huang, Guanghua
- ORCID
- Venue
- Emerging Microbes & Infections
- Publisher
- Informa UK Limited
- Published
- 2018-05-18
- Volume
- 7
- Issue
- 1
- Pages
- 1-9
- ISSN
- 2222-1751 (ISSN-L)
- PMC
- PMC5959928
- OpenAlex
- W2803141418
- Cited by
- 191
- References
- 32
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 27 · 2023: 22 · 2022: 17 · 2021: 23 · 2020: 27 · 2019: 22 · 2018: 8
- FWCI
- 15.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Emerging Microbes & Infections (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China
- Peking University
- National Science and Technology Major Project
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida auris, bronchoalveolar lavage fluid, antifungal susceptibility, copper sulfate, morphological phenotypes, pseudohyphal growth, sodium chloride, virulence, Galleria mellonella, multidrug resistance, emerging fungal pathogens
- MeSH terms
- Caspofungin, Aged, Amphotericin B, Animals, Antifungal Agents, Bronchoalveolar Lavage Fluid, Candida, China, Female, Humans, Mice, Inbred BALB C, Microbial Sensitivity Tests, Moths, Fluconazole, Copper Sulfate, Mice, Echinocandins, Lipopeptides, Candidemia
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