Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter
Abstract
Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, and thus, intraoperative identification of ureters is of paramount importance but lacks efficient methods and probes. Herein, we used near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging with advantages of higher spatial resolution, deeper tissue penetration, lower light scattering, and less tissue autofluorescence to identify ureters by aggregation-induced emission luminogen dots (AIE dots). The intraoperative ureteral injuries and common ureteral diseases can be visualized timely and precisely. Due to the longer emission wavelength and higher quantum yield of the AIE dots, it largely outperforms the commercial indocyanine green dye in brightness and penetration depth. It was the first time to realize the intraoperative identification of ureters in vivo using NIR-II imaging. Thus, our work provides a new platform for intraoperative monitoring during clinical operation.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm.
“A general rule, as exemplified in cyanine dyes, is that each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm111–123.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [114]
The BBTD core and its derivatives are potent electron-accepting units with excellent quantum efficiency, making them ideal for low-bandgap polymers and long-wavelength NIR-II fluorophores.
“The benzobisthiadiazole (BBTD) core and its derivatives are potent electron-accepting units with excellent quantum efficiency, making them ideal for the design of low-bandgap polymers and long-wavelength NIR-II fluorophores (Fig. 5 and Table 2)114–150.”
From Organic small-molecule NIR-II fluorophores for tumor phototheranostics (2026) · cites this paper as [114]
Cites
Near-infrared fluorophores for biomedical imaging
Hong, G., Antaris, A. L., & Dai, H. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-016-0010 · Cited by 3,013 · see citing works
Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics
Chen, G., Qiu, H., Prasad, P. N., & Chen, X. S. (2014) · Chemical Reviews · doi:10.1021/cr400425h · Cited by 2,704 · see citing works
EAU Guidelines on Interventional Treatment for Urolithiasis
Türk, C., Petřík, A., Sarıca, K., Seitz, C., Skolarikos, A. A., Straub, M., & Knoll, T. M. (2015) · European Urology · doi:10.1016/j.eururo.2015.07.041 · Cited by 1,806 · see citing works
A small-molecule dye for NIR-II imaging
Antaris, A. L., Chen, H., Cheng, K., Sun, Y., Hong, G., Qu, C., Diao, S., Deng, Z., Hu, X., Zhang, B., et al. (2016) · Nature Materials · doi:10.1038/nmat4476 · Cited by 1,778 · see citing works
Image-guided cancer surgery using near-infrared fluorescence
Vahrmeijer, A. L., Hutteman, M., van der Vorst, J. R., van de Velde, C. J. �., & Frangioni, J. V. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.123 · Cited by 1,470 · see citing works
Relative fluorescence quantum yields using a computer-controlled luminescence spectrometer
Williams, A. T. R., Winfield, S. A., & Miller, J. N. (1983) · The Analyst · doi:10.1039/an9830801067 · Cited by 1,461 · see citing works
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287 · see citing works
Li, J., & Pu, K. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00001h · Cited by 1,171 · see citing works
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052 · see citing works
Molecular afterglow imaging with bright, biodegradable polymer nanoparticles
Miao, Q., Xie, C., Xu, Z. J., Lyu, Y., Duan, H., Liu, X., Jokerst, J. V., & Pu, K. (2017) · Nature Biotechnology · doi:10.1038/nbt.3987 · Cited by 979 · see citing works
Near‐Infrared‐II Molecular Dyes for Cancer Imaging and Surgery
Zhu, S., Tian, R., Antaris, A. L., Chen, X. S., & Dai, H. (2019) · Advanced Materials · doi:10.1002/adma.201900321 · Cited by 968 · see citing works
Aggregation-induced emission: fundamental understanding and future developments
Chen, Y., Lam, J. W. Y., Kwok, R. T. K., Liu, B., & Tang, B. Z. (2018) · Materials Horizons · doi:10.1039/c8mh01331d · Cited by 897 · see citing works
Self-citationRecent Advances of Optical Imaging in the Second Near‐Infrared Window
Kenry, K., Duan, Y., & Liu, B. (2018) · Advanced Materials · doi:10.1002/adma.201802394 · Cited by 813 · see citing works
Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging
Fan, Y., Wang, P., Lu, Y., Wang, R., Zhou, L., Zheng, X., Li, X., Piper, J. A., & Zhang, F. (2018) · Nature Nanotechnology · doi:10.1038/s41565-018-0221-0 · Cited by 800 · see citing works
Clusterization-triggered emission: Uncommon luminescence from common materials
Zhang, H., Zhao, Z., McGonigal, P. R., Ye, R., Liu, S., Lam, J. W. Y., Kwok, R. T. K., Yuan, W. Z., Xie, J., Rogach, A. L., et al. (2019) · Materials Today · doi:10.1016/j.mattod.2019.08.010 · Cited by 726 · see citing works
Self-citationMolecular optical imaging probes for early diagnosis of drug-induced acute kidney injury
Huang, J., Li, J., Lyu, Y., Miao, Q., & Pu, K. (2019) · Nature Materials · doi:10.1038/s41563-019-0378-4 · Cited by 723 · see citing works
Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721 · see citing works
Li, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658 · see citing works
Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics
Liu, S., Zhou, X., Zhang, H., Ou, H., Lam, J. W. Y., Liu, Y., Shi, L., Ding, D., & Tang, B. Z. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b13889 · Cited by 647 · see citing works
Self-citationOptical nano-agents in the second near-infrared window for biomedical applications
Cai, Y., Wei, Z., Song, C., Tang, C., Han, W., & Dong, X. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00494c · Cited by 603 · see citing works
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582 · see citing works
AIE Luminogens for Bioimaging and Theranostics: From Organelles to Animals
Qian, J., & Tang, B. Z. (2017) · Chem · doi:10.1016/j.chempr.2017.05.010 · Cited by 576 · see citing works
Self-citationHong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563 · see citing works
Molecular Imaging with Theranostic Nanoparticles
Jokerst, J. V., & Gambhir, S. S. (2011) · Accounts of Chemical Research · doi:10.1021/ar200106e · Cited by 554 · see citing works
Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Ding, F., Zhan, Y., Lu, X., & Sun, Y. (2018) · Chemical Science · doi:10.1039/c8sc01153b · Cited by 540 · see citing works
Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510 · see citing works
Liang, C., Diao, S., Wang, C., Gong, H., Liu, T., Hong, G., Shi, X., Dai, H., & Liu, Z. (2014) · Advanced Materials · doi:10.1002/adma.201401825 · Cited by 502 · see citing works
Gu, Z., Yan, L., Tian, G., Li, S., Chai, Z., & Zhao, Y. (2013) · Advanced Materials · doi:10.1002/adma.201301197 · Cited by 492 · see citing works
Ni, X., Zhang, X., Duan, X., Zheng, H., Xue, X., & Ding, D. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b03936 · Cited by 483 · see citing works
Aqueous Based Semiconductor Nanocrystals
Jing, L., Kershaw, S. V., Li, Y., Huang, X., Li, Y., Rogach, A. L., & Gao, M. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00041 · Cited by 453 · see citing works
Self-citationNIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer
Wang, P., Fan, Y., Lu, L., Liu, L., Fan, L., Zhao, M., Xie, Y., Xu, C., & Zhang, F. (2018) · Nature Communications · doi:10.1038/s41467-018-05113-8 · Cited by 453 · see citing works
Qi, J., Chen, C., Zhang, X., Hu, X., Ji, S., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2018) · Nature Communications · doi:10.1038/s41467-018-04222-8 · Cited by 350 · see citing works
Self-citationAggregation-Induced Emission: A Trailblazing Journey to the Field of Biomedicine
Zhu, C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2018) · ACS Applied Bio Materials · doi:10.1021/acsabm.8b00600 · Cited by 346 · see citing works
Self-citationChen, C., Ou, H., Liu, R., & Ding, D. (2019) · Advanced Materials · doi:10.1002/adma.201806331 · Cited by 344 · see citing works
Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging
Liu, S., Chen, C., Li, Y., Zhang, H., Liu, J., Wang, R., Wong, S. T. H., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201908125 · Cited by 266 · see citing works
Self-citationHuang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201909560 · Cited by 258 · see citing works
Ghosh, D., Bagley, A. F., Na, Y. J., Birrer, M. J., Bhatia, S. N., & Belcher, A. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400821111 · Cited by 253 · see citing works
Wang, R., Zhou, L., Wang, W.-X., Li, X.-M., & Zhang, F. (2017) · Nature Communications · doi:10.1038/ncomms14702 · Cited by 240 · see citing works
In Situ Monitoring Apoptosis Process by a Self-Reporting Photosensitizer
Zhang, T., Li, Y., Zheng, Z., Ye, R., Zhang, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b00636 · Cited by 236 · see citing works
Self-citationLei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie · doi:10.1002/ange.201904182 · Cited by 209 · see citing works
Randomized Trial of Near-infrared Incisionless Fluorescent Cholangiography
Dip, F., Menzo, E. L., Sarotto, L. E., Phillips, E. H., Todeschini, H., Nahmod, M. S., Alle, L., Schneider, S., Ludwig, K., Boni, L., et al. (2019) · Annals of Surgery · doi:10.1097/sla.0000000000003178 · Cited by 206 · see citing works
Optical Multiplexed Bioassays for Improved Biomedical Diagnostics
Fan, Y., Wang, S., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201901964 · Cited by 170 · see citing works
Urinary Tract Injures: Recognition and Management
Delacroix, S. E., & Winters, J. C. (2010) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0030-1254297 · Cited by 167 · see citing works
Carr, J. A., Aellen, M., Franke, D., So, P. T. C., Bruns†, O. T., & Bawendi, M. G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1803210115 · Cited by 156 · see citing works
Wang, S., Liu, J., Goh, C. C., Ng, L. G., & Liu, B. (2019) · Advanced Materials · doi:10.1002/adma.201904447 · Cited by 148 · see citing works
Li, C., Zhang, Y., Chen, G., Hu, F., Zhao, K., & Wang, Q. (2017) · Advanced Materials · doi:10.1002/adma.201605754 · Cited by 134 · see citing works
Self-citationDeep-tissue optical imaging of near cellular-sized features
Dang, X., Bardhan, N. M., Qi, J., Gu, L., Eze, N. A., Lin, C., Kataria, S., Hammond, P. T., & Belcher, A. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-39502-w · Cited by 102 · see citing works
Molecular Motion in the Solid State
Liu, S., Li, Y., Zhang, H., Zhao, Z., Lu, X., Lam, J. W. Y., & Tang, B. Z. (2019) · ACS Materials Letters · doi:10.1021/acsmaterialslett.9b00292 · Cited by 95 · see citing works
Self-citationQian, G., Qi, J., Davey, J. A., Wright, J. S., & Wang, Z. Y. (2012) · Chemistry of Materials · doi:10.1021/cm300938s · Cited by 89 · see citing works
Methylene blue fluorescence of the ureter during colorectal surgery
Barnes, T. G., Hompes, R., Birks, J., Mortensen, N. J. M., Jones, O. M., Lindsey, I., Guy, R., George, B. D., Cunningham, C., & Yeung, T. M. (2018) · Surgical Endoscopy · doi:10.1007/s00464-018-6219-8 · Cited by 85 · see citing works
Stability studies on indocyanine green dye
Gathje, J., Steuer, R. R., & Nicholes, K. R. (1970) · Journal of Applied Physiology · doi:10.1152/jappl.1970.29.2.181 · Cited by 82 · see citing works
Drawing a clear mechanistic picture for the aggregation-induced emission process
Zhang, H., Liu, J., Du, L., Ma, C., Leung, N. L. C., Niu, Y., Qin, A., Sun, J. Z., Peng, Q., Sung, H. H. Y., et al. (2019) · Materials Chemistry Frontiers · doi:10.1039/c9qm00156e · Cited by 80 · see citing works
Self-citationde Valk, K. S., Handgraaf, H. J. M., Deken, M. M., Mulder, B. G. S., Valentijn, A. R. P. M., van Scheltinga, A. G. T. T., Kuil, J., van Esdonk, M. J., Vuijk, J., Bevers, R. F. M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11014-1 · Cited by 79 · see citing works
Sparks fly when AIE meets with polymers
Li, Y., Liu, S., Han, T., Zhang, H., Chuah, C., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2019) · Materials Chemistry Frontiers · doi:10.1039/c9qm00404a · Cited by 77 · see citing works
Self-citationUniversal ureteral stent placement at hysterectomy to identify ureteral injury: a decision analysis
Mo, S., GOTTENGER, E. E., & Wagner, J. (2008) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2008.01757.x · Cited by 75 · see citing works
Near-infrared fluorescence imaging in the largely unexplored window of 900-1,000 nm
Deng, G., Li, S., Sun, Z., Li, W., Zhou, L., Zhang, J., Gong, P., & Cai, L. (2018) · Theranostics · doi:10.7150/thno.26539 · Cited by 74 · see citing works
Self-citationvan den Berg, N. S., Buckle, T., KleinJan, G. H., van der Poel, H. G., & van Leeuwen, F. W. B. (2016) · European Urology · doi:10.1016/j.eururo.2016.06.012 · Cited by 65 · see citing works
Prevention of iatrogenic ureteral injuries during robotic gynecologic surgery: a review
Lee, Z., Kaplan, J. R., Giusto, L., & Eun, D. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.10.150 · Cited by 60 · see citing works
Utility of Cystoscopy During Hysterectomy
Sandberg, E. M., Cohen, S. L., Hurwitz, S., & Einarsson, J. I. (2012) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e318272393b · Cited by 51 · see citing works
Identifying Ureters In Situ Under Fluorescence During Laparoscopic and Open Colorectal Surgery
Yeung, T. M., Volpi, D., Tullis, I. D. C., Nicholson, G. A., Buchs, N. C., Cunningham, C., Guy, R., Lindsey, I., George, B. D., Jones, O. M., et al. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001513 · Cited by 50 · see citing works
Zhao, M., Wang, R., Li, B., Fan, Y., Wu, Y., Zhu, X., & Zhang, F. (2018) · Angewandte Chemie · doi:10.1002/ange.201812878 · Cited by 46 · see citing works
Huang, J., Lyu, Y., Li, J., Cheng, P., Jiang, Y., & Pu, K. (2019) · Angewandte Chemie · doi:10.1002/ange.201910137 · Cited by 36 · see citing works
Intraoperative Ureter Visualization Using a Novel Near-Infrared Fluorescent Dye
Mahalingam, S. M., Dip, F., Castillo, M., Roy, M., Wexner, S. D., Rosenthal, R. J., & Low, P. S. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00427 · Cited by 35 · see citing works
Rowe, C. K., Franco, F. B., Barbosa, J. A. B. A., Minnillo, B. J., Chow, J. S., Treves, S. T., Retik, A. B., & Nguyen, H. T. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.07.002 · Cited by 15 · see citing works
Chen, C., Ni, X., Jia, S., Liang, Y., Wu, X., Kong, D., & Ding, D. (2019) · Advanced Materials · doi:10.1002/adma.201970372 · Cited by 10 · see citing works
Chen, D., Dong, L., Jiang, S., Li, W., Shi, J., Feng, X., Zhi, J., Tong, B., Li, M., Zheng, Q., et al. (2017) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2017.08.142 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Liu, Y., Li, Y., Koo, S., Sun, Y., Liu, Y., Liu, X., Pan, Y., Zhang, Z., Du, M., Lu, S., et al. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00553 · Cited by 544 · see citing works
Self-citationNIR‐II AIEgens: A Win–Win Integration towards Bioapplications
Xu, W., Wang, D., & Tang, B. Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202005899 · Cited by 460 · see citing works
Self-citationNIR-II light in clinical oncology: opportunities and challenges
Zhang, Z., Du, Y., Shi, X., Wang, K., Qu, Q., Liang, Q. Y., Ma, X., He, K., Chi, C., Tang, J., et al. (2024) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-024-00892-0 · Cited by 364 · see citing works
Gathering brings strength: How organic aggregates boost disease phototheranostics
Qi, J., Ou, H., Liu, Q., & Ding, D. (2021) · Aggregate · doi:10.1002/agt2.25 · Cited by 284 · see citing works
Liu, S., Ou, H., Li, Y., Zhang, H., Liu, J., Lu, X., Kwok, R. T. K., Lam, J. W. Y., Ding, D., & Tang, B. Z. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07193 · Cited by 277 · see citing works
Self-citationStructural and process controls of AIEgens for NIR-II theranostics
Liu, S., Li, Y., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2020) · Chemical Science · doi:10.1039/d0sc02911d · Cited by 276 · see citing works
Self-citationZhao, M., Li, B., Wu, Y., He, H., Zhu, X., Zhang, H., Dou, C., Feng, L., Fan, Y., & Zhang, F. (2020) · Advanced Materials · doi:10.1002/adma.202001172 · Cited by 237 · see citing works
Nanomaterials with Supramolecular Assembly Based on AIE Luminogens for Theranostic Applications
Song, N., Zhang, Z., Liu, P., Yang, Y., Wang, L., Wang, D., & Tang, B. Z. (2020) · Advanced Materials · doi:10.1002/adma.202004208 · Cited by 229 · see citing works
Self-citationChen, R., Ren, C., Liu, M., Ge, X., Qu, M., Zhou, X., Liang, M., Liu, Y., & Li, F. (2021) · ACS Nano · doi:10.1021/acsnano.1c01932 · Cited by 188 · see citing works
Zhu, W., Kang, M., Wu, Q., Zhang, Z., Wu, Y., Li, C., Li, K., Wang, L., Wang, D., & Tang, B. Z. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202007026 · Cited by 162 · see citing works
Self-citationSurgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging
Yang, R., Lou, K., Wang, P., Gao, Y., Zhang, Y., Chen, M., Huang, W., & Zhang, G. (2021) · Small Methods · doi:10.1002/smtd.202001066 · Cited by 150 · see citing works
Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases
Huang, J., & Pu, K. (2020) · Chemical Science · doi:10.1039/d0sc02925d · Cited by 145 · see citing works
AIEgens for microbial detection and antimicrobial therapy
Bai, H., He, W., Chau, J. H. C., Zheng, Z., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2020.120598 · Cited by 130 · see citing works
Self-citationA short review on NIR-II organic small molecule dyes
Li, L., Dong, X., Li, J., & Wei, J. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108756 · Cited by 113 · see citing works
Noncancerous disease-targeting AIEgens
Duo, Y., Luo, G., Zhang, W., Wang, R., Xiao, G. G., Li, Z., Li, X., Chen, M., Yoon, J., & Tang, B. Z. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00610c · Cited by 106 · see citing works
Self-citationZhang, T., Zhang, J., Wang, F., Cao, H., Zhu, D., Chen, X., Xu, C., Yang, X., Huang, W., Wang, Z., et al. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202110526 · Cited by 106 · see citing works
Self-citationTracking tumor heterogeneity and progression with near‐infrared II fluorophores
Qi, X., Ma, H., Wang, H., & Zhang, X. (2023) · Exploration · doi:10.1002/exp.20220011 · Cited by 95 · see citing works
Recent Advances in Second Near-Infrared Region (NIR-II) Fluorophores and Biomedical Applications
Chen, Y., Xue, L., Zhu, Q., Feng, Y., & Wu, M. (2021) · Frontiers in Chemistry · doi:10.3389/fchem.2021.750404 · Cited by 94 · see citing works
Aggregation-induced emission luminogens for assisted cancer surgery
Dai, J., Xue, H., Chen, D., Lou, X., Xia, F., & Wang, S. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214552 · Cited by 89 · see citing works
Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy
Lin, H., Lin, Z., Konghua, Z., Wang, C., Lin, L., Chen, J., & Song, J. (2021) · Advanced Optical Materials · doi:10.1002/adom.202002177 · Cited by 81 · see citing works
Yang, J., He, S., Hu, Z., Zhang, Z., Cao, C., Cheng, Z., Fang, C., & Tian, J. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101120 · Cited by 78 · see citing works
PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics
Dai, J., Dong, X., Wang, Q., Lou, X., Xia, F., & Wang, S. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101036 · Cited by 72 · see citing works
Phototherapy and optical waveguides for the treatment of infection
Wang, D., Kuzma, M. L., Tan, X., He, T., Dong, C., Liu, Z., & Yang, J. Y. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114036 · Cited by 72 · see citing works
NIR‐II AIEgens: A Win–Win Integration towards Bioapplications
Xu, W., Wang, D., & Tang, B. Z. (2020) · Angewandte Chemie · doi:10.1002/ange.202005899 · Cited by 70 · see citing works
Self-citationXu, Z., Jiang, Y., Fan, M., Tang, S., Liu, M., Law, W., Yang, C., Ying, M., Ma, M., Dong, B., et al. (2021) · Advanced Optical Materials · doi:10.1002/adom.202100859 · Cited by 67 · see citing works
He, W., Zhang, T., Bai, H., Kwok, R. T. K., Lam, J. W. Y., & Tang, B. Z. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101055 · Cited by 66 · see citing works
Self-citationHe, Q., Wang, M., Li, Z., Xu, B., Tian, W., & Zhang, L. (2024) · Aggregate · doi:10.1002/agt2.505 · Cited by 65 · see citing works
Shen, Q., Wang, S., Yang, N., Zhang, C., Wu, Q., & Yu, C. (2020) · Journal of Luminescence · doi:10.1016/j.jlumin.2020.117338 · Cited by 60 · see citing works
Recent advances on inorganic lanthanide-doped NIR-II fluorescence nanoprobes for bioapplication
Li, Z., Ding, X., Cong, H., Wang, S., Yu, B., & Shen, Y. (2020) · Journal of Luminescence · doi:10.1016/j.jlumin.2020.117627 · Cited by 51 · see citing works
White-light activatable organic NIR-II luminescence nanomaterials for imaging-guided surgery
Li, C., Du, J., Jiang, G., Gong, J., Zhang, Y., Yao, M., Wang, J., Wu, L., & Tang, B. Z. (2024) · Nature Communications · doi:10.1038/s41467-024-50202-6 · Cited by 49 · see citing works
Self-citationLi, S., Cheng, T., Yin, C., Zhou, S., Fan, Q., Wu, W., & Jiang, X. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c12773 · Cited by 47 · see citing works
Nanotherapeutics targeting autophagy regulation for improved cancer therapy
Liu, Y., Wang, Y., Zhang, J., Peng, Q., Wang, X., Xiao, X., & Shi, K. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.03.019 · Cited by 44 · see citing works
Near-Infrared Fluorescence Probes for Monitoring and Diagnosing Nephron-Urological Diseases
Wang, J., Sheng, Z., Guo, J., Wang, H.-Y., Sun, X., & Liu, Y. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215137 · Cited by 43 · see citing works
Zhang, R., Bi, Z., Zhang, L., Han, Y., Wang, H., Zhang, W., Qiu, Z., Zhang, C., Xiong, Y., Li, Y., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c06061 · Cited by 42 · see citing works
Self-citationYe, F., Huang, W., Li, C., Li, G., Yang, W., Liu, S. H., Yin, J., Sun, Y., & Yang, G. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000170 · Cited by 39 · see citing works
Self-citationLighting up forensic science by aggregation-induced emission: A review
Yan, Y., Zhang, J., Yi, S., Liu, L., & Huang, C. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.11.051 · Cited by 38 · see citing works
Conjugated Polymer Nanoparticles for Tumor Theranostics
Li, T., Wu, M., Wei, Q., Xu, D., He, X., Wang, J., Wu, J., & Chen, L. (2023) · Biomacromolecules · doi:10.1021/acs.biomac.2c01446 · Cited by 35 · see citing works
Liu, S., Li, Y., Zhang, J., Zhang, H., Wang, Y., Chuah, C., Tang, Y., Lam, J. W. Y., Kwok, R. T. K., Ou, H., et al. (2020) · Materials Today Bio · doi:10.1016/j.mtbio.2020.100087 · Cited by 34 · see citing works
Self-citationUtilization of aggregation‐induced emission materials in urinary system diseases
Xu, H., Chen, X., Wang, H., Wang, C., Guo, Y., Lin, Y., Huang, Y., Hou, J., & Wei, X. (2024) · Aggregate · doi:10.1002/agt2.580 · Cited by 31 · see citing works
Self-citationXie, D., Yan, X., Shang, W., Ren, H., Wen, W., Tang, B. Z., & Su, H. (2025) · ACS Nano · doi:10.1021/acsnano.5c00942 · Cited by 30 · see citing works
Self-citationWei, Z., Duan, G., Huang, B., Qiu, S., Zhou, D., Zeng, J., Cui, J., Hu, C., Wang, X., Wen, L., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01112-y · Cited by 28 · see citing works
Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores
Wang, Z., She, M., Chen, J., Cheng, Z.-Q., & Li, J. (2021) · Advanced Optical Materials · doi:10.1002/adom.202101634 · Cited by 22 · see citing works
Pediatric Urolithiasis: Current Surgical Strategies and Future Perspectives
Paraboschi, I., Gnech, M., Marco, E. A. D., Minoli, D. G., Bebi, C., Zanetti, S. P., Manzoni, G., Montanari, E., & Berrettini, A. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.886425 · Cited by 21 · see citing works
Tao, M., Mao, J., Bao, Y., Liu, F., Mai, Y., Guan, S., Luo, S., Huang, Y., Li, Z., Zhong, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202205435 · Cited by 20 · see citing works
Self-citationOrganic small-molecule NIR-II fluorophores for tumor phototheranostics
Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
Wang, W., Liu, Y., Xu, J., Deng, Y., Chen, W., Lin, Y., Tang, B. Z., & Zhang, M. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217553 · Cited by 16 · see citing works
Self-citationRecent advances of aggregation‐induced emission in body surface organs
Li, H., Zhang, T., Liao, Y., Liu, C., He, Y., Wang, Y., Li, C., Jiang, C., Li, C., Luo, G., et al. (2023) · Aggregate · doi:10.1002/agt2.470 · Cited by 15 · see citing works
Self-citationSupramolecular engineering cascade regulates NIR-II J-aggregates to improve photodynamic therapy
Wang, H., Liu, H., Li, W., Li, S., Zhang, J., Zang, J., Liu, L., & Wang, P. (2024) · Chemical Science · doi:10.1039/d4sc03020f · Cited by 15 · see citing works
Self-citationRetractedHarnessing Aggregation‐Induced Emission‐Based Detection Toolbox for Diagnostics of Urogenital Tumors
Chen, W., Guan, H., Lu, Y., Zeng, G., Gu, D., Guo, K., Jiang, C., & Liu, H. (2025) · Aggregate · doi:10.1002/agt2.70008 · Cited by 14 · see citing works
Self-citationZhang, Y., Peng, S., Guo, J., Li, J., Lu, Z., Wu, T., Chen, L., Liu, W., Feng, Z., Zhang, M., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c15799 · Cited by 13 · see citing works
Advances in the near-infrared Ⅱ for in vivo fluorescence imaging applications: A review
Zou, M., Wang, Y., Jiao, J., Lv, M., & Mo, T. (2025) · Talanta · doi:10.1016/j.talanta.2025.128630 · Cited by 12 · see citing works
Xie, H., Tian, Z., Zhang, R., Huang, Z., Wang, Y., Liu, Z., Kwok, R. T. K., Lam, J. W. Y., Zhao, Z., Huang, Y., et al. (2025) · Journal of the American Chemical Society · doi:10.1021/jacs.5c17089 · Cited by 11 · see citing works
Self-citationDeep learning: step forward to high‐resolution in vivo shortwave infrared imaging
Baulin, V. A., Usson, Y., & Le Guével, X. (2021) · Journal of Biophotonics · doi:10.1002/jbio.202100102 · Cited by 10 · see citing works
Zang, S., Wu, S., Lili, X., Deng, X., & Zhao, Y. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c00872 · Cited by 8 · see citing works
Zhang, J., Yang, Q., Zhao, C., Cao, S., Xia, M., Mu, X., & Yin, H. (2026) · RSC Advances · doi:10.1039/d5ra08225k · Cited by 6 · see citing works
Moghal, Z. K. B., Oh, H. C., & Son, Y.-Α. (2022) · Dyes and Pigments · doi:10.1016/j.dyepig.2022.110159 · Cited by 6 · see citing works
Hettie, K. S. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.670251 · Cited by 5 · see citing works
Biomedical applications of the engineered AIEgen-lipid nanostructure in vitro and in vivo
Suo, M., Zhang, T.-F., & Liang, X.-J. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad9aeb · Cited by 6 · see citing works
Intramolecular motion-associated biomaterials for image-guided cancer surgery
Chen, C., Tang, Y., & Ding, D. (2020) · Smart Materials in Medicine · doi:10.1016/j.smaim.2020.05.001 · Cited by 4 · see citing works
Recent advances in Aggregation-Induced Emission in body surface organsPreprint
Li, H., Zhang, T., Liao, Y., Liu, C., Luo, G., Xiang, Z., & Duo, Y. (2023) · doi:10.22541/au.169698075.56291622/v1 · Cited by 1 · see citing works
Zhao, H., Li, C., Zhu, W., Yu, M., Huang, B., Wang, X., Li, J., Yang, Y., Xue, L., Ni, J., et al. (2021) · ChemRxiv · doi:10.26434/chemrxiv.14131775.v1 · Cited by 1 · see citing works
Self-citationAIE Nanoprobes for NIR‐II Fluorescence In Vivo Functional Bioimaging
Feng, Z., Yu, X., & Qian, J. (2022) · doi:10.1002/9781119643098.ch55 · Cited by 1 · see citing works
Kamimura, M. (2020) · Springer eBooks · doi:10.1007/978-981-15-9627-8_3
Deep learning: step forward to high-resolution in vivo shortwave infrared imagingPreprint
Baulin, V. A., Usson, Y., & Guével, X. L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.03.04.433844
Visualization of Polymer Microstructures
Liu, S., Li, Y., Han, T., Lam, J. W. Y., & Tang, B. Z. (2022) · doi:10.1002/9781119643098.ch47
Self-citationZhao, H., Li, C., Zhu, W., Yu, M., Huang, B., Wang, X., Li, J., Yang, Y., Xue, L., Ni, J., et al. (2021) · ChemRxiv · doi:10.26434/chemrxiv.14131775
Self-citationAIE-based Fluorescence Imaging
Dong, L., & Han, H. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/9781837673117-00132
Xiao, P., Dong, J., & Xie, F. (2026) · Springer eBooks · doi:10.1007/978-981-97-1574-9_186-1
AIEgens: A New Generation of Medical Fluorescent Navigation Probes
Chen, D., Zhang, J., & Li, M. (2026) · Springer eBooks · doi:10.1007/978-981-97-1574-9_15-1
Wang, H., Xu, H., & Zhang, W. (2026) · Springer eBooks · doi:10.1007/978-981-97-1574-9_12-1
Self-citation
- Authors
- Du, J., Liu, S., Zhang, P., Liu, H., Li, Y., He, W., Li, C., Chau, J. H. C., Kwok, R. T. K., Lam, J. W. Y., Cai, L., Huang, Y., Zhang, W., Hou, J., & Tang, B. Z.
- Affiliations
- Chinese Academy of Sciences (CN)
- Hong Kong University of Science and Technology (HK)
- First Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Zhang, Weijie
- Hou, Jianquan
- Tang, Ben Zhong
- ORCID
- Venue
- ACS Applied Materials & Interfaces
- Publisher
- American Chemical Society (ACS)
- Published
- 2020-01-23
- Volume
- 12
- Issue
- 7
- Pages
- 8040-8049
- ISSN
- 1944-8244 (ISSN-L)
- 1944-8252
- OpenAlex
- W3002404890
- Cited by
- 70
- References
- 66
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 18 · 2020: 18
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- ACS Applied Materials & Interfaces (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- Research Grants Council, University Grants Committee (A-HKUST605/16, C6009-17G)
- Natural Science Foundation of Jiangsu Province (BK20190175)
- Shenzhen Science and Technology Innovation Commission (JCYJ20180507183832744)
- Innovation and Technology Commission (ITC-CNERC14SC01, ITCPD/17-9, ITS/254/17)
- National Natural Science Foundation of China (21788102, 21805002, 81472401, 81772708)
- Jiangsu Provincial Key Medical Discipline (ZDXKA2016012)
- Science and Technology Project for the Youth of Suzhou (KJXW2018006)
- Ming Wai Lau Centre for Reparative Medicine Associate Member Programme
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Keywords
- aggregation-induced emission, NIR-II fluorescence imaging, ureter identification, intraoperative fluorescence imaging, iatrogenic ureteral injury, ureteral diseases, indocyanine green, quantum yield, tissue penetration depth
- MeSH terms
- Animals, Urinary Bladder, Cells, Cultured, Fluorescence, Fluorescent Dyes, Humans, Kidney, Phosphatidylethanolamines, Polyethylene Glycols, Rabbits, Staining and Labeling, Ureter, Monitoring, Intraoperative, Microscopy, Electron, Transmission, Nanocomposites, Optical Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review