Cited by 70Luminescence and Fluorescent MaterialsOptical Imaging and Spectroscopy TechniquesMolecular Sensors and Ion Detection

Highly Stable and Bright NIR-II AIE Dots for Intraoperative Identification of Ureter

Du, Jian, Liu, Shunjie, Zhang, Pengfei, Liu, Haixiang, Li, Yuanyuan, He, Wei, Li, Chunbin, Chau, Joe H. C. +7 more·2020·ACS Applied Materials & Interfaces

Abstract

Iatrogenic ureteral injury is a dreaded complication of abdominal and pelvic surgeries, and thus, intraoperative identification of ureters is of paramount importance but lacks efficient methods and probes. Herein, we used near-infrared II (NIR-II, 1000-1700 nm) fluorescence imaging with advantages of higher spatial resolution, deeper tissue penetration, lower light scattering, and less tissue autofluorescence to identify ureters by aggregation-induced emission luminogen dots (AIE dots). The intraoperative ureteral injuries and common ureteral diseases can be visualized timely and precisely. Due to the longer emission wavelength and higher quantum yield of the AIE dots, it largely outperforms the commercial indocyanine green dye in brightness and penetration depth. It was the first time to realize the intraoperative identification of ureters in vivo using NIR-II imaging. Thus, our work provides a new platform for intraoperative monitoring during clinical operation.

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Crossref · 10.1021/acsami.9b22957

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  • Each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm.

    “A general rule, as exemplified in cyanine dyes, is that each methylene unit inserted between donor and acceptor typically induces a red-shift of ~100 nm111–123.”
  • The BBTD core and its derivatives are potent electron-accepting units with excellent quantum efficiency, making them ideal for low-bandgap polymers and long-wavelength NIR-II fluorophores.

    “The benzobisthiadiazole (BBTD) core and its derivatives are potent electron-accepting units with excellent quantum efficiency, making them ideal for the design of low-bandgap polymers and long-wavelength NIR-II fluorophores (Fig. 5 and Table 2)114–150.”

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Authors
Du, J., Liu, S., Zhang, P., Liu, H., Li, Y., He, W., Li, C., Chau, J. H. C., Kwok, R. T. K., Lam, J. W. Y., Cai, L., Huang, Y., Zhang, W., Hou, J., & Tang, B. Z.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Hong Kong University of Science and Technology (HK)
  • First Affiliated Hospital of Soochow University (CN)
Corresponding author
  • Zhang, Weijie
  • Hou, Jianquan
  • Tang, Ben Zhong
Venue
ACS Applied Materials & Interfaces
Published
2020-01-23
Volume
12
Issue
7
Pages
8040-8049
ISSN
  • 1944-8244 (ISSN-L)
  • 1944-8252
OpenAlex
W3002404890
Cited by
70
References
66
Citations by year
2026: 5 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 18 · 2020: 18
FWCI
4.96
Type
journal article
Language
en
Open access
closed
Locations
  • ACS Applied Materials & Interfaces (publishedVersion)
  • PubMed (publishedVersion)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders
  • Research Grants Council, University Grants Committee (A-HKUST605/16, C6009-17G)
  • Natural Science Foundation of Jiangsu Province (BK20190175)
  • Shenzhen Science and Technology Innovation Commission (JCYJ20180507183832744)
  • Innovation and Technology Commission (ITC-CNERC14SC01, ITCPD/17-9, ITS/254/17)
  • National Natural Science Foundation of China (21788102, 21805002, 81472401, 81772708)
  • Jiangsu Provincial Key Medical Discipline (ZDXKA2016012)
  • Science and Technology Project for the Youth of Suzhou (KJXW2018006)
  • Ming Wai Lau Centre for Reparative Medicine Associate Member Programme
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Keywords
aggregation-induced emission, NIR-II fluorescence imaging, ureter identification, intraoperative fluorescence imaging, iatrogenic ureteral injury, ureteral diseases, indocyanine green, quantum yield, tissue penetration depth
MeSH terms
Animals, Urinary Bladder, Cells, Cultured, Fluorescence, Fluorescent Dyes, Humans, Kidney, Phosphatidylethanolamines, Polyethylene Glycols, Rabbits, Staining and Labeling, Ureter, Monitoring, Intraoperative, Microscopy, Electron, Transmission, Nanocomposites, Optical Imaging

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