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Tumour predisposition and cancer syndromes as models to study gene–environment interactions
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“In this regard, for example, heritable mutations of the germline BAP1 and other tumor suppressor genes have been reported to increase susceptibility to asbestos carcinogenesis.”
From Fiber burden and asbestos-related diseases: an umbrella review (2022) · cites this paper as [37]
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“It is estimated that 12% of mesotheliomas occur in carriers of these mutations.36,37”
From Fiber burden and asbestos-related diseases: an umbrella review (2022) · cites this paper as [37]
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“In any case, the most recent cutting-edge research shows that “safe” levels could vary greatly from one individual to another depending on the genetics of each individual.”
From Fiber burden and asbestos-related diseases: an umbrella review (2022) · cites this paper as [37]
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Metadata
- Authors
- Carbone, M., Arron, S. T., Beutler, B., Bononi, A., Cavenee, W., Cleaver, J. E., Croce, C. M., D’Andrea, A., Foulkes, W. D., Gaudino, G., Groden, J. L., Henske, E. P., Hickson, I. D., Hwang, P. M., Kolodner, R. D., Mak, T. W., Malkin, D., Monnat, R. J., Novelli, F., Pass, H. I., Petrini, J. H., Schmidt, L. S., & Yang, H.
- ORCID
- Venue
- Nature Reviews Cancer
- Published
- 2020-05-29
- Volume
- 20
- Issue
- 9
- Pages
- 533-549
- ISSN
- 1474-175X
- 1474-1768
- PMC
- PMC8104546
- Cited by
- 147
- References
- 28
- Language
- en
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