Cited by 205Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesHypothalamic control of reproductive hormones

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Brain insulin signalling in metabolic homeostasis and disease

Scherer, Thomas, Sakamoto, Kenichi, Buettner, Christoph·2021·Nature Reviews Endocrinology

DOI 10.1038/s41574-021-00498-x

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Abstract

Insulin signalling in the central nervous system regulates energy homeostasis by controlling metabolism in several organs and by coordinating organ crosstalk. Studies performed in rodents, non-human primates and humans over more than five decades using intracerebroventricular, direct hypothalamic or intranasal application of insulin provide evidence that brain insulin action might reduce food intake and, more importantly, regulates energy homeostasis by orchestrating nutrient partitioning. This Review discusses the metabolic pathways that are under the control of brain insulin action and explains how brain insulin resistance contributes to metabolic disease in obesity, the metabolic syndrome and type 2 diabetes mellitus.

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See all 205

Authors: Scherer, T., Sakamoto, K., & Buettner, C.
Affiliations: Medical University of Vienna (AT)
Rutgers, The State University of New Jersey (US)
Corresponding author: Scherer, Thomas
Buettner, Christoph
ORCID: Scherer, Thomas
Sakamoto, Kenichi
Buettner, Christoph
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2021-06-09
Volume: 17
Issue: 8
Pages: 468-483
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/s41574-021-00498-x
OpenAlex: W3167467420
Cited by: 205
References: 255
Citations by year: 2026: 38 · 2025: 36 · 2024: 61 · 2023: 35 · 2022: 30 · 2021: 5
FWCI: 4.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: insulin resistance, energy homeostasis, nutrient partitioning, food intake regulation, obesity, metabolic syndrome, type 2 diabetes, hypothalamus, intranasal insulin, organ crosstalk, metabolic disease treatment
MeSH terms: Animals, Brain, Diabetes Mellitus, Type 2, Energy Metabolism, Homeostasis, Humans, Insulin, Insulin Resistance, Metabolic Diseases, Signal Transduction, Metabolic Syndrome

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Brain insulin signalling in metabolic homeostasis and disease

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