The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Human organs-on-chips for disease modelling, drug development and personalized medicine
Open accessAbstract
The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and pathophysiology with high fidelity. Here, I review how single and multiple human organ chip systems have been used to model complex diseases and rare genetic disorders, to study host–microbiome interactions, to recapitulate whole-body inter-organ physiology and to reproduce human clinical responses to drugs, radiation, toxins and infectious pathogens. I also address the challenges that must be overcome for organ chips to be accepted by the pharmaceutical industry and regulatory agencies, as well as discuss recent advances in the field. It is evident that the use of human organ chips instead of animal models for drug development and as living avatars for personalized medicine is ever closer to realization. This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modelling, drug development and personalized medicine, as well as the challenges that must be overcome for organ chips to reach their full potential.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“most animal models poorly resemble human conditions and thus have low predictive values.”
From Human disease models in drug development (2023) · cites this paper as [6]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“OoCs are perfused microfluidic platforms that contain bioengineered or miniaturized tissues or organs interconnected by 3D microchannels to simulate the in vivo functions, biomechanics and (patho)physiological responses of organs6,52–54.”
From Human disease models in drug development (2023) · cites this paper as [6]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Animal models, however, often fail to filter out harmful or ineffective drugs6.”
From Human disease models in drug development (2023) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Self-citationModeling Development and Disease with Organoids
Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
PDMS absorption of small molecules and consequences in microfluidic applications
Toepke, M. W., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b612140c · Cited by 1,193
Fogel, D. B. (2018) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2018.08.001 · Cited by 1,035
Advances in organ-on-a-chip engineering
Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017
A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993
Self-citationBioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip
Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell’Erba, V., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.003 · Cited by 979
Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522193112 · Cited by 922
Self-citationHuman kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
Jang, K., Mehr, A. P., Hamilton, G. A., McPartlin, L. A., Chung, S., Suh, K. Y., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40049b · Cited by 867
Self-citation
Research works printed but not linked: 1
- Victor, I. A., Andem, A. B., Archibong, I. A. & Iwok, E. O. Interplay between cell proliferation and cellular differentiation: a mutually exclusive paradigm. Glob. Sci. J. 8, 1328–1338 (2020).
Cited by
Sorted by citations
Items 501–600 of 1,000
Brennen, W. N., Magnen, C. L., Karkampouna, S., Anselmino, N., Bock, N., Choo, N., Clark, A. K., Coleman, I. M., Dolgos, R., Ferguson, A. M., et al. (2024) · The Prostate · doi:10.1002/pros.24682 · Cited by 12
Beyond the hype and toward application: liver complex in vitro models in preclinical drug safety
Jadalannagari, S., & Ewart, L. C. (2024) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2024.2328794 · Cited by 11
Reconstitution of human tissue barrier function for precision and personalized medicine
Kim, J., Yoon, T., Lee, S. W., Kim, P. J., & Kim, Y. (2024) · Lab on a Chip · doi:10.1039/d4lc00104d · Cited by 13
Efficient Parahydrogen-Induced 13 C Hyperpolarization on a Microfluidic Device
Barker, S. J., Dagys, L., Levitt, M. H., & Utz, M. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.4c03271 · Cited by 8
Targeted Cancer Therapy‐on‐A‐Chip
Abed, H., Radha, R., Anjum, S., Paul, V., AlSawaftah, N., Pitt, W. G., Ashammakhi, N. A., & Husseini, G. A. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400833 · Cited by 12
Fabrication Strategies for Bioinspired and Functional Lung‐on‐Chips
Doryab, A., Braig, J., Jüngst, T., Ryma, M., & Gröll, J. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202407725 · Cited by 12
Reproductive organ on-a-chip technologies and assessments of the fetal-maternal interface
Richards, H. A., Eastman, A. J., Miller, D. R., & Cliffel, D. E. (2024) · Frontiers in Lab on a Chip Technologies · doi:10.3389/frlct.2024.1449303 · Cited by 11
The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis
Zhang, X., Su, R., Wang, H., Wu, R., Fan, Y., Bin, Z., Gao, C., & Wang, C. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1408501 · Cited by 11
Roadmap of algal autotrophic tissue engineering in the avenue of regenerative wound therapy
Pandian, N., Chaurasia, R., Chatterjee, S., Biswas, B., Patra, P., Tiwari, A., & Mukherjee, M. (2024) · Materials Advances · doi:10.1039/d4ma00492b · Cited by 11
Wang, W., Lian, H., Liang, Y., Ye, Y., Tam, P. K. H., & Chen, Y. (2024) · Cells · doi:10.3390/cells13231997 · Cited by 11
Lekkala, V. K. R., Shrestha, S., Qaryoute, A. A., Dhinoja, S., Acharya, P., Raheem, A., Jagadeeswaran, P., & Lee, M. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01658 · Cited by 13
Autonomous Nucleic Acid and Protein Nanocomputing Agents Engineered to Operate in Living Cells
Panigaj, M., Roy, T. B., Skelly, E., Chandler, M. R., Wang, J., Ekambaram, S., Bircsak, K. M., Dokholyan, N. V., & Afonin, K. A. (2025) · ACS Nano · doi:10.1021/acsnano.4c13663 · Cited by 13
A Novel Tumor on Chip Mimicking the Breast Cancer Microenvironment for Dynamic Drug Screening
Testa, M., Gaggianesi, M., D’Accardo, C., Porcelli, G., Turdo, A., Marco, C. D., Patella, B., Franco, S. D., Modica, C., Bella, S. D., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031028 · Cited by 11
Antich, C., Kundu, S., Frebert, S., Voss, T. C., Song, M. J., & Ferrer, M. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123156 · Cited by 13
Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids
Tsai, Y., Ozaki, H., Morikawa, A., Shiraiwa, K., Pin, A. P., Salem, A. G., Phommahasay, K. A., Sugita, B. K., Vu, C. H., Hammad, S., et al. (2025) · RSC Advances · doi:10.1039/d4ra04194a · Cited by 20
Application progress of bio-manufacturing technology in kidney organoids
Mao, R., Zhang, J., Qin, H., Liu, Y., Xing, Y., & Zeng, W. (2025) · Biofabrication · doi:10.1088/1758-5090/adb4a1 · Cited by 12
Coxon, J., Linder, E., Sweet, C. W., Magness, S. T., & Green, L. N. (2025) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110122-122343 · Cited by 12
Jităreanu, A., Agoroaei, L., Caba, I.-C., Cojocaru, F.-D., Vereștiuc, L., Vieriu, M., & Mârţu, I. (2025) · Toxics · doi:10.3390/toxics13030195 · Cited by 11
Xu, X., Qiu, Y., Chen, C., Carton, M., Campbell, P. M. R., Chowdhury, A. M., Bandyopadhyay, B. C., Bentley, W. E., Smith, B. R., & Sochol, R. D. (2025) · Lab on a Chip · doi:10.1039/d4lc01051e · Cited by 11
Advanced passive 3D bioelectronics: powerful tool for the cardiac electrophysiology investigation
Shi, K., He, C., Pan, H., Liu, D., Zhang, J., Han, W., Xiang, Y., & Hu, N. (2025) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-00891-w · Cited by 12
Acoustofluidic bioassembly induced morphogenesis for therapeutic tissue fabrication
Kang, B., Jeong, E., Han, S. Y., Heo, J. H., Lee, Y., Choi, S., Choi, Y., Kang, D., Hwang, Y.-H., Lee, J., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59026-4 · Cited by 14
Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects
Mugaanyi, J., Huang, J., Fang, J., Musinguzi, A., Lu, C., & Chen, Z. (2025) · Biomedicines · doi:10.3390/biomedicines13061272 · Cited by 11
Utagawa, Y., Miyake, T., Shinoda, Y., Yamazaki, M., Abe, H., Shiku, H., & Ino, K. (2025) · Lab on a Chip · doi:10.1039/d5lc00341e · Cited by 11
Shi, J., Li, J., Ma, J., Yang, X., Xue, C., Zhang, Y., & Gao, X. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123480 · Cited by 12
Contribution of keratinocytes to dermal fibrosis
Russo, B. F., Brembilla, N. C., & Chizzolini, C. (2022) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000895 · Cited by 11
The role of endothelial cells in pulmonary hypertension: old concepts and new science
Haensel, M., & Wójciak‐Stothard, B. (2023) · Current Opinion in Physiology · doi:10.1016/j.cophys.2023.100667 · Cited by 11
Nature‐Inspired Multidisciplinary Strategies for Tissue and Organ Cryopreservation
Liu, Z., Han, C., Wang, L.-Q., Cao, H., Xu, Z., & Wang, J. (2025) · Advanced Materials · doi:10.1002/adma.202510982 · Cited by 12
Supervised-Learning-Driven Interrogation of Organ-on-a-Chip Quality from Microscopy Images
George, R. M., & Kenry, K. (2025) · Chem & Bio Engineering · doi:10.1021/cbe.5c00087 · Cited by 10
Squitieri, D., Rizzo, S., Torelli, R., Mariotti, M., Sanguinetti, M., Cacaci, M., & Bugli, F. (2025) · Pharmaceuticals · doi:10.3390/ph19010008 · Cited by 12
Tumor immune organoids in immunotherapy resistance and drug screening
Zhang, M., Li, L., Pu, H., Yan, W., Zhang, X., Guo, X., Zhao, Y., Meng, Q., & Yin, M. (2026) · Drug Resistance Updates · doi:10.1016/j.drup.2026.101360 · Cited by 11
Heart-on-a-chip and vasculature-on-a-chip platforms as models of cardiovascular disease
Khosravi, R., & Radisic, M. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01255-1 · Cited by 12
Dittfeld, C., Winkelkotte, M., Scheer, A., Voigt, E., Schmieder, F., Behrens, S., Jannasch, A., Matschke, K., Sonntag, F., & Tugtekin, S. (2023) · Journal of Biological Engineering · doi:10.1186/s13036-023-00377-1 · Cited by 10
Multi-cellular engineered living systems to assess reproductive toxicology
Lopez, I., & Truskey, G. A. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108609 · Cited by 10
Utagawa, Y., Ino, K., Shinoda, Y., Yamazaki, M., Abe, H., & Shiku, H. (2024) · ACS Sensors · doi:10.1021/acssensors.4c01230 · Cited by 11
Moon, B., Li, K., Malic, L., Morton, K. J., Shao, H., Banh, L., Viswanathan, S., Young, E. W. K., & Veres, T. (2024) · Lab on a Chip · doi:10.1039/d4lc00530a · Cited by 11
Calogiuri, A., Bellisario, D., Sciurti, E., Blasi, L., Esposito, V., Casino, F., Siciliano, P. A., & Francioso, L. N. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1458404 · Cited by 10
Approaches for studying neuroimmune interactions in Alzheimer’s disease
Lin, C., Tian, Y., Tanzi, R. E., & Jorfi, M. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.10.002 · Cited by 11
Microfabricated sensors for non-invasive, real-time monitoring of organoids
Kim, Y., Chica, E., & Lee, H. J. (2024) · Micro and Nano Systems Letters · doi:10.1186/s40486-024-00216-y · Cited by 14
The Role of Silicon Technology in Organ‐On‐Chip: Current Status and Future Perspective
Skottvoll, F. S., Escobedo‐Cousin, E., & Mielnik, M. M. (2024) · Advanced Materials Technologies · doi:10.1002/admt.202401254 · Cited by 10
Organ-on-a-chip platforms for drug development, cellular toxicity assessment, and disease modelling
KHURRAM, M. M., CİNEL, G., Yeşil-Çeliktaş, Ö., & Bedіr, E. (2024) · TURKISH JOURNAL OF BIOLOGY · doi:10.55730/1300-0152.2711 · Cited by 12
Gonzalez‐Rubio, J., Kubiza, H., Xu, Y., Königs‐Werner, H., Schmitz, M., Schedel, M., Apel, C., Jockenhoevel, S., Cornelissen, C. G., & Thiebes, A. L. (2025) · Advanced Science · doi:10.1002/advs.202408131 · Cited by 11
Jouybar, M., van der Kallen, S., Sahebali, S. S., Bouten, C. V. C., & den Toonder, J. M. J. (2025) · Advanced Materials Technologies · doi:10.1002/admt.202401994 · Cited by 10
Corredera, I. G., Amato, G., Moya‐Rull, D., Garreta, E., & Montserrat, N. (2025) · Kidney International · doi:10.1016/j.kint.2025.01.043 · Cited by 10
Buchholz, M., Bernal, P. N., Bessler, N., Bonhomme, C., Levato, R., & Rios, A. C. (2025) · Biofabrication · doi:10.1088/1758-5090/add20f · Cited by 10
Ciringione, A., & Rizzi, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104572 · Cited by 10
Critical Role of Skin in Pathogenesis: Bidirectional Crosstalk Between Skin and Multiple Organs
Deng, W., Liu, J., Tang, C., Li, Z., Qiu, Y., Zhou, H., Yang, L., & Li, T. (2025) · MedComm – Future Medicine · doi:10.1002/mef2.70020 · Cited by 10
Agency in the Evolutionary Transition to Multicellularity
Newman, S. A., Benítez, M., Bhat, R., Glimm, T., Kumar, K. V., Nanjundiah, V., Nicholson, D. J., & Sarkar, S. (2025) · The Quarterly Review of Biology · doi:10.1086/735964 · Cited by 20
Rodríguez, C. F., Quezada, V., Guzmán-Sastoque, P., Orozco, J. C., Reyes, L. H., Osma, J. F., Muñoz-Camargo, C., & Cruz, J. C. (2025) · Scientific Reports · doi:10.1038/s41598-025-04495-2 · Cited by 11
A Concise Review of Organoid Tissue Engineering: Regenerative Applications and Precision Medicine
Makesh, K. Y., Navaneethan, A., Ajay, M., Munuswamy‐Ramanujam, G., Chinnasamy, A., Gnanasampanthapandian, D., & Palaniyandi, K. (2025) · Organoids · doi:10.3390/organoids4030016 · Cited by 12
Breaking down the barriers to animal-free research
Hope, L., & Bailey, J. (2025) · Alternatives to Laboratory Animals · doi:10.1177/02611929251349465 · Cited by 12
Guan, H., Zhao, S., Fang, X., Miao, R., Zhang, Y., Zhang, Y., & Tian, J. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118445 · Cited by 11
Man, Y., Posey, R. R., Bai, H., Jiang, A. R., Dosta, P., Ocampo-Alvarado, D., Plebani, R., Ji, J., Belgur, C., Artzi, N., et al. (2025) · Lab on a Chip · doi:10.1039/d5lc00156k · Cited by 11
Self-citationLuk, C. H., Conway, G. L., Goh, K. J., Fearns, A., Hernández, I. R., Day, N. J., Athanasiadi, N., D’Antuono, R., Pellegrino, E., Stucki, J. D., et al. (2026) · Science Advances · doi:10.1126/sciadv.aea9874 · Cited by 10
A 3D Perfusable Platform for In Vitro Culture of Patient Derived Xenografts
Sablatura, L. K., Bircsak, K. M., Shepherd, P. D. A., Bathina, M., Queiroz, K. C. S., Farach‐Carson, M. C., Kittles, R. A., Constantinou, P. E., Saleh, A. D., Navone, N. M., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201434 · Cited by 10
A proof-of-concept study poised to remodel the drug development process
Nahle, Z. A. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.1053588 · Cited by 11
Xue, B., Schüler, J. B., Harrod, C. M., Lashuk, K., Bomya, Z., & Hribar, K. C. (2023) · Cells · doi:10.3390/cells12081145 · Cited by 12
Recent and advanced therapy for oral cancer
Baskar, G., Palaniyandi, T., Viswanathan, S., Wahab, M. R. A., Surendran, H., Ravi, M., Sivaji, A., Rajendran, B. K., Natarajan, S., & Govindasamy, G. (2023) · Biotechnology and Bioengineering · doi:10.1002/bit.28452 · Cited by 13
Deng, L., Olea, A. R., Ortiz‐Perez, A., Sun, B., Wang, J., Pujals, S., Palmans, A. R. A., & Albertazzi, L. (2024) · Small Methods · doi:10.1002/smtd.202301072 · Cited by 10
Three-Dimensional Cell Culture Methods in Infectious Diseases and Vaccine Research
Varan, G., & Ünal, S. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3010004 · Cited by 10
Nezamabadi, M., Balali, E., & Qomi, M. (2023) · Inorganic Chemistry Communications · doi:10.1016/j.inoche.2023.111098 · Cited by 10
Microfluidics for brain endothelial cell-astrocyte interactions
Sanapathi, J., Vipparthi, P., Mishra, S., Sosnik, A., & Kumarasamy, M. (2023) · Organs-on-a-Chip · doi:10.1016/j.ooc.2023.100033 · Cited by 11
Beal, M. A., Chen, G., Dearfield, K. L., Gi, M., Gollapudi, B. B., Heflich, R. H., Horibata, K., Long, A. S., Lovell, D. P., Parsons, B. L., et al. (2023) · Environmental and Molecular Mutagenesis · doi:10.1002/em.22582 · Cited by 9
Yang, Y., Yang, H., Kiskin, F. N., & Zhang, J. Z. (2024) · Medical Review · doi:10.1515/mr-2023-0059 · Cited by 10
Development of Organ-on-a-Chip System with Continuous Flow in Simulated Microgravity
Strods, A., Narbute, K., Movčana, V., Gillois, K., Rimša, R., Hollós, P., Rūmnieks, F., Spule, A., Mozoļevskis, G., & Ābols, A. (2024) · Micromachines · doi:10.3390/mi15030370 · Cited by 9
Confronting the bias towards animal experimentation (animal methods bias)
Krebs, C. E., & Herrmann, K. (2024) · Frontiers in Drug Discovery · doi:10.3389/fddsv.2024.1347798 · Cited by 12
Cherukuri, R., Kammala, A. K., Thomas, T. J., Saylor, L., Richardson, L., Kim, S., Ferrer, M., Antich, C., Song, M. J., Gaharwar, A. K., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c08731 · Cited by 9
Mankhong, S., Den-Udom, T., Tanawattanasuntorn, T., Suriyun, T., Muta, K., Kitiyakara, C., & Ketsawatsomkron, P. (2024) · Scientific Reports · doi:10.1038/s41598-024-69124-w · Cited by 9
Varda, L., Ekart, R., Lainščak, M., Maver, U., & Bevc, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169088 · Cited by 9
Drug Delivery Targeting Neuroinflammation to Treat Brain Diseases
Wang, J., Jia, R., Wan, W., Han, H., Wang, G., Li, Z., & Li, J. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00414 · Cited by 9
Bucking, C., Bury, N. R., Sundh, H., & Wood, C. M. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246440 · Cited by 9
Development and Applications of Organoids in Gynecological Diseases
Yang, J., Li, W., Zhang, Z., Xu, Z., Zhu, W., Wang, J., & Wang, W. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10833-0 · Cited by 9
Yamazaki, D., & Ishida, S. (2024) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2024.101047 · Cited by 10
Nomadic Nanomedicines: Medicines Enabled by the Paracrine Transfer Effect
Paranandi, K. S., Amar‐Lewis, E., Mirkin, C. A., & Artzi, N. (2025) · ACS Nano · doi:10.1021/acsnano.4c15052 · Cited by 9
Niri, P., Saha, A., Polopalli, S., Kumar, M., Das, S., Saha, B., Goyary, D., Bhutia, Y. D., Karmakar, S., Kishor, S., et al. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151286 · Cited by 9
An update on drug repurposing in Parkinson’s disease: Preclinical and clinical considerations
Salvadè, M., Luca, M. D., & Gardoni, F. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117862 · Cited by 12
Gaillard, M., Pence, C. H., & Baum, M. B. (2025) · Biology of the Cell · doi:10.1111/boc.202400093 · Cited by 9
Organ‐on‐chip for advancing CAR therapy
Ngashangva, L., & Martin, S. (2025) · Clinical & Translational Immunology · doi:10.1002/cti2.70024 · Cited by 11
Adebayo, G. P., Ayanda, O. I., Rottmann, M., Ajibaye, O., Oduselu, G., Mulindwa, J., Ajani, O. O., Aina, O. O., Mäser, P., & Adebiyi, E. F. (2025) · Pharmaceuticals · doi:10.3390/ph18030424 · Cited by 9
Choi, S., Lee, J.-H., Kim, O., Jung, Y., Ryu, T., Kim, S. J., Kim, E. J., Sung, J. H., Cha, H. J., & Han, S. (2025) · BioChip Journal · doi:10.1007/s13206-025-00207-0 · Cited by 10
Engineering advanced in vitro models of endothelial dysfunction
Singh, J., Ruhoff, A. M., Ashok, D., Wise, S. G., & Waterhouse, A. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.03.004 · Cited by 9
Karay, M., Sabir, Z., Akkılıc, A. N., & Bulut, H. (2025) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2025.108629 · Cited by 9
Beyond preservation: future machine perfusion for liver assessment and repair
Huwyler, F., Binz, J., Cunningham, L., Pfister, M., Schuler, M. J., Tibbitt, M. W., & Clavien, P. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01111-6 · Cited by 14
Barua, D. R., Das, D., & Biswas, N. (2025) · Biomicrofluidics · doi:10.1063/5.0268362 · Cited by 9
Pancreatic Cancer Organoids: Modeling Disease and Guiding Therapy
Morceau, F., El‐Khoury, V., Lee, K., Berna, M. J., & Kwon, Y. (2025) · Cancers · doi:10.3390/cancers17233850 · Cited by 10
Bisconti, F., Abreu, H., Nguyen, T. D., Stolfi, F., Corbezzolo, N., Gigli, G., Raineri, D., Cappellano, G., Polini, A., Gervaso, F., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1712796 · Cited by 9
Human Cardiac Organoids: Advances and Prospects from Construction to Preclinical Drug Evaluation
Chen, M., Zhang, T., Yang, S., Niu, Y., Ge, Y., Chen, Z., Zhang, J., Pu, Y., Gu, Z., & Liang, G. (2025) · Cells · doi:10.3390/cells15010007 · Cited by 9
Design of a microfluidic lung chip and its application in assessing the toxicity of formaldehyde
Su, M. R., Li, X., Li, Z., Hua, C., Shang, P., Zhao, J., Liu, K., & Xie, F. (2022) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2022.2159903 · Cited by 9
Gökçe, F., Kaestli, A. J., Lohasz, C., de Geus, M., Kaltenbach, H., Renggli, K., Bornhauser, B. C., Hierlemann, A. R., & Modena, M. M. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202202506 · Cited by 8
Simple design for membrane-free microphysiological systems to model the blood-tissue barriers
Young, B. A. T., Deal, H. E., Rusch, G., Pozdin, V. A., Brown, A. C., & Daniele, M. A.-A. (2023) · Organs-on-a-Chip · doi:10.1016/j.ooc.2023.100032 · Cited by 10
Florido, M. H. C., & Ziats, N. P. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37669 · Cited by 9
van Aken, G. A. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1339711 · Cited by 9
Wang, W., Liu, Y., Huang, X., Liang, F., Luo, H., Mao, Z., Shi, J., Wang, L., Peng, J., & Chen, Y. (2024) · Talanta · doi:10.1016/j.talanta.2024.126473 · Cited by 9
Organoids in Dynamic Culture: Microfluidics and 3D Printing Technologies
Su, X., Wang, M., Yuan, R., Guo, L., Han, Y., Huang, C., Li, A., Kaplan, D. L., & Wang, X. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c02245 · Cited by 9
In vitro high-content tissue models to address precision medicine challenges
Afewerki, S., Stocco, T. D., Silva, A. D. R., Furtado, A. S. A., de Sousa, G. F., Ruiz‐Esparza, G. U., Webster, T. J., Marciano, F. R., Strømme, M., Zhang, Y. S., et al. (2022) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2022.101108 · Cited by 8
Latest developments in engineered skeletal muscle tissues for drug discovery and development
Ostrovidov, S., Ramalingam, M., Bae, H., Orive, G., Fujie, T., Shi, X., & Kaji, H. (2022) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2023.2160438 · Cited by 9
Multi-organ microphysiological system: A new paradigm for COVID-19 research
Wang, P., Wang, Y., & Qin, J. (2023) · Organs-on-a-Chip · doi:10.1016/j.ooc.2023.100029 · Cited by 11
Jun, Y., Nguyen-Ngoc, K.-V., Sai, S., Bender, R., Gong, W., Kravets, V., Zhu, H., Hatch, C. J., Schlichting, M., Gaetani, R., et al. (2022) · bioRxiv · doi:10.1101/2022.10.28.513298 · Cited by 42
Garibyan, M., Hoffman, T., Makaske, T., Do, S., March, A. R., Cho, N., Pedroncelli, N., Lima, R. E., Soto, J., Jackson, B., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.19.541497 · Cited by 9
Weener, H. J., Middelkamp, H. H. T., & Van der Meer, A. D. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1513002 · Cited by 10
Vascular dysfunction in hemorrhagic viral fevers: opportunities for organotypic modeling
Zarate-Sanchez, E., George, S. C., Moya, M. L., & Robertson, C. (2024) · Biofabrication · doi:10.1088/1758-5090/ad4c0b · Cited by 10
Metadata
- Authors
- Ingber, D. E.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Ingber, Donald E.
- ORCID
- Ingber, Donald E.
- Venue
- Nature Reviews Genetics
- Published
- 2022-03-25
- Volume
- 23
- Issue
- 8
- Pages
- 467-491
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC8951665
- OpenAlex
- W4220652963
- Cited by
- 1,589
- References
- 151
- Citations by year
- 2026: 457 · 2025: 440 · 2024: 389 · 2023: 215 · 2022: 87
- FWCI
- 25.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Reviews Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Biomedical Advanced Research and Development Authority
- National Heart, Lung, and Blood Institute (UH3HL141797)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, microfluidics, disease modeling, drug development, personalized medicine, alternative to animal models, rare genetic disorders, host-microbiome interactions, drug toxicity, infectious agents, regulatory acceptance, pharmaceutical industry
- MeSH terms
- Drug Development, Animals, Humans, Rare Diseases, Lab-On-A-Chip Devices, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
