The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
Human organs-on-chips for disease modelling, drug development and personalized medicine
Open accessAbstract
The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research. Organ-on-a-chip (organ chip) microfluidic devices lined with living cells cultured under fluid flow can recapitulate organ-level physiology and pathophysiology with high fidelity. Here, I review how single and multiple human organ chip systems have been used to model complex diseases and rare genetic disorders, to study host–microbiome interactions, to recapitulate whole-body inter-organ physiology and to reproduce human clinical responses to drugs, radiation, toxins and infectious pathogens. I also address the challenges that must be overcome for organ chips to be accepted by the pharmaceutical industry and regulatory agencies, as well as discuss recent advances in the field. It is evident that the use of human organ chips instead of animal models for drug development and as living avatars for personalized medicine is ever closer to realization. This Review discusses the types of single and multiple human organ-on-a-chip (organ chip) microfluidic devices and their diverse applications for disease modelling, drug development and personalized medicine, as well as the challenges that must be overcome for organ chips to reach their full potential.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“most animal models poorly resemble human conditions and thus have low predictive values.”
From Human disease models in drug development (2023) · cites this paper as [6]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“OoCs are perfused microfluidic platforms that contain bioengineered or miniaturized tissues or organs interconnected by 3D microchannels to simulate the in vivo functions, biomechanics and (patho)physiological responses of organs6,52–54.”
From Human disease models in drug development (2023) · cites this paper as [6]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Animal models, however, often fail to filter out harmful or ineffective drugs6.”
From Human disease models in drug development (2023) · cites this paper as [6]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reconstituting organ-level lung functions on a chip
Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250
Self-citationModeling Development and Disease with Organoids
Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
PDMS absorption of small molecules and consequences in microfluidic applications
Toepke, M. W., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b612140c · Cited by 1,193
Fogel, D. B. (2018) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2018.08.001 · Cited by 1,035
Advances in organ-on-a-chip engineering
Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017
A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993
Self-citationBioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip
Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell’Erba, V., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.003 · Cited by 979
Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522193112 · Cited by 922
Self-citationHuman kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
Jang, K., Mehr, A. P., Hamilton, G. A., McPartlin, L. A., Chung, S., Suh, K. Y., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40049b · Cited by 867
Self-citation
Research works printed but not linked: 1
- Victor, I. A., Andem, A. B., Archibong, I. A. & Iwok, E. O. Interplay between cell proliferation and cellular differentiation: a mutually exclusive paradigm. Glob. Sci. J. 8, 1328–1338 (2020).
Cited by
Sorted by citations
Items 601–700 of 1,000
Huang, J., Xia, L., Xiao, X., & Li, G. (2024) · New Journal of Chemistry · doi:10.1039/d4nj01825g · Cited by 8
Lindner, N., Mejia-Wille, A., Fritschen, A., & Blaeser, A. (2024) · HardwareX · doi:10.1016/j.ohx.2024.e00572 · Cited by 8
Microfluidic Applications in Prostate Cancer Research
Szewczyk, K., Jiang, L., Khawaja, H., Miranti, C. K., & Zohar, Y. (2024) · Micromachines · doi:10.3390/mi15101195 · Cited by 8
Sarna, N. S., Curry, N. M., Aalaei, E., Kaufman, B. G., & King, M. R. (2024) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2024.3505073 · Cited by 9
Saglam‐Metiner, P., Yanasik, S., Odabasi, Y. C., Modamio, J., Negwer, M., Avcı, Ç. B., Güler, A., Ertürk, A., Yıldırım, E., & Yeşil-Çeliktaş, Ö. (2024) · Communications Biology · doi:10.1038/s42003-024-07313-z · Cited by 13
Mazzaglia, C., Huang, Y. Y. S., & Shields, J. D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115485 · Cited by 10
Biomaterials meet organ-on-chips – a perspective on tumor modeling
Monteiro, C. F., Deus, I. A., Custódio, C. A., & Mano, J. F. (2024) · International Materials Reviews · doi:10.1177/09506608241303436 · Cited by 9
Tarn, M. D., Shaw, K. J., Foster, P. B., West, J. S., Johnston, I. D., McCluskey, D. K., Peyman, S. A., & Murray, B. J. (2025) · Biomicrofluidics · doi:10.1063/5.0236911 · Cited by 9
Li, J., Isaakidou, A., van Zanten, L. J., Tas, R. P., Mirzaali, M. J., Fratila-Apachitei, L. E., & ZADPOOR, A. A. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.03.005 · Cited by 8
Vinken, M., Grimm, D. G., Baatout, S., Baselet, B., Beheshti, A., Braun, M., Carstens, A. C., Casaletto, J. A., Cools, B., Costes, S. V., et al. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108574 · Cited by 8
Pai, V., Singh, B. N., & Singh, A. K. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102753 · Cited by 8
Wang, H., Guo, J., Zhang, Y., Fu, Z. Q., & Yao, Y. (2025) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-025-01617-9 · Cited by 8
A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation
Ikeda, Y., Kondō, M., Suehiro, J., Oshima, H., Kok, S. Y., Takahashi, K., Pauty, J., Wang, D., Sakurai, H., Watabe, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112517 · Cited by 9
Drug Screening of Primary Human Endometriotic Cells Based on Micro‐Encapsulating Microfluidic Chip
Chen, Q., Wang, J., Li, W., Shang, L., Wang, D., & Duan, P. (2025) · Advanced Science · doi:10.1002/advs.202504647 · Cited by 8
Organoids-on-Chips Technology: Unveiling New Perspectives in Rare-Disease Research
Li, X., Wang, H., You, X., & Zhao, G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094367 · Cited by 8
Izadifar, Z., Stejskalová, A., Gulati, A., Gutzeit, O., & Ingber, D. E. (2025) · BioEssays · doi:10.1002/bies.70014 · Cited by 9
Self-citationThe Development of 3D Primary Co-Culture Models of the Human Airway
Iriondo, C., Koornneef, S., Skarp, K., Kempen, M. B., Munck, A. B., & Rottier, R. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26115027 · Cited by 8
Deciphering Breast Tumor Heterogeneity Through Patient-Derived Organoids and Circulating Tumor Cells
Policastro, B., Nissen, N., & Alves, C. L. (2025) · Journal of Personalized Medicine · doi:10.3390/jpm15070271 · Cited by 8
AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics
Lee, Y., Min, J., Kim, S., & Ko, J. (2025) · Advanced Intelligent Systems · doi:10.1002/aisy.202500022 · Cited by 8
A microphysiological systems approach to design gastrointestinal system
Mathur, V., Gadre, M. A., Amrutha, H. K., & Vasanthan, K. S. (2025) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2025.2532567 · Cited by 8
Recent Progress in 2D, 3D, and On-a-Chip Models of the Placenta
Harrison, A. M., & Bailey‐Hytholt, C. M. (2025) · Cells Tissues Organs · doi:10.1159/000547560 · Cited by 9
Advancements in Microfluidic Organ-on-a-chip for Oral Medicine
Fan, S., Ge, Y., Li, B., Liu, P., & Liu, X. (2025) · International Dental Journal · doi:10.1016/j.identj.2025.100925 · Cited by 8
Minahan, D. J., Nelson, K. M., Ribeiro, F., Ferrick, B. J., Zurzolo, A. M., Byers, K., Mckeown, V., & Gleghorn, J. P. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502202 · Cited by 11
Microsystem technologies for accelerating the discovery and translation of immunotherapies
Wang, Z., Liu, C. Y., Chen, K., Song, J. W., & Kelley, S. O. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01268-4 · Cited by 8
Hendriks, H. R. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189467 · Cited by 11
Xue, C., Sun, F., Zhu, H. J., Shi, J., Wang, J., Sun, Q., Tong, M., Gu, X., Han, Q., & Shi, W. (2025) · Engineering · doi:10.1016/j.eng.2025.10.013 · Cited by 8
Wang, Y., Liu, A., Zhang, X., Lyu, Y., Rong, X., Niu, C., Jia, C., Sun, J., Ye, F., Shao, C., et al. (2025) · Journal of Tissue Engineering · doi:10.1177/20417314251394447 · Cited by 8
Organoid: a promising solution to current challenges in cancer immunotherapy
Kang, X., Cheemalamarri, S. K., & Yin, Q. (2025) · npj Biomedical Innovations. · doi:10.1038/s44385-025-00051-9 · Cited by 9
Cherukuri, R., Kim, S., Moyer, H. L., Jesse, H., Lam, P. Y., Richardson, L., Kammala, A. K., Menon, R., Rusyn, I., & Han, A. (2026) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c20917 · Cited by 8
Tumor-on-chip’s alliance with molecular pathology against metastatic disease
Carlo, E. D. (2026) · Journal of Biomedical Science · doi:10.1186/s12929-025-01209-8 · Cited by 9
Antimicrobial Resistance: The Answers
Millar, B. C., Cates, M. J., Torrisi, M. S., Round, A. J., Warde, A., Lowery, C. J., & Moore, J. E. (2026) · British Journal of Biomedical Science · doi:10.3389/bjbs.2026.15559 · Cited by 9
Özkan, A., Merry, G. E., Chou, D. B., Posey, R. R., Stejskalová, A., Calderon, K., Sperry, M. M., Piatok, J., Horvath, V., Ferri, L. E., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-026-01686-8 · Cited by 8
Self-citationCurrent methodology and cell sources for lacrimal gland tissue engineering
Kasal, K., Güven, S., & Utine, C. A. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109138 · Cited by 8
Mathur, T., Kumar, A., Flanagan, J. M., & Jain, A. (2022) · Current Protocols · doi:10.1002/cpz1.582 · Cited by 8
Olsen, C., Wang, C., Aizenshtadt, A., Abadpour, S., Lundanes, E., Skottvoll, F. S., Golovin, A., Busek, M., Krauss, S. J. K., Scholz, H., et al. (2023) · Electrophoresis · doi:10.1002/elps.202300095 · Cited by 8
The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation
Searson, P. C. (2023) · Nature Nanotechnology · doi:10.1038/s41565-023-01486-0 · Cited by 8
Biomimetic Gland Models with Engineered Stratagems
Lin, X., Sun, L., Lu, M., & Zhao, Y. (2023) · Research · doi:10.34133/research.0232 · Cited by 8
Facts and Hopes in Using Omics to Advance Combined Immunotherapy Strategies
Augustin, R. C., Cai, W. L., Luke, J. J., & Bao, R. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2241 · Cited by 7
Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry
Lachance, G. P., Gauvreau, D., Boisselier, É., Boukadoum, M., & Miled, A. (2024) · Sensors · doi:10.3390/s24020647 · Cited by 8
Bassan, A., Steigerwalt, R. W., Keller, D. A., Beilke, L. D., Bradley, P. M., Bringezu, F., Brock, W. J., Burns‐Naas, L. A., Chambers, J. K., Cross, K. P., et al. (2024) · Frontiers in Toxicology · doi:10.3389/ftox.2024.1370045 · Cited by 8
Rocking- and diffusion-based culture of tumor spheroids-on-a-chip
Tian, D., Mao, Z., Wang, L., Huang, X., Wang, W., Luo, H., Peng, J., & Chen, Y. (2024) · Lab on a Chip · doi:10.1039/d3lc01116j · Cited by 8
Yang, Q., Zhong, R., Chang, W., Chen, K., Wang, M., Yuan, S., Zheng, L., Wang, W., Wang, C., Tong, G., et al. (2024) · Lab on a Chip · doi:10.1039/d4lc00210e · Cited by 8
CHIP and aging: a key regulator of proteostasis and cellular senescence
Pandey, S. N., Agrawal, N., Moglad, E. H. O., Priya, G. P., Srivastava, M., Chennakesavulu, K., Mohanty, B., Arya, R., Kazmi, I. A., Alzarea, S. I., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10247-6 · Cited by 8
Better In Vitro Tools for Exploring Chlamydia trachomatis Pathogenesis
Filardo, S., Pietro, M. D., & Sessa, R. (2022) · Life · doi:10.3390/life12071065 · Cited by 7
Biochips under COVID-19: a new stage of well-grounded development and accelerated translation
Liu, J., Xu, Y., & Cheng, J. (2022) · 中国科学通报：英文版 · doi:10.1016/j.scib.2022.08.003 · Cited by 8
Kim, H., Kim, E.-J., Ngo, H. V., Nguyen, H. D., Park, C., Choi, K. H., Park, J.-B., & Lee, B. (2023) · Pharmaceuticals · doi:10.3390/ph16091330 · Cited by 9
Vascularized microfluidic models of major organ structures and cancerous tissues
Varma, A. R., & Fathi, P. (2023) · Biomicrofluidics · doi:10.1063/5.0159800 · Cited by 8
Rahav, N., Marrero, D., Soffer, A., Glickman, E., Beldjilali‐Labro, M., Yaffe, Y., Tadmor, K., Leichtmann‐Bardoogo, Y., Ashery, U., & Maoz, B. M. (2024) · Advanced Science · doi:10.1002/advs.202305555 · Cited by 7
Microfluidic flow sensor based on chronoamperometric measurements in a microchannel
Deswal, H., Pandey, U., Singh, S. G., & Agrawal, A. (2024) · International Journal of Thermofluids · doi:10.1016/j.ijft.2024.100760 · Cited by 7
Human breast tissue engineering in health and disease
Buchholz, M., Scheerman, D. I., Levato, R., Wehrens, E. J., & Rios, A. C. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00112-3 · Cited by 8
Study Models for Chlamydia trachomatis Infection of the Female Reproductive Tract
Kim, J., Ślęczkowska, M., Nobre, B., & Wieringa, P. A. (2025) · Microorganisms · doi:10.3390/microorganisms13030553 · Cited by 10
Bone-on-a-Chip Systems for Hematological Cancers
Kozalak, G., & Koşar, A. (2025) · Biosensors · doi:10.3390/bios15030176 · Cited by 7
Yun, J., Jeon, T., & Kim, S. M. (2025) · Biomimetics · doi:10.3390/biomimetics10070443 · Cited by 8
Heart-on-a-chip: A novel microfluidic approach to organ modelling and cellular mechanobiology
Kołodziejek, D., Tadko, O., Iwoń, Z., Baranowska, P., Drozd, M., Wojasiński, M., & Jastrzębska, E. (2025) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2025.116957 · Cited by 7
Phan, T. V., Pimpakan, T., Suwanchaikasem, P., Phoolcharoen, W., Kesdangsakonwut, S., Tummaruk, P., Yodmuang, S., Chaisuparat, R., Matangkasombut, O., Yoon, Y.-J., et al. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.106115 · Cited by 8
Pierre, A., Favory, R., Lancel, S., & Préau, S. (2025) · Intensive Care Medicine Experimental · doi:10.1186/s40635-025-00814-z · Cited by 7
Designing and integrating microfluidic electrodes for biosensing and micromanipulation
Shen, Y., Li, H., Ya, L., Wang, Y., Chen, K., Li, J., Ma, J., Chen, S., Hu, Y., Wen, J., et al. (2025) · Device · doi:10.1016/j.device.2025.100964 · Cited by 7
Human preclinical multiple myeloma in vitro models for disease modeling and therapy screening
Ybarra, M., Lee, J., Chen, Y.-Y., Lin, J.-H., Zhao, J.-J., & Ma, C. (2025) · Journal of Biological Engineering · doi:10.1186/s13036-025-00570-4 · Cited by 8
Ultrahigh Cell Density 3D Bioprinting by Acoustic Fluids‐mediated Stereolithography
Wu, Z., Wang, J., Huang, D., Cheng, Y., & Zhao, Y. (2025) · Advanced Materials · doi:10.1002/adma.202511418 · Cited by 9
Tieghi, R. S., Høeg, T. B., Makary, M. A., & Kleinstreuer, N. (2025) · NEJM AI · doi:10.1056/aipc2500587 · Cited by 7
Advances and Applications of Organ-on-a-Chip and Tissue-on-a-Chip Technology
Moore, M., Sriram, S., Ku, J. C., & Li, Y. (2025) · Bioengineering · doi:10.3390/bioengineering13010009 · Cited by 8
You, L., Chen, Y., Zhang, Z., Wang, Y., Gu, Z., Shen, L., & Ge, J. (2025) · 中国科学通报：英文版 · doi:10.1016/j.scib.2025.12.051 · Cited by 13
Yang, S., Zhang, T., Ge, Y., Niu, Y., Chen, M., Yin, L., Pu, Y., Chen, Z., Gu, Z., & Liang, G. (2026) · The Innovation · doi:10.1016/j.xinn.2025.101252 · Cited by 7
Liao, A., Xiong, J., Tong, Z., Zhou, L., & Liu, J. (2026) · Biosensors · doi:10.3390/bios16010049 · Cited by 7
Microfluidics for cell therapy and manufacturing in oncology and regenerative medicine
Duncan, J. L., Arroyo, J. P., & Davalos, R. V. (2026) · Lab on a Chip · doi:10.1039/d5lc00492f · Cited by 7
Ntekoumes, D., & Gerecht, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137416 · Cited by 7
Ascendancy of semi-synthetic biomaterials from design towards democratization
Speidel, A. T., Grigsby, C. L., & Stevens, M. M. (2022) · Nature Materials · doi:10.1038/s41563-022-01348-5 · Cited by 7
Optimizing health-span: advances in stem cell medicine and longevity research
Zhang, Y., Chen, H., & Huang, C. (2023) · Medical Review · doi:10.1515/mr-2023-0040 · Cited by 8
Pahuja, A., Corredera, I. G., Moya‐Rull, D., Garreta, E., & Montserrat, N. (2024) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102306 · Cited by 9
Dey, S., Kinoshita, M., Puttick, S. G., Rose, S., Trau, M., Roberts, M. J., & Koo, K. M. (2024) · Advanced Sensor Research · doi:10.1002/adsr.202300193 · Cited by 7
State of the Art in 3D Culture Models Applied to Thyroid Cancer
Prete, A., Matrone, A., & Plebani, R. (2024) · Medicina · doi:10.3390/medicina60040520 · Cited by 7
Exploring the detailed role of interleukins in cancer: A comprehensive review of literature
Saleh, R. O., Jasim, S. A., Kadhum, W. R., Hjazi, A. M., Faraz, A., Abid, M. K., Yumashev, A., Alawadi, A. H., Aiad, I. A. Z., & Alsalamy, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155284 · Cited by 8
Shariff, S., Kantawala, B., Franco, W. X. G., Ayele, N. D., Munyangaju, I., Alzain, F. E., Nazir, A., Wojtara, M., & Uwishema, O. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002078 · Cited by 8
Sharallah, O. A., Poddar, N. K., & Alwadan, O. A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102394 · Cited by 7
Leong, W. Y., Leong, Y. Z., & Leong, W. S. (2024) · IEEE International Workshop on Electromagnetics: Applications and Student Innovation Competition · doi:10.1109/iwem59914.2024.10649387 · Cited by 7
Goluba, K., Parfejevs, V., Rostoka, E., Jēkabsons, K., Blāķe, I., Neimane, A., Ule, A. A., Rimša, R., Vangravs, R., Pčolkins, A., et al. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101262 · Cited by 7
Shukla, S., Comerci, C. J., Süel, G. M., & Jahed, Z. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116843 · Cited by 7
Bató, L., & Fürjes, P. (2024) · Sensors · doi:10.3390/s24206638 · Cited by 7
Automated Design for Multiorgan-on-Chip Geometries
Emmerich, M., Ebner, P., & Wille, R. (2024) · IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems · doi:10.1109/tcad.2024.3509795 · Cited by 6
Jæger, K. H., Charwat, V., Healy, K. E., Wall, S., & Tveito, A. (2025) · The Journal of Physiology · doi:10.1113/jp287275 · Cited by 7
Qu, K.-Y., Cheng, H., Qiao, L., Jiao, J., Chang, S., Peng, X., Cui, C., Zhang, F., & Huang, N. (2025) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2025.117478 · Cited by 6
Aparici‐Herraiz, I., Caires, H. R., Castillo‐Fernández, Ó., Sima, N., Méndez-Mora, L., Risueño, R. M., Sattabongkot, J., Roobsoong, W., Hernández-Machado, A., Fernández-Becerra, C., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.920204 · Cited by 7
Liu, M., Chen, C., Gao, K., Gao, F., Qin, C., Yuan, Q., Zhang, H., Zhuang, L., & Wang, P. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114619 · Cited by 7
Human Brain Organoids in Migraine Research: Pathogenesis and Drug Development
Gazerani, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043113 · Cited by 5
Establishing a Microfluidic Tumor Slice Culture Platform to Study Drug Response
Komar, Z. M., van Gent, D. C., & Chakrabarty, S. (2023) · Current Protocols · doi:10.1002/cpz1.693 · Cited by 7
Current status of research in rare genetic disorders and drug discovery in India
Bhattacharya, A., Bhattacharya, S., & Mishra, R. K. (2024) · Journal of Biosciences · doi:10.1007/s12038-024-00434-x · Cited by 7
A patterned human heart tube organoid model generated by pluripotent stem cell self-assemblyPreprint
Volmert, B. D., Riggs, A., Wang, F., Juhong, A., Kiselev, A. M., Kostina, A. S., O’Hern, C., Muniyandi, P., Wasserman, A. H., Huang, A., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.16.519611 · Cited by 7
Man, Y., Zhai, Y., Jiang, A. R., Bai, H., Gulati, A., Plebani, R., Mannix, R. J., Merry, G. E., Goyal, G., Belgur, C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.13.607799 · Cited by 7
Self-citationDhand, A. P., Juarros, M. A., Martin, T. G., Rodriguez‐Rivera, G. J., Hunt, D. R., Obenreder, M. C., Crosby, C. O., Meurer-Zeman, B., Mcafee, Q. W., Valle-Ayala, H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.01.616163 · Cited by 7
Organoids and 3D In Vitro Models as a Platform for Precision Medicine (PM): An Update
Ganguly, P. (2024) · Organoids · doi:10.3390/organoids3030011 · Cited by 6
Exploring animal methods bias in biomedical research funding: Workshop proceedings and action steps
Krebs, C. E., Geißler, S., Herrmann, K., Kandaras, K., Kavanagh, O. V., Langan, L. M., Pistollato, F., Raha, S., Tripodi, I. J., & Trunnell, E. R. (2024) · NAM journal. · doi:10.1016/j.namjnl.2024.100004 · Cited by 7
A Versatile and Modular Microfluidic System for Dynamic Cell Culture and Cellular Interactions
Ramadan, Q., Hazaymeh, R., & Zourob, M. M. (2025) · Micromachines · doi:10.3390/mi16020237 · Cited by 6
Sharma, S., Vidal, M. S., Paul, S., Han, A., Menon, R., & Richardson, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1543710 · Cited by 6
Large animal models in gynecology: status and future perspectives
Zhao, D., Li, X., Zheng, X., Xie, X., Zhao, Y., & Liu, Y. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1588098 · Cited by 8
Evaluation of NFκB-dependent inflammatory responses induced by TNFα in 3D human microvessels
Den-Udom, T., Asavapanumas, N., Bunyapraphatsara, N., Muta, K., & Ketsawatsomkron, P. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e43397 · Cited by 6
-Omics approaches to study and model cell-cell interactions in engineered tissues
Stark, C., Jenison, S. E., & Ngo, M. T. (2025) · Frontiers in Chemical Engineering · doi:10.3389/fceng.2025.1629455 · Cited by 7
Dai, Y., Zhao, F., Chen, Q., Zeng, B., Gu, W., Zhang, Y., Sun, F., Wang, X., Lin, X., Liu, N., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.08.035 · Cited by 8
Paggi, C. A. (2025) · Osteoarthritis and Cartilage Open · doi:10.1016/j.ocarto.2025.100686 · Cited by 8
Dey, S., Mehra, P., Jaiswal, C., Jadhav, T. D., Kirtonia, A., Bhar, B., Mishra, S. B., Gupta, R., & Mandal, B. B. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123719 · Cited by 6
History and Evolution of Innovations in Clinical Pharmacology
Lesko, L. J., & van der Graaf, P. H. (2025) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.70048 · Cited by 7
Metadata
- Authors
- Ingber, D. E.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Ingber, Donald E.
- ORCID
- Ingber, Donald E.
- Venue
- Nature Reviews Genetics
- Published
- 2022-03-25
- Volume
- 23
- Issue
- 8
- Pages
- 467-491
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- PMC
- PMC8951665
- OpenAlex
- W4220652963
- Cited by
- 1,589
- References
- 151
- Citations by year
- 2026: 457 · 2025: 440 · 2024: 389 · 2023: 215 · 2022: 87
- FWCI
- 25.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nature Reviews Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bill and Melinda Gates Foundation
- National Institutes of Health
- Defense Advanced Research Projects Agency
- Biomedical Advanced Research and Development Authority
- National Heart, Lung, and Blood Institute (UH3HL141797)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- organ-on-a-chip, microfluidics, disease modeling, drug development, personalized medicine, alternative to animal models, rare genetic disorders, host-microbiome interactions, drug toxicity, infectious agents, regulatory acceptance, pharmaceutical industry
- MeSH terms
- Drug Development, Animals, Humans, Rare Diseases, Lab-On-A-Chip Devices, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
