Human organs-on-chips for disease modelling, drug development and personalized medicine

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005

PDMS absorption of small molecules and consequences in microfluidic applications

Toepke, M. W., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b612140c · Cited by 1,193

Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: A review

Fogel, D. B. (2018) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2018.08.001 · Cited by 1,035

Advances in organ-on-a-chip engineering

Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell’Erba, V., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.003 · Cited by 979

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522193112 · Cited by 922

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Jang, K., Mehr, A. P., Hamilton, G. A., McPartlin, L. A., Chung, S., Suh, K. Y., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40049b · Cited by 867

Opportunities for Microphysiological Systems in Toxicity Testing of New Drug Modalities

Maulana, T. I., Wevers, N. R., Kristoforus, T., Chandler, M. R., Lanz, H. L., Joore, J., Vulto, P., Villenave, R., Kustermann, S., Loskill, P., et al. (2024) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-061724-080621 · Cited by 18

Understanding the cellular dynamics, engineering perspectives and translation prospects in bioprinting epithelial tissues

Derman, İ. D., Moses, J. C., Rivera, T., & Ozbolat, I. T. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.09.025 · Cited by 15

Revolutionizing Biomedical Research: Unveiling the Power of Microphysiological Systems with Advanced Assays, Integrated Sensor Technologies, and Real-Time Monitoring

Samantasinghar, A., Sunildutt, N., Ahmed, F., Memon, F. H., Kang, C.-U., & Choi, K. H. (2025) · ACS Omega · doi:10.1021/acsomega.4c11227 · Cited by 15

A hollow fiber membrane-based liver organoid-on-a-chip model for examining drug metabolism and transport

Myszczyszyn, A., Muench, A., Lehmann, V., Sinnige, T., van Steenbeek, F. G., Bouwmeester, M., Samsom, R.-A., Keuper-Navis, M., van der Made, T. K., Kogan, D., et al. (2025) · Biofabrication · doi:10.1088/1758-5090/adc3ce · Cited by 14

Biotechnological advances and applications of human pluripotent stem cell-derived heart models

Muniyandi, P., O’Hern, C., Popa, M. A., & Aguirre, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214431 · Cited by 14

Synthetic Biology-Based Approaches to Investigate Host–Pathogen Interactions

Banerjee, R. (2025) · SynBio · doi:10.3390/synbio3010004 · Cited by 16

Oral tissue spheroid, organoid, and organ‐on chip microphysiological modeling strategies towards enhanced emulation of health and disease

Gouveia, Z., Özkan, A., Giannobile, W. V., Santerre, J. P., & Wu, D. T. S. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70020 · Cited by 14

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

Wang, P., Liu, J., Zhang, M., Yang, J., Lian, P., Cheng, X., & Qin, J. (2025) · Advanced Science · doi:10.1002/advs.202502356 · Cited by 14

Advancements and challenges in SLA-based microfluidic devices for organ-on-chip applications

Barbosa, F., Coutinho, P., Ribeiro, M. P., Moreira, A. F., Lourenço, L. M., & Miguel, S. P. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.114254 · Cited by 15

Gut-on-chip methodology based on 3D-printed molds: a cost-effective and accessible approach

Delannoy, E., Burette, A., Janel, S., Poiret, S., Deboosère, N., Daniel, C., & Grassart, A. (2025) · Lab on a Chip · doi:10.1039/d5lc00147a · Cited by 14

Strategies to control cellular spatial organization in microphysiological systems

Truong, H. D., Ge, Z., Chng, E., Tran, Y.-V., Zhang, Y., & Lim, C. T. (2026) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-01141-9 · Cited by 18

Rapid integration of screen-printed electrodes into thermoplastic organ-on-a-chip devices for real-time monitoring of trans-endothelial electrical resistance

Kawakita, S., Li, S., Nguyen, H. T., Maity, S., Haghniaz, R., Bahari, J., Yu, N., Mandal, K., Bandaru, P., Mou, L., et al. (2023) · Biomedical Microdevices · doi:10.1007/s10544-023-00669-9 · Cited by 14

Numerical simulation, fabrication, and characterization of a heating system for integration into an Organ-on-a-Chip

Ferreira, G. M., Azevedo, F., Sousa, P. J., Pinto, V. C., Catarino, S. O., Sousa, P. C., & Minas, G. M. H. (2023) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2023.114699 · Cited by 14

Mucopolysaccharidosis IVA: Current Disease Models and Drawbacks

Leal, A. F., Alméciga-Díaz, C. J., & Tomatsu, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216148 · Cited by 14

Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach

Bayona, C., Alza, L., Ranđelović, T., Sallan, M. C., Visa, A., Cantı́, C., Ochoa, I., Oliván, S., & Herreros, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06492-1 · Cited by 15

Recombinant Human Keratinocyte Growth Factor Ameliorates Cancer Treatment‐Induced Oral Mucositis on a Chip

Ly, K. L., Rajtboriraks, M., Elgerbi, A., Luo, X., & Raub, C. B. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302970 · Cited by 14

Modeling Structural Elements and Functional Responses to Lymphatic‐Delivered Cues in a Murine Lymph Node on a Chip

Mazzaglia, C., Munir, H., Lei, I. M., Gerigk, M., Huang, Y. Y. S., & Shields, J. D. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303720 · Cited by 13

hiPSC-derived macrophages improve drug sensitivity and selectivity in a macrophage-incorporating organoid culture model

Jo, S., Park, S. B., Kim, H., Im, I., Noh, H., Kim, E., Kim, K. Y., Oelgeschläger, M., Kim, J., & Park, H. (2024) · Biofabrication · doi:10.1088/1758-5090/ad4c0a · Cited by 15

Progress and application of lung-on-a-chip for lung cancer

Li, L., Bo, W., Wang, G., Juan, X., Xue, H., & Zhang, H. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1378299 · Cited by 14

Neurological insights into brain-targeted cancer therapy and bioinspired microrobots

Ghosh, S., Bhaskar, R., Mishra, R., Babu, M. A., Abomughaid, M. M., Jha, N. K., & Sinha, J. K. (2024) · Drug Discovery Today · doi:10.1016/j.drudis.2024.104105 · Cited by 14

Development of in vitro model of exosome transport in microfluidic gut-brain axis-on-a-chip

Seo, G. M., Lee, H., Kang, Y. J., Kim, D., & Sung, J. H. (2024) · Lab on a Chip · doi:10.1039/d4lc00490f · Cited by 14

Electroactive Nanomaterials for the Prevention and Treatment of Heart Failure: From Materials and Mechanisms to Applications

Kong, C., Guo, Z., Teng, T., Yao, Q., Yu, J., Wang, M., Ma, Y., Wang, P., & Tang, Q. (2024) · Small · doi:10.1002/smll.202406206 · Cited by 14

In Vitro Modeling of Idiopathic Pulmonary Fibrosis: Lung-on-a-Chip Systems and Other 3D Cultures

Corona, C., Man, K., Newton, C. A., Nguyen, K. T., & Yang, Y. S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111751 · Cited by 13

Advances in Microfluidic Bioprinting for Multi-Material Multi-Cellular Tissue Constructs

Chand, R., Kamei, K., & Vijayavenkataraman, S. (2025) · Cell Therapy & Engineering Connect · doi:10.69709/cellengc.2024.111335 · Cited by 18

PEGylated PLGA nanoparticles prepared from nano-emulsion templates as versatile platforms to cross blood-brain barrier models

López-Mitjavila, J.-J., Palma-Florez, S., Lagunas, A., Mir, M., Samitier, J., Rodríguez‐Abreu, C., & Grijalvo, S. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107057 · Cited by 15

Proof-of-Concept Human Organ-on-Chip Study: First Step of Platform to Assess Neuro-Immunological Communication Involved in Inflammatory Bowel Diseases

Gabriel-Segard, T., Rontard, J., Miny, L., Dubuisson, L., Batut, A., Debis, D., Gleyzes, M., Francois, F., Larramendy, F., Soriano, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310568 · Cited by 14

Modelling adult stem cells and their niche in health and disease with epithelial organoids

Szabó, L., Seubert, A. C., & Kretzschmar, K. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.09.006 · Cited by 14

A similarity scaling approach for organ-on-chip devices

Feng, J. J., & Hedtrich, S. (2022) · Lab on a Chip · doi:10.1039/d2lc00641c · Cited by 13

A Biomimetic Optical Cardiac Fibrosis-on-a-Chip for High-Throughput Anti-Fibrotic Drug Screening

Shang, Y., Xu, D., Sun, L., Zhao, Y., & Sun, L. (2024) · Research · doi:10.34133/research.0471 · Cited by 13

Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?

Budharaju, H., Singh, R. K., & Kim, H. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.07.006 · Cited by 15

Real-Time, Continuous Monitoring of Tissue Chips as an Emerging Opportunity for Biosensing

Cognetti, J. S., & Miller, B. L. (2025) · Sensors · doi:10.3390/s25165153 · Cited by 13

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

Cordiale, A., Stanco, D., Visone, R., Stadlinger, B., Pagella, P., Rasponi, M., & Mitsiadis, T. A. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502080 · Cited by 14

The ethical aspects of human organ-on-chip models: A mapping review

Weidema, J., de Vries, M., Mummery, C. L., & de Graeff, N. (2025) · Stem Cell Reports · doi:10.1016/j.stemcr.2025.102686 · Cited by 13

A microphysiological system for screening lipid nanoparticle−mRNA complexes predicts in vivo heart transfection efficacy

Neiman, G., Costa, M. W., Han, H., Zhao, S., Ng, T. K., Siemons, B. A., Nishino, T., Huang, Y., Jinagal, S. L., Wu, K., et al. (2025) · Nature Biomedical Engineering · doi:10.1038/s41551-025-01523-4 · Cited by 15

Organoids for disease modeling and treatment: state-of-the-art

Xu, M., Kong, D., Sun, S., Wang, Y., Su, G., Zhang, S., Yan, J., Han, Z., Li, J., & Zhang, L. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00743-x · Cited by 14

Immunometabolism Reframes Alzheimer’s Disease: From Systemic Dysmetabolism to Glial Rewiring

Bach, D., & Nguyen, L. L. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01691-0 · Cited by 15

Sourcing cells for in vitro models of human vascular barriers of inflammation

McCloskey, M. C., Zhang, V. Z., Ahmad, S. D., Walker, S. N., Romanick, S., Awad, H. A., & McGrath, J. L. (2022) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.979768 · Cited by 13

Developmental pathways linked to the vulnerability of adult midbrain dopaminergic neurons to neurodegeneration

Prakash, N. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1071731 · Cited by 15

Advancements in organs-on-chips technology for viral disease and anti-viral research

Li, J., Bai, H., Wang, Z., Beibei, X., Olson, K. N. P., Liu, C., Su, Y., Hao, J., Shen, J., Xi, X., et al. (2023) · Organs-on-a-Chip · doi:10.1016/j.ooc.2023.100030 · Cited by 13

Recent advances in in vitro skin-on-a-chip models for drug testing

Sung, J. H., & Kim, J. J. (2023) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2023.2227379 · Cited by 14

Recent advances in micro-physiological systems for investigating tumor metastasis and organotropism

Yoon, H., del Río, J. S., Cho, S. W., & Park, T. (2024) · Lab on a Chip · doi:10.1039/d3lc01033c · Cited by 13

Facilitating long-term cell examinations and time-lapse recordings in cell biology research with CO2 mini-incubators

Talebipour, A., Saviz, M., Vafaiee, M., & Faraji‐Dana, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-52866-y · Cited by 13

Complex or not too complex? One size does not fit all in next generation microphysiological systems

Bersini, S., Arrigoni, C., Talò, G., Candrian, C., & Moretti, M. (2024) · iScience · doi:10.1016/j.isci.2024.109199 · Cited by 13

A Versatile Microfluidic Platform for Extravasation Studies Based on DNA Origami—Cell Interactions

García‐Chamé, M., Wadhwani, P., Pfeifer, J., Schepers, U., Niemeyer, C. M., & Domínguez, C. M. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202318805 · Cited by 14

Ethical Principles and Rules in Experimental Animal Studies: A Comprehensive Review

Kalkan, K. K., & Kekeçoğlu, M. (2024) · Düzce Tıp Fakültesi Dergisi · doi:10.18678/dtfd.1497730 · Cited by 13

An FDA-Validated, Self-Cleaning Liquid Chromatography–Mass Spectrometry System for Determining Small-Molecule Drugs and Metabolites in Organoid/Organ-on-Chip Medium

Kogler, S., Pedersen, G. M., Martínez-Ramírez, F., Aizenshtadt, A., Busek, M., Krauss, S. J. K., Wilson, S. R., & Røberg‐Larsen, H. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c02246 · Cited by 13

Studying the impact of geometrical and cellular cues on myogenesis with a skeletal muscle-on-chip

Nguyen, M., Demri, N., Lapin, B., Federico, F. D., Gropplero, G., Cayrac, F., Hennig, K., Gomes, E. R., Wilhelm, C., Roman, W., et al. (2024) · Lab on a Chip · doi:10.1039/d4lc00417e · Cited by 13

Recreating chronic respiratory infectionsin vitrousing physiologically relevant models

Grassi, L. C., & Crabbé, A. (2024) · European Respiratory Review · doi:10.1183/16000617.0062-2024 · Cited by 13

Human organoids and organ-on-chips in coeliac disease research

Simpson, H. L., Smits, E., Moerkens, R., Wijmenga, C., Mooiweer, J., Jonkers, I. H., & Withoff, S. (2024) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2024.10.003 · Cited by 14

Characterization of human melanoma skin cancer models: A step towards model-based melanoma research

Daugaard, N. D., Tholstrup, R., Tornby, J. R., Bendixen, S. M., Larsen, F. T., Zio, D. D., Barnkob, M. B., Ravnskjær, K., & Brewer, J. R. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.11.018 · Cited by 13

Clinical Microbiome Analysis by Mass Spectrometry–Based Metaproteomics

Zhang, X., Ning, Z., Mayne, J., & Figeys, D. (2025) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-071124-113819 · Cited by 15

Benchtop Fabrication and Integration of Laser‐Induced Graphene Strain Gauges and Stimulation Electrodes in Muscle on a Chip Devices

Svetlova, A., Law, H. T. J., Kim, D., Enriquez, N., Soleimani, A., Al‐Shami, A., Kohan, S., Peck, R. A., Eremina, O. E., Zavaleta, C. L., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202417184 · Cited by 14

Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut–lung axis

Koceva, H., Amiratashani, M., Akbarimoghaddam, P., Hoffmann, B., Zhurgenbayeva, G., Gresnigt, M. S., Marcelino, V. R., Eggeling, C., Figge, M. T., Amorim, M. J., et al. (2025) · Open Biology · doi:10.1098/rsob.240231 · Cited by 15

Recent advances in 3D models for multiparametric blood–brain barrier detection in microfluidic systems

Boncristiani, C., Gilio, A. D., Castro, F. D., Nardini, A., Palmisani, J., Vàzquez, R. M., de Gennaro, G., Fanizzi, F. P., Ciccarella, G., & Vergaro, V. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb02499k · Cited by 14

Synovium‐on‐a‐Chip Reveals Fibroblast–Macrophage Crosstalk Underpinning Joint Homeostasis and Evaluation of Gout Therapies

Lee, M. S., Kim, S., Lee, J., Bae, Y., & Lee, S. K. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501471 · Cited by 13

Organ-on-a-chip systems for modeling tumor and normal tissue microenvironments in radiotherapy research

Nasiri, R., Sankaranthi, A., & Pratx, G. (2025) · Trends in biotechnology · doi:10.1016/j.tibtech.2025.07.002 · Cited by 14

Why Can Organoids Improve Current Organ-on-Chip Platforms?

Sokołowska, P., Żuchowska, A., & Brzózka, Z. (2022) · Organoids · doi:10.3390/organoids1010007 · Cited by 15

Microwell‐based flow culture increases viability and restores drug response in prostate cancer spheroids

Payne, M. C., Ho, S. Y., Hashimoto, T., Imboden, S., Diaz, J. A., Lee, B. S., Rupert, M. J., Cai, N., Goldstein, A. S., & Lin, N. Y. C. (2023) · Biotechnology Journal · doi:10.1002/biot.202200434 · Cited by 11

Challenges in the Development and Application of Organ-on-Chips for Intranasal Drug Delivery Studies

Khan, M. U., Cai, X., Shen, Z., Mekonnen, T. T., Kourmatzis, A., Cheng, S., & Gholizadeh, H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051557 · Cited by 14

Applications of Lab on a Chip in Antimicrobial Susceptibility of Staphylococcus aureus: A Systematic Review

Ardila, C. M., Gómez, M. Z., & Vivares‐Builes, A. M. (2023) · Medicina · doi:10.3390/medicina59101719 · Cited by 14

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

Bai, H., Olson, K. N. P., Pan, M., Marshall, T., Singh, H., Ma, J., Gilbride, P., Yuan, Y., McCormack, J., Si, L., et al. (2023) · Advanced Science · doi:10.1002/advs.202304332 · Cited by 11

SliceChip: a benchtop fluidic platform for organotypic culture and serial assessment of human and rodent pancreatic slices

Alver, C. G., Álvarez-Cubela, S., Altilio, I., Hutchison, E., Warrner, E., Viso, M. E., Vitale, G., Oliver, D., Pastori, R. L., Domínguez‐Bendala, J., et al. (2024) · Lab on a Chip · doi:10.1039/d3lc00850a · Cited by 13

Crosstalk between kidney and bones: New perspective for modulating osteoporosis

Duan, Y., Zhao, L., Lu, Y., Li, J., & Li, S. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102776 · Cited by 16

Inter‐organ crosstalk: The kidney's role in systemic health and disease

Zoccali, C., Agarwal, R., Mallamaci, F., Jager, K. J., Stel, V. S., Kanbay, M., Pollock, C. A., Kalantar‐Zadeh, K., Ronco, C., & Vanholder, R. (2025) · Journal of Internal Medicine · doi:10.1111/joim.70015 · Cited by 14

Generation of a perfusable three-dimensional human neurovascular chip to model brain drug delivery and immune cell extravasation

Qiu, B., Pompe, S., Xenaki, K. T., Maggio, A. D., Henegouwen, P. M. P. V. B. E., Oliveira, S., Mastrobattista, E., & Caiazzo, M. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114257 · Cited by 13

Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity

Shrimali, S., Li, D., Knox, B., Tong, W., & Ning, B. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100187 · Cited by 13

Wnt Signaling Pathway: Biological Function, Diseases, and Therapeutic Interventions

Jin, X., Wang, J., Cao, R., & Jiang, D. (2026) · MedComm · doi:10.1002/mco2.70580 · Cited by 14

Organ‐on‐a‐Chip Technology and Global Multi‐Omics: Current Applications and Future Directions

Cao, X., Xia, C., Li, C., Deng, S., Cao, J., Yang, H., Wang, S., & Chen, P. (2026) · MedComm · doi:10.1002/mco2.70603 · Cited by 13

Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation

Roy, N., & Cucullo, L. (2026) · Biosensors · doi:10.3390/bios16030155 · Cited by 16

The neurovascular unit-on-a-chip: modeling ischemic stroke to stem cell therapy

Kim, S., Kim, M. J., Grant, G. A., & Lee, W. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.385296 · Cited by 12

Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease

Cadavid, J. L., Li, N. T., & McGuigan, A. P. (2024) · Biophysics Reviews · doi:10.1063/5.0179125 · Cited by 11

Biomaterial engineering strategies for modeling the Bruch’s membrane in age-related macular degeneration

Molins, B., Rodríguez, A., Llorenç, V., & Adán, A. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01789 · Cited by 12

Taurine activates the AKT–mTOR axis to restore muscle mass and contractile strength in human 3D in vitro models of steroid myopathy

Mughal, S., Sabater-Arcis, M., Artero, R. D., Ramón‐Azcón, J., & Fernández‐Costa, J. M. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050540 · Cited by 12

Metabolism and bioenergetics in the pathophysiology of organ fibrosis

Miguel, V., Alcalde‐Estévez, E., Sirera, B., Rodríguez‐Pascual, F., & Lamas, S. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.06.001 · Cited by 13

Microphysiological systems for realizing microenvironment that mimics human physiology—functional material and its standardization applied to microfluidics

Ito, Y., Kawauchi, I., Yanagita, Y., Sakai, Y., Nishikawa, M., Arakawa, H., Kadoguchi, M., Tamai, I., Esashika, K., Takahashi, J., et al. (2024) · Emergent Materials · doi:10.1007/s42247-024-00822-x · Cited by 12

Understanding neurotropic enteric viruses: routes of infection and mechanisms of attenuation

Lulla, V., & Sridhar, A. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05450-6 · Cited by 13

Modeling of skeletal development and diseases using human pluripotent stem cells

Hojo, H., Tani, S., & Ohba, S. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae178 · Cited by 12

Development of a Microphysiological Cartilage‐on‐Chip Platform for Dynamic Biomechanical Stimulation of Three‐Dimensional Encapsulated Chondrocytes in Agarose Hydrogels

Peitso, V., Sarmadian, Z., Henriques, J. A. P., Lauwers, E., Paggi, C. A., & Mobasheri, A. (2024) · Current Protocols · doi:10.1002/cpz1.70079 · Cited by 12

Sensor-combined organ-on-a-chip for pharmaceutical and medical sciences: from design and materials to typical biomedical applications

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