Human organs-on-chips for disease modelling, drug development and personalized medicine

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005

PDMS absorption of small molecules and consequences in microfluidic applications

Toepke, M. W., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b612140c · Cited by 1,193

Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: A review

Fogel, D. B. (2018) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2018.08.001 · Cited by 1,035

Advances in organ-on-a-chip engineering

Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell’Erba, V., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.003 · Cited by 979

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522193112 · Cited by 922

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Jang, K., Mehr, A. P., Hamilton, G. A., McPartlin, L. A., Chung, S., Suh, K. Y., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40049b · Cited by 867

Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours

Flugel, C., Majzner, R. G., Krenciute, G., Dotti, G., Riddell, S. R., Wagner, D. L., & Abou‐El‐Enein, M. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00704-3 · Cited by 586

Fecal microbiota transplantation: current challenges and future landscapes

Yadegar, A., Bar‐Yoseph, H., Monaghan, T. M., Pakpour, S., Severino, A., Kuijper, E. J., Smits, W. K., Terveer, E. M., Neupane, S., Nabavi-Rad, A., et al. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00060-22 · Cited by 397

Human disease models in drug development

Loewa, A., Feng, J. J., & Hedtrich, S. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00063-3 · Cited by 331

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections

Ney, L.-M., Wipplinger, M., Grossmann, M., Engert, N., Wegner, V. D., & Mosig, A. S. (2023) · Open Biology · doi:10.1098/rsob.230014 · Cited by 367

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Desai, N., Rana, D., Patel, M., Bajwa, N., Prasad, R., & Vora, L. K. (2025) · Small · doi:10.1002/smll.202502315 · Cited by 341

Organ-on-a-chip meets artificial intelligence in drug evaluation

Deng, S., Li, C., Cao, J., Cui, Z., Du, J., Fu, Z. H., Yang, H., & Chen, P. (2023) · Theranostics · doi:10.7150/thno.87266 · Cited by 274

Strategies to reduce the risks of mRNA drug and vaccine toxicity

Bitounis, D., Jacquinet, E., Rogers, M. A., & Amiji, M. M. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00859-3 · Cited by 242

Poor Translatability of Biomedical Research Using Animals — A Narrative Review

Marshall, L. J., Bailey, J., Cassotta, M., Herrmann, K., & Pistollato, F. (2023) · Alternatives to Laboratory Animals · doi:10.1177/02611929231157756 · Cited by 219

Clinical applications of human organoids

Verstegen, M. M. A., Coppes, R. P., Béghin, A., Coppi, P. D., Gerli, M., de Graeff, N., Pan, Q., Saito, Y., Shi, S., ZADPOOR, A. A., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03489-3 · Cited by 230

Integrating organoids and organ-on-a-chip devices

Zhao, Y., Landau, S., Okhovatian, S., Liu, C., Lu, R. X. Z., Lai, B. F. L., Wu, Q., Kieda, J., Cheung, K., Rajasekar, S., et al. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00207-z · Cited by 217

Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy

Chehelgerdi, M., Dehkordi, F. B., Chehelgerdi, M., Kabiri, H., Salehian-Dehkordi, H., Abdolvand, M. A., Salmanizadeh, S., Rashidi, M., Niazmand, A., Ahmadi, S., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01873-0 · Cited by 189

Patient-derived organoids in precision cancer medicine

Tong, L., Cui, W., Zhang, B., Fonseca, P., Zhao, Q. C., Zhang, P., Xu, B., Zhang, Q., Li, Z., Seashore-Ludlow, B. A., et al. (2024) · Med · doi:10.1016/j.medj.2024.08.010 · Cited by 192

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip

Mahajan, G., Doherty, E. R., To, T., Sutherland, A. D., Grant, J. L., Junaid, A., Gulati, A., LoGrande, N., Izadifar, Z., Timilsina, S. S., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01400-1 · Cited by 152

Acquired resistance in cancer: towards targeted therapeutic strategies

Soragni, A., Knudsen, E. S., O’Connor, T. N., Tognon, C. E., Tyner, J. W., Gini, B., Kim, D., Bivona, T. G., Zang, X., Witkiewicz, A. K., et al. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00824-9 · Cited by 151

Human organoids-on-chips for biomedical research and applications

Wang, H., Ning, X., Zhao, F. H., Zhao, H., & Li, D. (2024) · Theranostics · doi:10.7150/thno.90492 · Cited by 148

The Discovery of Extracellular Vesicles and Their Emergence as a Next-Generation Therapy

Rai, A., Claridge, B., Lozano, J., & Greening, D. W. (2024) · Circulation Research · doi:10.1161/circresaha.123.323054 · Cited by 136

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025

Allgayer, H., Mahapatra, S., Mishra, B., Swain, B., Saha, S., Khanra, S., Kumari, K., Panda, V. K., Malhotra, D., Patil, N. S., et al. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02338-2 · Cited by 127

A patterned human primitive heart organoid model generated by pluripotent stem cell self-organization

Volmert, B. D., Kiselev, A. M., Juhong, A., Wang, F., Riggs, A., Kostina, A. S., O’Hern, C., Muniyandi, P., Wasserman, A. H., Huang, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43999-1 · Cited by 117

Neuropathogenesis-on-chips for neurodegenerative diseases

Amartumur, S., Nguyen, H. M., Huynh, T., Kim, T. S., Woo, R., Oh, E., Kim, K. K., Lee, L. P., & Heo, C. (2024) · Nature Communications · doi:10.1038/s41467-024-46554-8 · Cited by 131

Sensing the Future─Frontiers in Biosensors: Exploring Classifications, Principles, and Recent Advances

Kumari, S. M. N. S., & Xavier, T. S. (2024) · ACS Omega · doi:10.1021/acsomega.4c07991 · Cited by 120

Gut-on-a-chip models for dissecting the gut microbiology and physiology

Valiei, A., Aminian-Dehkordi, J., & Mofrad, M. R. K. (2023) · APL Bioengineering · doi:10.1063/5.0126541 · Cited by 120

Breakthroughs and Applications of Organ-on-a-Chip Technology

Koyilot, M. C., Natarajan, P., Hunt, C. R., Sivarajkumar, S., Roy, R., Joglekar, S. S., Pandita, S., Tong, C. W.-C., Marakkar, S., Subramanian, L., et al. (2022) · Cells · doi:10.3390/cells11111828 · Cited by 110

Additive Manufacturing and Physicomechanical Characteristics of PEGDA Hydrogels: Recent Advances and Perspective for Tissue Engineering

Hakim Khalili, M., Zhang, R., Wilson, S., Goel, S., Impey, S. A., & Aria, A. I. (2023) · Polymers · doi:10.3390/polym15102341 · Cited by 114

Organ-on-chip technology: Opportunities and challenges

Srivastava, S. K., Foo, G. W., Aggarwal, N., & Chang, M. W. (2024) · Biotechnology Notes · doi:10.1016/j.biotno.2024.01.001 · Cited by 108

A human kidney and liver organoid‐based multi‐organ‐on‐a‐chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell‐derived extracellular vesicles

Nguyen, V. V. T., Ye, S., Gkouzioti, V., van Wolferen, M. E., Yengej, F. Y., Melkert, D., Siti, S., de Jong, B., Besseling, P. J., Spee, B., et al. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12280 · Cited by 105

Simulation-based approaches for drug delivery systems: Navigating advancements, opportunities, and challenges

Salahshoori, I., Golriz, M., Nobre, M. A. L., Mahdavi, S., Malekshah, R. E., Javdani-Mallak, A., Jorabchi, M. N., Khonakdar, H. A., Wang, Q., Mohammadi, A. H., et al. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2023.123888 · Cited by 109

Alternatives of Animal Models for Biomedical Research: a Comprehensive Review of Modern Approaches

Vashishat, A., Patel, P., Gupta, G. D., & Kurmi, B. D. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10701-x · Cited by 109

The immune microenvironment of colorectal cancer

Kennel, K. B., & Greten, F. R. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00872-1 · Cited by 122

Gene therapy for CNS disorders: modalities, delivery and translational challenges

Gao, J., Gunasekar, S., Xia, Z. J., Shalin, K., Jiang, C., Chen, H., Lee, D., Lee, S., Pisal, N. D., Luo, J. N., et al. (2024) · Nature reviews. Neuroscience · doi:10.1038/s41583-024-00829-7 · Cited by 100

Artificial intelligence in preclinical research: enhancing digital twins and organ-on-chip to reduce animal testing

Gangwal, A., & Lavecchia, A. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104360 · Cited by 113

Towards in vitro models for reducing or replacing the use of animals in drug testing

Stresser, D. M., Kopec, A. K., Hewitt, P., Hardwick, R. N., Van Vleet, T. R., Mahalingaiah, P. K. S., O’Connell, D., Jenkins, G. J., David, R., Graham, J., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01154-7 · Cited by 94

Organ‐On‐A‐Chip Models of the Blood–Brain Barrier: Recent Advances and Future Prospects

Kawakita, S., Mandal, K., Mou, L., Mecwan, M. M., Zhu, Y., Li, S., Sharma, S., Hernández, A. L., Nguyen, H. T., Maity, S., et al. (2022) · Small · doi:10.1002/smll.202201401 · Cited by 103

3D cancer models: One step closer to in vitro human studies

Manduca, N., Maccafeo, E., Maria, R. D., Sistigu, A., & Musella, M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1175503 · Cited by 103

Landscape of human organoids: Ideal model in clinics and research

Han, X., Cai, C., Deng, W., Shi, Y., Li, L., Wang, C., Zhang, J., Rong, M., Liu, J., Fang, B., et al. (2024) · The Innovation · doi:10.1016/j.xinn.2024.100620 · Cited by 101

A Systematic Review of Toxicity, Biodistribution, and Biosafety in Upconversion Nanomaterials: Critical Insights into Toxicity Mitigation Strategies and Future Directions for Safe Applications

Khan, I. A., Yu, T. Y., Yang, M., Liu, J., & Chen, Z. (2025) · BME Frontiers · doi:10.34133/bmef.0120 · Cited by 93

3d organ-on-a-chip: the convergence of microphysiological systems and organoids

Baptista, L. S., Porrini, C., Kronemberger, G. S., Kelly, D. J., & Perrault, C. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1043117 · Cited by 90

Microfluidic high-throughput 3D cell culture

Ko, J., Park, D., Lee, J., Jung, S., Baek, K., Sung, K. E., Lee, J., & Jeon, N. L. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00163-8 · Cited by 88

A microengineered Brain-Chip to model neuroinflammation in humans

Pediaditakis, I., Kodella, K. R., Manatakis, D. V., Le, C. Y., Barthakur, S., Sorets, A. G., Gravanis, A., Ewart, L. C., Rubin, L. L., Manolakos, E. S., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104813 · Cited by 84

iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies

Palasantzas, V. E. J. M., Tamargo-Rubio, I., Le, K. T. T., Slager, J., Wijmenga, C., Jonkers, I. H., Kumar, V., Fu, J., & Withoff, S. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.01.002 · Cited by 94

Organ-on-chip models for infectious disease research

Alonso‐Román, R., Mosig, A. S., Figge, M. T., Papenfort, K., Eggeling, C., Schacher, F. H., Hube, B., & Gresnigt, M. S. (2024) · Nature Microbiology · doi:10.1038/s41564-024-01645-6 · Cited by 95

Intestinal organ chips for disease modelling and personalized medicine

Özkan, A., LoGrande, N., Feitor, J. F., Goyal, G., & Ingber, D. E. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00968-3 · Cited by 92

The advancement of artificial intelligence in biomedical research and health innovation: challenges and opportunities in emerging economies

da Silva, R. G. L. (2024) · Globalization and Health · doi:10.1186/s12992-024-01049-5 · Cited by 111

Immune-infiltrated kidney organoid-on-chip model for assessing T cell bispecific antibodies

Kroll, K. T., Mata, M. M., Homan, K. A., Micallef, V., Carpy, A., Hiratsuka, K., Morizane, R., Moisan, A., Gubler, M., Walz, A.-C., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2305322120 · Cited by 79

Understanding disruption of the gut barrier during inflammation: Should we abandon traditional epithelial cell lines and switch to intestinal organoids?

Lechuga, S., Neto, M. B. B., Naydenov, N. G., Rieder, F., & Ivanov, A. I. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1108289 · Cited by 83

Progress in toxicogenomics to protect human health

Meier, M. J., Harrill, J., Johnson, K. J., Thomas, R. S., Tong, W., Rager, J. E., & Yauk, C. L. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00767-1 · Cited by 84

Roadblocks confronting widespread dissemination and deployment of Organs on Chips

Alver, C. G., Drabbe, E., Ishahak, M., & Agarwal, A. (2024) · Nature Communications · doi:10.1038/s41467-024-48864-3 · Cited by 74

Organ chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levels

Izadifar, Z., Charrez, B., Almeida, M., Robben, S., Pilobello, K. T., van der Graaf-Mas, J., Benz, M., Marquez, S. L., Ferrante, T. C., Shcherbina, K., et al. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116683 · Cited by 77

3D bioprinting strategy for engineering vascularized tissue models

Chae, S., Ha, D., & Lee, H. (2023) · International Journal of Bioprinting · doi:10.18063/ijb.748 · Cited by 82

Revolutionizing immune research with organoid-based co-culture and chip systems

Papp, D., Korcsmáros, T., & Hautefort, I. (2024) · Clinical & Experimental Immunology · doi:10.1093/cei/uxae004 · Cited by 74

De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model

He, H., He, B., Guan, L., Zhao, Y., Jiang, F., Chen, G., Zhu, Q.-G., Chen, C. Y., Li, T., & Yao, J. (2024) · Nature Communications · doi:10.1038/s41467-024-50903-y · Cited by 78

Recent Advances of Biosensor-Integrated Organ-on-a-Chip Technologies for Diagnostics and Therapeutics

Shinde, A. S., Illath, K., Kasiviswanathan, U., Nagabooshanam, S., Gupta, P., Dey, K., Chakrabarty, P., Nagai, M., Rao, S. R., Kar, S., et al. (2023) · Analytical Chemistry · doi:10.1021/acs.analchem.2c05036 · Cited by 70

Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery

Sunildutt, N., Parihar, P., Salih, A. R. C., Lee, S. H., & Choi, K. H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1139229 · Cited by 68

A review on the recent applications of deep learning in predictive drug toxicological studies

Sinha, K., Ghosh, N., & Sil, P. C. (2023) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00375 · Cited by 64

Organoids/organs-on-a-chip: new frontiers of intestinal pathophysiological models

Wu, L., Ai, Y., Xie, R., Xiong, J., Wang, Y., & Liang, Q. (2023) · Lab on a Chip · doi:10.1039/d2lc00804a · Cited by 66

Next-Generation Microfluidics for Biomedical Research and Healthcare Applications

Deliorman, M., Ali, D. S., & Qasaimeh, M. A. (2023) · Biomedical Engineering and Computational Biology · doi:10.1177/11795972231214387 · Cited by 64

Advancements in 3D-printable polysaccharides, proteins, and synthetic polymers for wound dressing and skin scaffolding – A review

Sadeghianmaryan, A., Ahmadian, N., Wheatley, S., Sardroud, H. A., Nasrollah, S. A. S., Naseri, E., & Ahmadi, A. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131207 · Cited by 64

A perfusable, vascularized kidney organoid-on-chip model

Kroll, K. T., Homan, K. A., Uzel, S. G. M., Mata, M. M., Wolf, K. J., Rubins, J. E., & Lewis, J. A. (2024) · Biofabrication · doi:10.1088/1758-5090/ad5ac0 · Cited by 68

Decoding the Liver-Heart Axis in Cardiometabolic Diseases

Capone, F., Vacca, A., Bidault, G., Sarver, D. C., Kamińska, D., Strocchi, S., Vidal‐Puig, A., Greco, C. M., Lusis, A. J., & Schiattarella, G. G. (2025) · Circulation Research · doi:10.1161/circresaha.125.325492 · Cited by 76

Flowmetering for microfluidics

Cavaniol, C., César, W., Descroix, S., & Viovy, J. (2022) · Lab on a Chip · doi:10.1039/d2lc00188h · Cited by 62

Blood–brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research

Peng, B., Hao, S., Tong, Z., Bai, H., Pan, S., Lim, K., Li, L., Voelcker, N. H., & Huang, W. (2022) · Lab on a Chip · doi:10.1039/d2lc00305h · Cited by 61

3D-bioprinted human tissue and the path toward clinical translation

Bliley, J. M., Shiwarski, D. J., & Feinberg, A. W. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abo7047 · Cited by 67

Development of a perfusable, hierarchical microvasculature-on-a-chip model

Chen, S. W., Blazeski, A., Zhang, S., Shelton, S. E., Offeddu, G. S., & Kamm, R. D. (2023) · Lab on a Chip · doi:10.1039/d3lc00512g · Cited by 62

Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips

Izadifar, Z., Cotton, J., Chen, S., Bustos, N. A., Horvath, V., Stejskalová, A., Wu, C. M., Gulati, A., LoGrande, N., Budnik, B., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48910-0 · Cited by 64

An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells

Moerkens, R., Mooiweer, J., Ramírez-Sánchez, A. D., Oelen, R., Franke, L., Wijmenga, C., Barrett, R. J., Jonkers, I. H., & Withoff, S. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114247 · Cited by 68

The Application of Organs-on-a-Chip in Dental, Oral, and Craniofacial Research

Huang, C.-Y., Sanaei, F., Verdurmen, W. P. R., Yang, F., Ji, W., & Walboomers, X. F. (2023) · Journal of Dental Research · doi:10.1177/00220345221145555 · Cited by 60

Gastrointestinal organs and organoids-on-a-chip: advances and translation into the clinics

Carvalho, M. R., Yan, L., Li, B., Zhang, C., He, Y., Reis, R. L., & Oliveira, J. M. (2023) · Biofabrication · doi:10.1088/1758-5090/acf8fb · Cited by 65

An Organ‐on‐Chip Platform for Simulating Drug Metabolism Along the Gut–Liver Axis

Lucchetti, M., Aina, K. O., Grandmougin, L., Jäger, C., Escriva, P. P., Letellier, E., Mosig, A. S., & Wilmes, P. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303943 · Cited by 63

Standardizing designed and emergent quantitative features in microphysiological systems

Nahon, D. M., Moerkens, R., Aydoğmuş, H., Lendemeijer, B., Martínez-Silgado, A., Stein, J. M., Dostanić, M., Frimat, J., Gontan, C., de Graaf, M. N. S., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01236-0 · Cited by 65

33 Unresolved Questions in Nanoscience and Nanotechnology

Mirkin, C. A., Petrosko, S. H., Artzi, N., Aydın, K., Biaggne, A., Brinker, C. J., Bujold, K. E., Cao, Y. C., Chan, R. R., Chen, C., et al. (2025) · ACS Nano · doi:10.1021/acsnano.5c12854 · Cited by 64

Modelling and targeting mechanical forces in organ fibrosis

Mascharak, S., L. Guo, J., Griffin, M., E. Berry, C., C. Wan, D., & T. Longaker, M. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00144-3 · Cited by 59

Vascular inflammation on a chip: A scalable platform for trans-endothelial electrical resistance and immune cell migration

Ehlers, H., Nicolas, A., Schavemaker, F., Heijmans, J. P. M., Bulst, M., Trietsch, S. J., & van den Broek, L. J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1118624 · Cited by 61

Glioblastoma-on-a-chip construction and therapeutic applications

Xie, Z., Chen, M., Lian, J., Wang, H., & Ma, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1183059 · Cited by 64

Engineering in vitro vascular microsystems

Liu, Q., Ying, G., Hu, C., Du, L., Zhang, H., Wang, Z., Yue, H., Yetisen, A. K., Wang, G., Shen, Y., et al. (2025) · Microsystems & Nanoengineering · doi:10.1038/s41378-025-00956-w · Cited by 63

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

Bouquerel, C., Dubrova, A., Hofer, I., Phan, D. T. T., Bernheim, M., Ladaigue, S., Cavaniol, C., Maddalo, D., Cabel, L., Mechta-Grigoriou, F., et al. (2023) · Lab on a Chip · doi:10.1039/d3lc00531c · Cited by 58

Basement membrane properties and their recapitulation in organ-on-chip applications

Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100301 · Cited by 57

Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions

del Río, J. S., Ro, J., Yoon, H., Park, T., & Cho, Y. (2023) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.115057 · Cited by 57

Inhaled drug delivery for the targeted treatment of asthma

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