Human organs-on-chips for disease modelling, drug development and personalized medicine

Reconstituting organ-level lung functions on a chip

Huh, D., Matthews, B. D., Mammoto, A., Montoya-Zavala, M., Hsin, H. Y., & Ingber, D. E. (2010) · Science · doi:10.1126/science.1188302 · Cited by 4,250

Modeling Development and Disease with Organoids

Clevers, H. (2016) · Cell · doi:10.1016/j.cell.2016.05.082 · Cited by 3,196

Genomic responses in mouse models poorly mimic human inflammatory diseases

Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005

PDMS absorption of small molecules and consequences in microfluidic applications

Toepke, M. W., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b612140c · Cited by 1,193

Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: A review

Fogel, D. B. (2018) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2018.08.001 · Cited by 1,035

Advances in organ-on-a-chip engineering

Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017

A Human Disease Model of Drug Toxicity–Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice

Huh, D., Leslie, D. C., Matthews, B. D., Fraser, J. P., Jurek, S., Hamilton, G. A., Thorneloe, K. S., McAlexander, M. A., & Ingber, D. E. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004249 · Cited by 993

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell’Erba, V., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.003 · Cited by 979

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Kim, H. J., Li, H., Collins, J. J., & Ingber, D. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522193112 · Cited by 922

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Jang, K., Mehr, A. P., Hamilton, G. A., McPartlin, L. A., Chung, S., Suh, K. Y., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40049b · Cited by 867

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Jalili-Firoozinezhad, S., Gazzaniga, F. S., Calamari, E. L., Camacho, D. M., Fadel, C. W., Bein, A., Swenor, B., Nestor, B., Cronce, M. J., Tovaglieri, A., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0397-0 · Cited by 855

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

Benam, K. H., Villenave, R., Lucchesi, C., Varone, A., Hubeau, C., Lee, H., Alves, S. E., Salmon, M., Ferrante, T. C., Weaver, J. C., et al. (2015) · Nature Methods · doi:10.1038/nmeth.3697 · Cited by 850

CDK4/6 Inhibition Augments Antitumor Immunity by Enhancing T-cell Activation

Deng, J., Wang, E. S., Jenkins, R. W., Li, S., Dries, R., Yates, K., Chhabra, S., Huang, W., Liu, H., Aref, A. R., et al. (2018) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-0915 · Cited by 770

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Kasendra, M., Tovaglieri, A., Sontheimer-Phelps, A., Jalili-Firoozinezhad, S., Bein, A., Chalkiadaki, A., Scholl, W., Zhang, C., Rickner, H., Richmond, C. A., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-21201-7 · Cited by 754

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Kim, H. J., & Ingber, D. E. (2013) · Integrative Biology · doi:10.1039/c3ib40126j · Cited by 750

Bioprinting of 3D convoluted renal proximal tubules on perfusable chips

Homan, K. A., Kolesky, D. B., Skylar-Scott, M. A., Herrmann, J., Obuobi, H., Moisan, A., & Lewis, J. A. (2016) · Scientific Reports · doi:10.1038/srep34845 · Cited by 699

A microfluidics-based in vitro model of the gastrointestinal human–microbe interface

Shah, P., Fritz, J. V., Glaab, E., Desai, M. S., Greenhalgh, K., Frachet, A., Niegowska, M., Estes, M., Jäger, C., Seguin-Devaux, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms11535 · Cited by 660

Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications

Vatine, G. D., Barrile, R., Workman, M. J., Sances, S., Barriga, B. K., Rahnama, M., Barthakur, S., Kasendra, M., Lucchesi, C., Kerns, J., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.05.011 · Cited by 632

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Shrike Zhang, Y., Shin, S.-R., Zhao, L., Aleman, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08879-x · Cited by 623

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

Park, T., Mustafaoğlu, N., Herland, A., Hasselkus, R., Mannix, R. J., Fitzgerald, E. A., Prantil‐Baun, R., Watters, A. L., Henry, O., Benz, M. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10588-0 · Cited by 621

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

Morad, G., Carman, C. V., Hagedorn, E. J., Perlin, J. R., Zon, L. I., Mustafaoğlu, N., Park, T., Ingber, D. E., Daisy, C. C., & Moses, M. A. (2019) · ACS Nano · doi:10.1021/acsnano.9b04397 · Cited by 572

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

Musah, S., Mammoto, A., Ferrante, T. C., Jeanty, S. S. F., Hirano-Kobayashi, M., Mammoto, T., Roberts, K., Chung, S., Novak, R., Ingram, M., et al. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0069 · Cited by 550

Reproducing human and cross-species drug toxicities using a liver-chip

Jang, K.-J., Otieno, M. A., Ronxhi, J., Lim, H.-K., Ewart, L., Kodella, K. R., Petropolis, D. B., Kulkarni, G., Rubins, J. E., Conegliano, D., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aax5516 · Cited by 511

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

Herland, A., Maoz, B. M., Das, D., Somayaji, M. R., Prantil‐Baun, R., Novak, R., Cronce, M. J., Huffstater, T. M., Jeanty, S. S. F., Ingram, M., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0498-9 · Cited by 511

An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture

Lee, P. J., Hung, P. J., & Lee, L. P. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21360 · Cited by 507

Small molecule absorption by PDMS in the context of drug response bioassays

van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P., & Mummery, C. L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.062 · Cited by 502

Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems

Huh, D., Fujioka, H., Tung, Y., Futai, N., Paine, R., Grotberg, J. B., & Takayama, S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610868104 · Cited by 496

Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro

Nguyen, D.-H. T., Stapleton, S. C., Yang, M. T., Cha, S. S., Choi, C. K., Galie, P. A., & Chen, C. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221526110 · Cited by 495

A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle

Xiao, S., Coppeta, J. R., Rogers, H. B., Isenberg, B. C., Zhu, J., Olalekan, S. A., McKinnon, K. E., Đokić, D., Rashedi, A. S., Haisenleder, D. J., et al. (2017) · Nature Communications · doi:10.1038/ncomms14584 · Cited by 492

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Edington, C. D., Chen, W. L. K., Geishecker, E., Kassis, T., Soenksen, L. R., Bhushan, B. M., Freake, D., Kirschner, J., Maass, C., Tsamandouras, N., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-22749-0 · Cited by 487

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

Wagner, I., Materne, E.-M., Brincker, S., Süßbier, U., Frädrich, C., Busek, M., Sonntag, F., Sakharov, D. A., Trushkin, E. V., Tonevitsky, A. G., et al. (2013) · Lab on a Chip · doi:10.1039/c3lc50234a · Cited by 476

Human organ chip models recapitulate orthotopic lung cancer growth, therapeutic responses, and tumor dormancy in vitro

Hassell, B. A., Goyal, G., Lee, E., Sontheimer-Phelps, A., Levy, O., Chen, C. S., & Ingber, D. E. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.043 · Cited by 467

Robotic fluidic coupling and interrogation of multiple vascularized organ chips

Novak, R., Ingram, M., Marquez, S. L., Das, D., Delahanty, A., Herland, A., Maoz, B. M., Jeanty, S. S. F., Somayaji, M. R., Burt, M. A., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0497-x · Cited by 457

Perfused multiwell plate for 3D liver tissue engineering

Domanský, K., Inman, W., Serdy, J., Dash, A., Lim, M. H. M., & Griffith, L. G. (2009) · Lab on a Chip · doi:10.1039/b913221j · Cited by 449

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

Oleaga, C., Bernabini, C., Smith, A. S. T., Srinivasan, B., Jackson, M., McLamb, W., Platt, V., Bridges, R., Cai, Y., Santhanam, N., et al. (2016) · Scientific Reports · doi:10.1038/srep20030 · Cited by 442

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Si, L., Bai, H., Rodas, M., Cao, W., Oh, C. Y., Jiang, A., Moller, R., Hoagland, D., Oishi, K., Horiuchi, S., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00718-9 · Cited by 440

Organ-on-a-chip devices advance to market

Zhang, B., & Radisic, M. (2017) · Lab on a Chip · doi:10.1039/c6lc01554a · Cited by 437

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

Maoz, B. M., Herland, A., Fitzgerald, E. A., Grevesse, T., Vidoudez, C., Pacheco, A. R., Sheehy, S. P., Park, T., Dauth, S., Mannix, R. J., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4226 · Cited by 437

Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

Achberger, K., Probst, C., Haderspeck, J., Bolz, S., Rogal, J., Chuchuy, J., Nikolova, M., Cora, V., Antkowiak, L., Haq, W., et al. (2019) · eLife · doi:10.7554/elife.46188 · Cited by 380

Renal reabsorption in 3D vascularized proximal tubule models

Lin, N. Y. C., Homan, K. A., Robinson, S. S., Kolesky, D. B., Duarte, N., Moisan, A., & Lewis, J. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815208116 · Cited by 366

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

Phan, D. T. T., Wang, X., Craver, B. M., Sobrino, A., Zhao, D., Chen, J. C., Lee, L. Y. N., George, S. C., Lee, A. P., & Hughes, C. C. W. (2017) · Lab on a Chip · doi:10.1039/c6lc01422d · Cited by 325

Primary human lung alveolus-on-a-chip model of intravascular thrombosis for assessment of therapeutics

Jain, A., Barrile, R., van der Meer, A., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M., Louden, C., Hamilton, G., et al. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.742 · Cited by 325

On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology

Chou, D. B., Frismantas, V., Milton, Y., David, R. M., Pop-Damkov, P., Ferguson, D., MacDonald, A., Bölükbaşı, Ö. V., Joyce, C. E., Teixeira, L. M., et al. (2020) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0495-z · Cited by 324

Matched-comparative modeling of normal and diseased human airway responses using a microengineered breathing lung chip

Benam, K. H., Novak, R., Nawroth, J., Hirano-Kobayashi, M., Ferrante, T. C., Choe, Y., Prantil-Baun, R., Weaver, J. C., Bahinski, A., Parker, K. K., et al. (2016) · Cell Systems · doi:10.1016/j.cels.2016.10.003 · Cited by 309

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Vernetti, L. A., Gough, A., Baetz, N. W., Blutt, S. E., Broughman, J. R., Brown, J. A., Foulke-Abel, J. D., Hasan, N. M., In, J., Kelly, E. J., et al. (2017) · Scientific Reports · doi:10.1038/srep42296 · Cited by 279

Functional coupling of human pancreatic islets and liver spheroids on-a-chip: Towards a novel human ex vivo type 2 diabetes model

Bauer, S., Wennberg Huldt, C., Kanebratt, K. P., Durieux, I., Gunne, D., Andersson, S., Ewart, L., Haynes, W. G., Maschmeyer, I., Winter, A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14815-w · Cited by 272

A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors

Pavesi, A., Tan, A. T., Koh, S., Chia, A., Colombo, M., Antonecchia, E., Miccolis, C., Ceccarello, E., Adriani, G., Raimondi, M. T., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.89762 · Cited by 239

A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier

Petrosyan, A., Cravedi, P., Villani, V., Angeletti, A., Manrique, J., Renieri, A., Filippo, R. E. D., Perin, L., & Sacco, S. D. (2019) · Nature Communications · doi:10.1038/s41467-019-11577-z · Cited by 239

Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology

Sontheimer-Phelps, A., Chou, D. B., Tovaglieri, A., Ferrante, T. C., Duckworth, T., Fadel, C., Frismantas, V., Sutherland, A. D., Jalili-Firoozinezhad, S., Kasendra, M., et al. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.11.008 · Cited by 239

Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption

Pediaditakis, I., Kodella, K. R., Manatakis, D. V., Le, C. Y., Hinojosa, C., Tien-Street, W., Manolakos, E. S., Vekrellis, K., Hamilton, G. A., Ewart, L. C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26066-5 · Cited by 239

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

Paek, J., Park, S. E., Lu, Q., Park, K.-T., Cho, M., Oh, J. M., Kwon, K. W., Yi, Y.-S., Song, J. W., Edelstein, H. I., et al. (2019) · ACS Nano · doi:10.1021/acsnano.9b00686 · Cited by 238

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

Ortega-Prieto, A. M., Skelton, J. K., Wai, S. N., Large, E., Lussignol, M., Vizcay-Barrena, G., Hughes, D., Fleck, R. A., Thursz, M., Catanese, M. T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-02969-8 · Cited by 236

Biomimetic Human Disease Model of SARS‐CoV‐2‐Induced Lung Injury and Immune Responses on Organ Chip System

Zhang, M., Wang, P., Luo, R., Wang, Y., Li, Z., Guo, Y., Yao, Y., Li, M., Tao, T., Chen, W., et al. (2021) · Advanced Science · doi:10.1002/advs.202002928 · Cited by 236

A reductionist metastasis‐on‐a‐chip platform for in vitro tumor progression modeling and drug screening

Skardal, A., Devarasetty, M., Forsythe, S., Atala, A., & Soker, S. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.25950 · Cited by 230

Chip-based human liver–intestine and liver–skin co-cultures – A first step toward systemic repeated dose substance testing in vitro

Maschmeyer, I., Hasenberg, T., Jaenicke, A., Lindner, M., Lorenz, A., Zech, J., Garbe, L., Sonntag, F., Hayden, P. J., Ayehunie, S., et al. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.03.002 · Cited by 228

Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies

Tsamandouras, N., Chen, W. L. K., Edington, C. D., Stokes, C. L., Griffith, L. G., & Cirit, M. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0122-4 · Cited by 222

A comprehensive atlas of immunological differences between humans, mice, and non-human primates

Bjornson-Hooper, Z. B., Fragiadakis, G. K., Spitzer, M. H., Chen, H., Madhireddy, D., Hu, K., Lundsten, K., McIlwain, D. R., & Nolan, G. P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.867015 · Cited by 215

Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems

Odijk, M., van der Meer, A. D., Levner, D., Kim, H. J., van der Helm, M. W., Segerink, L. I., Frimat, J.-P., Hamilton, G. A., Ingber, D. E., & van den Berg, A. (2015) · Lab on a Chip · doi:10.1039/c4lc01219d · Cited by 209

Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip

Jalili-Firoozinezhad, S., Prantil-Baun, R., Jiang, A., Potla, R., Mammoto, T., Weaver, J. C., Ferrante, T. C., Kim, H. J., Cabral, J. M. S., Levy, O., et al. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0304-8 · Cited by 209

Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection

Grassart, A., Malardé, V., Gobaa, S., Sartori-Rupp, A., Kerns, J., Karalis, K., Marteyn, B., Sansonetti, P., & Sauvonnet, N. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.08.007 · Cited by 206

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit

Brown, J. A., Codreanu, S. G., Shi, M., Sherrod, S. D., Markov, D. A., Neely, M. D., Britt, C. M., Hoilett, O. S., Reiserer, R. S., Samson, P. C., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0760-y · Cited by 204

Human Gut-On-A-Chip Supports Polarized Infection of Coxsackie B1 Virus In Vitro

Villenave, R., Wales, S. Q., Hamkins-Indik, T., Papafragkou, E., Weaver, J. C., Ferrante, T. C., Bahinski, A., Elkins, C. A., Kulka, M., & Ingber, D. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169412 · Cited by 199

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

McAleer, C. W., Long, C. J., Elbrecht, D., Sasserath, T., Bridges, L. R., Rumsey, J. W., Martin, C., Schnepper, M., Wang, Y., Schuler, F., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aav1386 · Cited by 199

A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®

Bircsak, K. M., DeBiasio, R., Miedel, M. T., Alsebahi, A., Reddinger, R. M., Saleh, A. D., Shun, T., Vernetti, L. A., & Gough, A. (2021) · Toxicology · doi:10.1016/j.tox.2020.152667 · Cited by 198

Microfluidic titer plate for stratified 3D cell culture

Trietsch, S. J., Israëls, G. D., Joore, J., Hankemeier, T., & Vulto, P. (2013) · Lab on a Chip · doi:10.1039/c3lc50210d · Cited by 189

Correction: Corrigendum: Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Vernetti, L. A., Gough, A., Baetz, N. W., Blutt, S. E., Broughman, J. R., Brown, J. A., Foulke-Abel, J. D., Hasan, N. M., In, J., Kelly, E. J., et al. (2017) · Scientific Reports · doi:10.1038/srep44517 · Cited by 189

Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier

Blundell, C., Yi, Y., Ma, L., Tess, E. R., Farrell, M. J., Georgescu, A., Aleksunes, L. M., & Huh, D. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700786 · Cited by 187

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

Franco, R., & Cedazo-Minguez, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00146 · Cited by 183

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Chang, S., Weber, E. J., Sidorenko, V. S., Chapron, A., Yeung, C. K., Gao, C., Mao, Q., Shen, D. D., Wang, J., Rosenquist, T. A., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.95978 · Cited by 180

Impact of organ-on-a-chip technology on pharmaceutical R&D costs

Franzen, N., van Harten, W. H., Retèl, V. P., Loskill, P., Raaij, J. V. D. E., & IJzerman, M. J. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.06.003 · Cited by 178

Microengineered Multi‐Organoid System from hiPSCs to Recapitulate Human Liver‐Islet Axis in Normal and Type 2 Diabetes

Tao, T., Deng, P., Wang, Y., Zhang, X., Guo, Y., Chen, W., & Qin, J. (2022) · Advanced Science · doi:10.1002/advs.202103495 · Cited by 178

Physiologically based pharmacokinetic and pharmacodynamic analysis enabled by microfluidically linked organs-on-chips

Prantil-Baun, R., Novak, R., Das, D., Somayaji, M. R., Przekwas, A., & Ingber, D. E. (2018) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104748 · Cited by 176 · cited 6×

Effects of Human Milk Oligosaccharides on the Adult Gut Microbiota and Barrier Function

Šuligoj, T., Vigsnæs, L. K., den Abbeele, P. V., Apostolou, A. P., Karalis, K., Savva, G. M., McConnell, B., & Juge, N. (2020) · Nutrients · doi:10.3390/nu12092808 · Cited by 173

Development of a human primary gut-on-a-chip to model inflammatory processes

Beaurivage, C., Kanapeckaitė, A., Loomans, C. J. M., Erdmann, K. S., Stallen, J., & Janssen, R. A. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-78359-2 · Cited by 173

Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk

Chen, W. L. K., Edington, C., Suter, E., Yu, J., Velazquez, J. J., Velazquez, J. G., Shockley, M., Large, E. M., Venkataramanan, R., Hughes, D. J., et al. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26370 · Cited by 172

Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier

Kim, J., Lee, K.-T., Lee, J. S., Shin, J., Cui, B., Yang, K., Choi, Y. S., Choi, N., Lee, S. H., Lee, J.-H., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00743-8 · Cited by 172

Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip

Bai, H., Si, L., Jiang, A., Belgur, C., Zhai, Y., Plebani, R., Oh, C. Y., Rodas, M., Patil, A., Nurani, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29562-4 · Cited by 171

Human iPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development

Sances, S., Ho, R., Vatine, G. D., West, D., Laperle, A., Meyer, A. S., Godoy, M. I., Kay, P., Mandefro, B., Hatata, S., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.02.012 · Cited by 170

SARS-CoV-2 induced intestinal responses with a biomimetic human gut-on-chip

Guo, Y., Luo, R., Wang, Y., Deng, P., Song, T., Zhang, M., Wang, P., Zhang, X., Cui, K., Tao, T., et al. (2020) · 中国科学通报：英文版 · doi:10.1016/j.scib.2020.11.015 · Cited by 164

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

Zhou, M., Zhang, X., Wen, X., Wu, T., Wang, W., Yang, M., Wang, J., Fang, M., Lin, B., & Lin, H. (2016) · Scientific Reports · doi:10.1038/srep31771 · Cited by 162

Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy

van der Helm, M. W., Henry, O., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., et al. (2019) · Lab on a Chip · doi:10.1039/c8lc00129d · Cited by 161

Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip

Plebani, R., Potla, R., Soong, M., Bai, H., Izadifar, Z., Jiang, A. R., Travis, R. N., Belgur, C., Dinis, A., Cartwright, M. J., et al. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2021.10.004 · Cited by 156

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

Baudy, A. R., Otieno, M. A., Hewitt, P., Gan, J., Roth, A., Keller, D., Sura, R., Van Vleet, T. R., & Proctor, W. R. (2020) · Lab on a Chip · doi:10.1039/c9lc00768g · Cited by 150

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites

Tovaglieri, A., Sontheimer-Phelps, A., Geirnaert, A., Prantil‐Baun, R., Camacho, D. M., Chou, D. B., Jalili‐Firoozinezhad, S., de Wouters, T., Kasendra, M. J., Super, M., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0650-5 · Cited by 140

Organ‐on‐Chip recapitulates thrombosis induced by an anti‐CD154 monoclonal antibody: translational potential of advanced microengineered systems

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., et al. (2018) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1054 · Cited by 138

Clear castable polyurethane elastomer for fabrication of microfluidic devices

Domanský, K., Leslie, D. C., McKinney, J., Fraser, J. P., Sliz, J. D., Hamkins-Indik, T., Hamilton, G. A., Bahinski, A., & Ingber, D. E. (2013) · Lab on a Chip · doi:10.1039/c3lc50558h · Cited by 132

Autologous Induced Pluripotent Stem Cell-Derived Four-Organ-Chip

Ramme, A. P., Koenig, L., Hasenberg, T., Schwenk, C., Magauer, C., Faust, D., Lorenz, A., Krebs, A.-C., Drewell, C., Schirrmann, K., et al. (2019) · Future Science OA · doi:10.2144/fsoa-2019-0065 · Cited by 131

A Microengineered Airway Lung Chip Models Key Features of Viral-induced Exacerbation of Asthma

Nawroth, J. C., Lucchesi, C., Cheng, D., Shukla, A., Ngyuen, J., Shroff, T., Varone, A., Karalis, K., Lee, H., Alves, S. E., et al. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0010ma · Cited by 131

An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy

Hachey, S. J., Movsesyan, S., Nguyen, Q. H., Burton-Sojo, G., Tankazyan, A., Wu, J., Hoang, T., Zhao, D., Wang, S., Hatch, M. M., et al. (2021) · Lab on a Chip · doi:10.1039/d0lc01216e · Cited by 124

Ectopic Lymphoid Follicle Formation and Human Seasonal Influenza Vaccination Responses Recapitulated in an Organ‐on‐a‐Chip

Goyal, G., Prabhala, P., Mahajan, G., Bausk, B., Gilboa, T., Xie, L., Zhai, Y., Lazarovits, R., Mansour, A., Kim, M. S., et al. (2022) · Advanced Science · doi:10.1002/advs.202103241 · Cited by 124

Synchronized stimulation and continuous insulin sensing in a microfluidic human Islet on a Chip designed for scalable manufacturing

Glieberman, A. L., Pope, B. D., Zimmerman, J. F., Liu, Q., Ferrier, J. P., Kenty, J. H.-R., Schrell, A. M., Mukhitov, N., Shores, K. L., Tepole, A. B., et al. (2019) · Lab on a Chip · doi:10.1039/c9lc00253g · Cited by 122

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

Chramiec, A. G., Teles, D., Yeager, K. J., Marturano-Kruik, A., Pak, J., Chen, T. F., Hao, L. Y., Wang, M. C., Lock, R. I., Tavakol, D. N., et al. (2020) · Lab on a Chip · doi:10.1039/d0lc00424c · Cited by 121

The tooth on-a-chip: a microphysiologic model system mimicking the biologic interface of the tooth with biomaterials

França, C. M., Tahayeri, A., Rodrigues, N. S., Ferdosian, S., Puppin‐Rontani, R. M., Sereda, G. A., Ferracane, J. L., & Bertassoni, L. E. (2019) · Lab on a Chip · doi:10.1039/c9lc00915a · Cited by 120

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System

Tsamandouras, N., Kostrzewski, T. M., Stokes, C. L., Griffith, L. G., Hughes, D. J., & Cirit, M. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.237495 · Cited by 119

A multi-organ-chip co-culture of liver and testis equivalents: a first step toward a systemic male reprotoxicity model

Baert, Y., Rütschle, I., Cools, W., Oehme, A., Lorenz, A., Marx, U., Goossens, E., & Maschmeyer, I. (2020) · Human Reproduction · doi:10.1093/humrep/deaa057 · Cited by 119

Biomechanical Strain Exacerbates Inflammation on a Progeria‐on‐a‐Chip Model

Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J., Miscuglio, M., Rouwkema, J., Dokmeci, M. R., Nissan, X., Ferreira, L., & Khademhosseini, A. (2017) · Small · doi:10.1002/smll.201603737 · Cited by 118

Three-dimensional microengineered vascularised endometrium-on-a-chip

Ahn, J., Yoon, M.-J., Hong, S.-H., Cha, H., Lee, D., Koo, H. S., Ko, J., Lee, J., Oh, S., Jeon, N. L., et al. (2021) · Human Reproduction · doi:10.1093/humrep/deab186 · Cited by 118

Compartmentalized Culture of Perivascular Stroma and Endothelial Cells in a Microfluidic Model of the Human Endometrium

Gnecco, J. S., Pensabene, V., Li, D. J., Ding, T., Hui, E. E., Bruner‐Tran, K. L., & Osteen, K. G. (2017) · Annals of Biomedical Engineering · doi:10.1007/s10439-017-1797-5 · Cited by 116

Introduction to a manuscript series on the characterization and use of microphysiological systems (MPS) in pharmaceutical safety and ADME applications

Fabre, K., Berridge, B., Proctor, W. R., Ralston, S., Will, Y., Baran, S. W., Yoder, G., & Van Vleet, T. R. (2020) · Lab on a Chip · doi:10.1039/c9lc01168d · Cited by 116

SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion

Domanský, K., Sliz, J. D., Wen, N., Hinojosa, C. D., Thompson, G., Fraser, J. P., Hamkins-Indik, T., Hamilton, G. A., Levner, D., & Ingber, D. E. (2017) · Microfluidics and Nanofluidics · doi:10.1007/s10404-017-1941-4 · Cited by 113

An in vitro intestinal platform with a self-sustaining oxygen gradient to study the human gut/microbiome interface

Kim, R., Attayek, P. J., Wang, Y., Furtado, K. L., Tamayo, R., Sims, C. E., & Allbritton, N. L. (2019) · Biofabrication · doi:10.1088/1758-5090/ab446e · Cited by 108

Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature

Lee, S. W. L., Campisi, M., Osaki, T., Possenti, L., Mattu, C., Adriani, G., Kamm, R. D., & Chiono, V. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.201901486 · Cited by 107

Wet‐AMD on a Chip: Modeling Outer Blood‐Retinal Barrier In Vitro

Chung, M., Lee, S., Lee, B. J., Son, K., Jeon, N. L., & Kim, J. H. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201700028 · Cited by 105

A 3D human renal cell carcinoma-on-a-chip for the study of tumor angiogenesis

Miller, C. P., Tsuchida, C., Zheng, Y., Himmelfarb, J., & Akilesh, S. (2018) · Neoplasia · doi:10.1016/j.neo.2018.02.011 · Cited by 105

Human Nonalcoholic Steatohepatitis on a Chip

Freag, M. S., Namgung, B., Reyna Fernandez, M. E., Gherardi, E., Sengupta, S., & Jang, H. L. (2021) · Hepatology Communications · doi:10.1002/hep4.1647 · Cited by 102

Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor

Sarkar, U., Rivera‐Burgos, D., Large, E. M., Hughes, D. J., Ravindra, K. C., Dyer, R. L., Ebrahimkhani, M. R., Wishnok, J. S., Griffith, L. G., & Tannenbaum, S. R. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.063495 · Cited by 96

Differential Monocyte Actuation in a Three‐Organ Functional Innate Immune System‐on‐a‐Chip

Sasserath, T., Rumsey, J. W., McAleer, C. W., Bridges, L. R., Long, C. J., Elbrecht, D. H., Schuler, F., Roth, A. B., Bertinetti‐LaPatki, C., Shuler, M. L., et al. (2020) · Advanced Science · doi:10.1002/advs.202000323 · Cited by 95

Modeling Therapeutic Antibody–Small Molecule Drug-Drug Interactions Using a Three-Dimensional Perfusable Human Liver Coculture Platform

Long, T. J., Cosgrove, P. A., Dunn, R. T., Stolz, D. B., Hamadeh, H. K., Afshari, C. A., McBride, H. J., & Griffith, L. G. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.071456 · Cited by 94

WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications

Rogal, J., Binder, C., Kromidas, E., Roosz, J., Probst, C., Schneider, S., Schenke‐Layland, K., & Loskill, P. (2020) · Scientific Reports · doi:10.1038/s41598-020-63710-4 · Cited by 93

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate)

Baran, S. W. (2022) · ALTEX · doi:10.14573/altex.2112203 · Cited by 92

Laminar ventricular myocardium on a microelectrode array-based chip

Kujala, V. J., Pasqualini, F. S., Goss, J. A., Nawroth, J. C., & Parker, K. K. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00324a · Cited by 91

Metal‐Specific Biomaterial Accumulation in Human Peri‐Implant Bone and Bone Marrow

Schoon, J., Hesse, B., Rakow, A., Ort, M., Lagrange, A., Jacobi, D., Winter, A., Huesker, K., Reinke, S., Cotte, M., et al. (2020) · Advanced Science · doi:10.1002/advs.202000412 · Cited by 89

Recapitulating monocyte extravasation to the synovium in an organotypic microfluidic model of the articular joint

Mondadori, C., Palombella, S., Salehi, S., Talò, G., Visone, R., Rasponi, M., Redaelli, A. C. L., Sansone, V. C., Moretti, M., & Lopa, S. (2021) · Biofabrication · doi:10.1088/1758-5090/ac0c5e · Cited by 89

A virus-induced kidney disease model based on organ-on-a-chip: Pathogenesis exploration of virus-related renal dysfunctions

Wang, J., Wang, C., Xu, N., Liu, Z., Pang, D., & Zhang, Z. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119367 · Cited by 88

Implementation of a Human Renal Proximal Tubule on a Chip for Nephrotoxicity and Drug Interaction Studies

Vormann, M. K., Vriend, J., Lanz, H. L., Gijzen, L., van den Heuvel, A., Hutter, S., Joore, J., Trietsch, S. J., Stuut, C., Nieskens, T. T. G., et al. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.01.028 · Cited by 88

In vitro test systems and their limitations

Ghallab, A. (2013) · EXCLI journal · doi:10.17877/de290r-7558 · Cited by 86

Forensic Analysis of Human Microbiome in Skin and Body Fluids Based on Geographic Location

Cho, H., & Eom, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.695191 · Cited by 85

A novel organ-chip system emulates three-dimensional architecture of the human epithelia and the mechanical forces acting on it

Varone, A., Nguyen, J. K., Leng, L., Barrile, R., Sliz, J. D., Lucchesi, C., Wen, N., Gravanis, A., Hamilton, G. A., Karalis, K., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120957 · Cited by 83

Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Bein, A., Kim, S., Goyal, G., Cao, W., Fadel, C., Naziripour, A., Sharma, S., Swenor, B., LoGrande, N., Nurani, A., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.718484 · Cited by 83

Human immunocompetent Organ-on-Chip platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

Kerns, S. J., Belgur, C., Petropolis, D., Kanellias, M., Barrile, R., Sam, J., Weinzierl, T., Fauti, T., Freimoser-Grundschober, A., Eckmann, J., et al. (2021) · eLife · doi:10.7554/elife.67106 · Cited by 82

Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction

Bein, A., Fadel, C. W., Swenor, B., Cao, W., Powers, R. K., Camacho, D. M., Naziripour, A., Parsons, A., LoGrande, N., Sanjay, S. T., et al. (2022) · Nature Biomedical Engineering · doi:10.1038/s41551-022-00899-x · Cited by 81

Simultaneous evaluation of anti-EGFR-induced tumour and adverse skin effects in a microfluidic human 3D co-culture model

Hübner, J., Raschke, M., Rütschle, I., Gräßle, S., Hasenberg, T., Schirrmann, K., Lorenz, A., Schnurre, S., Lauster, R., Maschmeyer, I., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33462-3 · Cited by 80

High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro

Gard, A. L., Luu, R. J., Miller, C. R., Maloney, R., Cain, B. P., Marr, E. E., Burns, D. M., Gaibler, R. B., Mulhern, T. J., Wong, C. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94095-7 · Cited by 79

Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors

Achberger, K., Cipriano, M., Duechs, M. J., Schön, C., Michelfelder, S., Stierstorfer, B., Lamla, T., Kauschke, S. G., Chuchuy, J., Roosz, J., et al. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.08.008 · Cited by 75

A Personalized Glomerulus Chip Engineered from Stem Cell-Derived Epithelium and Vascular Endothelium

Roye, Y., Bhattacharya, R., Mou, X., Zhou, Y., Burt, M. A., & Musah, S. (2021) · Micromachines · doi:10.3390/mi12080967 · Cited by 74

Construction of a high fidelity epidermis-on-a-chip for scalable in vitro irritation evaluation

Zhang, J., Chen, Z., Zhang, Y., Wang, X., Ouyang, J., Zhu, J., Yan, Y., Sun, X., Wang, F., Li, X., et al. (2021) · Lab on a Chip · doi:10.1039/d1lc00099c · Cited by 73

What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?: The Importance of Bridging Studies and Species-Independent Correlates of Protection

Golding, H., Khurana, S., & Zaitseva, M. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028902 · Cited by 67

A comprehensive atlas of immunological differences between humans, mice and non-human primatesPreprint

Bjornson-Hooper, Z. B., Fragiadakis, G. K., Spitzer, M. H., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/574160 · Cited by 66

Biomaterial and Biofilm Interactions with the Pulp-Dentin Complex-on-a-Chip

Rodrigues, N. S., França, C. M., Tahayeri, A., Ren, Z. F., Sabóia, V. P. A., Smith, A. J., Ferracane, J. L., Koo, H., & Bertassoni, L. E. (2021) · Journal of Dental Research · doi:10.1177/00220345211016429 · Cited by 66

A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability

Apostolou, A. P., Panchakshari, R. A., Banerjee, A., Manatakis, D. V., Paraskevopoulou, M. D., Luc, R., Abu-Ali, G., Dimitriou, A., Lucchesi, C., Kulkarni, G., et al. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.07.004 · Cited by 66

Integrated Isogenic Human Induced Pluripotent Stem Cell–Based Liver and Heart Microphysiological Systems Predict Unsafe Drug–Drug Interaction

Lee-Montiel, F. T., Laemmle, A., Charwat, V., Lee, C. S., Lee, C. S., Huebsch, N., Okochi, H., HANCOCK, M. J., Siemons, B. A., Boggess, S. C., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.667010 · Cited by 65

Microphysiological Systems: Stakeholder Challenges to Adoption in Drug Development

Hargrove-Grimes, P., Low, L. A., & Tagle, D. A. (2021) · Cells Tissues Organs · doi:10.1159/000517422 · Cited by 59

Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

Kutys, M. L., Polacheck, W. J., Welch, M., Gagnon, K. A., Koorman, T., Kim, S., Li, L., McClatchey, A. I., & Chen, C. S. (2020) · Nature Communications · doi:10.1038/s41467-020-17102-x · Cited by 57

A directional 3D neurite outgrowth model for studying motor axon biology and disease

Spijkers, X. M., Pasteuning-Vuhman, S., Dorleijn, J. C., Vulto, P., Wevers, N. R., & Pasterkamp, R. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-81335-z · Cited by 55

Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip

Si, L., Bai, H., Oh, C. Y., Jin, L., Prantil‐Baun, R., & Ingber, D. E. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00257-21 · Cited by 53

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip

Schneider, S., Brás, E. J. S., Schneider, O., Schlünder, K., & Loskill, P. (2021) · Micromachines · doi:10.3390/mi12050575 · Cited by 48

Aorta smooth muscle-on-a-chip reveals impaired mitochondrial dynamics as a therapeutic target for aortic aneurysm in bicuspid aortic valve disease

Abudupataer, M., Zhu, S., Yan, S., Xu, K., Zhang, J., Luo, S., Ma, W., Alam, M. F., Tang, Y., Huang, H., et al. (2021) · eLife · doi:10.7554/elife.69310 · Cited by 47

Transferrin receptor targeting by de novo sheet extension

Sahtoe, D. D., Coscia, A., Mustafaoğlu, N., Miller, L. M., Olal, D., Vulovic, I., Yu, T.-Y., Goreshnik, I., Lin, Y., Clark, L. E., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021569118 · Cited by 43

Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins

Rowe, C., Shaeri, M., Large, E. M., Cornforth, T. V., Robinson, A., Kostrzewski, T. M., Sison-Young, R. L. C., Goldring, C. E., Park, K., & Hughes, D. J. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.09.012 · Cited by 39

Microfluidic Model for Evaluation of Immune Checkpoint Inhibitors in Human Tumors

Beckwith, A. L., Velásquez–García, L. F., & Borenstein, J. T. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900289 · Cited by 39

Microphysiological flux balance platform unravels the dynamics of drug induced steatosis

Ehrlich, A., Tsytkin-Kirschenzweig, S., Ioannidis, K., Ayyash, M., Riu, A., Note, R., Ouédraogo, G., Vanfleteren, J., Cohen, M., & Nahmias, Y. (2018) · Lab on a Chip · doi:10.1039/c8lc00357b · Cited by 38

L-Cysteine capped zinc oxide nanoparticles induced cellular response on adenocarcinomic human alveolar basal epithelial cells using a conventional and organ-on-a-chip approach

Arathi, A., Joseph, X., Akhil, V., & Mohanan, P. V. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.112300 · Cited by 37

Qualifying a human Liver-Chip for predictive toxicology: Performance assessment and economic implicationsPreprint

Ewart, L. C., Apostolou, A. P., Briggs, S. A., Carman, C. V., Chaff, J. T., Heng, A. R., Jadalannagari, S., Janardhanan, J., Jang, K., Joshipura, S. R., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.14.472674 · Cited by 36

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors

Bagley, A. F., Scherz‐Shouval, R., Galie, P. A., Zhang, A. Q., Wyckoff, J. B., Whitesell, L. J., Chen, C. S., Lindquist, S. L., & Bhatia, S. N. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0325 · Cited by 31

AAV-mediated gene therapy targeting TRPV4 mechanotransduction for inhibition of pulmonary vascular leakage

Li, J., Wen, A. M., Potla, R., Benshirim, E., Seebarran, A., Benz, M. A., Henry, O., Matthews, B. D., Prantil‐Baun, R., Gilpin, S. E., et al. (2019) · APL Bioengineering · doi:10.1063/1.5122967 · Cited by 28

Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment

Cho, Y., Na, K., Jun, Y., Won, J., Yang, J. H., & Chung, S. H. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.697657 · Cited by 24

Self-assembling short immunostimulatory duplex RNAs with broad-spectrum antiviral activity

Si, L., Bai, H., Oh, C. Y., Jiang, A. R., Hong, F., Zhang, T., Ye, A. Y., Jordan, T. X., Logue, J., McGrath, M. E., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.08.031 · Cited by 23

A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy

Naik, S., Wood, A. R., Ongenaert, M., Saidiyan, P., Elstak, E., Lanz, H. L., Stallen, J., Janssen, R. A. J., Smythe, E., & Erdmann, K. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105361 · Cited by 20

Modular 3D In Vitro Artery-Mimicking Multichannel System for Recapitulating Vascular Stenosis and Inflammation

Cho, M., & Park, J. (2021) · Micromachines · doi:10.3390/mi12121528 · Cited by 19

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus ChipPreprint

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Advances in Engineered Three-Dimensional (3D) Body Articulation Unit Models

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