Cited by 272Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

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Cellular and epigenetic drivers of stem cell ageing

Ermolaeva, Maria, Neri, Francesco, Ori, Alessandro, Rudolph, K. Lenhard·2018·Nature Reviews Molecular Cell Biology

DOI 10.1038/s41580-018-0020-3

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Abstract

Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post-reproductive lifespan is caused, at least in part, by a decline in stem cell function and is associated with an increased incidence of diseases. Hallmarks of ageing include the accumulation of molecular damage, failure of quality control systems, metabolic changes and alterations in epigenome stability. In this Review, we discuss recent evidence in support of a novel concept whereby cell-intrinsic damage that accumulates during ageing and cell-extrinsic changes in ageing stem cell niches and the blood result in modifications of the stem cell epigenome. These cumulative epigenetic alterations in stem cells might be the cause of the deregulation of developmental pathways seen during ageing. In turn, they could confer a selective advantage to mutant and epigenetically drifted stem cells with altered self-renewal and functions, which contribute to the development of ageing-associated organ dysfunction and disease.

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Gou, M., Li, J., Yi, L., Li, H., Ye, X., Wang, H., Liu, L., Sun, B., Zhang, S., Zhu, Z., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgac310 · Cited by 33
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Save your gut save your age: The role of the microbiome in stem cell ageing
Tan, Y. J., Wei, Z., Chen, J., An, J., Li, M., Zhou, L., Men, Y., & Zhao, S. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14373 · Cited by 32
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Beeler, J. S., Marshall, C. B., Ericsson, P. I. G., Shaver, T. M., Guasch, G. L. S., Lea, S. T., Johnson, K. N., Jin, H., Venters, B. J., Sanders, M. E., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0218458 · Cited by 30
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Chen, R., Morris, B. J., Donlon, T. A., Masaki, K., Willcox, D. C., Davy, P. M. C., Allsopp, R., & Willcox, B. J. (2020) · Aging · doi:10.18632/aging.202175 · Cited by 28
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Authors: Ermolaeva, M., Neri, F., Ori, A., & Rudolph, K. L.
Affiliations: Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) (DE)
Corresponding author: Ermolaeva, Maria
Neri, Francesco
Rudolph, K. Lenhard
ORCID: Ermolaeva, Maria
Neri, Francesco
Rudolph, K. Lenhard
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2018-06-01
Volume: 19
Issue: 9
Pages: 594-610
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/s41580-018-0020-3
OpenAlex: W2805636495
Semantic Scholar: 422884d09599558429d720d9e413dadf9c506510
Cited by: 272
References: 258
Citations by year: 2026: 16 · 2025: 29 · 2024: 37 · 2023: 42 · 2022: 33 · 2021: 49 · 2020: 33 · 2019: 27 · 2018: 5
FWCI: 1.91
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: stem cell aging, epigenetic drift, stem cell niche, tissue homeostasis, age-related diseases, stem cell self-renewal, organ dysfunction
MeSH terms: Animals, Homeostasis, Humans, Stem Cells, Cellular Senescence, Epigenesis, Genetic, Epigenomics

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Cellular and epigenetic drivers of stem cell ageing

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