Cellular and epigenetic drivers of stem cell ageing

Translating the Histone Code

Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

Bolstad, B. M., Irizarry, R. A., Åstrand, M., & Speed, T. P. (2003) · Bioinformatics · doi:10.1093/bioinformatics/19.2.185 · Cited by 8,328

DNA methylation age of human tissues and cell types

Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909

Wnt/β-Catenin Signaling in Development and Disease

Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568

The Wnt Signaling Pathway in Development and Disease

Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325

Age-related clonal hematopoiesis associated with adverse outcomes

Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

Genovese, G., Kähler, A. K., Handsaker, R. E., Lindberg, J., Rose, S. A., Bakhoum, S. F., Chambert, K., Mick, E., Neale, B. M., Fromer, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1409405 · Cited by 3,531

Aging, Cellular Senescence, and Cancer

Campisi, J. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183653 · Cited by 2,954

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Baker, D. J., Childs, B. G., Durik, M., Wijers, M. E., Sieben, C. J., Zhong, J., A. Saltness, R., Jeganathan, K. B., Verzosa, G. C., Pezeshki, A., et al. (2016) · Nature · doi:10.1038/nature16932 · Cited by 2,876

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766

Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease

Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature · doi:10.1038/nature12984 · Cited by 2,451

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287

Satellite Cells and the Muscle Stem Cell Niche

Yin, H., Price, F., & Rudnicki, M. A. (2013) · Physiological Reviews · doi:10.1152/physrev.00043.2011 · Cited by 2,166

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., Laberge, R.-M., Vijg, J., Van Steeg, H., Dollé, M. E. T., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.11.012 · Cited by 2,045

Defining the Epithelial Stem Cell Niche in Skin

Tumbar, T., Guasch, G., Greco, V., Blanpain, C., Lowry, W. E., Rendl, M., & Fuchs, E. (2004) · Science · doi:10.1126/science.1092436 · Cited by 2,031

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

Snippert, H. J., van der Flier, L. G., Sato, T., van Es, J. H., van den Born, M., Kroon-Veenboer, C., Barker, N., Klein, A. M., van Rheenen, J., Simons, B. D., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.016 · Cited by 1,951

The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms.Preprint

Kingsley, D. M. (1994) · Genes & Development · doi:10.1101/gad.8.2.133 · Cited by 1,920

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Spence, J. R., Mayhew, C. N., Rankin, S. A., Kuhar, M. F., Vallance, J. E., Tolle, K. A., Hoskins, E. E., Kalinichenko, V. V., Wells, S. I., Zorn, A. M., et al. (2010) · Nature · doi:10.1038/nature09691 · Cited by 1,911

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, J., Wang, Y., Shao, L., Laberge, R.-M., Demaria, M., Campisi, J., Janakiraman, K., Sharpless, N. E., Ding, S., Feng, W., et al. (2016) · Nature Medicine · doi:10.1038/nm.4010 · Cited by 1,819

High burden and pervasive positive selection of somatic mutations in normal human skin

Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D. C., Fullam, A., Alexandrov, L. B., Tubio, J. M., et al. (2015) · Science · doi:10.1126/science.aaa6806 · Cited by 1,770

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763

Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

van Es, J. H., van Gijn, M. E., Riccio, O., van den Born, M., Vooijs, M., Begthel, H., Cozijnsen, M., Robine, S., Winton, D. J., Radtke, F., et al. (2005) · Nature · doi:10.1038/nature03659 · Cited by 1,587

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

Fuster, J. J., MacLauchlan, S., Zuriaga, M. A., Polackal, M. N., Ostriker, A. C., Chakraborty, R., Wu, C.-L., Sano, S., Muralidharan, S., Rius, C., et al. (2017) · Science · doi:10.1126/science.aag1381 · Cited by 1,536

NAD+ and sirtuins in aging and disease

Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

Shlush, L. I., Zandi, S., Mitchell, A., Chen, W. C., Brandwein, J. M., Gupta, V., Kennedy, J. A., Schimmer, A. D., Schuh, A. C., Yee, K. W., et al. (2014) · Nature · doi:10.1038/nature13038 · Cited by 1,443

Programmed cell senescence during mammalian embryonic development

Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., Rodríguez-Baeza, A., Varela-Nieto, I., Ruberte, J., Collado, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.019 · Cited by 1,428

Designer matrices for intestinal stem cell and organoid culture

Gjorevski, N., Sachs, N., Manfrin, A., Giger, S., Bragina, M. E., Ordóñez-Morán, P., Clevers, H., & Lutolf, M. P. (2016) · Nature · doi:10.1038/nature20168 · Cited by 1,426

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

Barker, N. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3721 · Cited by 1,424

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362

Autophagy maintains stemness by preventing senescence

García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355

Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction

Thevaranjan, N., Puchta, A., Schulz, C., Naidoo, A., Szamosi, J. C., Verschoor, C. P., Loukov, D., Schenck, L. P., Jury, J., Foley, K. P., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.002 · Cited by 1,322

MLL translocations, histone modifications and leukaemia stem-cell development

Krivtsov, A. V., & Armstrong, S. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2253 · Cited by 1,290

NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice

Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D’Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., et al. (2016) · Science · doi:10.1126/science.aaf2693 · Cited by 1,255

Promoting Health and Longevity through Diet: From Model Organisms to Humans

Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

You, J. S., & Jones, P. A. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.06.008 · Cited by 1,206

Senescence is a developmental mechanism that contributes to embryonic growth and patterning

Storer, M., Mas, A., Robert-Moreno, A., Pecoraro, M., Ortells, M. C., Di Giacomo, V., Yosef, R., Pilpel, N., Krizhanovsky, V., Sharpe, J., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.041 · Cited by 1,186

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Lindemans, C. A., Calafiore, M., Mertelsmann, A. M., O'Connor, M. H., Dudakov, J. A., Jenq, R. R., Velardi, E., Young, L. F., Smith, O. M., Lawrence, G., et al. (2015) · Nature · doi:10.1038/nature16460 · Cited by 1,144

Dnmt3a is essential for hematopoietic stem cell differentiation

Challen, G. A., Sun, D., Jeong, M., Luo, M., Jelinek, J., Berg, J. S., Bock, C., Vasanthakumar, A., Gu, H., Xi, Y., et al. (2012) · Nature Genetics · doi:10.1038/ng.1009 · Cited by 1,122

Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

Conboy, I. M., Conboy, M. J., Smythe, G. M., & Rando, T. A. (2003) · Science · doi:10.1126/science.1087573 · Cited by 1,121

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106

Cellular Senescence in Aging Primates

Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Simsek, T., Kocabas, F., Zheng, J., DeBerardinis, R. J., Mahmoud, A. I., Olson, E. N., Schneider, J. W., Zhang, C. C., & Sadek, H. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.011 · Cited by 1,101

Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties

Schwitalla, S., Fingerle, A. A., Cammareri, P., Nebelsiek, T., Göktuna, S. İ., Ziegler, P. K., Canli, Ö., Heijmans, J., Huels, D. J., Moreaux, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.12.012 · Cited by 1,098

Feedback between p21 and reactive oxygen production is necessary for cell senescence

Passos, J. F., Nelson, G., Wang, C., Richter, T., Simillion, C., Proctor, C. J., Miwa, S., Olijslagers, S., Hallinan, J., Wipat, A., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.5 · Cited by 1,019

Geriatric muscle stem cells switch reversible quiescence into senescence

Sousa-Victor, P., Gutarra, S., García-Prat, L., Rodriguez-Ubreva, J., Ortet, L., Ruiz-Bonilla, V., Jardí, M., Ballestar, E., González, S., Serrano, A. L., et al. (2014) · Nature · doi:10.1038/nature13013 · Cited by 1,010

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.

Ocampo, A., Reddy, P., Martinez-Redondo, P., Platero-Luengo, A., Hatanaka, F., Hishida, T., Li, M., Lam, D., Kurita, M., Beyret, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.052 · Cited by 988

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

Shukla, S., Kavak, E., Gregory, M., Imashimizu, M., Shutinoski, B., Kashlev, M., Oberdoerffer, P., Sandberg, R., & Oberdoerffer, S. (2011) · Nature · doi:10.1038/nature10442 · Cited by 973

daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

Henderson, S. T., & Johnson, T. E. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00594-2 · Cited by 949

Tissue-specific mutation accumulation in human adult stem cells during life

Blokzijl, F., de Ligt, J., Jager, M., Sasselli, V., Roerink, S., Sasaki, N., Huch, M., Boymans, S., Kuijk, E., Prins, P., et al. (2016) · Nature · doi:10.1038/nature19768 · Cited by 935

Autophagy maintains the metabolism and function of young and old stem cells

Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E., & Passegué, E. (2017) · Nature · doi:10.1038/nature21388 · Cited by 896

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.020 · Cited by 891

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Takubo, K., Nagamatsu, G., Kobayashi, C. I., Nakamura‐Ishizu, A., Kobayashi, H., Ikeda, E., Goda, N., Rahimi, Y., Johnson, R. S., Soga, T., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.10.011 · Cited by 864

The aged niche disrupts muscle stem cell quiescence

Chakkalakal, J. V., Jones, K. M., Basson, M. A., & Brack, A. S. (2012) · Nature · doi:10.1038/nature11438 · Cited by 851

A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan

Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L. P., Park, R., Vinciguerra, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.012 · Cited by 850

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

Weidner, C. I., Lin, Q., Koch, C. M., Eisele, L., Beier, F., Ziegler, P., Bauerschlag, D. O., Jöckel, K.-H., Erbel, R., Mühleisen, T. W., et al. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r24 · Cited by 837

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

Busque, L., Patel, J. P., Figueroa, M. E., Vasanthakumar, A., Provost, S., Hamilou, Z., Mollica, L., Li, J., Viale, A., Heguy, A., et al. (2012) · Nature Genetics · doi:10.1038/ng.2413 · Cited by 830

Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle

Sinha, M., Jang, Y. C., Oh, J., Khong, D., Wu, E. Y., Manohar, R., Miller, C., Regalado, S. G., Loffredo, F. S., Pancoast, J. R., et al. (2014) · Science · doi:10.1126/science.1251152 · Cited by 824

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

Mendelson, A., & Frenette, P. S. (2014) · Nature Medicine · doi:10.1038/nm.3647 · Cited by 819

Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

Duncan, A. W., Rattis, F. M., DiMascio, L. N., Congdon, K. L., Pazianos, G., Zhao, C., Yoon, K., Cook, J. M., Willert, K., Gaiano, N., et al. (2005) · Nature Immunology · doi:10.1038/ni1164 · Cited by 792

Intestinal label-retaining cells are secretory precursors expressing Lgr5

Buczacki, S. J. A., Zecchini, H. I., Nicholson, A. M., Russell, R., Vermeulen, L., Kemp, R., & Winton, D. J. (2013) · Nature · doi:10.1038/nature11965 · Cited by 761

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

Kaiko, G. E., Ryu, H., Koues, O. I., Collins, P. L., Solnica‐Krezel, L., Pearce, E. J., Pearce, E. L., Oltz, E. M., & Stappenbeck, T. S. (2016) · Cell · doi:10.1016/j.cell.2016.05.018 · Cited by 761

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Yilmaz, Ö. H., Katajisto, P., Lamming, D. W., Gültekin, Y., Bauer-Rowe, K. E., Sengupta, S., Birsoy, K., Dursun, A., Yilmaz, V. O., Selig, M., et al. (2012) · Nature · doi:10.1038/nature11163 · Cited by 753

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

Shpilka, T., & Haynes, C. M. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.110 · Cited by 742

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

Owusu-Ansah, E., & Banerjee, U. (2009) · Nature · doi:10.1038/nature08313 · Cited by 742

Intragenic DNA methylation prevents spurious transcription initiation

Neri, F., Rapelli, S., Krepelova, A., Incarnato, D., Parlato, C., Basile, G., Maldotti, M., Anselmi, F., & Oliviero, S. (2017) · Nature · doi:10.1038/nature21373 · Cited by 739

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, L., Dolgalev, I., Wang, Y., Yoshimi, A., Martin, G. H., Wang, J., Ng, V., Xia, B., Witkowski, M. T., Mitchell-Flack, M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.032 · Cited by 707

Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal

Sun, D., Luo, M., Jeong, M., Rodriguez, B., Xia, Z., Hannah, R., Wang, H., Le, T., Faull, K. F., Chen, R., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.03.002 · Cited by 686

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

Cosgrove, B. D., Gilbert, P. M., Porpiglia, E., Mourkioti, F., Lee, S. P., Corbel, S. Y., Llewellyn, M. E., Delp, S. L., & Blau, H. M. (2014) · Nature Medicine · doi:10.1038/nm.3464 · Cited by 677

Haematopoietic stem cells require a highly regulated protein synthesis rate

Signer, R. A. J., Magee, J. A., Salic, A., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature13035 · Cited by 674

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells

Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M., Levy, G., Barasch, D., Nemirovski, A., Shen-Orr, S., Laevsky, I., Amit, M., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.002 · Cited by 666

Aging effects on DNA methylation modules in human brain and blood tissue

Horvath, S., Zhang, Y., Langfelder, P., Kahn, R. S., Boks, M. P., van Eijk, K. R., van den Berg, L. H., & Ophoff, R. A. (2012) · Genome biology · doi:10.1186/gb-2012-13-10-r97 · Cited by 652

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Flach, J., Bakker, S. T., Mohrin, M., Conroy, P. C., Pietras, E. M., Reynaud, D., Alvarez, S., Diolaiti, M. E., Ugarte, F., Forsberg, E. C., et al. (2014) · Nature · doi:10.1038/nature13619 · Cited by 650

Mitochondrial DNA mutations in disease and aging

Wallace, D. C. (2010) · Environmental and Molecular Mutagenesis · doi:10.1002/em.20586 · Cited by 622

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells

Walter, D., Lier, A., Geiselhart, A., Thalheimer, F. B., Huntscha, S., Sobotta, M. C., Moehrle, B., Brocks, D., Bayindir, I., Kaschutnig, P., et al. (2015) · Nature · doi:10.1038/nature14131 · Cited by 619

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

Ko, M., Bandukwala, H. S., An, J., Lamperti, E. D., Thompson, E. C., Hastie, R., Tsangaratou, A., Rajewsky, K., Koralov, S. B., & Rao, A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112317108 · Cited by 616

The ageing haematopoietic stem cell compartment

Geiger, H., de Haan, G., & Florian, M. C. (2013) · Nature Reviews Immunology · doi:10.1038/nri3433 · Cited by 604

Increased cell-to-cell variation in gene expression in ageing mouse heart

Bahar, R., Hartmann, C. H., Rodriguez, K. A., Denny, A. D., Busuttil, R. A., Dollé, M. E. T., Calder, R. B., Chisholm, G. B., Pollock, B. H., Klein, C. A., et al. (2006) · Nature · doi:10.1038/nature04844 · Cited by 603

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

Mohrin, M., Bourke, E., Alexander, D., Warr, M. R., Barry-Holson, K., Le Beau, M. M., Morrison, C. G., & Passegué, E. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.014 · Cited by 599

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo

Mosteiro, L., Pantoja, C., Alcazar, N., Marión, R. M., Chondronasiou, D., Rovira, M., Fernandez-Marcos, P. J., Muñoz-Martin, M., Blanco-Aparicio, C., Pastor, J., et al. (2016) · Science · doi:10.1126/science.aaf4445 · Cited by 589

JNK Activity in Somatic Stem Cells Causes Loss of Tissue Homeostasis in the Aging Drosophila Gut

Biteau, B., Hochmuth, C. E., & Jasper, H. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.024 · Cited by 583

The NAD+-Dependent SIRT1 Deacetylase Translates a Metabolic Switch into Regulatory Epigenetics in Skeletal Muscle Stem Cells

Ryall, J. G., Dell’Orso, S., Derfoul, A., Juan, A., Zare, H., Feng, X., Clermont, D., Koulnis, M., Gutierrez-Cruz, G., Fulco, M., et al. (2015) · Cell Stem Cell · doi:10.1016/j.stem.2014.12.004 · Cited by 575

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

Bernet, J. D., Doles, J. D., Hall, J. K., Kelly Tanaka, K., Carter, T. A., & Olwin, B. B. (2014) · Nature Medicine · doi:10.1038/nm.3465 · Cited by 573

Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns

Enge, M., Arda, H. E., Mignardi, M., Beausang, J., Bottino, R., Kim, S. K., & Quake, S. R. (2017) · Cell · doi:10.1016/j.cell.2017.09.004 · Cited by 568

Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation

Florian, M. C., Dörr, K., Niebel, A., Daria, D., Schrezenmeier, H., Rojewski, M., Filippi, M.-D., Hasenberg, A., Gunzer, M., Scharffetter-Kochanek, K., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.007 · Cited by 564

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

Katajisto, P., Döhla, J., Chaffer, C. L., Pentinmikko, N., Marjanovic, N. D., Iqbal, S., Zoncu, R., Chen, W. W., Weinberg, R. A., & Sabatini, D. M. (2015) · Science · doi:10.1126/science.1260384 · Cited by 558

Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

Maunakea, A. K., Chepelev, I., Cui, K., & Zhao, K. (2013) · Cell Research · doi:10.1038/cr.2013.110 · Cited by 552

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

Agathocleous, M., Meacham, C. E., Burgess, R. J., Piskounova, E., Zhao, Z., Crane, G. M., Cowin, B. L., Bruner, E., Murphy, M. M., Chen, W., et al. (2017) · Nature · doi:10.1038/nature23876 · Cited by 545

Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging

Liu, L., Cheung, T. H., Charville, G. W., Hurgo, B. M. C., Leavitt, T., Shih, J., Brunet, A., & Rando, T. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.043 · Cited by 544

Histone chaperone networks shaping chromatin function

Hammond, C. M., Strømme, C. B., Huang, H., Patel, D. J., & Groth, A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.159 · Cited by 539

Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis

McKerrell, T., Park, N., Moreno, T., Grove, C. S., Ponstingl, H., Stephens, J., Crawley, C., Craig, J., Scott, M. A., Hodkinson, C., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.005 · Cited by 534

GDF11 increases with age and inhibits skeletal muscle regeneration

Egerman, M. A., Cadena, S. M., Gilbert, J. A., Meyer, A., Nelson, H. N., Swalley, S. E., Mallozzi, C., Jacobi, C., Jennings, L. L., Clay, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.010 · Cited by 527

Autophagy and aging: keeping that old broom working

Cuervo, A. M. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.002 · Cited by 527

DNMT3A in haematological malignancies

Yang, L., Rau, R. E., & Goodell, M. A. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3895 · Cited by 525

Interplay between metabolic identities in the intestinal crypt supports stem cell function

Rodríguez-Colman, M. J., Schewe, M., Meerlo, M., Stigter, E., Gerrits, J., Pras-Raves, M., Sacchetti, A., Hornsveld, M., Oost, K. C., Snippert, H. J., et al. (2017) · Nature · doi:10.1038/nature21673 · Cited by 522

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

Scaffidi, P., & Misteli, T. (2008) · Nature Cell Biology · doi:10.1038/ncb1708 · Cited by 518

DNA repair is limiting for haematopoietic stem cells during ageing

Nijnik, A., Woodbine, L., Marchetti, C., Dawson, S., Lambe, T., Liu, C., Rodrigues, N. P., Crockford, T. L., Cabuy, E., Vindigni, A., et al. (2007) · Nature · doi:10.1038/nature05875 · Cited by 518

UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells

Zhang, J., Khvorostov, I., Hong, J. S., Oktay, Y., Vergnes, L., Nuebel, E., Wahjudi, P. N., Setoguchi, K., Wang, G., Do, A., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.401 · Cited by 512

A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division

Rocheteau, P., Gayraud-Morel, B., Siegl-Cachedenier, I., Blasco, M. A., & Tajbakhsh, S. (2012) · Cell · doi:10.1016/j.cell.2011.11.049 · Cited by 510

Functions and regulations of fibroblast growth factor signaling during embryonic development

Thisse, B., & Thisse, C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.09.011 · Cited by 508

The Aging Epigenome

Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Carlson, M. E., Hsu, M., & Conboy, I. M. (2008) · Nature · doi:10.1038/nature07034 · Cited by 498

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C. M., & Chen, D. (2015) · Science · doi:10.1126/science.aaa2361 · Cited by 490

Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging

Beerman, I., Bock, C., Garrison, B. S., Smith, Z. D., Gu, H., Meissner, A., & Rossi, D. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.017 · Cited by 485

PGRP-SC2 Promotes Gut Immune Homeostasis to Limit Commensal Dysbiosis and Extend Lifespan

Guo, L., Karpac, J., Tran, S. L., & Jasper, H. (2014) · Cell · doi:10.1016/j.cell.2013.12.018 · Cited by 464

Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal

Yan, K. S., Janda, C. Y., Chang, J., Zheng, G. X. Y., Larkin, K. A., Luca, V. C., Chia, L. A., Mah, A. T., Han, A. S., Terry, J. M., et al. (2017) · Nature · doi:10.1038/nature22313 · Cited by 463

Structural modulation of gut microbiota in life-long calorie-restricted mice

Zhang, C., Li, S., Yang, L., Huang, P., Li, W., Wang, S., Zhao, G., Zhang, M., Pang, X., Yan, Z., et al. (2013) · Nature Communications · doi:10.1038/ncomms3163 · Cited by 461

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements

De Cecco, M., Criscione, S. W., Peckham, E. J., Hillenmeyer, S., Hamm, E. A., Manivannan, J., Peterson, A. L., Kreiling, J. A., Neretti, N., & Sedivy, J. M. (2013) · Aging Cell · doi:10.1111/acel.12047 · Cited by 459

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

Van Meter, M., Kashyap, M., Rezazadeh, S., Geneva, A. J., Morello, T. D., Seluanov, A., & Gorbunova, V. (2014) · Nature Communications · doi:10.1038/ncomms6011 · Cited by 456

Vitamin A-Retinoic Acid Signaling Regulates Hematopoietic Stem Cell Dormancy

Cabezas-Wallscheid, N., Buettner, F., Sommerkamp, P., Klimmeck, D., Ladel, L., Thalheimer, F. B., Pastor-Flores, D., Roma, L. P., Renders, S., Zeisberger, P., et al. (2017) · Cell · doi:10.1016/j.cell.2017.04.018 · Cited by 454

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

Beerman, I., Seita, J., Inlay, M. A., Weissman, I. L., & Rossi, D. J. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.04.016 · Cited by 445

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Castellano, J. M., Mosher, K. I., Abbey, R. J., McBride, A. A., James, M. L., Berdnik, D., Shen, J. C., Zou, B., Xie, X. S., Tingle, M., et al. (2017) · Nature · doi:10.1038/nature22067 · Cited by 445

The central role of muscle stem cells in regenerative failure with aging

Blau, H. M., Cosgrove, B. D., & Ho, A. T. V. (2015) · Nature Medicine · doi:10.1038/nm.3918 · Cited by 437

TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis

Tefferi, A., Pardanani, A. D., Lim, K.-H., Abdel-Wahab, O. I., Lasho, T. L., Patel, J. D., Gangat, N., Finke, C. M., Schwager, S. M., Mullally, A., et al. (2009) · Leukemia · doi:10.1038/leu.2009.47 · Cited by 436

Elevated histone expression promotes life span extension

Feser, J., Truong, D., Das, C., Carson, J. J., Kieft, J., Harkness, T., & Tyler, J. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.08.015 · Cited by 435

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1937 · Cited by 426

Human mutation rate associated with DNA replication timing

Stamatoyannopoulos, J. A., Adzhubei, I. A., Thurman, R. E., Kryukov, G. V., Mirkin, S. M., & Sunyaev, S. R. (2009) · Nature Genetics · doi:10.1038/ng.363 · Cited by 423

Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

Smith, P., Willemsen, D., Popkes, M., Metge, F., Gandiwa, E., Reichard, M., & Valenzano, D. R. (2017) · eLife · doi:10.7554/elife.27014 · Cited by 423

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres

O'Sullivan, R. J., Kubicek, S., Schreiber, S. L., & Karlseder, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1897 · Cited by 416

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration

Elabd, C., Cousin, W., Upadhyayula, P., Chen, R. Y., Chooljian, M. S., Li, J., Kung, S., Jiang, K. P., & Conboy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms5082 · Cited by 411

Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy

Nakada, D., Oguro, H., Levi, B. P., Ryan, N., Kitano, A., Saitoh, Y., Takeichi, M., Wendt, G. R., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature12932 · Cited by 409

Paternal Diet Defines Offspring Chromatin State and Intergenerational Obesity

Öst, A., Lempradl, A., Casas, E., Weigert, M., Tiko, T., Deniz, M., Pantano, L., Boenisch, U., Itskov, P. M., Stoeckius, M., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.005 · Cited by 406

Using DNA methylation profiling to evaluate biological age and longevity interventions

Petkovich, D. A., Podolskiy, D. I., Lobanov, A. V., Lee, S.-G., Miller, R. A., & Gladyshev, V. N. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.016 · Cited by 398

DNA damage checkpoints in stem cells, ageing and cancer

Sperka, T., Wang, J., & Rudolph, K. L. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3420 · Cited by 393

M-CSF instructs myeloid lineage fate in single haematopoietic stem cells

Mossadegh‐Keller, N., Sarrazin, S., Kandalla, P. K., Espinosa, L., Stanley, E. R., Nutt, S. L., Moore, J. T., & Sieweke, M. H. (2013) · Nature · doi:10.1038/nature12026 · Cited by 392

TNF/p38α/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration

Palacios, D., Mozzetta, C., Consalvi, S., Caretti, G., Saccone, V., Proserpio, V., Marquez, V. E., Valente, S., Mai, A., Forcales, S. V., et al. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.013 · Cited by 392

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

Vilchez, D., Boyer, L., Morantte, I., Lutz, M., Merkwirth, C., Joyce, D., Spencer, B., Page, L., Masliah, E., Berggren, W. T., et al. (2012) · Nature · doi:10.1038/nature11468 · Cited by 388

Multi-tissue DNA methylation age predictor in mouse

BI Ageing Clock Team, Stubbs, T. M., Bonder, M. J., Stark, A.-K., Krueger, F., von Meyenn, F., Stegle, O., & Reik, W. (2017) · Genome Biology · doi:10.1186/s13059-017-1203-5 · Cited by 384

Protein homeostasis and aging in neurodegeneration

Douglas, P. M., & Dillin, A. G. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201005144 · Cited by 381

The p38 MAPK signaling pathway: A major regulator of skeletal muscle development

Keren, A., Tamir, Y., & Bengal, E. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.017 · Cited by 372

Myogenic progenitor cells control extracellular matrix production by fibroblasts during skeletal muscle hypertrophy

Fry, C. S., Kirby, T. J., Kosmac, K., McCarthy, J. J., & Peterson, C. A. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.09.010 · Cited by 372

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling

Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D., & Mair, W. B. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.09.024 · Cited by 372

Short-term calorie restriction enhances skeletal muscle stem cell function

Cerletti, M., Jang, Y. C., Finley, L. W. S., Haigis, M. C., & Wagers, A. J. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.04.002 · Cited by 371

Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104pPreprint

Erjavec, N., Larsson, L., Grantham, J., & Nyström, T. (2007) · Genes & Development · doi:10.1101/gad.439307 · Cited by 368

Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells

Başak, O., Beumer, J., Wiebrands, K., Seno, H., van Oudenaarden, A., & Clevers, H. C. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.11.001 · Cited by 365

Paternal Age Effect Mutations and Selfish Spermatogonial Selection: Causes and Consequences for Human Disease

Goriely, A., & Wilkie, A. O. M. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.12.017 · Cited by 365

Two conserved histone demethylases regulate mitochondrial stress-induced longevity

Merkwirth, C., Jovaisaite, V., Durieux, J., Matilainen, O., Jordan, S. D., Quiros, P. M., Steffen, K. K., Williams, E. G., Mouchiroud, L., Tronnes, S. U., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.012 · Cited by 363

Lifespan Extension by Preserving Proliferative Homeostasis in Drosophila

Biteau, B., Karpac, J., Supoyo, S., DeGennaro, M., Lehmann, R., & Jasper, H. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001159 · Cited by 363

The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress

van Galen, P., Kreso, A., Mbong, N., Kent, D. G., Fitzmaurice, T., Chambers, J. E., Xie, S., Laurenti, E., Hermans, K., Eppert, K., et al. (2014) · Nature · doi:10.1038/nature13228 · Cited by 363

CpG island methylator phenotype (CIMP) of colorectal cancer is best characterised by quantitative DNA methylation analysis and prospective cohort studies

Ogino, S., Cantor, M., Kawasaki, T., Brahmandam, M., Kirkner, G. J., Weisenberger, D. J., Campan, M., Laird, P. W., Loda, M. F., & Fuchs, C. S. (2006) · Gut · doi:10.1136/gut.2005.082933 · Cited by 355

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Mantel, C., O’Leary, H. A., Chitteti, B. R., Huang, X., Cooper, S. H., Hangoc, G., Brustovetsky, N., Srour, E. F., Lee, M. R., Messina‐Graham, S., et al. (2015) · Cell · doi:10.1016/j.cell.2015.04.054 · Cited by 349

Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

Lukjanenko, L., Jung, M. J., Hegde, N., Perruisseau-Carrier, C., Migliavacca, E., Rozo, M., Karaz, S., Jacot, G. E., Schmidt, M., Li, L., et al. (2016) · Nature Medicine · doi:10.1038/nm.4126 · Cited by 347

Transcriptional and epigenetic regulation of autophagy in aging

Lapierre, L. R., Kumsta, C., Sandri, M., Ballabio, A., & Hansen, M. (2015) · Autophagy · doi:10.1080/15548627.2015.1034410 · Cited by 344

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

Cheng, C., Villani, V., Buono, R., Wei, M., Kumar, S., Yilmaz, Ö. H., Cohen, P., Sneddon, J. B., Perin, L., & Longo, V. D. (2017) · Cell · doi:10.1016/j.cell.2017.01.040 · Cited by 335

Chromatin Dynamics During DNA Replication and Uncharacterized Replication Factors determined by Nascent Chromatin Capture (NCC) Proteomics

Alabert, C., Bukowski-Wills, J.-C., Lee, S.-B., Kustatscher, G., Nakamura, K., Alves, F. D. L., Ménard, P., Mejlvang, J., Rappsilber, J., & Groth, A. (2014) · Nature Cell Biology · doi:10.1038/ncb2918 · Cited by 334

Single-cell chromatin modification profiling reveals increased epigenetic variations with aging

Cheung, P., Vallania, F., Warsinske, H. C., Donato, M., Schaffert, S., Chang, S. E., Dvorak, M., Dekker, C. L., Davis, M. M., Utz, P. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.079 · Cited by 323

Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation

Nemeth, M. J., Topol, L. Z., Anderson, S. M., Yang, Y., & Bodine, D. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704747104 · Cited by 316

Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche

Sugimura, R., He, X., Venkatraman, A., Arai, F., Box, A., Semerad, C. L., Haug, J. S., Peng, L., Zhong, X.-B., Suda, T., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.041 · Cited by 306

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction

Igarashi, M., & Guarente, L. (2016) · Cell · doi:10.1016/j.cell.2016.05.044 · Cited by 305

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells

Jadhav, U., Saxena, M., O’Neill, N. K., Saadatpour, A., Yuan, G., Herbert, Z. T., Murata, K., & Shivdasani, R. A. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.05.001 · Cited by 296

Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission

Greaves, L. C., Preston, S. L., Tadrous, P. J., Taylor, R. W., Barron, M. J., Oukrif, D., Leedham, S. J., Deheragoda, M. G., Sasieni, P. D., Novelli, M. R., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505903103 · Cited by 293

Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

Ju, Z., Jiang, H., Jaworski, M., Rathinam, C., Gompf, A., Klein, C., Trumpp, A., & Rudolph, K. L. (2007) · Nature Medicine · doi:10.1038/nm1578 · Cited by 284

Rantes/Ccl5 influences hematopoietic stem cell subtypes and causes myeloid skewing

Ergen, A. V., Boles, N. C., & Goodell, M. A. (2012) · Blood · doi:10.1182/blood-2011-11-391730 · Cited by 280

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

Nalapareddy, K., Nattamai, K. J., Kumar, R. S., Karns, R., Wikenheiser-Brokamp, K. A., Sampson, L. L., Mahe, M. M., Sundaram, N., Yacyshyn, M.-B., Yacyshyn, B., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.056 · Cited by 280

Mitochondrial DNA mutations in disease and aging

Park, C. B., & Larsson, N.-G. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201010024 · Cited by 277

Caloric restriction delays age-related methylation drift

Maegawa, S., Lu, Y., Tahara, T., Lee, J. T., Madzo, J., Liang, S., Jelinek, J., Colman, R. J., & Issa, J.-P. J. (2017) · Nature Communications · doi:10.1038/s41467-017-00607-3 · Cited by 270

Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction

Regan, J. C., Khericha, M., Dobson, A. J., Bolukbasi, E., Rattanavirotkul, N., & Partridge, L. (2016) · eLife · doi:10.7554/elife.10956 · Cited by 269

Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

Boyle, M., Wong, C., Rocha, M., & Jones, D. L. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.002 · Cited by 268

Aging of the skeletal muscle extracellular matrix drives a stem cell fibrogenic conversion

Stearns-Reider, K. M., D'Amore, A., Beezhold, K., Rothrauff, B., Cavalli, L., Wagner, W. R., Vorp, D. A., Tsamis, A., Shinde, S., Zhang, C., et al. (2017) · Aging Cell · doi:10.1111/acel.12578 · Cited by 265

Nucleolar expansion and elevated protein translation in premature aging

Buchwalter, A., & Hetzer, M. W. (2017) · Nature Communications · doi:10.1038/s41467-017-00322-z · Cited by 263

Targeting β1-integrin signaling enhances regeneration in aged and dystrophic muscle in mice

Rozo, M., Li, L., & Fan, C. (2016) · Nature Medicine · doi:10.1038/nm.4116 · Cited by 260

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

Zhang, X., Su, J., Jeong, M., Ko, M., Huang, Y., Park, H. J., Guzman, A., Lei, Y., Huang, Y.-H., Rao, A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3610 · Cited by 258

Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death

Sotiropoulou, P. A., Candi, A., Mascré, G., Clercq, S. D., Youssef, K. K., Lapouge, G., Dahl, E., Semeraro, C., Denecker, G., Marine, J., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2059 · Cited by 252

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

Maryanovich, M., Zaltsman, Y., Ruggiero, A., Goldman, A., Shachnai, L., Levin‐Zaidman, S., Porat, Z., Golan, K., Lapidot, T., & Gross, A. (2015) · Nature Communications · doi:10.1038/ncomms8901 · Cited by 247

Material Cues as Potent Regulators of Epigenetics and Stem Cell Function

Crowder, S. W., Leonardo, V., Whittaker, T. E., Papathanasiou, P., & Stevens, M. M. (2016) · Cell stem cell · doi:10.1016/j.stem.2015.12.012 · Cited by 234

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress

Solanas, G., Peixoto, F. O., Perdiguero, E., Jardí, M., Ruiz‐Bonilla, V., Datta, D., Symeonidi, A., Castellanos‐Martín, A., Welz, P.-S., Caballero, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.035 · Cited by 234

HP1 Is Involved in Regulating the Global Impact of DNA Methylation on Alternative Splicing

Yearim, A., Gelfman, S., Shayevitch, R., Melcer, S., Glaich, O., Mallm, J., Nissim‐Rafinia, M., Cohen, A.-H., Rippe, K., Meshorer, E., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.038 · Cited by 229

Epigenetic changes of DNA repair genes in cancer

Lahtz, C., & Pfeifer, G. P. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq053 · Cited by 227

Dietary restriction protects from age-associated DNA methylation and induces epigenetic reprogramming of lipid metabolism

Hahn, O., Grönke, S., Stubbs, T. M., Ficz, G., Hendrich, O., Krueger, F., Andrews, S., Zhang, Q., Wakelam, M. J., Beyer, A., et al. (2017) · Genome Biology · doi:10.1186/s13059-017-1187-1 · Cited by 226

Epigenetic control of adult stem cell function

Avgustinova, A., & Benitah, S. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.76 · Cited by 222

Methylation of Polycomb Target Genes in Intestinal Cancer Is Mediated by Inflammation

Hahn, M. A., Hahn, T., Lee, D.-H., Esworthy, R. S., Kim, B.-W., Riggs, A. D., Chu, F., & Pfeifer, G. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1957 · Cited by 217

Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

Berry, D. C., Jiang, Y., Arpke, R. W., Close, E. L., Uchida, A., Reading, D., Berglund, E. D., Kyba, M., & Graff, J. M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.023 · Cited by 214

Impact of genomic damage and ageing on stem cell function

Behrens, A., van Deursen, J. M., Rudolph, K. L., & Schumacher, B. (2014) · Nature Cell Biology · doi:10.1038/ncb2928 · Cited by 207

DNA methylation is required for the control of stem cell differentiation in the small intestinePreprint

Sheaffer, K. L., Kim, R., Aoki, R., Elliott, E. N., Schug, J., Burger, L., Schübeler, D., & Kaestner, K. H. (2014) · Genes & Development · doi:10.1101/gad.230318.113 · Cited by 206

Statistical control of peptide and protein error rates in large-scale targeted data-independent acquisition analyses

Rosenberger, G., Bludau, I., Schmitt, U., Heusel, M., Hunter, C. L., Liu, Y., MacCoss, M. J., MacLean, B. X., Nesvizhskii, A. I., Pedrioli, P. G. A., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4398 · Cited by 203

Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow

Yang, L. C., Wang, L., Geiger, H., Cancelas, J. A., Mo, J., & Zheng, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610819104 · Cited by 184

Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease

Beerman, I., & Rossi, D. J. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.05.009 · Cited by 182

Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

Cole, J. J., Robertson, N. A., Rather, M. I., Thomson, J. P., McBryan, T., Sproul, D., Wang, T., Brock, C., Clark, W., Ideker, T., et al. (2017) · Genome Biology · doi:10.1186/s13059-017-1185-3 · Cited by 182

Epigenetic Control of the Host Gene by Commensal Bacteria in Large Intestinal Epithelial Cells

Takahashi, K., Sugi, Y., Nakano, K., Tsuda, M., Kurihara, K., Hosono, A., & Kaminogawa, S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.271007 · Cited by 180

Alternative splicing: decoding an expansive regulatory layer

Irimia, M., & Blencowe, B. J. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.03.005 · Cited by 177

Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells

Guidi, N., Saçma, M., Ständker, L., Soller, K., Marka, G., Eiwen, K., Weiss, J. M., Kirchhoff, F., Weil, T., Cancelas, J. A., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201694969 · Cited by 173

DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias

Yang, L., Rodriguez, B. A. T., Mayle, A., Park, H. J., Lin, X., Luo, M., Jeong, M., Curry, C. V., Kim, S.-B., Ruau, D., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.003 · Cited by 165

Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change

Alcolea, M. P., Greulich, P., Wabik, A., Frede, J., Simons, B. D., & Jones, P. H. (2014) · Nature Cell Biology · doi:10.1038/ncb2963 · Cited by 164

In Vitro Generation of Long-Term Repopulating Hematopoietic Stem Cells by Fibroblast Growth Factor-1

de Haan, G., Weersing, E., Dontje, B., van Os, R. P., Bystrykh, L. V., Vellenga, E., & Miller, G. G. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00018-2 · Cited by 164

The CpG island methylator phenotype (CIMP) in colorectal cancer.

Mojarad, E. N., Kuppen, P. J. K., Aghdaei, H. A., & Zali, M. R. (2013) · Europe PMC (PubMed Central) · Cited by 164

Metabolic consequences of oncogenic IDH mutations

Parker, S. J., & Metallo, C. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.003 · Cited by 162

Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development

Lu, R., Wang, P., Parton, T., Zhou, Y., Chrysovergis, K., Rockowitz, S., Chen, W., Abdel-Wahab, O. I., Wade, P. A., Zheng, D., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.05.008 · Cited by 162

A mechanism for the segregation of age in mammalian neural stem cells

Moore, D. L., Pilz, G.-A., Araúzo-Bravo, M. J., Barral, Y., & Jessberger, S. (2015) · Science · doi:10.1126/science.aac9868 · Cited by 156

An integrative multi-scale analysis of the dynamic DNA methylation landscape in aging

Yuan, T., Jiao, Y., de Jong, S., Ophoff, R. A., Beck, S., & Teschendorff, A. E. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1004996 · Cited by 155

Aging is not programmed

Blagosklonny, M. V. (2013) · Cell Cycle · doi:10.4161/cc.27188 · Cited by 148

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

Espada, J., Varela, I., Flores, I., Ugalde, A. P., Cadiñanos, J., Pendás, A. M., Stewart, C. L., Tryggvason, K., Blasco, M. A., Freije, J. M. P., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801096 · Cited by 144

Microbiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscapePreprint

Camp, J. G., Frank, C. L., Lickwar, C. R., Guturu, H., Rube, T., Wenger, A. M., Chen, J., Bejerano, G., Crawford, G. E., & Rawls, J. F. (2014) · Genome Research · doi:10.1101/gr.165845.113 · Cited by 143

The ATP Costs and Time Required to Degrade Ubiquitinated Proteins by the 26 S Proteasome

Peth, A., Nathan, J. A., & Goldberg, A. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.482570 · Cited by 140

Benefits of Metformin in Attenuating the Hallmarks of Aging

Kulkarni, A. S., Gubbi, S., & Barzilai, N. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.04.001 · Cited by 766

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506

Establishment of H3K9-methylated heterochromatin and its functions in tissue differentiation and maintenance

Padeken, J., Methot, S. P., & Gasser, S. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00483-w · Cited by 532

The ageing epigenome and its rejuvenation

Zhang, W., Qu, J., Liu, G.-H., & Belmonte, J. C. I. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0204-5 · Cited by 458

mTOR as a central regulator of lifespan and aging

Papadopoli, D. J., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirović, I., & Hulea, L. (2019) · F1000Research · doi:10.12688/f1000research.17196.1 · Cited by 447

The role of the stem cell epigenome in normal aging and rejuvenative therapy

Jayarajan, J., & Milsom, M. D. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa167 · Cited by 8

Concise Review: The Epigenetic Contribution to Stem Cell Ageing: Can We Rejuvenate Our Older Cells?

Armstrong, L., Al-Aama, J. Y., Stojković, M., & Lako, M. (2014) · Stem Cells · doi:10.1002/stem.1720 · Cited by 11

Epigenetic perturbations in aging stem cells

Krauss, S. R., & de Haan, G. (2016) · Mammalian Genome · doi:10.1007/s00335-016-9645-8 · Cited by 14

Epigenetic Erosion in Adult Stem Cells: Drivers and Passengers of Aging

Kosan, C., Heidel, F. H., Godmann, M., & Bierhoff, H. (2018) · Cells · doi:10.3390/cells7120237 · Cited by 29

Epigenetic alterations in stem cell ageing—a promising target for age-reversing interventions?

Pouikli, A., & Tessarz, P. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab010 · Cited by 11