Running improves pattern separation during novel object recognition
Open accessAbstract
Running increases adult neurogenesis and improves pattern separation in various memory tasks including context fear conditioning or touch-screen based spatial learning. However, it is unknown whether pattern separation is improved in spontaneous behavior, not emotionally biased by positive or negative reinforcement. Here we investigated the effect of voluntary running on pattern separation during novel object recognition in mice using relatively similar or substantially different objects.We show that running increases hippocampal neurogenesis but does not affect object recognition memory with 1.5 h delay after sample phase. By contrast, at 24 h delay, running significantly improves recognition memory for similar objects, whereas highly different objects can be distinguished by both, running and sedentary mice. These data show that physical exercise improves pattern separation, independent of negative or positive reinforcement. In sedentary mice there is a pronounced temporal gradient for remembering object details. In running mice, however, increased neurogenesis improves hippocampal coding and temporally preserves distinction of novel objects from familiar ones.
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Running induces an increase of performance in different hippocampus-dependent cognitive tasks, such as spatial memory and spatial pattern separation, novel object recognition, and contextual fear conditioning.
“As for running, there is straightforward evidence that, in parallel with the surge of proliferation of progenitor cells, it induces an increase of performance in different hippocampus-dependent cognitive tasks, such as spatial memory and spatial pattern separation (Voss et al., 2013;Creer et al., 2010), or novel object recognition (Bolz et al., 2015) and contextual fear conditioning (Kohman et al.”
From Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise (2018) · cites this paper as Bolz et al., 2015
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- Authors
- Bolz, L., Heigele, S., & Bischofberger, J.
- Affiliations
- University of Basel (CH)
- Corresponding author
- Bischofberger, Josef
- ORCID
- Bischofberger, Josef
- Venue
- Brain Plasticity
- Publisher
- IOS Press
- Published
- 2015-06
- Volume
- 1
- Issue
- 1
- Pages
- 129-141
- ISSN
- 2213-6304 (ISSN-L)
- 2213-6312
- PMC
- PMC5928530
- OpenAlex
- W1937888283
- Cited by
- 80
- References
- 61
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 9 · 2022: 9 · 2021: 13 · 2020: 5 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 3 · 2015: 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Plasticity (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (31003A)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- voluntary running, physical activity, pattern separation, novel object recognition, adult neurogenesis, hippocampus, object recognition memory, memory delay, sedentary mice
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