Beyond the GFAP-Astrocyte Protein Markers in the Brain

Jurga, Agnieszka M.; Paleczna, Martyna; Kadluczka, Justyna; Kuter, Katarzyna Z.

doi:10.3390/biom11091361

Cited by 321Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Beyond the GFAP-Astrocyte Protein Markers in the Brain

Open access

Jurga, Agnieszka M., Paleczna, Martyna, Kadluczka, Justyna, Kuter, Katarzyna Z.·2021·Biomolecules

DOI 10.3390/biom11091361PMC PMC8468264

Open this paper in CoChat — free account Open PDF

Abstract

The idea of central nervous system as one-man band favoring neurons is long gone. Now we all are aware that neurons and neuroglia are team players and constant communication between those various cell types is essential to maintain functional efficiency and a quick response to danger. Here, we summarize and discuss known and new markers of astroglial multiple functions, their natural heterogeneity, cellular interactions, aging and disease-induced dysfunctions. This review is focused on newly reported facts regarding astrocytes, which are beyond the old stereotypes. We present an up-to-date list of marker proteins used to identify a broad spectrum of astroglial phenotypes related to the various physiological and pathological nervous system conditions. The aim of this review is to help choose markers that are well-tailored for specific needs of further experimental studies, precisely recognizing differential glial phenotypes, or for diagnostic purposes. We hope it will help to categorize the functional and structural diversity of the astroglial population and ease a clear readout of future experimental results.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.3390/biom11091361

Cites

213 of 213 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Many genes whose expression increased most with age are selectively expressed by astrocytes.
“Many of the genes whose expression increased the most with age are selectively expressed by astrocytes.49”
From Uncovering the signatures of aging and senescence in the human dorsolateral prefrontal cortex (2026) · cites this paper as [49]
Section 6, “Astroglial Markers in the Aging Brain” (page not provided), says that aged astrocytes show enhanced expression of activation markers and that many markers with enhanced expression during aging follow a cytotoxic activation pattern. It does not establish that the genes increasing most with age, relative to other genes, are selectively expressed by astrocytes. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Glutamate neurotoxicity and diseases of the nervous system
Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works
Neurotoxic reactive astrocytes are induced by activated microglia
Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works
Astrocyte-endothelial interactions at the blood-brain barrier
Abbott, N. J., Rönnbäck, L., & Hansson, E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1824 · Cited by 5,595 · see citing works
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex
Zhang, Y., Chen, K., Sloan, S. A., Bennett, M. L., Scholze, A. R., O'Keeffe, S., Phatnani, H. P., Guarnieri, P., Caneda, C., Ruderisch, N., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.1860-14.2014 · Cited by 4,875 · cited 1× · see citing works
“Analysis of transcriptome demonstrated that PDK4 expression is 30 times higher in astrocytes than in neurons [56].”
Background
A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel, A., Muñoz-Manchado, A. B., Codeluppi, S., Lönnerberg, P., La Manno, G., Juréus, A., Marques, S., Munguba, H., He, L., Betsholtz, C., et al. (2015) · Science · doi:10.1126/science.aaa1934 · Cited by 3,124 · see citing works
Cellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
Santos, S. E. D., Porfírio, J., Cunha, F., Manger, P. R., Tavares, W. C., Pessôa, L. M., Raghanti, M. A., Sherwood, C. C., & Herculano‐Houzel, S. (2017) · Brain Behavior and Evolution · doi:10.1159/000452856 · Cited by 2,651 · see citing works
Single-cell transcriptomic analysis of Alzheimer’s disease
Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568 · see citing works
Reactive astrocyte nomenclature, definitions, and future directions
Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · cited 3× · see citing works
“Unfortunately, current knowledge does not allow proposing definitive categorization in this matter yet [97,101].”
Background
Genomic analysis of reactive astrogliosis
Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works
Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain
Azevedo, F. A. C., Carvalho, L. R. B., Grinberg, L. T., Farfel, J. M., Ferretti, R. E. L., Leite, R. E. P., Filho, W. J., Lent, R., & Herculano‐Houzel, S. (2009) · Journal of Comparative Neurology · doi:10.1002/cne.21974 · Cited by 2,337 · see citing works
Reactive Astrocytes: Production, Function, and Therapeutic Potential
Liddelow, S. A., & Barres, B. A. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.006 · Cited by 2,336 · see citing works
The glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075 · see citing works
Localization of neuronal and glial glutamate transporters
Rothstein, J. D., Martin, L. J., Levey, A. I., Dykes‐Hoberg, M., Jin, L., Wu, D. M., Nash, N. R., & Kuncl, R. W. (1994) · Neuron · doi:10.1016/0896-6273(94)90038-8 · Cited by 1,703 · see citing works
Physiology of Astroglia
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works
Uniquely Hominid Features of Adult Human Astrocytes
Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works
Diversity of astrocyte functions and phenotypes in neural circuits
Khakh, B. S., & Sofroniew, M. V. (2015) · Nature Neuroscience · doi:10.1038/nn.4043 · Cited by 1,239 · see citing works
Normal aging induces A1-like astrocyte reactivity
Clarke, L. E., Liddelow, S. A., Chakraborty, C., Münch, A. E., Heiman, M., & Barres, B. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800165115 · Cited by 1,237 · see citing works
GFAP in health and disease
Middeldorp, J., & Hol, E. M. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.005 · Cited by 1,080 · see citing works
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works
Self-citation
Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system
Hol, E. M., & Pekny, M. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.02.004 · Cited by 917 · see citing works
Cell type- and brain region-resolved mouse brain proteome
Sharma, K., Schmitt, S., Bergner, C. G., Tyanova, S., Kannaiyan, N., Manrique-Hoyos, N., Kongi, K., Cantuti, L., Hanisch, U.-K., Philips, M.-A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4160 · Cited by 871 · cited 4× · see citing works
“Interestingly, AQP4 is not present in oligodendrocytes, which makes it a good glial differentiating factor, but it is also present in ependymal cells and especially highly expressed in Bergmann glia [33].”
BackgroundInfluential
Overview of complement activation and regulation
Noris, M., & Remuzzi, G. (2013) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2013.08.001 · Cited by 864 · see citing works
Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
Chaudhry, F. A., Lehre, K. P., Campagne, M. V. L., Ottersen, O. P., Danbolt, N. C., & Storm‐Mathisen, J. (1995) · Neuron · doi:10.1016/0896-6273(95)90158-2 · Cited by 827 · see citing works
Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence
Chai, H., Diaz-Castro, B., Shigetomi, E., Monte, E., Octeau, J. C., Yu, X., Cohn, W., Rajendran, P. S., Vondriska, T. M., Whitelegge, J. P., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.029 · Cited by 769 · see citing works
Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema
Papadopoulos, M. C., Manley, G. T., Krishna, S., & Verkman, A. S. (2004) · The FASEB Journal · doi:10.1096/fj.04-1723fje · Cited by 749 · see citing works
Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution
Mathys, H., Adaikkan, C., Gao, F., Young, J. Z., Manet, E., Hemberg, M., De Jager, P. L., Ransohoff, R. M., Regev, A., & Tsai, L.-H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.039 · Cited by 740 · see citing works
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity
Sofroniew, M. V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.004 · Cited by 721 · see citing works
The aging astrocyte transcriptome from multiple regions of the mouse brain.
Boisvert, M. M., Erikson, G. A., Shokhirev, M. N., & Allen, N. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.039 · Cited by 702 · see citing works
The Number of Glutamate Transporter Subtype Molecules at Glutamatergic Synapses: Chemical and Stereological Quantification in Young Adult Rat Brain
Lehre, K. P., & Danbolt, N. C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08751.1998 · Cited by 675 · see citing works
Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development
Vainchtein, I. D., Chin, G., Cho, F. S., Kelley, K. W., Miller, J. G., Chien, E. C., Liddelow, S. A., Nguyen, P. T., Nakao-Inoue, H., Dorman, L. C., et al. (2018) · Science · doi:10.1126/science.aal3589 · Cited by 657 · see citing works
Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat
Nair‐Roberts, R. G., Chatelain-Badie, S. D., Benson, E. M., White‐Cooper, H., Bolam, J. P., & Ungless, M. A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.046 · Cited by 653 · see citing works
The Role of Astrocytes in CNS Inflammation
Giovannoni, F., & Quintana, F. J. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.007 · Cited by 651 · see citing works
Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury
Wilhelmsson, U., Bushong, E. A., Price, D. L., Smarr, B. L., Phung, V., Terada, M., Ellisman, M. H., & Pekny, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602841103 · Cited by 643 · cited 2× · see citing works
“GFAP immunoreactivity is reflected by changes in the cytoskeleton, but its reorganization may not be followed by hypertrophy [98].”
Background
Heterogeneity of astrocytic form and function.
Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638 · see citing works
Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
Parri, H. R., Gould, T. M., & Crunelli, V. (2001) · Nature Neuroscience · doi:10.1038/90507 · Cited by 625 · see citing works
Functional diversity of astrocytes in neural circuit regulation
Haim, L. B., & Rowitch, D. H. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.159 · Cited by 618 · see citing works
S100B in brain damage and neurodegeneration
Rothermundt, M., Peters, M., Prehn, J. H. M., & Arolt, V. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10303 · Cited by 610 · see citing works
Neocortical glial cell numbers in human brains
Pelvig, D. P., Pakkenberg, H., Stark, A. K., & Pakkenberg, B. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.013 · Cited by 601 · see citing works
Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice
Tong, X., Ao, Y., Faas, G. C., Nwaobi, S. E., Xu, J., Haustein, M. D., Anderson, M. A., Mody, I., Olsen, M. L., Sofroniew, M. V., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3691 · Cited by 592 · see citing works
The “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS
Schafer, D. P., Lehrman, E. K., & Stevens, B. (2013) · Glia · doi:10.1002/glia.22389 · Cited by 570 · see citing works
GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination
(1996) · doi:10.1016/s0896-6273(00)80194-4 · Cited by 538 · see citing works
Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease
Chinta, S. J., Woods, G., Demaria, M., Rane, A., Zou, Y., McQuade, A., Rajagopalan, S., Limbad, C., Madden, D. T., Campisi, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.092 · Cited by 530 · see citing works
Identification of diverse astrocyte populations and their malignant analogs
John Lin, C.-C., Yu, K., Hatcher, A., Huang, T.-W., Lee, H. K., Carlson, J., Weston, M. C., Chen, F., Zhang, Y., Zhu, W., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4493 · Cited by 525 · see citing works
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
Priego, N., Zhu, L., Monteiro, C., Mulders, M., Wasilewski, D., Bindeman, W., Doglio, L., Martínez, L., Martínez-Saez, E., Ramón y Cajal, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0044-4 · Cited by 452 · see citing works
Astrocytes in physiological aging and Alzheimer’s disease
Rodríguez-Arellano, J. J., Parpura, V., Zorec, R., & Verkhratsky, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.007 · Cited by 439 · see citing works
Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development
Bushong, E. A., Martone, M. E., & Ellisman, M. H. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2003.12.008 · Cited by 438 · see citing works
Segregated Expression of AMPA-Type Glutamate Receptors and Glutamate Transporters Defines Distinct Astrocyte Populations in the Mouse Hippocampus
Matthias, K., Kirchhoff, F., Seifert, G., Hüttmann, K., Matyash, M., Kettenmann, H., & Steinhäuser, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01750.2003 · Cited by 431 · see citing works
Energy Contribution of Octanoate to Intact Rat Brain Metabolism Measured by 13 C Nuclear Magnetic Resonance Spectroscopy
Ebert, D., Haller, R. G., & Walton, M. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05928.2003 · Cited by 427 · see citing works
Glia: Initiators and progressors of pathology in Parkinson's disease
Halliday, G. M., & Stevens, C. H. (2011) · Movement Disorders · doi:10.1002/mds.23455 · Cited by 423 · see citing works
Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging
Soreq, L., Rose, J., Soreq, E., Hardy, J., Trabzuni, D., Cookson, M. R., Smith, C., Ryten, M., Patani, R., & Ule, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.011 · Cited by 419 · see citing works
Human Astrocytes: Secretome Profiles of Cytokines and Chemokines
Choi, S. S., Lee, H. J., Lim, I., Satoh, J., & Kim, S. U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092325 · Cited by 411 · see citing works
Thrombospondins: Multifunctional Regulators of Cell Interactions
Adams, J. C. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.25 · Cited by 407 · see citing works
Fibrous and protoplasmic astrocytes are biochemically and developmentally distinct
Miller, R., & RAFF, M. C. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-02-00585.1984 · Cited by 396 · see citing works
Induction of Glial Fibrillary Acidic Protein Expression in Astrocytes by Nitric Oxide
Brahmachari, S., Fung, Y. K., & Pahan, K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5480-05.2006 · Cited by 390 · see citing works
The glutamate‐glutamine cycle is not stoichiometric: Fates of glutamate in brain
McKenna, M. C. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21444 · Cited by 385 · see citing works
Astroglial networks scale synaptic activity and plasticity
Pannasch, U., Vargová, L., Reingruber, J., Ezan, P., Holcman, D., Giaume, C., Syková, E., & Rouach, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016650108 · Cited by 383 · see citing works
Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage
Schachtrup, K., Ryu, J. K., Helmrick, M. J., Vagena, E., Galanakis, D. K., Degen, J. L., Margolis, R. U., & Akassoglou, K. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0137-10.2010 · Cited by 371 · see citing works
SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions
Sun, W., Cornwell, A., Li, J., Peng, S., Osorio, M. J., Aalling, N., Wang, S., Benraiss, A., Lou, N., Goldman, S. A., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3199-16.2017 · Cited by 357 · see citing works
Spatial and temporal relationship between monocyte chemoattractant protein‐1 expression and spinal glial activation following peripheral nerve injury
Zhang, J., & Koninck, Y. D. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03746.x · Cited by 345 · see citing works
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects
Faideau, M., Kim, J., Cormier, K., Gilmore, R., Welch, M. J., Aurégan, G., Dufour, N., Guillermier, M., Brouillet, E., Hantraye, P., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq212 · Cited by 343 · see citing works
Identification of positionally distinct astrocyte subtypes whose identities are specified by a homeodomain code
Hochstim, C., Deneen, B., Lukaszewicz, A., Zhou, Q., & Anderson, D. J. (2008) · Cell · doi:10.1016/j.cell.2008.02.046 · Cited by 331 · see citing works
The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson's disease
Mirza, B., Hadberg, H., Thomsen, P., & Moos, T. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00455-8 · Cited by 327 · see citing works
Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS
Regan, M. R., Huang, Y. H., Kim, Y., Dykes‐Hoberg, M., Jin, L., Watkins, A. M., Bergles, D. E., & Rothstein, J. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0790-07.2007 · Cited by 314 · see citing works
Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers
Lanjakornsiripan, D., Pior, B., Kawaguchi, D., Furutachi, S., Tahara, T., Katsuyama, Y., Suzuki, Y., Fukazawa, Y., & Gotoh, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-03940-3 · Cited by 308 · see citing works
Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS
Emsley, J. G., & Macklis, J. D. (2006) · Neuron Glia Biology · doi:10.1017/s1740925x06000202 · Cited by 304 · see citing works
Cytokines: Powerful Regulators of Glial Cell Activation
John, G. R., Lee, S. C., & Brosnan, C. F. (2003) · The Neuroscientist · doi:10.1177/1073858402239587 · Cited by 299 · see citing works
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
Itoh, Y., Esaki, T., Shimoji, K., Cook, M., Law, M. J., Kaufman, E., & Sokoloff, L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831078100 · Cited by 297 · see citing works
GAT-3, a High-Affinity GABA Plasma Membrane Transporter, Is Localized to Astrocytic Processes, and It Is Not Confined to the Vicinity of GABAergic Synapses in the Cerebral Cortex
Minelli, A., Debiasi, S., Brecha, N. C., Vitellaro‐Zuccarello, L., & Conti, F. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-19-06255.1996 · Cited by 295 · see citing works
Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats
Gwak, Y. S., Kang, J., Unabia, G. C., & Hulsebosch, C. E. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.010 · Cited by 270 · see citing works
Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling
Farmer, W. T., Abrahamsson, T., Chierzi, S., Lui, C. G., Zaelzer, C. A., Jones, E. V., Bally, B. P., Chen, G. G., Théroux, J., Peng, J., et al. (2016) · Science · doi:10.1126/science.aab3103 · Cited by 270 · see citing works
Molecular signals of plasticity at the tetrapartite synapse
Dityatev, A., & Rusakov, D. A. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.12.006 · Cited by 267 · see citing works
Single-nucleus RNA-seq identifies Huntington disease astrocyte states
Al-Dalahmah, O., Sosunov, A. A., Shaik, A., Ofori, K., Liu, Y., Vonsattel, J. P., Adorjan, I., Menon, V., & Goldman, J. E. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-0880-6 · Cited by 264 · see citing works
Bioenergetics and redox adaptations of astrocytes to neuronal activity
Bolaños, J. P. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13486 · Cited by 262 · see citing works
Molecular comparison of GLT1 + and ALDH1L1 + astrocytes in vivo in astroglial reporter mice
Yang, Y., Vidensky, S., Jin, L., Jie, C., Lorenzini, I., Frankl, M., & Rothstein, J. D. (2010) · Glia · doi:10.1002/glia.21089 · Cited by 255 · see citing works
Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain
Harada, K., Kamiya, T., & Tsuboi, T. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00499 · Cited by 246 · see citing works
Exocytotic Release of ATP from Cultured Astrocytes
Pangršič, T., Potokar, M., Stenovec, M., Kreft, M., Fabbretti, E., Nistri, A., Pryazhnikov, E., Khiroug, L. S., Giniatullin, R. A., & Zorec, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700290200 · Cited by 245 · see citing works
Molecular and Functional Properties of Regional Astrocytes in the Adult Brain
Morel, L., Chiang, M. S. R., Higashimori, H., Shoneye, T., Iyer, L. K., Yelick, J., Tai, A., & Yang, Y. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3956-16.2017 · Cited by 243 · see citing works
Analysis of Astroglial K+ Channel Expression in the Developing Hippocampus Reveals a Predominant Role of the Kir4.1 Subunit
Seifert, G., Hüttmann, K., Binder, D. K., Hartmann, C. J., Wyczynski, A., Neusch, C., & Steinhäuser, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3790-08.2009 · Cited by 236 · see citing works
Immune reactive cells in senile plaques and cognitive decline in Alzheimer’s disease
Vehmas, A. K., Kawas, C. H., Stewart, W. F., & Troncoso, J. C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00090-8 · Cited by 230 · see citing works
Phenotypic Polarization of Activated Astrocytes: The Critical Role of Lipocalin-2 in the Classical Inflammatory Activation of Astrocytes
Jang, E., Kim, J., Lee, S., Kim, J., Seo, J.-W., Jin, M., Lee, M., Jang, I., Lee, W., & Suk, K. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301637 · Cited by 223 · see citing works
Astrocytic GABA transporter activity modulates excitatory neurotransmission
Boddum, K., Jensen, T. P., Magloire, V., Kristiansen, U., Rusakov, D. A., Pavlov, I., & Walker, M. C. (2016) · Nature Communications · doi:10.1038/ncomms13572 · Cited by 222 · see citing works
Highly differential expression of the monocarboxylate transporters MCT2 and MCT4 in the developing rat brain
Rafiki, A., Boulland, J., Halestrap, A. P., Ottersen, O. P., & Bergersen, L. H. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.040 · Cited by 221 · see citing works
Reactive astrocytes as neural stem or progenitor cells: In vivo lineage, In vitro potential, and Genome‐wide expression analysis
Götz, M., Sirko, S., Beckers, J., & Irmler, M. (2015) · Glia · doi:10.1002/glia.22850 · Cited by 219 · see citing works
MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation
Fricker, M., Neher, J. J., Zhao, J.-W., Théry, C., Tolkovsky, A. M., & Brown, G. C. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4837-11.2012 · Cited by 218 · see citing works
3-Phosphoglycerate Dehydrogenase, a Key Enzyme forl-Serine Biosynthesis, Is Preferentially Expressed in the Radial Glia/Astrocyte Lineage and Olfactory Ensheathing Glia in the Mouse Brain
Yamasaki, M., Yamada, K., Furuya, S., Mitoma, J., Hirabayashi, Y., & Watanabe, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07691.2001 · Cited by 215 · see citing works
Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-7 through NFκB and MAPK dependent pathways in rat astrocytes
Thompson, W. L., & Eldik, L. J. V. (2009) · Brain Research · doi:10.1016/j.brainres.2009.06.081 · Cited by 211 · see citing works
The effects of microglia‐ and astrocyte‐derived factors on neurogenesis in health and disease
Araki, T., Ikegaya, Y., & Koyama, R. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14969 · Cited by 208 · see citing works
Epidermal Growth Factor Receptor Activation: An Upstream Signal for Transition of Quiescent Astrocytes into Reactive Astrocytes after Neural Injury
Liu, B., Chen, H., Johns, T. G., & Neufeld, A. H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1004-06.2006 · Cited by 202 · see citing works
Peripheral astrocyte processes: Monitoring by selective immunostaining for the actin‐binding ERM proteins
Derouiche, A., & Frotscher, M. (2001) · Glia · doi:10.1002/glia.1120 · Cited by 197 · see citing works
Focal degeneration of astrocytes in amyotrophic lateral sclerosis
Rossi, D., Brambilla, L., Valori, C. F., Roncoroni, C., Crugnola, A., Yokota, T., Bredesen, D. E., & Volterra, A. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.99 · Cited by 194 · see citing works
Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
Barreto, G. E., Veiga, S. J., Azcoitia, Í., García‐Segura, L. M., & García‐Ovejero, D. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05563.x · Cited by 193 · see citing works
Diverse subtypes of astrocytes and their development during corticogenesis
Tabata, H. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00114 · Cited by 192 · see citing works
MFG‐E8 reverses microglial‐induced neurotoxic astrocyte (A1) via NF‐κB and PI3K‐Akt pathways
Xu, X., Zhang, A., Zhu, Y., He, W., Di, W., Fang, Y., & Shi, X. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26918 · Cited by 189 · see citing works
ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes
Drago, F., Lombardi, M., Prada, I., Gabrielli, M., Joshi, P., Cojoc, D., Franck, J., Fournier, I., Vizioli, J., & Verderio, C. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00910 · Cited by 185 · see citing works
Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain
Sosunov, A. A., Wu, X., Tsankova, N. M., Guilfoyle, E., McKhann, G. M., & Goldman, J. E. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4037-13.2014 · Cited by 185 · see citing works
Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model
Gan, L., Vargas, M. R., Johnson, D. A., & Johnson, J. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3049-12.2012 · Cited by 182 · see citing works
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
Konishi, H., Okamoto, T., Hara, Y., Komine, O., Tamada, H., Maeda, M., Osako, F., Kobayashi, M., Nishiyama, A., Kataoka, Y., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020104464 · Cited by 179 · see citing works
Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1β and TNF-α
Hennessy, E., Griffin, É. W., & Cunningham, C. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2745-14.2015 · Cited by 178 · see citing works
Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head
Liu, B., & Neufeld, A. H. (2000) · Glia · doi:10.1002/(sici)1098-1136(200004)30:2 · Cited by 177 · see citing works
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
Timper, K., del Río-Martín, A., Cremer, A. L., Bremser, S., Alber, J., Giavalisco, P., Varela, L., Heilinger, C., Nolte, H., Trifunovic, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.05.001 · Cited by 170 · see citing works
S100A10/p11: family, friends and functions
Rescher, U., & Gerke, V. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-007-0313-4 · Cited by 170 · see citing works
Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Jones, E. V., & Bouvier, D. S. (2014) · Neural Plasticity · doi:10.1155/2014/321209 · Cited by 169 · see citing works
Co-stimulation with IL-1β and TNF-α induces an inflammatory reactive astrocyte phenotype with neurosupportive characteristics in a human pluripotent stem cell model system
Hyvärinen, T., Hagman, S., Ristola, M., Sukki, L., Veijula, K., Kreutzer, J., Kallio, P., & Narkilahti, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-53414-9 · Cited by 168 · see citing works
Proteome analysis of human substantia nigra in Parkinson's disease
Werner, C. J., Haußen, R. H., Mall, G., & Wolf, S. (2008) · Proteome Science · doi:10.1186/1477-5956-6-8 · Cited by 167 · see citing works
Are Astrocytes the Predominant Cell Type for Activation of Nrf2 in Aging and Neurodegeneration?
Liddell, J. R. (2017) · Antioxidants · doi:10.3390/antiox6030065 · Cited by 167 · see citing works
Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression
Tyzack, G. E., Sitnikov, S., Barson, D. G., Adams-Carr, K. L., Lau, N. K., Kwok, J. C. F., Zhao, C., Franklin, R. J. M., Káradóttir, R. T., Fawcett, J. W., et al. (2014) · Nature Communications · doi:10.1038/ncomms5294 · Cited by 166 · see citing works
Spatial and temporal expression of short, long/medium, or both opsins in human fetal cones
Xiao, M., & Hendrickson, A. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001002)425:4 · Cited by 165 · see citing works
Immunocytochemical localization of glycogen phosphorylase isozymes in rat nervous tissues by using isozyme‐specific antibodies
Pfeiffer-Guglielmi, B., Fleckenstein, B. T., Jung, G., & Hamprecht, B. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01644.x · Cited by 159 · see citing works
MFG-E8 Regulates Microglial Phagocytosis of Apoptotic Neurons
Fuller, A. D., & Eldik, L. J. V. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-008-9118-2 · Cited by 155 · see citing works
GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream
Paratcha, G., Ibáñez, C. F., & Ledda, F. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.11.007 · Cited by 152 · see citing works
Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway
Jiang, H., Wagner, É., Zhang, H., & Frank, M. M. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.11.1609 · Cited by 150 · see citing works
Estradiol inhibits ongoing autoimmune neuroinflammation and NFκB-dependent CCL2 expression in reactive astrocytes
Giraud, S., Caron, C., Pham-Dinh, D., Kitabgi, P., & Nicot, A. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0910627107 · Cited by 147 · see citing works
Inactivation of astroglial NF‐κB promotes survival of retinal neurons following ischemic injury
Dvoriantchikova, G., Barakat, D. J., Brambilla, R., Agudelo, C., Hernandez, E., Bethea, J. R., Shestopalov, V. I., & Ivanov, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06814.x · Cited by 146 · see citing works
Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration
Colombo, E., Cordiglieri, C., Melli, G., Newcombe, J., Krumbholz, M., Parada, L. F., Medico, E., Hohlfeld, R., Meinl, E., & Farina, C. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20110698 · Cited by 146 · see citing works
Prokineticin‐2 promotes chemotaxis and alternative A2 reactivity of astrocytes
Neal, M. P., Luo, J. D., Harischandra, D. S., Gordon, R., Sarkar, S., Jin, H., Anantharam, V., Désaubry, L., Kanthasamy, A. G., & Kanthasamy, A. (2018) · Glia · doi:10.1002/glia.23467 · Cited by 145 · see citing works
Neuronal–glial interactions in rats fed a ketogenic diet
Melø, T. M., Nehlig, A., & Sonnewald, U. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.037 · Cited by 144 · see citing works
Oriented astroglial cell growth on micropatterned polystyrene substrates
Recknor, J. B., Recknor, J. C., Sakaguchi, D. S., & Mallapragada, S. K. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.11.045 · Cited by 143 · see citing works
Glycogen distribution in the microwave‐fixed mouse brain reveals heterogeneous astrocytic patterns
Oe, Y., Baba, O., Ashida, H., Nakamura, K., & Hirase, H. (2016) · Glia · doi:10.1002/glia.23020 · Cited by 138 · see citing works
Cell‐specific expression pattern of monocarboxylate transporters in astrocytes and neurons observed in different mouse brain cortical cell cultures
Debernardi, R., Pierre, K., Lengacher, S., Magistretti, P. J., & Pellerin, L. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10660 · Cited by 136 · see citing works
Active secretion of S100B from astrocytes during metabolic stress
Gerlach, R., Demel, G., König, H., Groß, U., Prehn, J. H. M., Raabe, A., Seifert, V., & Kögel, D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.05.008 · Cited by 135 · see citing works
Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson’s Disease
Heo, J. Y., Nam, M.-H., Yoon, H. H., Kim, J., Hwang, Y. J., Won, W., Woo, D. H., Lee, J. A., Park, H.-J., Jo, S., et al. (2020) · Current Biology · doi:10.1016/j.cub.2019.11.079 · Cited by 135 · see citing works
Vimentin immunoreactivity in normal and pathological human brain tissue
Yamada, T., Kawamata, T., Walker, D. G., & McGeer, P. L. (1992) · Acta Neuropathologica · doi:10.1007/bf00311389 · Cited by 132 · see citing works
Emerging Roles of Astrocytes in Neuro-Vascular Unit and the Tripartite Synapse With Emphasis on Reactive Gliosis in the Context of Alzheimer’s Disease
Liu, C.-Y., Yang, Y., Ju, W.-N., Wang, X., & Zhang, H.-L. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00193 · Cited by 131 · see citing works
Microglia are required for astroglial toll‐like receptor 4 response and for optimal TLR2 and TLR3 response
Holm, T. H., Dræby, D., & Owens, T. (2012) · Glia · doi:10.1002/glia.22296 · Cited by 130 · see citing works
Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases
Gril, B., Paranjape, A. N., Woditschka, S., Hua, E., Dolan, E. L., Hanson, J., Wu, X., Kloc, W., Iżycka‐Świeszewska, E., Duchnowska, R., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05030-w · Cited by 128 · see citing works
ABCA7 and Pathogenic Pathways of Alzheimer’s Disease
Aikawa, T., Holm, M., & Kanekiyo, T. (2018) · Brain Sciences · doi:10.3390/brainsci8020027 · Cited by 124 · see citing works
Resolving Astrocyte Heterogeneity in the CNS
Farmer, W. T., & Murai, K. K. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00300 · Cited by 118 · see citing works
Microglial regulation of immunological and neuroprotective functions of astroglia
Chen, S., Oyarzabal, E. A., Sung, Y.-F., Chu, C., Wang, Q., Chen, S.-L., Lu, R., & Hong, J.-S. (2014) · Glia · doi:10.1002/glia.22738 · Cited by 115 · see citing works
Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration
Ip, J. P. K., Noçon, A. L., Hofer, M. J., Lim, S. L., Müller, M., & Campbell, I. L. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-124 · Cited by 115 · see citing works
Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke
Shindo, A., Maki, T., Mandeville, E. T., Liang, A. C., Egawa, N., Itoh, K., Itoh, N., Borlongan, M. C., Holder, J. C., Chuang, T. T., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.012133 · Cited by 115 · see citing works
CD36 is Involved in Astrocyte Activation and Astroglial Scar Formation
Bao, Y., Qin, L., Kim, E., Bhosle, S., Guo, H., Febbraio, M., Haskew-Layton, R. E., Ratan, R. R., & Cho, S. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.52 · Cited by 114 · see citing works
Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity
Hung, C., Lin, C.-H., Chang, H. H., Wang, C.-Y., Lin, S.-H., Hsu, P.-C., Sun, Y., Lin, T., Shie, F., Kao, L., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3457-15.2016 · Cited by 114 · see citing works
Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model
Fujita, A., Yamaguchi, H., Yamasaki, R., Cui, Y., Matsuoka, Y., Yamada, K., & Kira, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1251-0 · Cited by 114 · see citing works
Biomarkers of glial cell proliferation and differentiation in culture
Avola, R. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s85 · Cited by 111 · see citing works
Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation
Tong, J., Ang, L.-C., Williams, B., Furukawa, Y., Fitzmaurice, P. S., Guttman, M., Boileau, I., Hornykiewicz, O., & Kish, S. J. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.06.010 · Cited by 110 · see citing works
Synemin is expressed in reactive astrocytes in neurotrauma and interacts differentially with vimentin and GFAP intermediate filament networks
Jing, R., Wilhelmsson, U., Goodwill, W., Li, L., Pan, Y., Pekny, M., & Skalli, O. (2007) · Journal of Cell Science · doi:10.1242/jcs.03423 · Cited by 110 · see citing works
Interactions between TLR7 and TLR9 agonists and receptors regulate innate immune responses by astrocytes and microglia
Butchi, N. B., Du, M., & Peterson, K. E. (2010) · Glia · doi:10.1002/glia.20952 · Cited by 109 · see citing works
Imaging of translocator protein upregulation is selective for pro‐inflammatory polarized astrocytes and microglia
Pannell, M., Economopoulos, V., Wilson, T. C., Kersemans, V., Isenegger, P. G., Larkin, J. R., Smart, S., Gilchrist, S., Gouverneur, V., & Sibson, N. R. (2020) · Glia · doi:10.1002/glia.23716 · Cited by 109 · see citing works
Astrocytes modulate the chemokine network in a pathogen-specific manner
McKimmie, C. S., & Graham, G. J. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.03.111 · Cited by 108 · see citing works
GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes
Eraso‐Pichot, A., Brasó‐Vives, M., Golbano, A., Menacho, C., Claro, E., Galea, E., & Masgrau, R. (2018) · Glia · doi:10.1002/glia.23330 · Cited by 105 · see citing works
ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.
Jeong, W., Lee, H. G., Cho, S., & Seo, J. (2019) · PubMed Central · doi:10.14348/molcells.2019.0200 · Cited by 104 · see citing works
The ins and outs of virulence gene expression: Mg2 as a regulatory signal
Groisman, E. A. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199801)20:1 · Cited by 100 · see citing works
Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain
Kobayashi, E., Nakano, M., Kubota, K., Himuro, N., Mizoguchi, S., Chikenji, T., Otani, M., Mizue, Y., Nagaishi, K., & Fujimiya, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19442-7 · Cited by 98 · see citing works
Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury
Furman, J. L., Sompol, P. M., Kraner, S. D., Pleiss, M. M., Putman, E. J., Dunkerson, J., Abdul, H. M., Roberts, K. N., Scheff, S. W., & Norris, C. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1930-15.2016 · Cited by 94 · see citing works
Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling
Xin, W., Schuebel, K. E., Jair, K.-W., Cimbro, R., Biase, L. M. D., Goldman, D. A., & Bonci, A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0151-4 · Cited by 94 · see citing works
Novel transglutaminase-1 mutations and genotype–phenotype investigations of 104 patients with autosomal recessive congenital ichthyosis in the USA
Farasat, S., Wei, M.-H., Herman, M. L., Liewehr, D. J., Steinberg, S. M., Bale, S. J., Fleckman, P. H., & Toro, J. R. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.060905 · Cited by 93 · see citing works
Identification of Novel Glial Genes by Single-Cell Transcriptional Profiling of Bergmann Glial Cells from Mouse Cerebellum
Koirala, S., & Corfas, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009198 · Cited by 91 · see citing works
Astrocyte-derived extracellular vesicles: A double-edged sword in central nervous system disorders
Zhao, S., Sheng, S., Wang, Y., Ding, L., Xu, X., Xia, X., & Zheng, J. C. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.027 · Cited by 90 · see citing works
Effect of age on neocortical brain cells in 90+ year old human females—a cell counting study
Fabricius, K., Jacobsen, J. S., & Pakkenberg, B. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.009 · Cited by 89 · see citing works
MAPKs are key players in mediating cytokine release and cell death induced by unconjugated bilirubin in cultured rat cortical astrocytes
Fernandes, A. M. A., Falcão, A. S., Silva, R. F. M., Brito, M. A., & Brites, D. M. T. O. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05340.x · Cited by 89 · see citing works
Metabolic Plasticity of Astrocytes and Aging of the Brain
Morita, M., Ikeshima‐Kataoka, H., Kreft, M., Vardjan, N., Zorec, R., & Noda, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040941 · Cited by 88 · see citing works
Localization and Function of GABA Transporters GAT-1 and GAT-3 in the Basal Ganglia
Jin, X., Galván, A., Wichmann, T., & Smith, Y. (2011) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2011.00063 · Cited by 86 · see citing works
NDRG2 as a marker protein for brain astrocytes
Flügge, G., Araya-Callís, C., Garea‐Rodríguez, E., Stadelmann, C., & Fuchs, E. (2014) · Cell and Tissue Research · doi:10.1007/s00441-014-1837-5 · Cited by 81 · see citing works
Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases.
Singhrao, S., Thomas, P., Wood, J. D., Macmillan, J., Neal, J. W., Harper, P. S., & Jones, A. L. (1998) · Experimental Neurology · doi:10.1006/exnr.1998.6778 · Cited by 81 · see citing works
Intermediate filament change in astrocytes following mild cortical contusion
Baldwin, S. A., & Scheff, S. W. (1996) · Glia · doi:10.1002/(sici)1098-1136(199603)16:3 · Cited by 81 · see citing works
CD44 expression in astrocytes and microglia is associated with ALS progression in a mouse model
Matsumoto, T., Imagama, S., Hirano, K., Ohgomori, T., Natori, T., Kobayashi, K., Muramoto, A., Ishiguro, N., & Kadomatsu, K. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.05.048 · Cited by 80 · see citing works
Neural stem cell specific fluorescent chemical probe binding to FABP7
Yun, S., Leong, C., Zhai, D., Tan, Y. L., Lim, L. S., Bi, X., Lee, J., Kim, H. J., Kang, N., Ng, S. H., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200817109 · Cited by 80 · see citing works
Astrocytes: Heterogeneous and Dynamic Phenotypes in Neurodegeneration and Innate Immunity
Cunningham, C. M., Dunne, A., & López-Rodríguez, A. B. (2018) · The Neuroscientist · doi:10.1177/1073858418809941 · Cited by 78 · see citing works
Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain
Lozzi, B., Huang, T.-W., Sardar, D., Huang, A. Y.-S., & Deneen, B. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00061 · Cited by 78 · see citing works
Traumatically injured astrocytes release a proteomic signature modulated by <scp>STAT</scp>3‐dependent cell survival
Levine, J., Kwon, E., Paez, P., Yan, W., Czerwieniec, G., Loo, J. A., Sofroniew, M. V., & Wanner, I. (2016) · Glia · doi:10.1002/glia.22953 · Cited by 76 · see citing works
STAT3 but Not STAT1 Is Required for Astrocyte Differentiation
Hong, S., & Song, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086851 · Cited by 75 · see citing works
Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model
Jurga, A. M., Piotrowska, A., Makuch, W., Przewłocka, B., & Mika, J. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00048 · Cited by 75 · see citing works
Self-citation
Silencing miR‐21 induces polarization of astrocytes to the A2 phenotype and improves the formation of synapses by targeting glypican 6 via the signal transducer and activator of transcription‐3 pathway after acute ischemic spinal cord injury
Su, Y., Chen, Z., Du, H., Liu, R., Wang, W., Li, H., & Ning, B. (2019) · The FASEB Journal · doi:10.1096/fj.201900743r · Cited by 75 · see citing works
New astroglial injury-defined biomarkers for neurotrauma assessment
Halford, J., Shen, S., Itamura, K., Levine, J., Chong, A. C., Czerwieniec, G., Glenn, T. C., Hovda, D. A., Vespa, P., Bullock, R., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17724681 · Cited by 75 · see citing works
Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models
Izrael, M., Slutsky, S. G., Admoni, T., Cohen, L., Granit, A., Hasson, A., Itskovitz‐Eldor, J., Paker, L. K., Kuperstein, G., Lavon, N., et al. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0890-5 · Cited by 74 · see citing works
Nuclear factor I-A regulates diverse reactive astrocyte responses after CNS injury
Laug, D., Huang, T.-W., Huerta, N. A. B., Huang, A. Y.-S., Sardar, D., Ortiz‐Guzman, J., Carlson, J. C., Arenkiel, B. R., Kuo, C. T., Mohila, C., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci127492 · Cited by 68 · see citing works
Subregional differences in astrocytes underlie selective neurodegeneration or protection in Parkinson's disease models in culture
Kostuk, E. W., Cai, J., & Iacovitti, L. (2019) · Glia · doi:10.1002/glia.23627 · Cited by 67 · see citing works
Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective
Clarke, B. E., Taha, D. M., Tyzack, G. E., & Patani, R. (2020) · Glia · doi:10.1002/glia.23877 · Cited by 67 · see citing works
FABP7 upregulation induces a neurotoxic phenotype in astrocytes
Killoy, K. M., Harlan, B. A., Pehar, M., & Vargas, M. R. (2020) · Glia · doi:10.1002/glia.23879 · Cited by 67 · see citing works
Human microglia and astrocytes express cGAS-STING viral sensing components
Jeffries, A. M., & Marriott, I. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.08.039 · Cited by 66 · see citing works
Deficiency of Tenascin-C Alleviates Neuronal Apoptosis and Neuroinflammation After Experimental Subarachnoid Hemorrhage in Mice
Liu, L., Fujimoto, M., Nakano, F., Nishikawa, H., Okada, T., Kawakita, F., Imanaka‐Yoshida, K., Yoshida, T., & Suzuki, H. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1006-z · Cited by 65 · see citing works
ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation
Nahirny, A., Livne‐Bar, I., Guo, X., & Sivak, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083049 · Cited by 64 · see citing works
Cleavage of Hyaluronan and CD44 Adhesion Molecule Regulate Astrocyte Morphology via Rac1 Signalling
Konopka, A., Zeug, A., Skupien, A., Kaza, B., Mueller, F., Chwedorowicz, A., Ponimaskin, E. G., Wilczynski, G. M., & Dzwonek, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155053 · Cited by 64 · see citing works
The Epithelial Membrane Protein 1 is a Novel Tight Junction Protein of the Blood—Brain Barrier
Bangsow, T., Baumann, E., Bangsow, C., Jaeger, M. H., Pelzer, B., Gruhn, P., Wolf, S., von Melchner, H., & Stanimirovic, D. B. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.19 · Cited by 63 · see citing works
Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent Responses
Hwang, M., & Bergmann, C. C. (2018) · Journal of Virology · doi:10.1128/jvi.01901-17 · Cited by 63 · see citing works
Alpha‐smooth muscle actin (α‐SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor‐beta 1 (TGF‐β1)
Moreels, M., Vandenabeele, F., Dumont, D., Robben, J., & Lambrichts, I. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00910.x · Cited by 63 · see citing works
Extrasynaptic transmission and the diffusion parameters of the extracellular space
Syková, E., & Vargová, L. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.04.007 · Cited by 62 · see citing works
Astrocytes recognize intracellular polyinosinic‐polycytidylic acid via MDA‐5
Miranda, J. D., Yaddanapudi, K., Hornig, M., & Lipkin, W. I. (2008) · The FASEB Journal · doi:10.1096/fj.08-121434 · Cited by 60 · see citing works
Molecular imaging of nestin in neuroinflammatory conditions reveals marked signal induction in activated microglia
Krishnasamy, S., Weng, Y.-C., Thammisetty, S. S., Phaneuf, D., Lalancette–Hébert, M., & Križ, J. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0816-7 · Cited by 59 · see citing works
Expression and localization of the iron–siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity
Chia, W.-J., Dawe, G. S., & Ong, W. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.04.007 · Cited by 58 · see citing works
The Role of Tenascin-C in Tissue Injury and Repair After Stroke
Okada, T., & Suzuki, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607587 · Cited by 57 · see citing works
Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes
Campbell, S. C., Muñoz‐Ballester, C., Chaunsali, L., Mills, W. A., Yang, J. H., Sontheimer, H. W., & Robel, S. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104628 · Cited by 49 · see citing works
Astrocytic Cx43 and Cx30 differentially modulate adult neurogenesis in mice
Liebmann, M., Stahr, A., Guenther, M., Witte, O. W., & Frahm, C. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.04.013 · Cited by 47 · see citing works
S100B Transgenic Mice Develop Features of Parkinson's Disease
Liu, J., Wang, H., Zhang, L., Xu, Y., Deng, W., Zhu, H., & Qin, C. (2011) · Archives of Medical Research · doi:10.1016/j.arcmed.2011.01.005 · Cited by 46 · see citing works
In Vitro and In Vivo Activation of Astrocytes by Amyloid-β is Potentiated by Pro-Oxidant Agents
García‐Matas, S., de Vera, N., Aznar, A. O., Marimon, J. M., Adell, A., Planas, A. M., Cristòfol, R. M., & Sanfeliu, C. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1365 · Cited by 45 · see citing works
Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Orellana, J. A., Retamal, M. A., Moraga‐Amaro, R., & Stehberg, J. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2016.00026 · Cited by 44 · see citing works
Brain Region-Specific Gene Signatures Revealed by Distinct Astrocyte Subpopulations Unveil Links to Glioma and Neurodegenerative Diseases
Durán, R. C., Wang, C.-Y., Zheng, H., Deneen, B., & Wu, J. Q. (2019) · eNeuro · doi:10.1523/eneuro.0288-18.2019 · Cited by 42 · see citing works
Disrupted function of lactate transporter MCT1 , but not MCT4 , in Schwann cells affects the maintenance of motor end‐plate innervation
Bouçanova, F., Pollmeier, G., Sándor, K., Morado-Urbina, C. E., Nijssen, J., Médard, J., Bartesaghi, L., Pellerin, L., Svensson, C. I., Hedlund, E., et al. (2020) · Glia · doi:10.1002/glia.23889 · Cited by 42 · see citing works
Nkx2.1 regulates the generation of telencephalic astrocytes during embryonic development
Minocha, S., Valloton, D., Arsenijévic, Y., Cardinaux, J., Guidi, R., Hornung, J., & Lebrand, C. (2017) · Scientific Reports · doi:10.1038/srep43093 · Cited by 42 · see citing works
Astrocytic Ephrin-B1 Controls Synapse Formation in the Hippocampus During Learning and Memory
Nguyen, A. Q., Koeppen, J., Woodruff, S., Mina, K., Figueroa, Z. A., & Ethell, I. M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00010 · Cited by 41 · see citing works
Adult Spinal Cord Radial Glia Display a Unique Progenitor Phenotype
Petit, A., Sanders, A. D., Kennedy, T. E., Tetzlaff, W., Glattfelder, K. J., Dalley, R. A., Puchalski, R. B., Jones, A. R., & Roskams, A. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024538 · Cited by 41 · see citing works
Matrix Metalloproteinases, Neural Extracellular Matrix, and Central Nervous System Pathology
Luca, C. D., & Papa, M. (2017) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.04.002 · Cited by 39 · see citing works
Developmental expression of Kir4.1 in astrocytes and oligodendrocytes of rat somatosensory cortex and hippocampus
Moroni, R. F., Inverardi, F., Regondi, M. C., Pennacchio, P., & Frassoni, C. (2015) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2015.09.004 · Cited by 37 · see citing works
GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson’s Disease and Lewy Body Dementia
Maetzler, W., Deleersnijder, W., Hanssens, V., Bernard, A., Brockmann, K., Marquetand, J., Wurster, I., Rattay, T. W., Roncoroni, L., Schaeffer, E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149349 · Cited by 36 · see citing works
Astroglial Integrins in the Development and Regulation of Neurovascular Units
Tanigami, H., Okamoto, T., Yasue, Y., & Shimaoka, M. (2012) · Pain Research and Treatment · doi:10.1155/2012/964652 · Cited by 34 · see citing works
Cell-Penetrating Mx1 Enhances Anti-Viral Resistance against Mucosal Influenza Viral Infection
Jung, H. E., Oh, J. E., & Lee, H. K. (2019) · Viruses · doi:10.3390/v11020109 · Cited by 34 · see citing works
Mechanical elongation of astrocyte processes to create living scaffolds for nervous system regeneration
Katiyar, K. S., Winter, C. C., Struzyna, L. A., Harris, J. P., & Cullen, D. K. (2016) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2168 · Cited by 34 · see citing works
EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes
Rutkowska, A., Shimshek, D. R., Sailer, A. W., & Dev, K. K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.029 · Cited by 33 · see citing works
Temporal relationship between aquaporin-4 and glial fibrillary acidic protein in cerebellum of neonate and adult rats administered a BBB disrupting spider venom
Stávale, L. M., Soares, E. S., Mendonça, M. C. P., Irazusta, S. P., & Höfling, M. A. D. C. (2013) · Toxicon · doi:10.1016/j.toxicon.2013.01.026 · Cited by 32 · see citing works

Flagged first, then by citations

2 of the 215 references couldn’t be matched to a known paper.

Sorted by citations

GFAP as a Potential Biomarker for Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Kim, K. Y., Shin, K. Y., & Chang, K.-A. (2023) · Cells · doi:10.3390/cells12091309 · Cited by 309 · see citing works
Calcium signaling in astrocytes and gliotransmitter release
Goenaga, J. G., Araque, A., Kofuji, P., & Chao, D. H. M. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1138577 · Cited by 148 · see citing works
Astrocytes in Chronic Pain: Cellular and Molecular Mechanisms
Lu, H.-J., & Gao, Y.-J. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-022-00961-3 · Cited by 118 · see citing works
Smouldering‐Associated Worsening in Multiple Sclerosis: An International Consensus Statement on Definition, Biology, Clinical Implications, and Future Directions
Scalfari, A., Traboulsee, A. L., Oh, J., Airas, L. M., Bittner, S., Calabrese, M., García‐Domínguez, J. M., Granziera, C., Greenberg, B. M., Hellwig, K., et al. (2024) · Annals of Neurology · doi:10.1002/ana.27034 · Cited by 99 · see citing works
Astrocyte-Mediated Neuroinflammation in Neurological Conditions
Zhao, Y., Huang, Y., Cao, Y., & Yang, J. H. (2024) · Biomolecules · doi:10.3390/biom14101204 · Cited by 100 · see citing works
Neuroinflammatory fluid biomarkers in patients with Alzheimer’s disease: a systematic literature review
Heneka, M., Gauthier, S., Chandekar, S. A., Hahn-Pedersen, J. H., Bentsen, M. A., & Zetterberg, H. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02939-9 · Cited by 84 · see citing works
Association between hypertension and neurovascular inflammation in both normal-appearing white matter and white matter hyperintensities
Guardia, G. S., Custers, E., de Lange, A., Clijncke, E., Geenen, B., Gutierrez, J., Küsters, B., Claassen, J. A. H. R., de Leeuw, F., Wiesmann, M., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01497-3 · Cited by 73 · see citing works
Molecular Mechanisms Underlying Neuroinflammation Elicited by Occupational Injuries and Toxicants
Pathak, D., & Sriram, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032272 · Cited by 69 · see citing works
The Similar and Distinct Roles of Satellite Glial Cells and Spinal Astrocytes in Neuropathic Pain
McGinnis, A., & Ji, R. (2023) · Cells · doi:10.3390/cells12060965 · Cited by 63 · see citing works
TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis
Guise, A. J., Misal, S. A., Carson, R. H., Chu, J.-H., Boekweg, H., Watt, D. V. D., Welsh, N. C., Truong, T., Liang, Y., Xu, S., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113636 · Cited by 60 · see citing works
Polystyrene Nano- and Microplastic Particles Induce an Inflammatory Gene Expression Profile in Rat Neural Stem Cell-Derived Astrocytes In Vitro
Marcellus, K. A., Bugiel, S., Nunnikhoven, A., Curran, I., & Gill, S. S. (2024) · Nanomaterials · doi:10.3390/nano14050429 · Cited by 48 · see citing works
Resilience of females to acute blood–brain barrier damage and anxiety behavior following mild blast traumatic brain injury
Hubbard, W. B., Velmurugan, G. V., Brown, E., & Sullivan, P. G. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01395-8 · Cited by 49 · see citing works
Prefrontal cortex astroglia modulate anhedonia-like behavior
Codeluppi-Arrowsmith, S. A., Xu, M., Bansal, Y., Lepack, A. E., Duric, V., Chow, M., Muir, J., Bagot, R. C., Licznerski, P., Wilber, S. L., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02246-1 · Cited by 43 · see citing works
Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes
Santiago-Balmaseda, A., Aguirre-Orozco, A., Valenzuela-Arzeta, I. E., Villegas-Rojas, M. M., Pérez‐Segura, I., Jiménez-Barrios, N., Hurtado-Robles, E., Rodríguez-Hernández, L. D., Rivera-German, E. R., Guerra‐Crespo, M., et al. (2024) · Cells · doi:10.3390/cells13110921 · Cited by 43 · see citing works
Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury
Navabi, S. P., Badreh, F., Shooshtari, M. K., Hajipour, S., Vastegani, S. M., & Khoshnam, S. E. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35869 · Cited by 39 · see citing works
Pinocembrin Inhibits P2X4 Receptor–Mediated Pyroptosis in Hippocampus to Alleviate the Behaviours of Chronic Pain and Depression Comorbidity in Rats
Yang, R., Yang, J., Li, Z., Su, R., Zou, L., Li, L., Xu, X., Li, G., Liu, S., Liang, S., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03023-x · Cited by 39 · see citing works
High-resolution transcriptomics informs glial pathology in human temporal lobe epilepsy
Pai, B., Tomé-García, J., Cheng, W. S., Nudelman, G., Beaumont, K. G., Ghatan, S., Panov, F. E., Caballero, E., Sarpong, K., Marcuse, L. V., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01453-1 · Cited by 38 · see citing works
Brain Metabolism in Health and Neurodegeneration: The Interplay Among Neurons and Astrocytes
Shichkova, P., Coggan, J. S., Markram, H., & Keller, D. X. (2024) · Cells · doi:10.3390/cells13201714 · Cited by 37 · see citing works
A 3D Bioprinted Human Neurovascular Unit Model of Glioblastoma Tumor Growth
Tung, Y., Chen, Y., Derr, K., Wilson, K. M., Song, M. J., & Ferrer, M. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302831 · Cited by 34 · see citing works
Alleviating Recombinant Tissue Plasminogen Activator‐induced Hemorrhagic Transformation in Ischemic Stroke via Targeted Delivery of a Ferroptosis Inhibitor
Geng, Y., Qiu, L., Cheng, Y., Li, J., Ma, Y., Zhao, C., Cai, Y., Zhang, X., Chen, J., Pan, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202309517 · Cited by 33 · see citing works
scCAD: Cluster decomposition-based anomaly detection for rare cell identification in single-cell expression data
Xu, Y., Wang, S., Feng, Q., Xia, J., Li, Y., Li, H., & Wang, J. (2024) · Nature Communications · doi:10.1038/s41467-024-51891-9 · Cited by 31 · see citing works
Distribution Patterns of Astrocyte Populations in the Human Cortex
Forrest, S. L., Kim, J. H., Crockford, D. R., Huynh, K., Cheong, R., Knott, S., Kane, M. A., Ittner, L. M., Halliday, G. M., & Kril, J. J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03700-2 · Cited by 31 · see citing works
Codonopsis pilosula water extract delays D-galactose-induced aging of the brain in mice by activating autophagy and regulating metabolism
王学文, Kang, J., Li, X., Wu, P., Huang, Y., Huang, Y., Feng, J., & Feng, J. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118016 · Cited by 30 · see citing works
Role of Glial Cells in Neuronal Function, Mood Disorders, and Drug Addiction
Tizabi, Y., Getachew, B., Hauser, S. R., Tsytsarev, V., Manhães, A. C., & da Silva, V. D. A. (2024) · Brain Sciences · doi:10.3390/brainsci14060558 · Cited by 27 · see citing works
Astrocytes and Alpha-Synuclein: Friend or Foe?
Ozoran, H., & Srinivasan, R. (2023) · Journal of Parkinson s Disease · doi:10.3233/jpd-230284 · Cited by 26 · see citing works
Unveiling the role of astrogliosis in Alzheimer’s disease Pathology: Insights into mechanisms and therapeutic approaches
Paidlewar, M., Kumari, S., Dhapola, R., Sharma, P., & HariKrishnaReddy, D. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112940 · Cited by 25 · see citing works
Astroglial Dysfunctions in Mood Disorders and Rodent Stress Models: Consequences on Behavior and Potential as Treatment Target
Bansal, Y., Codeluppi-Arrowsmith, S. A., & Banasr, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126357 · Cited by 24 · see citing works
PI3K/AKT pathway: A potential therapeutic target in cerebral ischemia-reperfusion injury
Han, Y., Sun, Y., Peng, S., Tang, T., Zhang, B., Yu, R., Sun, X., Guo, S., Ma, L., Li, P., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177505 · Cited by 26 · see citing works
Blood-brain barrier biomarkers
Zapata-Acevedo, J. F., Mantilla-Galindo, A., Vargas-Sánchez, K., & González-Reyes, R. E. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.04.004 · Cited by 23 · see citing works
Myeloid cell–specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease
Dinkel, L., Hummel, S., Zenatti, V., Malara, M., Tillmann, Y., Colombo, A., Monasor, L. S., Suh, J. H., Logan, T., Roth, S., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adl4616 · Cited by 22 · see citing works
The rise of astrocytes: are they guardians or troublemakers of the brain disorder?
Kim, H. Y., Kim, S., Akaydin, A. N., Kim, S. S., Hyeon, S. J., Lee, J.-H., & Ryu, H. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-025-01627-6 · Cited by 22 · see citing works
Differential Diagnosis of Suspected Multiple Sclerosis in Pediatric and Late-Onset Populations
Hua, L. H., Solomon, A. J., Tenembaum, S. N., Scalfari, A., Rovira, À., Rostasy, K. M., Newsome, S. D., Marrie, R. A., Magyari, M., Kantarci, O. H., et al. (2024) · JAMA Neurology · doi:10.1001/jamaneurol.2024.3062 · Cited by 24 · see citing works
Postnatal age-differential ASD-like transcriptomic, synaptic, and behavioral deficits in Myt1l-mutant mice
Kim, S., Oh, H., Choi, S. H., Yoo, Y.-E., Noh, Y. W., Cho, Y., Im, G. H., Lee, C., Oh, Y., Yang, E., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111398 · Cited by 19 · see citing works
Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury
Czyżewski, W., Mazurek, M., Sakwa, L., Szymoniuk, M., Pham, J., Pasierb, B., Litak, J., Czyżewska, E., Turek, M., Piotrowski, B., et al. (2024) · Cells · doi:10.3390/cells13020148 · Cited by 22 · see citing works
Spatiotemporal dynamics of 5-HT6 receptor ciliary localization during mouse brain development
Dupuy, V., Prieur, M., Pizzoccaro, A., Margarido, C., Valjent, E., Bockaert, J., Bouschet, T., Marin, P., & Chaumont-Dubel, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105949 · Cited by 19 · see citing works
Influence of the properties of different graphene-based nanomaterials dispersed in polycaprolactone membranes on astrocytic differentiation
Mantecón‐Oria, M., Tapia, O., Lafarga, M., Berciano, M. T., Munuera, J., Villar-Rodil, S., Paredes, J. I., Rivero, M. J., Diban, N., & Urtiaga, A. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-17697-9 · Cited by 19 · see citing works
Copper pyrithione and zinc pyrithione induce cytotoxicity and neurotoxicity in neuronal/astrocytic co-cultured cells via oxidative stress
Oh, H., & Kim, W. (2023) · Scientific Reports · doi:10.1038/s41598-023-49740-8 · Cited by 19 · see citing works
The janus face of astrocytes in multiple sclerosis: Balancing protection and pathology
Abulaban, A. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Shokr, M. M., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111356 · Cited by 18 · see citing works
Pharmacologic Toll-like receptor 4 inhibition skews toward a favorable A1/A2 astrocytic ratio improving neurocognitive outcomes following traumatic brain injury
Baassiri, M. G. E., Rahal, S. S., Fulton, W. B., Sodhi, C. P., Hackam, D. J., & Nasr, I. W. (2023) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000003887 · Cited by 18 · see citing works
Are cytoskeleton changes observed in astrocytes functionally linked to aging?
Villablanca, C., Vidal, R. L., & González-Billault, C. E. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.03.007 · Cited by 18 · see citing works
Soybean as a model legume
Ferguson, B. J., & Gresshoff, P. M. (2009) · Cited by 18 · see citing works
BML-281 promotes neuronal differentiation by modulating Wnt/Ca2+ and Wnt/PCP signaling pathway
Choi, J., Gang, S., Ramalingam, M., Hwang, J., Jeong, H., Yoo, J., Cho, H., Kim, B. C., Jang, S., Jeong, H., et al. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04857-2 · Cited by 17 · see citing works
Serum and cerebrospinal fluid brain damage markers neurofilament light and glial fibrillary acidic protein correlate with tick‐borne encephalitis disease severity—a multicentre study on Lithuanian and Swedish patients
Veje, M., Griška, V., Pakalnienė, J., Mickienė, A., Bremell, D., Zetterberg, H., Blennow, K., Lindquist, L., & Studahl, M. (2023) · European Journal of Neurology · doi:10.1111/ene.15978 · Cited by 16 · see citing works
Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells
Ciarpella, F., Zamfir, R. G., Campanelli, A., Pedrotti, G., Chio, M. D., Bottani, E., & Decimo, I. (2023) · STAR Protocols · doi:10.1016/j.xpro.2023.102413 · Cited by 16 · see citing works
Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system
Schenck, J. K., Karl, M. T., Paredes, C. C., Bastin, A., Pushkarsky, T., Břicháček, B., Miller, R. H., & Bukrinsky, M. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03124-5 · Cited by 15 · see citing works
The Dual Role of Astrocytes in CNS Homeostasis and Dysfunction
Tiwari, A., Rout, S., Deep, P., Sahu, C., & Samal, P. K. (2025) · Neuroglia · doi:10.3390/neuroglia6040038 · Cited by 17 · see citing works
An independent regulator of global release pathways in astrocytes generates a subtype of extracellular vesicles required for postsynaptic function
Levy-Myers, R., Daudelin, D., Na, C. H., & Sockanathan, S. (2023) · Science Advances · doi:10.1126/sciadv.adg2067 · Cited by 15 · see citing works
Engineering circuits of human iPSC-derived neurons and rat primary glia
Girardin, S., Ihle, S. J., Menghini, A., Krubner, M., Tognola, L., Duru, J., Fruh, I., Müller, M., Ruff, T., & Vörös, J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1103437 · Cited by 14 · see citing works
Combined effect of Cerium oxide nanoparticles loaded scaffold and photobiomodulation therapy on pain and neuronal regeneration following spinal cord injury: an experimental study
Behroozi, Z., Rahimi, B., Motamednezhad, A., Ghadaksaz, A., Hormozi‐Moghaddam, Z., Moshiri, A., Jafarpour, M., Hajimirzaei, P., Ataie, A., & Janzadeh, A. (2024) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-023-00501-6 · Cited by 14 · see citing works
Overexpression of pathogenic tau in astrocytes causes a reduction in AQP4 and GLT1, an immunosuppressed phenotype and unique transcriptional responses to repetitive mild TBI without appreciable changes in tauopathy
Ortiz, C., Pearson, A., McCartan, R., Roche, S., Carothers, N., Browning, M., Perez, S. E., He, B., Ginsberg, S. D., MULLAN, M. J., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03117-4 · Cited by 14 · see citing works
Neuronal differentiation requires BRAT1 complex to remove REST from chromatin
Dokaneheifard, S., Santos, H. G. D., Valencia, M. G., Harikumar, A., Edupuganti, R. R., & Shiekhattar, R. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2318740121 · Cited by 13 · see citing works
Alpha-Pinene Decreases the Elevated Levels of Astrogliosis, Pyroptosis, and Autophagy Markers in the Hippocampus Triggered by Kainate in a Rat Model of Temporal Lobe Epilepsy
Hashemi, P., Mardani, P., Raz, Z. E., Saedi, A., Fatahi, E., Izapanah, E., & Ahmadi, S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04407-x · Cited by 14 · see citing works
Human iPSC-Derived Astrocytes: A Powerful Tool to Study Primary Astrocyte Dysfunction in the Pathogenesis of Rare Leukodystrophies
Lanciotti, A., Brignone, M. S., Macioce, P., Visentin, S., & Ambrosini, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010274 · Cited by 14 · see citing works
Diminished LC3-Associated Phagocytosis by Huntington’s Disease Striatal Astrocytes
Wakida, N. M., Lau, A., Nguyen, J., Cruz, G. M. S., Fote, G., Steffan, J. S., Thompson, L. M., & Berns, M. W. (2022) · Journal of Huntington s Disease · doi:10.3233/jhd-210502 · Cited by 15 · see citing works
Systemic Maternal Human sFLT1 Overexpression Leads to an Impaired Foetal Brain Development of Growth‐Restricted Foetuses upon Experimental Preeclampsia
Vogtmann, R., Burk, L. V., Serdar, M., Kimmig, R., Bendix, I., & Gellhaus, A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3024032 · Cited by 14 · see citing works
Central neuropeptides as key modulators of astrocyte function in neurodegenerative and neuropsychiatric disorders
Yang, M., Jia, M., Cai, M., Feng, X., Huang, L., & Yang, J. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06840-9 · Cited by 16 · see citing works
Role of astrocytes in the pathogenesis of perinatal brain injury
Li, L., Cui, X., Zhu, B., Zhou, L., Guo, Y., Liu, T., & Shi, Y. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01328-w · Cited by 13 · see citing works
A combined use of silver pretreatment and impregnation with consequent Nissl staining for cortex and striatum architectonics study
Piavchenko, G. A., Soldatov, V. O., Venediktov, A. A., Kartashkina, N. L., Novikova, N. S., Gorbunova, M., Boronikhina, T. V., Yatskovskiy, A. N., Meglinski, I. V., & Kuznetsov, S. L. (2022) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2022.940993 · Cited by 13 · see citing works
Changes in astrocyte function induced by stress-induced glucocorticoid exacerbate major depressive disorder
Park, B., & Choi, G. E. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102786 · Cited by 13 · see citing works
Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease
Soubannier, V., Chaineau, M., Gursu, L., Haghi, G., Franco-Flores, A. K., Rouleau, G. A., Durcan, T. M., & Stifani, S. (2022) · Cells · doi:10.3390/cells11030399 · Cited by 12 · see citing works
Astrocytes in the Neuropathology of Bipolar Disorder: Review of Current Evidence
Dai, N., Jones, B. D. M., & Husain, M. I. (2022) · Brain Sciences · doi:10.3390/brainsci12111513 · Cited by 13 · see citing works
Short-term biological variation of serum glial fibrillary acidic protein
Christensen, S. H., Hviid, C. V. B., Madsen, A. T., Parkner, T., & Winther‐Larsen, A. (2022) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2022-0480 · Cited by 13 · see citing works
Therapeutic Properties of Ayahuasca Components in Ischemia/Reperfusion Injury of the Eye
Szilágyi, A., Takács, B., Szekeres, R., Tarjányi, V., Bombicz, M., Priksz, D., Kovacs, A. I., Juhász, B., Frecska, E., Szilvássy, Z., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10050997 · Cited by 12 · see citing works
Utilization of ethanolamine phosphate phospholyase as a unique astrocytic marker
Tsujioka, H., & Yamashita, T. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1097512 · Cited by 11 · see citing works
Neuropathic-like Nociception and Spinal Cord Neuroinflammation Are Dependent on the TRPA1 Channel in Multiple Sclerosis Models in Mice
Dalenogare, D. P., de Araújo, D. S. M., Landini, L., Titiz, M., Siena, G. D., Logu, F. D., Geppetti, P., Nassini, R., & Trevisan, G. (2023) · Cells · doi:10.3390/cells12111511 · Cited by 12 · see citing works
Role of Cytoskeletal Elements in Regulation of Synaptic Functions: Implications Toward Alzheimer’s Disease and Phytochemicals-Based Interventions
Verma, H., Kaur, S., Kaur, S., Gangwar, P., Dhiman, M., & Mantha, A. K. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04053-3 · Cited by 11 · see citing works
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies
Rathee, S., Sen, D., Pandey, V., & Jain, S. (2024) · Current Drug Targets · doi:10.2174/0113894501320096240627071400 · Cited by 13 · see citing works
Cerebral Organoids Maintain the Expression of Neural Stem Cell-Associated Glycoepitopes and Extracellular Matrix
Roll, L., Lessmann, K., Brüstle, O., & Faissner, A. (2022) · Cells · doi:10.3390/cells11050760 · Cited by 12 · see citing works
Cortical Pathology in Vanishing White Matter
Man, J. H. K., van Gelder, C. A. G. H., Breur, M., Okkes, D., Molenaar, D., van der Sluis, S., Abbink, T. E. M., Altelaar, M. A. F., van der Knaap, M. S., & Bugiani, M. (2022) · Cells · doi:10.3390/cells11223581 · Cited by 11 · see citing works
Specific Methyl-CpG Configurations Define Cell Identity through Gene Expression Regulation
Improda, T., Morgera, V., Vitale, M., Chiariotti, L., Passaro, F., Feola, A., Porcellini, A., Cuomo, M., & Pezone, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24129951 · Cited by 11 · see citing works
CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells
Bayat, H., Mirahmadi, M., Azarshin, Z., Ohadi, H., Delbari, A., & Ohadi, M. (2024) · Scientific Reports · doi:10.1038/s41598-024-52675-3 · Cited by 11 · see citing works
Hepatic ketogenesis is not required for starvation adaptation in mice
Feola, K. C., Venable, A. H., Broomfield, T., Villegas, M., Fu, X., Burgess, S. C., & Huen, S. C. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.101967 · Cited by 11 · see citing works
Enrichment of Glial Cells From Human Post-mortem Tissue for Transcriptome and Proteome Analysis Using Immunopanning
Nölle, A., van Dijken, I., Waelti, C. M., Calini, D., Bryois, J., Lezan, E., Golling, S., Augustin, A., Foo, L. C., & Hoozemans, J. J. M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.772011 · Cited by 10 · see citing works
Neural lineage differentiation of human pluripotent stem cells: Advances in disease modeling
Yan, Y.-W., Qian, E. S., Woodard, L. E., & Bejoy, J. (2023) · World Journal of Stem Cells · doi:10.4252/wjsc.v15.i6.530 · Cited by 11 · see citing works
Comparison of two protocols for the generation of iPSC-derived human astrocytes
Mulica, P., Venegas, C., Landoulsi, Z., Badanjak, K., Delcambre, S., Tziortziou, M., Hezzaz, S., Ghelfi, J., Smajić, S., Schwamborn, J. C., et al. (2023) · Biological Procedures Online · doi:10.1186/s12575-023-00218-x · Cited by 10 · see citing works
Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment
Shen, K., Shi, Y., Wang, X., & Leung, S. W. S. (2024) · Aging and Disease · doi:10.14336/ad.202.0424 · Cited by 11 · see citing works
Role of tunneling nanotubes in neuroglia
Xu, W., Yang, X., Zheng, H., Chen, C., & Yuan, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01129 · Cited by 10 · see citing works
A human neuron Alzheimer’s disease model reveals barriers to senolytic translatability
Walton, C. C., Wang, E. Y., Lee, S., Siebrand, C. J., Bergo, N. J., Mayeri, Z., & Andersen, J. K. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01822-7 · Cited by 10 · see citing works
STORIES: learning cell fate landscapes from spatial transcriptomics using optimal transport
Huizing, G.-J., Samaran, J., Capocefalo, D., Audit, A., Gabriel Peyré, A., & Cantini, L. (2025) · Nature Methods · doi:10.1038/s41592-025-02855-4 · Cited by 14 · see citing works
Clickable Biomaterials for Modulating Neuroinflammation
Cornelison, R. C., & Fadel, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158496 · Cited by 10 · see citing works
Astrocytic Responses to Binge Alcohol Intake in the Mouse Hindbrain
Hasegawa, H., & Kondo, M. (2023) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b23-00140 · Cited by 9 · see citing works
Tuning a Bioengineered Hydrogel for Studying Astrocyte Reactivity in Glioblastoma
DePalma, T. J., Hisey, C. L., Hughes, K., Fraas, D., Tawfik, M., Scharenberg, J., Wiggins, S., Nguyen, K. T., Hansford, D. J., Reátegui, E., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.09.048 · Cited by 9 · see citing works
Identifying similar populations across independent single cell studies without data integration
González-Velasco, Ó., Simon, M., Yilmaz, R., Parlato, R., Weishaupt, J. H., Imbusch, C. D., & Brors, B. (2025) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqaf042 · Cited by 9 · see citing works
Neuroprotective potential of eugenol against acrylamide-induced brain toxicity by regulating Nrf2/NQO1/HO-1 and NLRP3/NF-κB/IL-1β signaling cascades
Baraka, S. M., Hussien, Y. A., Ahmed-Farid, O. A.-H., Hassan, A. M., & Saleh, D. O. (2026) · Scientific Reports · doi:10.1038/s41598-025-34650-8 · Cited by 9 · see citing works
Effects of Aloe-Emodin on the Expression of Brain Aquaporins and Secretion of Neurotrophic Factors in a Rat Model of Post-Stroke Depression
Liu, Y., Peng, J., Leng, Q., Tian, Y., Wu, X., & Tan, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065206 · Cited by 9 · see citing works
Neuroimmune Interactions in Fetal Alcohol Spectrum Disorders: Potential Therapeutic Targets and Intervention Strategies
Mukherjee, S., Tarale, P., & Sarkar, D. K. (2023) · Cells · doi:10.3390/cells12182323 · Cited by 9 · see citing works
Metabolic disorders exacerbate the formation of glial scar after stroke
Clain, J., Couret, D., Bringart, M., Lecadieu, A., Meilhac, O., d’Hellencourt, C. L., & Diotel, N. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16325 · Cited by 9 · see citing works
Effects of voluntary and forced physical exercise on the retinal health of aging Wistar rats
Szilágyi, A., Takács, B., Szekeres, R., Tarjányi, V., Nagy, D., Priksz, D., Bombicz, M., Kiss, R., Szabó, A. M., Lehoczki, A., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01208-x · Cited by 9 · see citing works
Predicting Role of GFAP and UCH-L1 biomarkers in Spontaneous Subarachnoid Hemorrhage: a preliminary study to evaluate in the short-term their correlation with severity of bleeding and prognosis
Auricchio, A., Baroni, S., Jahromi, B. R., Gris, A. V., Sturiale, C. L., Ceccarelli, G. M., Obersnel, M., Menna, G., Martinelli, R., Napoli, G., et al. (2024) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2024.06.003 · Cited by 9 · see citing works
Increased Acetylcholine Levels and Other Brain Effects in 5XFAD Mice after Treatment with 8,14-Dihydroxy Metabolite of Efavirenz
Mast, N., Li, Y., & Pikuleva, I. A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147669 · Cited by 9 · see citing works
Regulation of sleep quantity and intensity by long and short isoforms of SLEEPY kinase
Xu, J., Zhou, R., Wang, G., Guo, Y., Gao, X., Zhou, S., Ma, C., Chen, L., Shi, B., Wang, H., et al. (2022) · SLEEP · doi:10.1093/sleep/zsac198 · Cited by 9 · see citing works
Cortistatin exerts an immunomodulatory and neuroprotective role in a preclinical model of ischemic stroke
Castillo-González, J., Buscemi, L., Vargas-Rodríguez, P., Serrano-Martínez, I., Forte‐Lago, I., Caro, M., Price, M., Hernández‐Cortés, P., Hirt, L., & González‐Rey, E. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107501 · Cited by 8 · see citing works
The P38MAPK Pathway Mediates the Destruction of the Blood–Brain Barrier in Anti-NMDAR Encephalitis Mice
Lao, D., Gong, Z., Li, T., Mo, X., & Huang, W. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04270-1 · Cited by 8 · see citing works
Long-term live-cell imaging of GFAP+ astroglia and laminin+ vessels in organotypic mouse brain slices using microcontact printing
Humpel, C. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1540150 · Cited by 8 · see citing works
Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma
van Hijfte, L., Geurts, M., de Heer, I. J., Ghisai, S. A., Balcioglu, H. E., Hoogstrate, Y., Vallentgoed, W., Head, R., Luning, R., van den Bosch, T. P. P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-56441-5 · Cited by 8 · see citing works
Diagnostic dynamic contrast-enhanced magnetic resonance imaging blood-brain barrier assessment combined with plasma biomarkers for mild cognitive impairment
Sun, L. V., Xu, M., Zhou, C., Cao, S.-D., Zhang, X., Guan, S.-Q., Sang, W.-X., & Li, X. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i6.103661 · Cited by 8 · see citing works
Do astrocytes act as immune cells after pediatric TBI?
Panchenko, P. E., Hippauf, L., Konsman, J. P., & Badaut, J. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106231 · Cited by 8 · see citing works
How Can Proteomics Help to Elucidate the Pathophysiological Crosstalk in Muscular Dystrophy and Associated Multi-System Dysfunction?
Dowling, P., Trollet, C., Négroni, E., Swandulla, D., & Ohlendieck, K. (2024) · Proteomes · doi:10.3390/proteomes12010004 · Cited by 9 · see citing works
Positive impact of indicaxanthin from Opuntia ficus-indica fruit on high-fat diet–induced neuronal damage and gut microbiota dysbiosis
Terzo, S., Amato, A., Calvi, P., Giardina, M., Nuzzo, D., Picone, P., Piccionello, A. P., Amata, S., Giardina, I. C., Massaro, A. S., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-02039 · Cited by 8 · see citing works
Exploring the effects of moxibustion on cognitive function in rats with multiple cerebral infarctions from the perspective of glial vascular unit repairing
Wang, J., Du, K., Liu, C., Chen, X., Ban, W., Zhu, G., & Yang, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1428907 · Cited by 8 · see citing works

Astrocyte Activation Markers
Gorina, Y. V., Salmina, A. B., Erofeev, A. I., Gerasimov, E., Bolshakova, A. V., Balaban, P. M., Борисович, Б. И., & Власова, О. Л. (2022) · Biochemistry (Moscow) · doi:10.1134/s0006297922090012 · Cited by 21 · see citing works
Astrocyte phenotypes: Emphasis on potential markers in neuroinflammation.
Bozic, I. D., Savić, D. Z., & Lavrnja, I. C. (2021) · PubMed · doi:10.14670/hh-18-284 · Cited by 21 · see citing works
ASTROCYTE MARKER ENZYMES
Sukhorukova, E. G., & Гусельникова, В. В. (2015) · Medical academic journal · doi:10.17816/maj15331-37
Markers of Central Nervous System Glia and Neurons In Vivo During Normal and Pathological Conditions
Redwine, J. M., & Evans, C. F. (2002) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-09525-6_6 · Cited by 22 · see citing works
Neurodegenerative Diseases: Unraveling the Heterogeneity of Astrocytes
Santiago-Balmaseda, A., Aguirre-Orozco, A., Valenzuela-Arzeta, I. E., Villegas-Rojas, M. M., Pérez‐Segura, I., Jiménez-Barrios, N., Hurtado-Robles, E., Rodríguez-Hernández, L. D., Rivera-German, E. R., Guerra‐Crespo, M., et al. (2024) · Cells · doi:10.3390/cells13110921 · Cited by 43 · see citing works

Authors: Jurga, A. M., Paleczna, M., Kadluczka, J., & Kuter, K. Z.
Affiliations: Maj Institute of Pharmacology (PL)
Department of Neuropsychopharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences, 31-343 Kraków, Poland
Corresponding author: Kuter, Katarzyna Z.
ORCID: Jurga, Agnieszka M.
Paleczna, Martyna
Kuter, Katarzyna Z.
Venue: Biomolecules
Publisher: MDPI AG
Published: 2021-09-14
Volume: 11
Issue: 9
Pages: 1361
ISSN: 2218-273X (ISSN-L)
DOI: 10.3390/biom11091361
PMC: PMC8468264
OpenAlex: W3201129361
Cited by: 319
References: 215
Citations by year: 2026: 58 · 2025: 85 · 2024: 85 · 2023: 50 · 2022: 37 · 2021: 3
FWCI: 5.17
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Biomolecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, other-oa)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk (OPUS14 2017/27/B/NZ7/00289)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: astrocytes, astrocyte markers, glial fibrillary acidic protein, glial heterogeneity, glial phenotype, astrocyte-neuron interaction, glial cells, aging, neurodegenerative diseases, diagnostic biomarkers, central nervous system
MeSH terms: Aging, Animals, Astrocytes, Brain, Cell Communication, Glial Fibrillary Acidic Protein, Humans, Biomarkers

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Beyond the GFAP-Astrocyte Protein Markers in the Brain

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks