Oral neonatal antibiotic treatment perturbs gut microbiota and aggravates central nervous system autoimmunity in dark agouti rats
Open accessAbstract
Gut microbiota dysbiosis has been considered the essential element in the pathogenesis of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). Antibiotics were administered orally to Dark Agouti (DA) rats early in their life with the aim of perturbing gut microbiota and investigating the effects of such intervention on the course of EAE. As a result, the diversity of the gut microbiota was reduced under the influence of antibiotics. Mainly, Firmicutes and Actinobacteria were replaced by Proteobacteria and Bacteroidetes, while decreased proportions of Clostridia and Bacilli classes were accompanied by an increase in Gamma-Proteobacteria in antibiotic-treated animals. Interestingly, a notable decrease in the Helicobacteraceae, Spirochaetaceae and Turicibacteriaceae was scored in antibiotic-treated groups. Also, levels of short chain fatty acids were reduced in the faeces of antibiotic-treated rats. Consequently, aggravation of EAE, paralleled with stronger immune response in lymph nodes draining the site of immunization, and increased inflammation within the CNS, were observed in antibiotic-treated DA rats. Thus, the alteration of gut microbiota leads to an escalation of CNS-directed autoimmunity in DA rats. The results of this study indicate that antibiotic use in early life may have subsequent unfavourable effects on the regulation of the immune system.
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The central nervous system becomes more prone to extreme inflammatory responses when the microbiota is depleted by antibiotics early in life.
“the CNS, which becomes more prone to extreme inflammatory responses when the microbiota is depleted by antibiotics early in life (104).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [104]
The Results (‘Effects of antibiotic treatment on EAE’) report more severe induced CNS autoimmune disease in rats treated with antibiotics early in life, including more spinal-cord immune-cell infiltration and higher inflammatory cytokine levels. The claim omits that this was shown in EAE-susceptible rats after a later immune challenge, and ‘extreme inflammatory responses’ is stronger and broader than the reported finding. (LLM, conf=0.85)
Experimental — accuracy not yet measuredAntibiotic-treated and germ-free mice have pro-inflammatory systemic and CNS immune responses.
“Antibiotic-treated and germ-free mice have pro-inflammatory systemic and CNS immune system responses (120, 267).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [267]
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Stanisavljević, S., Dinić, M., Jevtić, B., Nikolovski, N., Momčilović, M. B., Đokić, J., Golić, N., Stojković, M. M., & Miljković, D. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00942 · Cited by 30 · see citing works
Self-citationStrain-specific helper T cell profile in the gut-associated lymphoid tissue
Stanisavljević, S., Nikolovski, N., Vujičić, M., Saksida, T., Jevtić, B., Milovanović, B., Momčilović, M. B., Miljković, D. M., & Stojanović, I. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.08.017 · Cited by 14 · see citing works
Self-citation
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The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043 · see citing works
“Among its etiological factors, the imbalance between pro and anti-inflammatory cells in the immune system seems to play an important role, which is highly affected by the gut microbiota composition and can be aggravated by dysbiosis (104, 176, 177).”
BackgroundSignalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Understanding the Gut–Brain Axis and Its Therapeutic Implications for Neurodegenerative Disorders
Zheng, Y., Bonfili, L., Wei, T., & Eleuteri, A. M. (2023) · Nutrients · doi:10.3390/nu15214631 · Cited by 175 · see citing works
- Authors
- Stanisavljević, S., Čepić, A., Bojić, S., Veljović, K., Mihajlović, S., Đedović, N., Jevtić, B., Momčilović, M., Lazarević, M., Mostarica Stojković, M., Miljković, Đ., & Golić, N.
- Affiliations
- University of Belgrade (RS)
- Corresponding author
- Golić, Nataša
- ORCID
- Venue
- Scientific Reports
- Published
- 2019-01-29
- Volume
- 9
- Issue
- 1
- Pages
- 918-918
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6351648
- OpenAlex
- W2912754252
- Cited by
- 43
- References
- 84
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 7 · 2022: 5 · 2021: 11 · 2020: 4 · 2019: 4
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Digital Repository of Archived Publications (University of Belgrade, Institute for Biological Research Sinisa Stankovic) (submittedVersion, cc-by)
- Funders
- Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (No. 173019, 173019, 173035, 173013)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- oral antibiotic therapy, neonatal antibiotic exposure, gut dysbiosis, experimental autoimmune encephalomyelitis, multiple sclerosis, central nervous system autoimmunity, Dark Agouti rats, short-chain fatty acids, Helicobacteraceae, Spirochaetaceae, neuroinflammation, immune regulation
- MeSH terms
- Gastrointestinal Microbiome, Administration, Oral, Animals, Anti-Bacterial Agents, Central Nervous System, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental, Autoimmunity, Cytokines, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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