Neural correlates of the DMT experience assessed with multivariate EEG
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Abstract
Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.
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The study excluded participants with more than 15 lifetime psychedelic experiences, resulting in a sample with no or only little previous psychedelic experience.
“While other studies investigating psychedelics often include participants with previous psychedelic experience (17, 18), we excluded participants more than 15 lifetime psychedelic experiences resulting in a sample with no or only little previous psychedelic experience.”
From Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects (2024) · cites this paper as [17]
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A complex systems perspective on psychedelic brain action
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Self-citationPhenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience
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Pharmacokinetics of N,N-dimethyltryptamine in Humans
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Self-citationNeural Correlates of the Shamanic State of Consciousness
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Psychological and physiological effects of extended DMT
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Self-citationRETRACTED ARTICLE: A mechanistic model of the neural entropy increase elicited by psychedelic drugs
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Prefrontal contributions to the stability and variability of thought and conscious experience
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Self-citationEffects of DMT on mental health outcomes in healthy volunteers
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Relational Processes in Ayahuasca Groups of Palestinians and Israelis
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Self-citationN,N‐dimethyltryptamine and Amazonian ayahuasca plant medicine
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Taking Different Roads: l ‐Tryptophan as the Origin of Psilocybe Natural Products
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Altered states phenomena induced by visual flicker light stimulation
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Psilocybin and Other Classic Psychedelics in Depression
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Self-citationCatalysts for change: the cellular neurobiology of psychedelics
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Dissolving the self:Active inference, psychedelics, and ego-dissolution
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Meditation and complexity: a review and synthesis of evidence
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Brain activity complexity has a nonlinear relation to the level of propofol sedation
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“While other studies investigating psychedelics often include participants with previous psychedelic experience (17, 18), we excluded participants more than 15 lifetime psychedelic experiences resulting in a sample with no or only little previous psychedelic experience.”
BackgroundExploring mechanisms of psychedelic action using neuroimaging
Erritzøe, D., Timmermann, C., Godfrey, K. E. M., Castro-Rodrigues, P., Peill, J. M., Carhart-Harris, R. L., Nutt, D., & Wall, M. B. (2024) · Nature Mental Health · doi:10.1038/s44220-023-00172-3 · Cited by 33 · see citing works
Self-citationBreathwork-induced psychedelic experiences modulate neural dynamics
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Within-treatment changes in a novel addiction treatment program using traditional Amazonian medicine
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Neural mechanisms of psychedelic visual imagery
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A Comprehensive Review of the Current Status of the Cellular Neurobiology of Psychedelics
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EEG Lempel-Ziv complexity varies with sleep stage, but does not seem to track dream experience
Aamodt, A., Sevenius Nilsen, A., Markhus, R., Kusztor, A., HasanzadehMoghadam, F., Kauppi, N., Thürer, B., Storm, J. F., & Juel, B. E. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.987714 · Cited by 30 · see citing works
A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex
Luppi, A. I., Girn, M., Rosas, F. E., Timmermann, C., Roseman, L., Erritzøe, D., Nutt, D., Stamatakis, E. A., Spreng, R. N., Xing, L., et al. (2023) · Brain · doi:10.1093/brain/awad311 · Cited by 30 · see citing works
Self-citationHuman brain changes after first psilocybin use
Lyons, T., Spriggs, M., Kerkelä, L., Rosas, F. E., Roseman, L., Mediano, P. A. M., Timmermann, C., Oestreich, L., Pagni, B. A., Zeifman, R. J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71962-3 · Cited by 30 · see citing works
Self-citationA neuroscientific model of near-death experiences
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The evolution of N, N-Dimethyltryptamine: from metabolic pathways to brain connectivity
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Frohlich, J., Chiang, J. N., Mediano, P. A. M., Nespeca, M., Saravanapandian, V., Toker, D., Dell’Italia, J., Hipp, J. F., Jeste, S., Chu, C. J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04331-7 · Cited by 30 · see citing works
Singleton, S. P., Luppi, A. I., Carhart-Harris, R. L., Cruzat, J., Roseman, L., Nutt, D. J., Deco, G., Kringelbach, M. L., Stamatakis, E. A., & Kuceyeski, A. F. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.14.444193 · Cited by 30 · see citing works
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A Computational Account of the Development and Evolution of Psychotic Symptoms
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Nonlinear EEG signatures of mind wandering during breath focus meditation
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Exploring 5-MeO-DMT as a pharmacological model for deconstructed consciousness
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Self-citationPredictors and potentiators of psychedelic-occasioned mystical experiences
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Complex slow waves in the human brain under 5-MeO-DMT
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DMT alters cortical travelling wavesPreprint
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Self-citationThe science of psychedelic medicine
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Self-citationLanguage as a Window Into the Altered State of Consciousness Elicited by Psychedelic Drugs
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Self-citation
- Authors
- Timmermann, C., Roseman, L., Schartner, M., Milliere, R., Williams, L. T. J., Erritzoe, D., Muthukumaraswamy, S., Ashton, M., Bendrioua, A., Kaur, O., Turton, S., Nour, M. M., Day, C. M., Leech, R., Nutt, D. J., & Carhart-Harris, R. L.
- Affiliations
- Imperial College London (GB)
- University of Geneva (CH)
- University of Auckland (NZ)
- University of Gothenburg (SE)
- King's College London (GB)
- University of Oxford (GB)
- Corresponding author
- Timmermann, Christopher
- ORCID
- Venue
- Scientific Reports
- Published
- 2019-11-19
- Volume
- 9
- Issue
- 1
- Pages
- 16324-16324
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6864083
- OpenAlex
- W2991342487
- Cited by
- 315
- References
- 66
- Citations by year
- 2026: 41 · 2025: 51 · 2024: 71 · 2023: 55 · 2022: 35 · 2021: 37 · 2020: 23 · 2019: 1
- FWCI
- 28.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, cc-by)
- Funders
- Consejo Nacional de Ciencia y Tecnología
- Imperial College President's PhD Scholarship Scheme and Albert Hobohm
- RCUK | STFC | Central Laser Facility, Science and Technology Facilities Council
- SM is supported by a Rutherford Discovery Fellowship
- DJN is supported by the Safra Foundation
- RCH is supported by the Alex Mosley Charitable Trust and Ad Astra Chandaria Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Social Sciences › Psychology › Social Psychology › Paranormal Experiences and Beliefs
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- N,N-dimethyltryptamine, DMT, altered states of consciousness, neural oscillations, signal diversity, subjective experience, neurophenomenology, delta oscillations, theta oscillations, plasma drug concentration
- MeSH terms
- Adult, Brain, Consciousness, N,N-Dimethyltryptamine, Electroencephalography, Female, Hallucinogens, Humans, Male, Multivariate Analysis, Case-Control Studies, Administration, Intravenous
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