Cited by 315Psychedelics and Drug StudiesParanormal Experiences and BeliefsNeural dynamics and brain function

Neural correlates of the DMT experience assessed with multivariate EEG

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Timmermann, Christopher, Roseman, Leor, Schartner, Michael, Milliere, Raphael, Williams, Luke T. J., Erritzoe, David, Muthukumaraswamy, Suresh, Ashton, Michael +8 more·2019·Scientific Reports

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Abstract

Studying transitions in and out of the altered state of consciousness caused by intravenous (IV) N,N-Dimethyltryptamine (DMT - a fast-acting tryptamine psychedelic) offers a safe and powerful means of advancing knowledge on the neurobiology of conscious states. Here we sought to investigate the effects of IV DMT on the power spectrum and signal diversity of human brain activity (6 female, 7 male) recorded via multivariate EEG, and plot relationships between subjective experience, brain activity and drug plasma concentrations across time. Compared with placebo, DMT markedly reduced oscillatory power in the alpha and beta bands and robustly increased spontaneous signal diversity. Time-referenced and neurophenomenological analyses revealed close relationships between changes in various aspects of subjective experience and changes in brain activity. Importantly, the emergence of oscillatory activity within the delta and theta frequency bands was found to correlate with the peak of the experience - particularly its eyes-closed visual component. These findings highlight marked changes in oscillatory activity and signal diversity with DMT that parallel broad and specific components of the subjective experience, thus advancing our understanding of the neurobiological underpinnings of immersive states of consciousness.

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  1. [4]Strassman, R. DMT: The spirit molecule. (Park Street Press, 2001).

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Authors
Timmermann, C., Roseman, L., Schartner, M., Milliere, R., Williams, L. T. J., Erritzoe, D., Muthukumaraswamy, S., Ashton, M., Bendrioua, A., Kaur, O., Turton, S., Nour, M. M., Day, C. M., Leech, R., Nutt, D. J., & Carhart-Harris, R. L.
Affiliations
  • Imperial College London (GB)
  • University of Geneva (CH)
  • University of Auckland (NZ)
  • University of Gothenburg (SE)
  • King's College London (GB)
  • University of Oxford (GB)
Corresponding author
Timmermann, Christopher
Venue
Scientific Reports
Published
2019-11-19
Volume
9
Issue
1
Pages
16324-16324
ISSN
2045-2322 (ISSN-L)
OpenAlex
W2991342487
Cited by
315
References
66
Citations by year
2026: 41 · 2025: 51 · 2024: 71 · 2023: 55 · 2022: 35 · 2021: 37 · 2020: 23 · 2019: 1
FWCI
28.03
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Funders
  • Consejo Nacional de Ciencia y Tecnología
  • Imperial College President's PhD Scholarship Scheme and Albert Hobohm
  • RCUK | STFC | Central Laser Facility, Science and Technology Facilities Council
  • SM is supported by a Rutherford Discovery Fellowship
  • DJN is supported by the Safra Foundation
  • RCH is supported by the Alex Mosley Charitable Trust and Ad Astra Chandaria Foundation
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Social Sciences › Psychology › Social Psychology › Paranormal Experiences and Beliefs
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
N,N-dimethyltryptamine, DMT, altered states of consciousness, neural oscillations, signal diversity, subjective experience, neurophenomenology, delta oscillations, theta oscillations, plasma drug concentration
MeSH terms
Adult, Brain, Consciousness, N,N-Dimethyltryptamine, Electroencephalography, Female, Hallucinogens, Humans, Male, Multivariate Analysis, Case-Control Studies, Administration, Intravenous

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