Decision making by p53: life, death and cancer

Surfing the p53 network

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Wnt signaling and cancer

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Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage

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Disruption of p53 in human cancer cells alters the responses to therapeutic agents.

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p53-Dependent apoptosis suppresses tumor growth and progression in vivo

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Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53

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ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

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MDM2 — master regulator of the p53 tumor suppressor protein

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Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

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Insulin and IGF-1 stimulate the β-catenin pathway through two signalling cascades involving GSK-3β inhibition and Ras activation

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Free radicals, metals and antioxidants in oxidative stress-induced cancer

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Cellular processing of platinum anticancer drugs

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Four faces of cellular senescence

Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,070

The p53 pathway: positive and negative feedback loops

Harris, S. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208615 · Cited by 1,967

The miR-34 family in cancer and apoptosis

Hermeking, H. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.56 · Cited by 1,236

When mutants gain new powers: News from the mutant p53 field

Brosh, R., & Rotter, V. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2693 · Cited by 1,132

p53 isoforms can regulate p53 transcriptional activity

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Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

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Inactivation of the p53 pathway in retinoblastoma

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MDM2 inhibitors for cancer therapy

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Structural Basis of DNA Recognition by p53 Tetramers

Kitayner, M., Rozenberg, H., Kessler, N., Rabinovich, D., Shaulov, L., Haran, T. E., & Shakked, Z. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.05.015 · Cited by 408

PML Is a Direct p53 Target that Modulates p53 Effector Functions

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., & Lowe, S. W. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00062-0 · Cited by 312

A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis.

Kracikova, M., Akiri, G., George, A., Sachidanandam, R., & Aaronson, S. A. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2012.155 · Cited by 261

Cell fate decision mediated by p53 pulses

Zhang, X.-P., Liu, F., Cheng, Z., & Wang, W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813088106 · Cited by 253

How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosis

Batista, L. F. Z., Kaina, B., Meneghini, R., & Menck, C. F. M. (2009) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.09.001 · Cited by 234

Ultraviolet radiation-induced apoptosis in keratinocytes: On the role of cytosolic factors

Assefa, Z., Van Laethem, A., Garmyn, M., & Agostinis, P. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.04.001 · Cited by 212

Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis

Yamaguchi, Y., Takahashi, K., Zmudzka, B. Z., Kornhauser, A., Miller, S. A., Tadokoro, T., Berens, W., Beer, J. Z., Hearing, V. J., Yamaguchi, Y., et al. (2006) · The FASEB Journal · doi:10.1096/fj.06-5725fje · Cited by 205

The Isoforms of the p53 Protein

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Regulation of AIF expression by p53

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p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site

Liu, X., Yue, P., Khuri, F. R., & Sun, S.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1195 · Cited by 184

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

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Role for KAP1 Serine 824 Phosphorylation and Sumoylation/Desumoylation Switch in Regulating KAP1-mediated Transcriptional Repression

Li, X., Lee, Y.-K., Jeng, J.-C., Yen, Y., Schultz, D. C., Shih, H.-M., & Ann, D. K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706912200 · Cited by 168

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo

Saville, M. K., Sparks, A., Xirodimas, D. P., Wardrop, J., Stevenson, L. F., Bourdon, J.-C., Woods, Y. L., & Lane, D. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403362200 · Cited by 158

Autophagy protects the retina from light-induced degeneration

Chen, Y., Sawada, O., Kohno, H., Le, Y.-Z., Subauste, C., Maeda, T., & Maeda, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439935 · Cited by 152

The UMD TP53 database and website: update and revisions

Hamroun, D., Kato, S., Ishioka, C., Claustres, M., Béroud, C., & Soussi, T. (2006) · Human Mutation · doi:10.1002/humu.20269 · Cited by 140

p53-dependent Down-regulation of Telomerase Is Mediated by p21

Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402502200 · Cited by 133

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

Gräff, J., Kahn, M., Samiei, A., Gao, J., Ota, K. T., Rei, D., & Tsai, L.-H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5657-12.2013 · Cited by 124

Protein–protein interactions as targets for small-molecule therapeutics in cancer

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Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors

North, S., Moenner, M., & Bikfalvi, A. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.08.007 · Cited by 113

Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay

Herman, A. G., Hayano, M., Poyurovsky, M. V., Shimada, K., Skouta, R., Prives, C., & Stockwell, B. R. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0104 · Cited by 100

The Pineal Gland from Development to Function

Sapède, D., & Cau, E. (2013) · Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416021-7.00005-5 · Cited by 102

Apoptosis or growth arrest: Modulation of tumor suppressor p53's specificity by bacterial redox protein azurin

Yamada, T., Hiraoka, Y., Ikehata, M., Kimbara, K., Avner, B. S., Das Gupta, T. K., & Chakrabarty, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400899101 · Cited by 98

Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

Pereg, Y., Lam, S., Teunisse, A., Biton, S., Meulmeester, E., Mittelman, L., Buscemi, G., Okamoto, K., Taya, Y., Shiloh, Y., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00562-06 · Cited by 93

Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53–MDM2 Inhibitor HDM201

Jeay, S., Ferretti, S., Holzer, P., Fuchs, J., Chapeau, E. A., Wartmann, M., Sterker, D., Romanet, V., Murakami, M., Kerr, G., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0338 · Cited by 87

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

Menendez, D., Inga, A., & Resnick, M. A. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.6.2297-2308.2006 · Cited by 81

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

Okamoto, K., Taya, Y., & Nakagama, H. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.07.021 · Cited by 76

Watching the watcher: Regulation of p53 by mitochondria

Holley, A. K., & St Clair, D. K. (2009) · Future Oncology · doi:10.2217/14796694.5.1.117 · Cited by 75

The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase

Sanduja, S., Kaza, V., & Dixon, D. A. (2009) · Aging · doi:10.18632/aging.100086 · Cited by 65

Molecular epidemiology of adrenocortical tumors in southern Brazil

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Full-length hdmX transcripts decrease following genotoxic stress

Markey, M., & Berberich, S. J. (2008) · Oncogene · doi:10.1038/onc.2008.266 · Cited by 38

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2

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DAZAP2 acts as specifier of the p53 response to DNA damage

Liebl, M. C., Moehlenbrink, J., Becker, H., Raddatz, G., Abdeen, S. K., Aqeilan, R. I., Lyko, F., & Hofmann, T. G. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab084 · Cited by 20

HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZ

Miyajima, C., Hayakawa, Y., Inoue, Y., Nagasaka, M., & Hayashi, H. (2022) · Pharmaceuticals · doi:10.3390/ph15081015 · Cited by 17

Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53

Fiorini, A., Sultana, R., Barone, E., Cenini, G., Perluigi, M., Mancuso, C., Cai, J., Klein, J. B., St. Clair, D., & Butterfield, D. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049846 · Cited by 16