Oxytocin and Reduction of Social Threat Hypersensitivity in Women With Borderline Personality Disorder
Abstract
OBJECTIVE: Patients with borderline personality disorder are characterized by emotional hyperarousal with increased stress levels, anger proneness, and hostile, impulsive behaviors. They tend to ascribe anger to ambiguous facial expressions and exhibit enhanced and prolonged reactions in response to threatening social cues, associated with enhanced and prolonged amygdala responses. Because the intranasal administration of the neuropeptide oxytocin has been shown to improve facial recognition and to shift attention away from negative social information, the authors investigated whether borderline patients would benefit from oxytocin administration. METHOD: In a randomized placebo-controlled double-blind group design, 40 nonmedicated, adult female patients with a current DSM-IV diagnosis of borderline personality disorder (two patients were excluded based on hormonal analyses) and 41 healthy women, matched on age, education, and IQ, took part in an emotion classification task 45 minutes after intranasal administration of 26 IU of oxytocin or placebo. Dependent variables were latencies and number or initial reflexive eye movements measured by eye tracking, manual response latencies, and blood-oxygen-level-dependent responses of the amygdala to angry and fearful compared with happy facial expressions. RESULTS: Borderline patients exhibited more and faster initial fixation changes to the eyes of angry faces combined with increased amygdala activation in response to angry faces compared with the control group. These abnormal behavioral and neural patterns were normalized after oxytocin administration. CONCLUSIONS: Borderline patients exhibit a hypersensitivity to social threat in early, reflexive stages of information processing. Oxytocin may decrease social threat hypersensitivity and thus reduce anger and aggressive behavior in borderline personality disorder or other psychiatric disorders with enhanced threat-driven reactive aggression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
OT administration dampened amygdala reactivity toward emotional stimuli in healthy males, males with GSAD, and females with BPD, although findings for females have been mixed.
“In addition, functional MRI (fMRI) studies have shown that OT administration dampened amygdala reactivity toward emotional stimuli in healthy males (Kirsch et al, 2005), males with generalized social anxiety disorder (GSAD; Labuschagne et al, 2010) and females with borderline personality disorder (BPD; Bertsch et al, 2013), although findings for females have been mixed (Domes et al, 2010).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Bertsch et al, 2013
The study cannot exclude the possibility that not standardizing menstrual cycle phase may have influenced the results.
“We cannot exclude the possibility that this may have influenced our results, although similar effects of OT on amygdala reactivity previously were found in females tested in the follicular phase (Domes et al, 2010) and luteal phase (Bertsch et al, 2013).”
From Intranasal oxytocin administration dampens amygdala reactivity towards emotional faces in male and female PTSD patients (2016) · cites this paper as Bertsch et al, 2013
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319 · see citing works
Heinrichs, M., Baumgartner, T., Kirschbaum, C., & Ehlert, U. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00465-7 · Cited by 2,091 · see citing works
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works
Self-citationOxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Kirsch, P., Esslinger, C., Chen, Q., Mier, D., Lis, S., Siddhanti, S., Gruppe, H., Mattay, V. S., Gallhofer, B., & Meyer-Lindenberg, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-05.2005 · Cited by 1,639 · see citing works
Social effects of oxytocin in humans: context and person matter
Bartz, J. A., Zaki, J., Bolger, N., & Ochsner, K. N. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.05.002 · Cited by 1,572 · see citing works
Jeurgen, K., Assheuer, J., & Paxinos, G. (1997) · Medical Entomology and Zoology · Cited by 1,403 · see citing works
Borderline personality disorder
Lieb, K., Zanarini, M. C., Schmahl, C., Linehan, M. M., & Bohus, M. (2004) · The Lancet · doi:10.1016/s0140-6736(04)16770-6 · Cited by 1,369 · see citing works
Sniffing neuropeptides: A transnasal approach to the human brain
Born, J., Lange, T., Kern, W., McGregor, G. P., Bickel, U., & Fehm, H. L. (2002) · Nature Neuroscience · doi:10.1038/nn0602-849 · Cited by 1,356 · see citing works
Oxytocin improves “mind-reading” in humans
Domes, G., Heinrichs, M., Michel, A., Berger, C., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.07.015 · Cited by 1,298 · see citing works
Self-citationLoranger, A. W. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030051005 · Cited by 1,069 · see citing works
Evoked axonal oxytocin release in the central amygdala attenuates fear response
Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
What does the amygdala contribute to social cognition
Adolphs, R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05445.x · Cited by 836 · see citing works
Oxytocin attenuates amygdala responses to emotional faces regardless of valence
Domes, G., Heinrichs, M., Gläscher, J., Büchel, C., Braus, D. F., & Herpertz, S. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.025 · Cited by 774 · see citing works
Self-citationTransmitting and Decoding Facial Expressions
Smith, M. L., Cottrell, G. W., Gosselin, F., & Schyns, P. G. (2005) · Psychological Science · doi:10.1111/j.0956-7976.2005.00801.x · Cited by 730 · see citing works
Zanarini, M. C., Frankenburg, F. R., Hennen, J. A., Reich, D. B., & Silk, K. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2108 · Cited by 525 · see citing works
Effects of intranasal oxytocin on emotional face processing in women
Domes, G., Lischke, A., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., & Herpertz, S. C. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.06.016 · Cited by 521 · see citing works
Self-citationEvidence of abnormal amygdala functioning in borderline personality disorder: a functional MRI study
Herpertz, S. C., Dietrich, T., Wenning, B., Krings, T., Erberich, S. G., Willmes, K., Thron, A. K., & Saß, H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01075-7 · Cited by 503 · see citing works
Self-citationDifferent amygdala subregions mediate valence-related and attentional effects of oxytocin in humans
Gamer, M., Zurowski, B., & Büchel, C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000985107 · Cited by 487 · see citing works
Self-citationOxytocin can hinder trust and cooperation in borderline personality disorder
Bartz, J., Simeon, D., Hamilton, H., Kim, S., Crystal, S., Braun, A., Vicens, V., & Hollander, E. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq085 · Cited by 452 · see citing works
Psychometric Properties of the Borderline Symptom List (BSL)
Bohus, M., Limberger, M. F., Frank, U., Chapman, A. L., Kühler, T., & Stieglitz, R. (2007) · Psychopathology · doi:10.1159/000098493 · Cited by 320 · see citing works
Minzenberg, M., Fan, J., New, A. S., Tang, C. Y., & Siever, L. J. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.03.006 · Cited by 314 · see citing works
Effects of intranasal oxytocin on the neural basis of face processing in autism spectrum disorder
Domes, G., Heinrichs, M., Kumbier, E., Grossmann, A., Hauenstein, K., & Herpertz, S. C. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.007 · Cited by 255 · see citing works
Self-citationRecognition of Facial Affect in Borderline Personality Disorder
Domes, G., Czieschnek, D., Weidler, F., Berger, C., Fast, K., & Herpertz, S. C. (2008) · Journal of Personality Disorders · doi:10.1521/pedi.2008.22.2.135 · Cited by 254 · see citing works
Self-citationFacial emotion recognition in borderline personality disorder
Daros, A. R., Zakzanis, K. K., & Ruocco, A. C. (2012) · Psychological Medicine · doi:10.1017/s0033291712002607 · Cited by 251 · see citing works
Lischke, A., Berger, C., Prehn, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.07.015 · Cited by 221 · see citing works
Amygdala Activation Predicts Gaze toward Fearful Eyes
Gamer, M., & Buchel, C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1883-09.2009 · Cited by 203 · see citing works
Self-citationAtypical Reflexive Gaze Patterns on Emotional Faces in Autism Spectrum Disorders
Kliemann, D., Dziobek, I., Hatri, A., Steimke, R., & Heekeren, H. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0688-10.2010 · Cited by 194 · see citing works
Oxytocin increases amygdala reactivity to threatening scenes in females
Lischke, A., Gamer, M., Berger, C., Grossmann, A., Hauenstein, K., Heinrichs, M., Herpertz, S. C., & Domes, G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.011 · Cited by 194 · see citing works
Self-citationInterpersonal evaluation bias in borderline personality disorder.
Barnow, S., Stopsack, M., Grabe, H., Meinke, C., Spitzer, C., Kronmüller, K., & Sieswerda, S. (2009) · Behaviour Research and Therapy · doi:10.1016/j.brat.2009.02.003 · Cited by 190 · see citing works
Reduced plasma oxytocin levels in female patients with borderline personality disorder
Bertsch, K., Schmidinger, I., Neumann, I. D., & Herpertz, S. C. (2013) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.11.013 · Cited by 189 · see citing works
Self-citationPotentiated amygdala response to repeated emotional pictures in borderline personality disorder
Hazlett, E. A., Zhang, J., New, A. S., Zelmanova, Y., Goldstein, K. E., Haznedar, M. M., Meyerson, D., Goodman, M., Siever, L. J., & Chu, K.-W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.03.027 · Cited by 186 · see citing works
The role of the amygdala in atypical gaze on emotional faces in autism spectrum disorders
Kliemann, D., Dziobek, I., Hatri, A., Baudewig, J., & Heekeren, H. R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5294-11.2012 · Cited by 183 · see citing works
Oxytocin increases recognition of masked emotional faces
Schulze, L., Lischke, A., Greif, J., Herpertz, S. C., Heinrichs, M., & Domes, G. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.011 · Cited by 180 · see citing works
Self-citationSimeon, D., Bartz, J. A., Hamilton, H., Crystal, S., Braun, A. R., Ketay, S., & Hollander, E. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.013 · Cited by 167 · see citing works
Oxytocin enhances pupil dilation and sensitivity to 'hidden' emotional expressions
Leknes, S., Wessberg, J., Ellingsen, D.-M., Chelnokova, O., Olausson, H., & Laeng, B. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss062 · Cited by 151 · see citing works
Intranasal oxytocin increases covert attention to positive social cues
Domes, G., Sibold, M., Schulze, L., Lischke, A., Herpertz, S. C., & Heinrichs, M. (2013) · Psychological Medicine · doi:10.1017/s0033291712002565 · Cited by 130 · see citing works
Self-citationEvaluations of Others by Borderline Patients
Arntz, A. R., & Veen, G. C. D.-D. (2001) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200108000-00004 · Cited by 116 · see citing works
Ellenbogen, M. A., Linnen, A., Grumet, R., Cardoso, C., & Joober, R. (2012) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01278.x · Cited by 82 · see citing works
von Ceumern-Lindenstjerna, I.-A., Brunner, R. M., Parzer, P., Mundt, C., Fiedler, P. A., & Resch, F. (2009) · Psychopathology · doi:10.1159/000255960 · Cited by 54 · see citing works
Initial Orienting to Emotional Faces in Female Adolescents with Borderline Personality Disorder
von Ceumern-Lindenstjerna, I.-A., Brunner, R. M., Parzer, P., Mundt, C., Fiedler, P. A., & Resch, F. (2010) · Psychopathology · doi:10.1159/000274176 · Cited by 54 · see citing works
Hirosawa, T., Kikuchi, M., Higashida, H., Okumura, E., Ueno, S., Shitamichi, K., Yoshimura, Y., Munesue, T., Tsubokawa, T., Haruta, Y., et al. (2012) · Scientific Reports · doi:10.1038/srep00384 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The oxytocin receptor: from intracellular signaling to behavior
Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works
Psychological therapies for people with borderline personality disorder.
Stoffers-Winterling, J. M., Völlm, B. A., Rücker, G., Timmer, A., Huband, N., & Lieb, K. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005652.pub2 · Cited by 895 · see citing works
Borderline personality disorder
Gunderson, J. G., Herpertz, S. C., Skodol, A. E., Torgersen, S. O., & Zanarini, M. C. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.29 · Cited by 480 · see citing works
Self-citationPsychological therapies for people with borderline personality disorder
Storebø, O. J., Stoffers-Winterling, J. M., Völlm, B. A., Kongerslev, M. T., Mattivi, J. T., Jørgensen, M. S., Faltinsen, E., Todorovac, A., Sales, C. P., Callesen, H. E., et al. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012955.pub2 · Cited by 450 · see citing works
Treatment of personality disorder.
Bateman, A., Gunderson, J., & Mulder, R. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61394-5 · Cited by 257 · see citing works
Schulze, L., Schmahl, C., & Niedtfeld, I. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.027 · Cited by 48 · see citing works
De Dreu, C. K. W., & Kret, M. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.020 · Cited by 297 · see citing works
Aggression in Women: Behavior, Brain and Hormones
Denson, T. F., O’Dean, S., Blake, K. R., & Beames, J. R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00081 · Cited by 171 · see citing works
Schmahl, C., Herpertz, S. C., Bertsch, K., Ende, G., Flor, H., Kirsch, P., Lis, S., Meyer-Lindenberg, A., Rietschel, M., Schneider, M., et al. (2014) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/2051-6673-1-12 · Cited by 168 · see citing works
Self-citationOxytocin׳s role in anxiety: A critical appraisal
MacDonald, K., & Feifel, D. (2014) · Brain Research · doi:10.1016/j.brainres.2014.01.025 · Cited by 139 · see citing works
Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.1 · Cited by 132 · see citing works
Herpertz, S. C., & Bertsch, K. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15020216 · Cited by 139 · see citing works
Self-citationUnderstanding Brain Mechanisms of Reactive Aggression
Bertsch, K., Florange, J. G., & Herpertz, S. C. (2020) · Current Psychiatry Reports · doi:10.1007/s11920-020-01208-6 · Cited by 137 · see citing works
Self-citationOxytocin, vasopressin, and the motivational forces that drive social behaviors
Caldwell, H. K., & Albers, H. E. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_390 · Cited by 129 · see citing works
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.11.018 · Cited by 123 · see citing works
Grace, S. A., Rossell, S. L., Heinrichs, M., Kordsachia, C., & Labuschagne, I. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.05.031 · Cited by 120 · see citing works
Oxytocin and the social brain: Neural mechanisms and perspectives in human research
Kanat, M., Heinrichs, M., & Domes, G. (2014) · Brain Research · doi:10.1016/j.brainres.2013.11.003 · Cited by 122 · see citing works
Self-citationOxytocin in the socioemotional brain: implications for psychiatric disorders
Kirsch, P. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.4/pkirsch · Cited by 122 · see citing works
Pharmacotherapy for Borderline Personality Disorder—Current Evidence and Recent Trends
Stoffers-Winterling, J. M., & Lieb, K. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0534-0 · Cited by 114 · see citing works
The social-cognitive basis of personality disorders
Herpertz, S. C., & Bertsch, K. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000026 · Cited by 109 · see citing works
Self-citationAggression in borderline personality disorder: A multidimensional model.
Mancke, F., Herpertz, S. C., & Bertsch, K. (2015) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000098 · Cited by 110 · see citing works
Self-citationQuintana, D. S., Westlye, L. T., Rustan, Ø. G., Tesli, N., Poppy, C. L., Smevik, H., Tesli, M., Røine, M., Mahmoud, R. A., Smerud, K. T., et al. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.93 · Cited by 103 · see citing works
Koch, S. B., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.299 · Cited by 98 · see citing works
Jobst, A., Sabass, L., Palagyi, A., Bauriedl-Schmidt, C., Mauer, M. C., Sarubin, N., Buchheim, A., Renneberg, B., Falkai, P., Zill, P., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.11.001 · Cited by 94 · see citing works
Calcagnoli, F., Kreutzmann, J. C., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.019 · Cited by 92 · see citing works
Müller, L. E., Bertsch, K., Bülau, K., Herpertz, S. C., & Buchheim, A. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.05.011 · Cited by 92 · see citing works
Self-citationLower Oxytocin Plasma Levels in Borderline Patients with Unresolved Attachment Representations
Jobst, A., Padberg, F., Mauer, M.-C., Daltrozzo, T., Bauriedl-Schmidt, C., Sabass, L., Sarubin, N., Falkai, P., Renneberg, B., Zill, P., et al. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00125 · Cited by 88 · see citing works
Wang, D., Yan, X., Li, M., & Ma, Y. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx085 · Cited by 86 · see citing works
The many faces of oxytocin: Implications for psychiatry
Zik, J. B., & Roberts, D. L. (2014) · Psychiatry Research · doi:10.1016/j.psychres.2014.11.048 · Cited by 85 · see citing works
Lonstein, J. S., Maguire, J. L., Meinlschmidt, G., & Neumann, I. D. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12188 · Cited by 83 · see citing works
Frijling, J. L. (2017) · European Journal of Psychotraumatology · doi:10.1080/20008198.2017.1302652 · Cited by 84 · see citing works
Chen, X., Hackett, P. D., DeMarco, A. C., Feng, C., Stair, S., Haroon, E., Ditzen, B., Pagnoni, G., & Rilling, J. K. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9411-7 · Cited by 81 · see citing works
Gender differences in borderline personality disorder: a narrative review
Bozzatello, P., Blua, C., Brandellero, D., Baldassarri, L., Brasso, C., Rocca, P., & Bellino, S. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1320546 · Cited by 80 · see citing works
Oxytocin attenuates neural reactivity to masked threat cues from the eyes
Kanat, M., Heinrichs, M., Schwarzwald, R., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.183 · Cited by 77 · see citing works
Self-citationPatients with Borderline Personality Disorder in Emergency Departments
Shaikh, U., Qamar, I., Jafry, F., Hassan, M., Shagufta, S., Odhejo, Y. I., & Ahmed, S. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00136 · Cited by 74 · see citing works
Calcagnoli, F., Stubbendorff, C., Meyer, N., de Boer, S. F., Althaus, M., & Koolhaas, J. M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.11.012 · Cited by 77 · see citing works
Rausch, J., Gäbel, A., Nagy, K., Kleindienst, N., Herpertz, S. C., & Bertsch, K. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.02.002 · Cited by 75 · see citing works
Self-citationHidalgo, N. A. I., Oelkers-Ax, R., Nagy, K., Mancke, F., Bohus, M., Herpertz, S., & Bertsch, K. (2016) · Journal of Psychiatry & Neuroscience · doi:10.1503/jpn.140215 · Cited by 73 · see citing works
Self-citationA, T. R. D. J., & Neumann, I. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_13 · Cited by 74 · see citing works
Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works
Restoring effects of oxytocin on the attentional preference for faces in autism
Kanat, M., Spenthof, I., Riedel, A., van Elst, L. T., Heinrichs, M., & Domes, G. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.67 · Cited by 70 · see citing works
Self-citationInterpersonal Threat Sensitivity in Borderline Personality Disorder: An Eye-Tracking Study
Bertsch, K., Krauch, M., Stopfer, K., Haeussler, K., Herpertz, S. C., & Gamer, M. (2017) · Journal of Personality Disorders · doi:10.1521/pedi_2017_31_273 · Cited by 68 · see citing works
Self-citationSex- and context-dependent effects of oxytocin on social sharing
Ma, X., Zhao, W., Luo, R., Zhou, F., Geng, Y., Xu, L., Gao, Z., Zheng, X., Becker, B., & Kendrick, K. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.08.004 · Cited by 64 · see citing works
Immunoceptive inference: why are psychiatric disorders and immune responses intertwined?
Bhat, A., Parr, T., Ramstead, M. J. D., & Friston, K. J. (2021) · Biology & Philosophy · doi:10.1007/s10539-021-09801-6 · Cited by 63 · see citing works
Oxytocin modulates amygdala reactivity to masked fearful eyes
Kanat, M., Heinrichs, M., Mader, I., van Elst, L. T., & Domes, G. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.111 · Cited by 65 · see citing works
Self-citationPowell, L., Guastella, A. J., McGreevy, P., Bauman, A., Edwards, K. M., & Stamatakis, E. (2019) · Journal of Veterinary Behavior · doi:10.1016/j.jveb.2018.10.008 · Cited by 63 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv116 · Cited by 62 · see citing works
Frijling, J. L., van Zuiden, M., Koch, S. B. J., Nawijn, L., Veltman, D. J., & Olff, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.278 · Cited by 60 · see citing works
Ferris, C. F., Yee, J. R., Kenkel, W. M., Dumais, K. M., Moore, K., Veenema, A. H., Kulkarni, P. P., Perkybile, A. M., & Carter, C. S. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00245 · Cited by 60 · see citing works
Genetic modulation of oxytocin sensitivity: A pharmacogenetic approach
Chen, F. S., Kumsta, R., Dvorak, F., Domes, G., Yim, O. S., Ebstein, R. P., & Heinrichs, M. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.163 · Cited by 59 · see citing works
Self-citationGiulio, P. (2020) · Annals of Psychiatry and Treatment · doi:10.17352/apt.000020 · Cited by 33 · see citing works
Bertsch, K., Hillmann, K., & Herpertz, S. (2018) · Psychopathology · doi:10.1159/000487363 · Cited by 53 · see citing works
Self-citationBertsch, K., Karin Roelofs, A., Roch, P. J., Ma, B., Hensel, S., Herpertz, S. C., & Volman, I. (2018) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.170102 · Cited by 57 · see citing works
Self-citationDomes, G., Ower, N., von Dawans, B., Spengler, F. B., Dziobek, I., Bohus, M., Matthies, S., Philipsen, A., & Heinrichs, M. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0658-4 · Cited by 58 · see citing works
Self-citationSzymanska, M., Schneider, M., Chateau‐Smith, C., Nezelof, S., & Vulliez‐Coady, L. (2017) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12544 · Cited by 54 · see citing works
How Do Stress Exposure and Stress Regulation Relate to Borderline Personality Disorder?
Bourvis, N., Aouidad, A., Cabelguen, C., Cohen, D., & Xavier, J. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.02054 · Cited by 48 · see citing works
Kim, Y., Kim, C., Park, S. J., Pyo, J., & Treasure, J. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090721 · Cited by 53 · see citing works
Oxytocin and social cognition in affective and psychotic disorders
Pérez-Rodríguez, M. M., Mahon, K., Russo, M., Ungar, A. K., & Burdick, K. E. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.07.012 · Cited by 52 · see citing works
Bozzatello, P., Rocca, P., Rosa, M. L. D., & Bellino, S. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1686482 · Cited by 51 · see citing works
On the role of oxytocin in borderline personality disorder
Brüne, M. (2015) · British Journal of Clinical Psychology · doi:10.1111/bjc.12100 · Cited by 50 · see citing works
Marceau, E., Meuldijk, D., Townsend, M., Solowij, N., & Grenyer, B. (2018) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.001 · Cited by 41 · see citing works
Correlates of Aggression in Personality Disorders: an Update
Mancke, F., Herpertz, S. C., & Bertsch, K. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0929-4 · Cited by 46 · see citing works
Self-citationFineberg, S. K., Leavitt, J., Stahl, D. S., Kronemer, S. I., Landry, C. D., Alexander‐Bloch, A. F., Hunt, L. T., & Corlett, P. R. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.05.020 · Cited by 48 · see citing works
Leppanen, J., Ng, K. W., Kim, Y.-R., Tchanturia, K., & Treasure, J. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.08.041 · Cited by 45 · see citing works
Koch, S. B. J., van Zuiden, M., Nawijn, L., Frijling, J. L., Veltman, D. J., & Olff, M. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.002 · Cited by 45 · see citing works
Lischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx107 · Cited by 46 · see citing works
Self-citationHanegraaf, L., van Baal, S. T., Hohwy, J., & Verdejo‐García, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.013 · Cited by 49 · see citing works
Age differences in right-wing authoritarianism and their relation to emotion recognition.
Ruffman, T., Wilson, M., Henry, J. D., Dawson, A. J., Chen, Y., Kladnitski, N., Myftari, E., Murray, J. E., Halberstadt, J. B., & Hunter, J. A. (2015) · Emotion · doi:10.1037/emo0000107 · Cited by 40 · see citing works
Oxytocin improves facial emotion recognition in young adults with antisocial personality disorder
Timmermann, M., Jeung, H., Schmitt, R., Boll, S., Freitag, C. M., Bertsch, K., & Herpertz, S. C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.07.483 · Cited by 41 · see citing works
Self-citationDumais, K. M., Alonso, A. G., Bredewold, R., & Veenema, A. H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.036 · Cited by 40 · see citing works
Lazarus, S. A., Scott, L. N., Beeney, J. E., Wright, A. G. C., Stepp, S. D., & Pilkonis, P. A. (2018) · Personality Disorders Theory Research and Treatment · doi:10.1037/per0000289 · Cited by 40 · see citing works
Social Cognition and Borderline Personality Disorder
Fertuck, E. A., Fischer, S., & Beeney, J. E. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.07.003 · Cited by 41 · see citing works
Quintana, D. S., Dieset, I., Elvsåshagen, T., Westlye, L. T., & Andreassen, O. A. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.004 · Cited by 39 · see citing works
Social Dysfunctioning and Brain in Borderline Personality Disorder
Herpertz, S. C., Jeung, H., Mancke, F., & Bertsch, K. (2014) · Psychopathology · doi:10.1159/000365106 · Cited by 38 · see citing works
Self-citationHerpertz, S., Schneider, I., Schmahl, C., & Bertsch, K. (2018) · Psychopathology · doi:10.1159/000488357 · Cited by 46 · see citing works
Self-citationCollaborative Deprescribing in Borderline Personality Disorder: A Narrative Review
Fineberg, S. K., Gupta, S., & Leavitt, J. (2019) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000200 · Cited by 37 · see citing works
Tully, J., Gabay, A. S., Brown, D., Murphy, D., & Blackwood, N. (2017) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2017.11.017 · Cited by 37 · see citing works
Winter, D. (2016) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-016-0047-z · Cited by 36 · see citing works
Brüne, M., Kolb, M., Ebert, A., Roser, P., & Edel, M.-A. (2015) · Journal of Nervous & Mental Disease · doi:10.1097/nmd.0000000000000240 · Cited by 35 · see citing works
Krauch, M., Ueltzhöffer, K. J., Brunner, R. M., Kaess, M., Hensel, S., Herpertz, S. C., & Bertsch, K. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00057 · Cited by 33 · see citing works
Self-citationOxytocin release deficit and social cognition in craniopharyngioma patients
Brandi, M., Gebert, D., Kopczak, A., Auer, M. K., & Schilbach, L. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12842 · Cited by 34 · see citing works
Schwaiger, M., Heinrichs, M., & Kumsta, R. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.08.025 · Cited by 34 · see citing works
Kaiser, D., Jacob, G. A., van Zutphen, L., Siep, N., Sprenger, A., Tuschen‐Caffier, B., Senft, A., Arntz, A. R., & Domes, G. (2019) · Journal of Personality Disorders · doi:10.1521/pedi_2019_33_363 · Cited by 32 · see citing works
Self-citationPsychopathic traits affect the visual exploration of facial expressions
Boll, S., & Gamer, M. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.03.010 · Cited by 32 · see citing works
Self-citationFertuck, E. A., Grinband, J., Mann, J. J., Joy Hirsch, C., Ochsner, K. N., Pilkonis, P. A., Erbe, J. K., & Stanley, B. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.101616 · Cited by 32 · see citing works
Oxytocin plasma levels predict the outcome of psychotherapy: A pilot study in chronic depression
Jobst, A., Sabaß, L., Hall, D., Brücklmeier, B., Buchheim, A., Hall, J., Sarubin, N., Zill, P., Falkai, P., Brakemeier, E.-L., et al. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.10.037 · Cited by 32 · see citing works
Schnell, K., & Herpertz, S. (2018) · Journal of Personality Disorders · doi:10.1521/pedi.2018.32.supp.12 · Cited by 32 · see citing works
Self-citationPatin, A., & Hurlemann, R. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-16522-6_10 · Cited by 32 · see citing works
Seitz, K. I., Leitenstorfer, J., Krauch, M., Hillmann, K., Boll, S., Ueltzhöffer, K. J., Neukel, C., Kleindienst, N., Herpertz, S. C., & Bertsch, K. (2021) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-020-00141-7 · Cited by 34 · see citing works
Self-citationOxytocin and Borderline Personality Disorder
Bertsch, K., & Herpertz, S. C. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_26 · Cited by 31 · see citing works
Self-citationLischke, A., Herpertz, S. C., Berger, C., Domes, G., & Gamer, M. (2017) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsx134 · Cited by 29 · see citing works
Self-citationOxytozin: Evidenz für ein therapeutisches Potenzial des sozialen Neuromodulators
Eckstein, M., & Hurlemann, R. (2013) · Der Nervenarzt · doi:10.1007/s00115-013-3832-6 · Cited by 28 · see citing works
The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders
Jin, Y., Song, D. F., Yan, Y., Quan, Z., & Qing, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310430 · Cited by 30 · see citing works
The effects of oxytocin on social cognition in borderline personality disorder
Servan, A., Brunelin, J., & Poulet, E. (2017) · L Encéphale · doi:10.1016/j.encep.2017.11.001 · Cited by 28 · see citing works
Back, S. N., & Bertsch, K. (2020) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-020-00217-2 · Cited by 27 · see citing works
Self-citationOxytocin Normalizes Approach–Avoidance Behavior in Women With Borderline Personality Disorder
Schneider, I., Boll, S., Volman, I., Karin Roelofs, A., Spohn, A., Herpertz, S. C., & Bertsch, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00120 · Cited by 26 · see citing works
Self-citationJeung-Maarse, H., Schmitgen, M. M., Schmitt, R., Bertsch, K., & Herpertz, S. C. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01549-9 · Cited by 26 · see citing works
Self-citationKovács, B., & Kéri, S. (2015) · European Psychiatry · doi:10.1016/j.eurpsy.2015.02.010 · Cited by 26 · see citing works
Bortolla, R., Cavicchioli, M., Galli, M., Verschure, P. F. M. J., & Maffei, C. (2019) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-019-0105-4 · Cited by 24 · see citing works
Childhood Maltreatment Alters the Neural Processing of Chemosensory Stress Signals
Maier, A., Heinen-Ludwig, L., Güntürkün, O., Hurlemann, R., & Scheele, D. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00783 · Cited by 25 · see citing works
- Authors
- Bertsch, K., Gamer, M., Schmidt, B., Schmidinger, I., Walther, S., Kästel, T., Schnell, K., Büchel, C., Domes, G., & Herpertz, S. C.
- Affiliations
- University of Freiburg (DE)
- Venue
- American Journal of Psychiatry
- Published
- 2013-10
- Volume
- 170
- Issue
- 10
- Pages
- 1169-1177
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2128455436
- Semantic Scholar
- 4aecba81946119f855d958c33ed5143911d98810
- Cited by
- 214
- References
- 42
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 11 · 2021: 18 · 2020: 18 · 2019: 19 · 2018: 29 · 2017: 25 · 2016: 12 · 2015: 26 · 2014: 17 · 2013: 5 · 2012: 1
- FWCI
- 29.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Keywords
- oxytocin, borderline personality disorder, amygdala activation, angry facial expressions, emotion classification, eye movements, intranasal administration, reactive aggression, women, facial expression recognition
- MeSH terms
- Administration, Intranasal, Adolescent, Adult, Aggression, Amygdala, Anger, Arousal, Borderline Personality Disorder, Double-Blind Method, Emotions, Facial Expression, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Oxytocin, Pattern Recognition, Visual, Reaction Time, Social Perception, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
