Cited by 563Dementia and Cognitive Impairment ResearchDiabetes Treatment and ManagementNeurological Disease Mechanisms and Treatments

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Type 2 diabetes mellitus, cognitive impairment and dementia

Stewart, R., Liolitsa, D.·1999·Diabetic Medicine

DOI 10.1046/j.1464-5491.1999.00027.x

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Abstract

Summary: Aims We set out to examine the evidence for an association between cognitive impairment or dementia and the presence of Type 2 diabetes mellitus (DM). We also sought evidence of potential mechanisms for such an association. Methods A literature search of three databases was performed and the reference lists of the papers so identified were examined, using English language papers only. Results We found evidence of cross‐sectional and prospective associations between Type 2 DM and cognitive impairment, probably both for memory and executive function. There is also evidence for an elevated risk of both vascular dementia and Alzheimer’s disease in Type 2 DM albeit with strong interaction of other factors such as hypertension, dyslipidaemia and apolipoprotein E phenotype. Both vascular and non‐vascular factors are likely to play a role in dementia in diabetes. Conclusions Current classification structures for dementia may not be adequate in diabetes, where mixed pathogenesis is likely. Further research into the mechanisms of cognitive impairment in Type 2 DM may allow us to challenge the concept of dementia, at least in these patients, as an irremediable disease. Diabet. Med. 16, 93–112 (1999)

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Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,052
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012
Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>
Snowdon, D. A. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540340047031 · Cited by 1,590
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.
Cooper, G. J., Willis, A. C., Clark, A., Turner, R. C., Sim, R. B., & Reid, K. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8628 · Cited by 1,299
Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.
Bucala, R., Tracey, K. J., & Cerami, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115014 · Cited by 1,162
Prevalence of Diabetes and Impaired Glucose Tolerance and Plasma Glucose Levels in U.S. Population Aged 20–74 Yr
Harris, M. I., Hadden, W. C., Knowler, W. C., & Bennett, P. H. (1987) · Diabetes · doi:10.2337/diab.36.4.523 · Cited by 1,096
Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study
Hofman, A., Ott, A., Breteler, M. M., Bots, M. L., Slooter, A. J., van Harskamp, F., van Duijn, C. N., Van Broeckhoven, C., & Grobbee, D. E. (1997) · The Lancet · doi:10.1016/s0140-6736(96)09328-2 · Cited by 1,062
Pathogenic effects of advanced glycosylation: biochemical, biologic, and clinical implications for diabetes and aging.
Vlassara, H., Bucala, R., & Striker, L. J. (1994) · PubMed · Cited by 848
Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: The Hisayama Study
Yoshitake, T., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., Nomiyama, K., Kawano, H., Ueda, K., et al. (1995) · Neurology · doi:10.1212/wnl.45.6.1161 · Cited by 829
Risk of Dementia among Persons with Diabetes Mellitus: A Population-based Cohort Study
Leibson, C. L., Rocca, W. A., Hanson, V. A., Cha, R., Kokmen, E., O'Brien, P. C., & Palumbo, P. J. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009106 · Cited by 700
Association of diabetes mellitus and dementia, the Rotterdam study
Ott, A., Stolk, R. P., Hofman, A., van Harskamp, F., Grobbee, D. E., & Breteler, M. M. B. (1996) · Diabetologia · doi:10.1007/s001250050588 · Cited by 677
Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam study
Breteler, M. M. B., Claus, J. J., Grobbee, D. E., & Albert Hofman, D. (1994) · BMJ · doi:10.1136/bmj.308.6944.1604 · Cited by 541
Is Type II Diabetes Associated With an Increased Risk of Cognitive Dysfunction?: A critical review of published studies
Strachan, M. W. J., Deary, I. J., Ewing, F. M. E., & Frier, B. M. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.438 · Cited by 529
Alzheimer's disease: A study of epidemiological aspects
Heyman, A., Wilkinson, W. E., Stafford, J. A., Helms, M. J., Sigmon, A. H., & Weinberg, T. (1984) · Annals of Neurology · doi:10.1002/ana.410150406 · Cited by 525
Insulin and Insulin-like Growth Factor-1 Regulate Tau Phosphorylation in Cultured Human Neurons
Hong, M., & Lee, V. M. ‐. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19547 · Cited by 522
Is hyperglycaemia an independent predictor of poor outcome after acute stroke? Results of a long term follow up study
Weir, C. J., Murray, G. D., Dyker, A. G., & Lees, K. R. (1997) · BMJ · doi:10.1136/bmj.314.7090.1303 · Cited by 520
Development of dementing illnesses in an 80‐year‐old volunteer cohort
Katzman, R., Aronson, M., Fuld, P. A., Kawas, C. H., Brown, T., Morgenstern, H., Frishman, W. H., Gidez, L. I., Eder, H., & Ooi, W. L. (1989) · Annals of Neurology · doi:10.1002/ana.410250402 · Cited by 453
A case‐control study of Alzheimer's disease in Australia
Broe, G. A., Henderson, A. S., Creasey, H. M., McCusker, E. A., Korten, A. E., Jorm, A. F., Longley, W. A., & Anthony, J. C. (1990) · Neurology · doi:10.1212/wnl.40.11.1698 · Cited by 446
Association between features of the insulin resistance syndrome and alzheimer's disease independently of apolipoprotein e4 phenotype: cross sectional population based study
Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Kervinen, K., Kesäniemi, Y. A., Riekkinen, P. J., & Laakso, M. (1997) · BMJ · doi:10.1136/bmj.315.7115.1045 · Cited by 426
Exogenous advanced glycosylation end products induce complex vascular dysfunction in normal animals: a model for diabetic and aging complications.
Vlassara, H., Fuh, H., Makita, Z., Krungkrai, S., Cerami, A., & Bucala, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.12043 · Cited by 378
NIDDM and Blood Pressure as Risk Factors for Poor Cognitive Performance: The Framingham Study
Elias, P. K., Elias, M. F., D'Agostino, R. B., Cupples, L. A., Wilson, P. W., Silbershatz, H., & Wolf, P. A. (1997) · Diabetes Care · doi:10.2337/diacare.20.9.1388 · Cited by 368
Sleep disturbance, psychosocial correlates, and cardiovascular disease in 5201 older adults: The cardiovascular health study
Newman, A. B., Enright, P. L., Manolio, T. A., Haponik, E. F., Wahl, P. W., & On behalf of the Cardiovascular Health Study Research Group (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb00970.x · Cited by 365
Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease
Seab, J. P., Jagust, W. J., Wong, S. T. S., Roos, M. S., Reed, B. R., & Budinger, T. F. (1988) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910080210 · Cited by 364
Cerebral function in diabetes mellitus
Biessels, G. J., Kappelle, A. C., Bravenboer, B., Erkelens, D. W., & Gispen, W. H. (1994) · Diabetologia · doi:10.1007/bf00417687 · Cited by 341
The Impact of Diabetes on the CNS
McCall, A. L. (1992) · Diabetes · doi:10.2337/diab.41.5.557 · Cited by 340
Relationship Between Hyperglycemia and Cognitive Function in Older NIDDM Patients
Reaven, G. M., Thompson, L. W., Nahum, D., & Haskins, E. (1990) · Diabetes Care · doi:10.2337/diacare.13.1.16 · Cited by 334
Analysis of microtubule-associated protein tau glycation in paired helical filaments.
Ledesma, M. D., Bonay, P., Colaço, C., & Avila, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31849-5 · Cited by 333
Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity
Doré, S., Kar, S., & Quirion, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4772 · Cited by 325
Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's treatment trial of hypertension in older adults
Prince, M. J., Bird, A. S., Blizard, R., & MANN, A. H. (1996) · BMJ · doi:10.1136/bmj.312.7034.801 · Cited by 317
Clinical Determinants of Poststroke Dementia
Pohjasvaara, T., Erkinjuntti, T., Ylikoski, R., Hietanen, M., Vataja, R., & Kaste, M. (1998) · Stroke · doi:10.1161/01.str.29.1.75 · Cited by 315
New Insights Into the Role and Mechanism of Glycogen Synthase Activation by Insulin
Lawrence, J. C., & Roach, P. J. (1997) · Diabetes · doi:10.2337/diab.46.4.541 · Cited by 311
Risk of dementia after stroke in a hospitalized cohort
Tatemichi, T. K., Paik, M. C., Bagiella, E., Desmond, D. W., Stern, Y., Sano, M. C., Hauser, W. A., & Mayeux, R. P. (1994) · Neurology · doi:10.1212/wnl.44.10.1885 · Cited by 309
Complications: Neuropathy, Pathogenetic Considerations
Greene, D. A., Sima, A. A. F., Stevens, M. J., Feldman, E. L., & Lattimer, S. A. (1992) · Diabetes Care · doi:10.2337/diacare.15.12.1902 · Cited by 300
Decreased cognitive function in aging non-insulin-dependent diabetic patients
Perlmuter, L. C., Hakami, M. K., Hodgson-Harrington, C., Ginsberg, J. P., Katz, J., Singer, D. E., & Nathan, D. M. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90186-4 · Cited by 295
Clinical determinants of dememtia related to stroke
Tatemichi, T. K., Desmond, D. W., Paik, M. C., Figueroa, M., Gropen, T., Stern, Y., Sano, M. C., Remien, R. H., Williams, J. B. W., Mohr, J. P., et al. (1993) · Annals of Neurology · doi:10.1002/ana.410330603 · Cited by 293
Apolipoprotein E genotype and Alzheimer's disease
Noguchi, S., Murakami, K., Yamada, N., Payami, H., Kaye, J. A., Heston, L. L., Bird, T. D., & Schellenberg, G. D. (1993) · The Lancet · doi:10.1016/0140-6736(93)91728-5 · Cited by 285
Low blood pressure and dementia in elderly people: the Kungsholmen project
Guo, Z., Viitanen, M. H., Fratiglioni, L., & Winblad, B. G. (1996) · BMJ · doi:10.1136/bmj.312.7034.805 · Cited by 280
Discussion
Lovestone, S., & Reynolds, C. H. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00577-5 · Cited by 278
Glucose intolerance, hyperinsulinaemia and cognitive function in a general population of elderly men
Kalmijn, S., Feskens, E. J. M., Launer, L. J., Stijnen, T., & Kromhout, D. (1995) · Diabetologia · doi:10.1007/bf00402181 · Cited by 274
CORRELATES OF COGNITIVE FUNCTION IN AN ELDERLY COMMUNITY POPULATION
Scherr, P. A., Albert, M., Funkenstein, H. H., Cook, N. R., Hennekens, C. H., Branch, L. G., White, L. R., Taylor, J. O., & Evans, D. A. (1988) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115051 · Cited by 257
Verbal Learning and/or Memory Improves with Glycemic Control in Older Subjects with Non‐Insulin‐Dependent Diabetes Mellitus
Gradman, T. J., Laws, A., Thompson, L. W., & Reaven, G. M. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06480.x · Cited by 235
Blood-Brain Glucose Transfer: Repression in Chronic Hyperglycemia
Gjedde, A., & Crone, C. (1981) · Science · doi:10.1126/science.7027439 · Cited by 235
A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies.
Almind, K., Inoue, G., Pedersen, O. B., & Kahn, C. R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118705 · Cited by 228
The Effect of Improved Glycemic Control on Cognitive Functions in the Elderly Patient With Diabetes
Meneilly, G. S., Cheung, E., Tessier, D., Yakura, C., & Tuokko, H. A. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.4.m117 · Cited by 221
A Survey of Cognitive Functioning at Different Glucose Levels in Diabetic Persons
Holmes, C. S., Hayford, J. T., González, J. L., & Weydert, J. A. (1983) · Diabetes Care · doi:10.2337/diacare.6.2.180 · Cited by 217
The Relation Between Morbidity and Cognitive Performance in a Normal Aging Population
van Boxtel, M. P. J., Buntinx, F., Houx, P. J., Metsemakers, J. F. M., Knottnerus, J. A., & Jolles, J. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.2.m147 · Cited by 215
Insulin and Cognitive Function in an Elderly Population: The Rotterdam Study
Stolk, R. P., Breteler, M. M. B., Ott, A., Pols, H. A. P., Lamberts, S. W. J., Grobbee, D. E., & Albert Hofman, D. (1997) · Diabetes Care · doi:10.2337/diacare.20.5.792 · Cited by 208
Neuropsychological correlates of hypertension: Review and methodologic considerations.
Waldstein, S. R., Manuck, S. B., Ryan, C. M., & Muldoon, M. F. (1991) · Psychological Bulletin · doi:10.1037/0033-2909.110.3.451 · Cited by 205
Risk Factors for Cerebrovascular Disease as Correlates of Cognitive Function in a Stroke-Free Cohort
Desmond, D. W., Tatemichi, T. K., Paik, M. C., & Stern, Y. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540020040015 · Cited by 201
Dementia After First Stroke
Censori, B., Manara, O., Agostinis, C., Camerlingo, M., Casto, L., Galavotti, B., Partziguian, T., Servalli, M. C., Cesana, B. M., Belloni, G., et al. (1996) · Stroke · doi:10.1161/01.str.27.7.1205 · Cited by 200
Altered Hierarchy of Protective Responses Against Severe Hypoglycemia in Normal Aging in Healthy Men
Matyka, K., Evans, M., Lomas, J., Cranston, I., Macdonald, I., & Amiel, S. A. (1997) · Diabetes Care · doi:10.2337/diacare.20.2.135 · Cited by 195
The Canadian Study of Health and Aging
Lindsay, J., Hébert, R., & Rockwood, K. J. (1997) · Stroke · doi:10.1161/01.str.28.3.526 · Cited by 194
Effects of hyperglycemia on memory and hormone levels in dementia of the Alzheimer type: A longitudinal study.
Craft, S., Dagogo-Jack, S. E., Wiethop, B. V., Murphy, C., Nevins, R. T., Fleischman, S., Rice, V., Newcomer, J. W., & Cryer, P. E. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.6.926 · Cited by 191
Epidemiology of Vascular Dementia
Hébert, R., & Brayne, C. (1995) · Neuroepidemiology · doi:10.1159/000109800 · Cited by 190
Cortical Function in Elderly Non—Insulin Dependent Diabetic Patients
Mooradian, A. D. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.148.11.2369 · Cited by 189
Cognitive dysfunction in adults with Type 1 (insulin-dependent) diabetes mellitus of long duration: effects of recurrent hypoglycaemia and other chronic complications
Ryan, C. M., Williams, T. M., Finegold, D. N., & Orchard, T. J. (1993) · Diabetologia · doi:10.1007/bf00400236 · Cited by 187
Longitudinal Analysis of the Association between Depressive Symptomatology and Cognitive Deterioration
Dufouil, C., Fuhrer, R., Dartigues, J., & Alpérovitch, A. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008974 · Cited by 181
Insulin inhibits pyramidal neurons in hippocampal slices
Palovcik, R. A., Phillips, M. I., Kappy, M. S., & Raizada, M. K. (1984) · Brain Research · doi:10.1016/0006-8993(84)91028-x · Cited by 174
Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects
Heitner, J., & Dickson, D. (1997) · Neurology · doi:10.1212/wnl.49.5.1306 · Cited by 173
Cognitive Impairment and Risk of Stroke in the Older Population
Verruca, L., Guralnik, J. M., Salive, M. E., Pahor, M., Corti, M., Baroni, A., & Havlik, R. J. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb00908.x · Cited by 171
Tracking Insulin to the Mind
Wickelgren, I. (1998) · Science · doi:10.1126/science.280.5363.517 · Cited by 169
Dementia associated with lacunar infarction.
Loeb, C., Gandolfo, C., Croce, R., & Conti, M. (1992) · Stroke · doi:10.1161/01.str.23.9.1225 · Cited by 169
Effects of intensive diabetes therapy on neuropsychological function in adults in the Diabetes Control and Complications Trial
The Diabetes Control and Complications Trial Research Group* (1996) · Annals of Internal Medicine · doi:10.7326/0003-4819-124-4-199602150-00001 · Cited by 160
Cerebrovascular Disease, the Apolipoprotein e4 Allele, and Cognitive Decline in a Community-Based Study of Elderly Men
Kalmijn, S., Feskens, E. J. M., Launer, L. J., & Kromhout, D. (1996) · Stroke · doi:10.1161/01.str.27.12.2230 · Cited by 159
Are Age and Education Independent Correlates of the Mini-Mental State Exam Performance of Community-Dwelling Elderly?
Launer, L. J., Dinkgreve, M. A. H. M., Jonker, C., Hooijer, C., & Lindeboom, J. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.6.p271 · Cited by 152
Complications in IDDM are caused by elevated blood glucose level: The Stockholm Diabetes Intervention Study (SDIS) at 10-year follow up
Reichard, P., Pihl, M., Rosenqvist, U., & Sule, J. (1996) · Diabetologia · doi:10.1007/s001250050602 · Cited by 152
Aging, Metabolism, and Alzheimer Disease: Review and Hypotheses
Finch, C. E., & Cohen, D. M. (1997) · Experimental Neurology · doi:10.1006/exnr.1996.6339 · Cited by 146
Expression and characterization of glycogen synthase kinase-3 mutants and their effect on glycogen synthase activity in intact cells.
Eldar-Finkelman, H., Argast, G. M., Foord, O., Fischer, E. H., & Krebs, E. G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10228 · Cited by 140
Are Alzheimer Patients Healthier?
Wolf‐Klein, G. P., Silverstone, F. A., Brod, M. S., Levy, A. P., Foley, C. J., Termotto, V., & Breuer, J. (1988) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1988.tb01804.x · Cited by 140
Clinical-neuropathologic findings in multi-infarct dementia: A report of six autopsied cases
Hulette, C., Nochlin, D., McKeel, D., Morris, J. C., Mirra, S. S., Sumi, S. M., & Heyman, A. (1997) · Neurology · doi:10.1212/wnl.48.3.668 · Cited by 138
Immunohistochemical Localization of Advanced Glycation End Products, Pentosidine, and Carboxymethyllysine in Lipofuscin Pigments of Alzheimer's Disease and Aged Neurons
Horie, K., Miyata, T., Yasuda, T., Takeda, A., Yasuda, Y., Maeda, K., Sobue, G., & Kurokawa, K. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6944 · Cited by 137
Essential hypertension and cognitive function. The role of hyperinsulinemia.
Kuusisto, J., Koivisto, K. J., Mykkänen, L. M., Helkala, E.-L., Vanhanen, M., Hänninen, T., Pyörälà, K., Riekkinen, P. J., & Laakso, M. (1993) · Hypertension · doi:10.1161/01.hyp.22.5.771 · Cited by 120
Cortical Function in Elderly Non—Insulin Dependent Diabetic Patients
Mooradian, A. D. (1988) · Archives of Internal Medicine · doi:10.1001/archinte.1988.00380110035007 · Cited by 118
Sleep and Sleep Disorders in Older Adults
Prinz, P. N. (1995) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199503000-00004 · Cited by 115
Prevalence of Diabetes and Effect on Quality of Life in Older French Living in the Community: The PAQUID Epidemiological Survey
Bourdel‐Marchasson, I., Dubroca, B., Manciet, G., Décamps, A., Émeriau, J. P., & Dartigues, J. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb00943.x · Cited by 113
Increased Amyloid Protein Precursor and Apolipoprotein E Immunoreactivity in the Selectively Vulnerable Hippocampus Following Transient Forebrain Ischemia in Gerbils
Hall, E. D., Oostveen, J. A., Dunn, E., & Carter, D. B. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1062 · Cited by 113
Low blood pressure and blood glucose levels in Alzheimer's disease Evidence for a hypometabolic disorder?
Landin‐Wilhelmsen, K., Blennow, K., Wallin, A., & GOTTFRIES, C. ‐. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00684.x · Cited by 112
Aetiological considerations and risk factors for multi-infarct dementia.
Meyer, J. S., McClintic, K., Rogers, R. L., Sims, P., & Mortel, K. F. (1988) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.51.12.1489 · Cited by 108
jun N-terminal Kinase Mediates Activation of Skeletal Muscle Glycogen Synthase by Insulin in Vivo
Moxham, C. M., Tabrizchi, A., Davis, R. J., & Malbon, C. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.48.30765 · Cited by 106
The Mental Efficiency of the Elderly Person with Type II Diabetes Mellitus
U’Ren, R. C., Riddle, M. C., Lezak, M. D., & Bennington‐Davis, M. (1990) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1990.tb02398.x · Cited by 97
Risk Factors for Dementia Associated With Multiple Cerebral Infarcts
Gorelick, P. B. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540070034011 · Cited by 93
Cognitive function in elderly non-insulin-dependent diabetic patients before and after inpatient treatment for metabolic control
Naor, M., Steingrüber, H.-J., Westhoff, K., Schottenfeld-Naor, Y., & Gries, A. F. (1997) · Journal of Diabetes and its Complications · doi:10.1016/1056-8727(95)00106-9 · Cited by 92
Association between rheology and components of lipoproteins in human blood. Results from the MONICA project.
Köenig, W., Sund, M., Ernst, E., Wilfried, M. R. A. Z., Hombach, V., & Keil, U. (1992) · Circulation · doi:10.1161/01.cir.85.6.2197 · Cited by 92
Short-Term and Long-Term Memory in Elderly Patients with NIDDM
Helkala, E., NISKANEN, L. K., Viinamäki, H. T., Partanen, J., & Uusitupa, M. I. J. (1995) · Diabetes Care · doi:10.2337/diacare.18.5.681 · Cited by 92
Diabetes and Cognitive Impairment: A Community-based Study of Elderly Subjects
Croxson, S. C. M., & Jagger, C. (1995) · Age and Ageing · doi:10.1093/ageing/24.5.421 · Cited by 88
Recombinant Advanced Glycation End Product Receptor Pharmacokinetics in Normal and Diabetic Rats
Renard, C., Chappey, O., Wautier, M.-P., Nagashima, M., Lundh, E., Morser, J., Zhao, L., Schmidt, A. M., Scherrmann, J., & Wautier, J. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.1.54 · Cited by 87
Apolipoprotein E phenotype is related to macro- and microangiopathy in patients with non-insulin-dependent diabetes mellitus
Ukkola, O. H., Kervinen, K., Salmela, P. I., von Dickhoff, K., Laakso, M., & Kesäniemi, Y. A. (1993) · Atherosclerosis · doi:10.1016/0021-9150(93)90096-d · Cited by 86
A widespread amino acid polymorphism at codon 905 of the glycogen-associated regulatory subunit of protein phosphatase-1 is associated with insulin resistance and hypersecretion of insulin
Hansen, L., Hansen, T., Vestergaard, H., Bjørbæk, C., Echwald, S. M., Clausen, J. O., Chen, Y. H., Chen, M. X., Cohen, P. T. W., & Pedersen, O. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.8.1313 · Cited by 84
Alterations in Glucose Metabolism in Patients with Alzheimer's Disease
Meneilly, G. S., & Hill, A. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb07458.x · Cited by 79
Cognitive function, vascular risk factors and education. A cross‐sectional study based on a cohort of 70‐year‐old men
Kilander, L., Nyman, H., Boberg, M., & Lithell, H. (1997) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1997.00196.x · Cited by 77
Age and diabetes related changes in verbal fluency
Perlmuter, L. C., Tun, P. A., Sizer, N. R., McGlinchey, R. E., & Nathan, D. M. (1987) · Experimental Aging Research · doi:10.1080/03610738708259294 · Cited by 76
Glycation and Microglial Reaction in Lesions of Alzheimer's Disease
Dickson, D. W., Sinicropi, S., Yen, S.-H. C., Ko, L., Mattiace, L. A., Bucala, R., & Vlassara, H. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00116-9 · Cited by 76
Cognitive Function in Younger Type II Diabetes
Dey, J., Misra, A., Desai, N. G., Mahapatra, A. K., & Padma, M. V. (1997) · Diabetes Care · doi:10.2337/diacare.20.1.32 · Cited by 75
Triglyceride levels affect cognitive function in noninsulin-dependent diabetics
Perlmuter, L. C., Nathan, D. M., Goldfinger, S. H., Russo, P. A., Yates, J., & Larkin, M. E. (1988) · Journal of Diabetes and its Complications · doi:10.1016/s0891-6632(88)80011-4 · Cited by 74
Apolipoprotein‐E Genotyping of Diabetic Dementia Patients: Is Diabetes Rare in Alzheimer's Disease?
Nielson, K. A., Nolan, J. H., Berchtold, N. C., Sandman, C. A., Mulnard, R. A., & Cotman, C. W. (1996) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1996.tb01857.x · Cited by 72
Clinical and Epidemiological Aspects of Alzheimer's Disease with Presenile Onset: A Case Control Study
Ferini‐Strambi, L., Smirne, S., Garancini, P., Pinto, P., & Franceschi, M. (1990) · Neuroepidemiology · doi:10.1159/000110750 · Cited by 71
Type II Diabetes and Cognitive Function: A population-based study of Native Americans
Lowe, L. P., Tranel, D., Wallace, R. B., & Welty, T. K. (1994) · Diabetes Care · doi:10.2337/diacare.17.8.891 · Cited by 69
Hospital management of diabetic ketoacidosis: are clinical guidelines implemented effectively?
Singh, R. K., Perros, P., & Frier, B. M. (1997) · Diabetic Medicine · doi:10.1002/(sici)1096-9136(199706)14:6 · Cited by 68
Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus
Sigal, R. J., Doria, A., Warram, J. H., & Królewski, A. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636384 · Cited by 67
Enhanced binding of advanced glycation endproducts (AGE) by the ApoE4 isoform links the mechanism of plaque deposition in Alzheimer's disease
Li, Y. M., & Dickson, D. W. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00266-8 · Cited by 62
Immunohistochemical study of advanced glycation end products in aging and Alzheimer's disease brain
Takeda, A., Yasuda, T., Miyata, T., Mizuno, K., Li, M., YONEYAMA, S., Horie, K., Maeda, K., & Sobue, G. (1996) · Neuroscience Letters · doi:10.1016/s0304-3940(96)13275-4 · Cited by 62
A longitudinal study of cognitive performance in noninsulin dependent (type II) diabetic men
Robertson‐Tchabo, E. A., Arenberg, D., Tobin, J. D., & Plotz, J. B. (1986) · Experimental Gerontology · doi:10.1016/0531-5565(86)90051-3 · Cited by 62
Hyperglycemia augments ischemic brain injury: in vivo MR imaging/spectroscopic study with nicardipine in cats with occluded middle cerebral arteries.
Chew, W., Kucharczyk, J. R., Moseley, M. E., Derugin, N., & Norman, D. M. (1991) · PubMed Central · Cited by 59
Diabetes mellitus and brain atrophy: A computed tomography study in an elderly population
Soininen, H. S., Puranen, M., Helkala, E.-L., Laakso, M., & Riekkinen, P. J. (1992) · Neurobiology of Aging · doi:10.1016/0197-4580(92)90095-f · Cited by 59
Correlates of Cognitive Function Scores in Elderly Outpatients
Mangione, C. M., Seddon, J. M., Cook, E. F., Krug, J. H., Sahagian, C. R., Campion, E. W., & Glynn, R. J. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb01883.x · Cited by 59
Blood-Brain Barrier Choline Transport Is Reduced in Diabetic Rats
Mooradian, A. D. (1987) · Diabetes · doi:10.2337/diab.36.10.1094 · Cited by 59
Inhibitory Effects of Tenilsetam on the Maillard Reaction
Shoda, H., Miyata, S., Liu, B.-F., Yamada, H., Ohara, T., Suzuki, K., Oimomi, M., & Kasuga, M. (1997) · Endocrinology · doi:10.1210/endo.138.5.5151 · Cited by 59
Prevalence of Cognitive Impairment and Associated Factors among Elderly Hong Kong Chinese Aged 70 Years and Over
Woo, J., Ho, S. C., Lau, S., Lau, J. T. F., & Yuen, K. (1994) · Neuroepidemiology · doi:10.1159/000110358 · Cited by 57
Cognition and depression in a cohort of aging men: Results from the Western Collaborative Group Study.
Rue, A. L., Swan, G. E., & Carmelli, D. (1995) · Psychology and Aging · doi:10.1037//0882-7974.10.1.30 · Cited by 54
The influence of depressive symptomatology on episodic memory functioning among clinically nondepressed older adults.
Bäckman, L., Hill, R. D., & Forsell, Y. (1996) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.105.1.97 · Cited by 53
Non-insulin-dependent diabetes mellitus is associated with a greater prevalence of depression in the elderly. The Osservatorio Geriatrico of Campania Region Group.
Amato, L., Paolisso, G., Cacciatore, F., Ferrara, N., Canonico, S., Rengo, F., & Varricchio, M. (1996) · PubMed · Cited by 51
Psychometric evaluation of performance in diabetes mellitus.
Meuter, F., Thomas, W. T. B., Grüneklee, D., Fa, G., & Lohmann, R. (1980) · PubMed · Cited by 51
Recurrent Severe Hypoglycaemia and Cognitive Function in Type 1 Diabetes
Gold, A. E., Deary, I. J., & Frier, B. M. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00110.x · Cited by 48
Localization of Insulin and Type 1 IGF Receptors in Rat Brain by in Vitro Autoradiography and in Situ Hybridization
Marks, J. L., King, M. G., & Baskin, D. G. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_41 · Cited by 47
Effect of type II diabetes mellitus on cognitive function.
Worrall, G. J., Moulton, N., & Briffett, E. (1993) · PubMed · Cited by 47
Analysis of Familial and Individual Risk Factors Among Patients with Ischemic Vascular Dementia and Alzheimer's Disease
Mortel, K. F., Wood, S. A., Pavol, M. A., Meyer, J. S., & Rexer, J. L. (1993) · Angiology · doi:10.1177/000331979304400802 · Cited by 46
Neuropsychological Function in Older Subjects with Non‐insulin‐dependent Diabetes Mellitus
Atiea, J., Moses, J. L., & Sinclair, A. J. (1995) · Diabetic Medicine · doi:10.1111/j.1464-5491.1995.tb00569.x · Cited by 46
Cognition and depression in a cohort of aging men: Results from the Western Collaborative Group Study.
Rue, A. L., Swan, G. E., & Carmelli, D. (1995) · Psychology and Aging · doi:10.1037/0882-7974.10.1.30 · Cited by 44
The influence of depressive symptomatology on episodic memory functioning among clinically nondepressed older adults.
Bäckman, L., Hill, R. D., & Forsell, Y. (1996) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.105.1.97 · Cited by 41
Chromosomal mapping and mutational analysis of the coding region of the glycogen synthase kinase-3α and β isoforms in patients with NIDDM
Hansen, L., Arden, K. C., Rasmussen, S., Viars, C. S., Vestergaard, H., Hansen, T. F., Møller, A. M., Woodgett, J. R., & Pedersen, O. B. (1997) · Diabetologia · doi:10.1007/s001250050771 · Cited by 39
Apolipoprotein E phenotype modifies metabolic and hemodynamic abnormalities related to central obesity in women
Uusitupa, M., Karhunen, L. J., Rissanen, A., Franssila-Kallunki, A., NISKANEN, L. K., Kervinen, K., & Kesäniemi, Y. A. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/64.2.131 · Cited by 39
Neuropsychological Cognitive Performance of Patients With type-2 Diabetes
Mattlar, C., Falck, B., Rönnemaa, T., & Hyyppä, M. T. (1985) · Journal of Rehabilitation Medicine · doi:10.2340/165019778517101105 · Cited by 36
Polyol pathway activity in nervous tissues of diabetic and galactose-fed rats: Effect of dietary galactose withdrawal or tolrestat intervention therapy
Sredy, J., Sawicki, D. R., & Notvest, R. R. (1991) · Journal of Diabetes and its Complications · doi:10.1016/0891-6632(91)90010-m · Cited by 31
Memory dysfunction and autonomic neuropathy in non-insulin-dependent (type 2) diabetic patients
Zaslavsky, L. M. A., Gross, J. L., Chaves, M. L. F., & Machado, R. F. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01150-1 · Cited by 30
Brain Atrophy on Computerized Axial Tomography Scans: Interaction of Age, Diabetes and General Morbidity
Pirttilä, T., Järvenpää, R., Laippala, P. J., & Frey, H. (2009) · Gerontology · doi:10.1159/000213342 · Cited by 29
Differential Effects of Insulin on Choline Acetyltransferase and Glutamic Acid Decarboxylase Activities in Neuron‐Rich Striatal Cultures
Brass, B. J., Nonner, D., & Barrett, J. N. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09387.x · Cited by 27
Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium
Sussman, I., Carson, M. P., Schultz, V., Wu, X. P., McCall, A. L., Ruderman, N. B., & Tornheim, K. (1988) · Diabetologia · doi:10.1007/bf00274782 · Cited by 25
Quality of Life in the Treatment of Hypertension
FLETCHER, A. E., & Bulpitt, C. J. (1992) · Drugs · doi:10.2165/00003495-199200441-00026 · Cited by 25
Angiotensin Converting Enzyme Inhibitors and Quality of Life
Breckenridge, A. M. (1991) · American Journal of Hypertension · doi:10.1093/ajh/4.1.79s · Cited by 25
Diabetes and cognitive function: preliminary studies
Assisi, A., Alimenti, M., Maceli, F., Pietro, S. D., Lalloni, G., & Montera, P. (1996) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(96)86942-1 · Cited by 12
Central nervous system involvement in elderly patients with non-insulin-dependent diabetes mellitus
Cerizza, M., Minciotti, G., Meregalli, S., Garosi, V. L., Crosti, P. F., & Frattola, L. (1990) · Acta Diabetologica · doi:10.1007/bf02580939 · Cited by 12
Cognitive impairment in the elderly diabetics
Motta, M., Sorace, S., Restuccia, S., Carnazzo, G., Corrao, G., Seminara, G., & Maugeri, D. (1996) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(96)86911-1 · Cited by 10
The Minnesota Diabetes Complications Clinical Trial cognitive functions under long-term maximized and standard metabolic controls.
Hung, J.-Y., Menth, L., Mj, T., Saner, B., Rao, K. V., & Barbosa, J. (1984) · PubMed · Cited by 9
Capacity to remember prescription drug changes: deficits associated with diabetes
ROST, K. M., ROTER, D. L., Quill, T., & Bertakis, K. D. (1990) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(90)90042-r · Cited by 7
Diabetes and Dementia: A Causal Association?
Amiel, S. A. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00301.x · Cited by 7
Decreased cerebral blood perfusion in an NIDDM patient with an A-to-G mutation in the mitochondrial gene; a possible contribution to cognition deficits in diabetes mellitus
Odawara, M. (1995) · Diabetologia · doi:10.1007/bf00400594 · Cited by 7
Qualitative differences in the visual retention test performance of older non-insulin dependent diabetic patients
Mooradian, A. D., & Siverly, F. D. (1993) · AGE · doi:10.1007/bf02435039 · Cited by 6
Amyloid Plaque and Diabetes
Edgington, S. M. (1994) · Nature Biotechnology · doi:10.1038/nbt0694-591 · Cited by 5
Complications of Diabetes in Childhood
Hamilton-Shield, J. P., & Baum, J. D. (1993) · Diabetic Medicine · doi:10.1111/j.1464-5491.1993.tb00109.x · Cited by 5
Detection of cerebrovascular disease in diabetic patients by means of the Kana test
Tetsutani, T., Yamaguchi, T., Kadono, K., Takahara, N., Nishimura, T., & Kaneko, M. (1994) · Current Therapeutic Research · doi:10.1016/s0011-393x(05)80266-8 · Cited by 1
Prevalence of beta allele of the insulin gene in type II diabetes mellitus
Horst−Sikorska, W., Zoll, B., Kwiatkowska, J., Willms, B., Kraszewski, A., Horst, A., & Słomski, R. (1994) · Human Genetics · doi:10.1007/bf00212031 · Cited by 1

Research works printed but not linked: 8

Jagusch W, 1992, Cognitive function and metabolic state in elderly diabetic patients., Diab Nutr Metab., 5, 265
Breteler MmB.Cognitive Decline in the Elderly.Published Thesis ISBN 90–90006241–6.1993.
Amato L, 1996, Non‐insulin‐dependent diabetes mellitus is associated with a greater prevalence of depression in the elderly., Diabetes Metab., 22, 314
Kokeman E, 1960, Dementia after ischemic stroke: a population‐based study in Rochester., Minnesota. Neurology 1996, 19, 154
Ott A, 1997, Risk of Dementia.
Chew W, 1991, Hyperglycemia augments ischemic brain injury., Am J Neuroradiol., 12, 603
10.1210/en.138.5.1886 · DOI
10.1210/jc.81.4.1657 · DOI

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See all 563

Authors: Stewart, R., & Liolitsa, D.
Corresponding author: Stewart, R.
ORCID: Stewart, R.
Venue: Diabetic Medicine
Publisher: Wiley
Published: 1999-02
Volume: 16
Issue: 2
Pages: 93-112
ISSN: 0742-3071 (ISSN-L)
1464-5491
DOI: 10.1046/j.1464-5491.1999.00027.x
OpenAlex: W2078868323
Cited by: 562
References: 145
Citations by year: 2026: 2 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 12 · 2021: 12 · 2020: 18 · 2019: 18 · 2018: 18 · 2017: 18 · 2016: 19 · 2015: 33 · 2014: 17 · 2013: 21 · 2012: 35
FWCI: 9.03
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 1057 d)
Locations: Diabetic Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords: type 2 diabetes, cognitive impairment, dementia, vascular dementia, Alzheimer's disease, memory, executive function, hypertension, dyslipidemia, apolipoprotein E, dementia classification
MeSH terms: Cognition Disorders, Cross-Sectional Studies, Dementia, Diabetes Mellitus, Type 2, Humans, Population Surveillance, Prospective Studies, Risk Factors, Case-Control Studies

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Type 2 diabetes mellitus, cognitive impairment and dementia

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