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Global Burden of Stroke
Open accessAbstract
Stroke is the second leading cause of death and a major cause of disability worldwide. Its incidence is increasing because the population ages. In addition, more young people are affected by stroke in low- and middle-income countries. Ischemic stroke is more frequent but hemorrhagic stroke is responsible for more deaths and disability-adjusted life-years lost. Incidence and mortality of stroke differ between countries, geographical regions, and ethnic groups. In high-income countries mainly, improvements in prevention, acute treatment, and neurorehabilitation have led to a substantial decrease in the burden of stroke over the past 30 years. This article reviews the epidemiological and clinical data concerning stroke incidence and burden around the globe.
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“In practice, however, electrocorticography (ECoG) and microelectrocorticography (µECoG) have facilitated high temporal-and spatial-resolution recordings for effective use in in vivo applications 56,64,65 , including brain-computer interfaces.”
From The Layer 7 Cortical Interface: A Scalable and Minimally Invasive Brain–Computer Interface Platform (2022) · cites this paper as [65]
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“Inclusion and Exclusion Criteria Inclusion criteria included the following: (1) types of studies: post-hoc analyses of RCT, prospective or retrospective cohort study; (2) characteristics of participants: adult patients (≥18 years) with AIS treated with IVT (with recombinant tissue plasminogen activator); (3) types of…”
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“Stroke, often referred to as a “brain attack,” stands as the second leading cause of death and a major contributor to disability worldwide (Katan & Luft, 2018).”
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“This relation was analyzed using the (1) % (”
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“…the second leading cause of death in the world and the number one cause of acquired long-term disability, especially in China, which is the greatest challenge of stroke in the world, ranking third among the leading causes of death in China, second only to malignant tumors and heart disease (2).”
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BackgroundDiaphragmatic ultrasound can help evaluate pulmonary dysfunction in patients with stroke
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BackgroundMethodInfluentialAssociation between PAI-1 Polymorphisms and Ischemic Stroke in a South Korean Case-Control Cohort
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“Cerebrovascular diseases include stroke, cerebral hemorrhage, and cerebral aneurysms [83].”
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“Background of the study Over the past decades, there has been growing concern on the increasing incidence and prevalence of stroke and its attendant high morbidity in developing countries [1, 2].”
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“Stroke is the second leading cause of death and a major cause of disability across the world (Katan & Luft, 2018).”
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“Those with disabilities in this group had disorders of mobility and limb movement, which led to difficulties in major life areas [3].”
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“Stroke is a significant cause of morbidity and mortality globally [1].”
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“E On a global scale, the burden of stroke has increased signi fi cantly in the past few decades due to the increase in population size and aging population and the prevalence of changeable risk factors for stroke [8, 9].”
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“Stroke is the second most common cause of death in the general population and it is a major cause of disability [4, 5].”
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“These debilitating diseases have a massive disease burden, both in terms of health suffering and economic costs [1, 2].”
BackgroundImpact of the COVID-19 pandemic on emergent stroke care in Beijing, China
Wang, Y., Liu, G., Zhu, Y., Song, H., Ren, Y. L., Liu, Y., & Ma, Q. (2023) · Scientific Reports · doi:10.1038/s41598-023-31530-x · Cited by 11
“The results showed the following: (1) there was a clear drop in the number of AIS patients in 2020, with an increased rate of IVT or EVT; (2) the delay mainly occurred after hospital arrival during the pandemic compared with the prepandemic period, especially in hospitals in the high-risk areas; and (3) the reduction…”
ResultMitochondrial pyruvate carrier 1 alleviates hypoxic-ischemic brain injury in rats
Liu, Y., Yuan, Y., Yan, Y., Wang, R., Wang, Z., Liu, X., Zhang, Y., Hua, J., Wang, Y., & Zhao, L. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121686 · Cited by 13
Exploring community reintegration among Nigerian stroke survivors
Ogunlana, M. O., Oyewole, O. O., Fafolahan, A. O., & Govender, P. (2023) · South African Journal of Physiotherapy · doi:10.4102/sajp.v79i1.1857 · Cited by 11
“The burden of stroke has substantially increased over the past few decades as a result of astronomical population growth and ageing with the increased prevalence and incidence of stroke-modifiable risk factors common in low- and middle-income countries (Katan & Luft 2018).”
BackgroundApplication of Nanotechnology-Based Products in Stroke
Wang, C., Sun, J., Chen, Q., Chen, J., Wan, H., Ni, Q., Yuan, H., Wu, J., Wang, Y., & Sun, B. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00804 · Cited by 11
Qin, R., Huang, L., Xu, W., Qin, Q., Liang, X., Lai, X., Huang, X., Xie, M., & Chen, L. (2023) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2023838 · Cited by 12
Zegarra-Valdivia, J. A., Pignatelli, J., Núñez, Á., & Torres‐Alemán, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216440 · Cited by 11
“Cerebrovascular accidents are considered the “silent pandemic” as they are the second cause of death worldwide [169].”
BackgroundLevel of Quality of Life among Post Stroke Patients; A Cross Sectional Survey
Safdar, Z., Asghar, M., & Tahir, M. (2023) · Journal of Health and Rehabilitation Research · doi:10.61919/jhrr.v3i2.129 · Cited by 11
Astilbin attenuates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB pathway
Li, J., Gu, Z., Liu, Y., Wang, Y., & Zhao, M. (2019) · Toxicology Research · doi:10.1039/c9tx00222g · Cited by 11
Chen, X., Zhang, X., Su, C., & Huang, S. (2020) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23500 · Cited by 11
Effects of tDCS on Brain Functional Network of Patients After Stroke
Wang, H., Yu, H., Liu, M., Xu, G., Guo, L., Wang, C., & Sun, C. (2020) · IEEE Access · doi:10.1109/access.2020.3037924 · Cited by 11
Tractography Alterations in the Arcuate and Uncinate Fasciculi in Post-Stroke Aphasia
Kierońska-Siwak, S., Świtońska, M., Meder, G., Piotrowska, M., & Sokal, P. (2021) · Brain Sciences · doi:10.3390/brainsci11010053 · Cited by 11
“Stroke is the second leading cause of death and one of the most common causes of disability in adults worldwide [1].”
BackgroundXu, W., Huang, J., Yu, Q., Yu, H., Pu, Y., & Shi, Q. (2021) · Neurological Sciences · doi:10.1007/s10072-021-05219-w · Cited by 11
Malaeb, D., Mansour, S., Barakat, M., Cherri, S., Kharaba, Z., Jirjees, F., Alzayer, R., Eltayib, E., Khidhair, Z., Alobaidi, H., et al. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1492756 · Cited by 13
Depression and quality of life after cerebral venous sinus thrombosis
Thorat, N., Saroja, A., & Naik, K. R. (2019) · Annals of Indian Academy of Neurology · doi:10.4103/aian.aian_191_19 · Cited by 10
Eid, M., Dzreyan, V., & Demyanenko, S. V. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.782684 · Cited by 10
“Stroke is one of the leading causes of mortality globally and a major cause of disability (Cushman et al., 2008; Donnan et al., 2008; Katan and Luft, 2018).”
BackgroundBoriesosdick, J., Michael, A. E., Kröger, J. R., Niehoff, J. H., Saeed, S., Pflug, M. A., Schellinger, P. D., Maus, V., Borggrefe, J., & Mönninghoff, C. (2022) · Interventional Neuroradiology · doi:10.1177/15910199221129097 · Cited by 10
Reeves, M. J., Thetford, C., McMahon, N. E., Forshaw, D., Brown, C., Joshi, M., & Watkins, C. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph192113848 · Cited by 10
“Stroke is a major cause of death and disability worldwide [1,2].”
BackgroundDual-Energy Computed Tomography in Stroke Imaging
Grkovski, R., Acu, L., Ahmadli, U., Nakhostin, D., Thurner, P., Wacht, L., Kulcsár, Z., Alkadhi, H., & Winklhofer, S. F.-X. (2023) · Clinical Neuroradiology · doi:10.1007/s00062-023-01270-6 · Cited by 10
“Stroke is the second leading cause of mortality worldwide and an important contributor to disability [1].”
BackgroundDevelopment of a clot-adhesive coating to improve the performance of thrombectomy devices
Skarbek, C., Anagnostakou, V., Propocio, E., Epshtein, M., Raskett, C. M., Romagnoli, R., Iviglia, G., Morra, M., Antonucci, M., Nicoletti, A., et al. (2023) · Journal of NeuroInterventional Surgery · doi:10.1136/jnis-2022-019779 · Cited by 10
Beker, M. Ç., Aydınlı, F. İ., Çağlayan, A. B., Beker, M., Baygül, O., Çağlayan, A., Popa‐Wagner, A., Doeppner, T. R., Hermann, D. M., & Kılıç, E. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03353-4 · Cited by 10
Aucubin promotes activation of AMPK and alleviates cerebral ischemia/reperfusion injury in rats
Zhao, J., Zhao, B., Xiao, B., Zhang, S., & Xu, R. P. (2023) · Cell Stress and Chaperones · doi:10.1007/s12192-023-01372-7 · Cited by 10
“Ischemic stroke results from thromboembolic occlusion of cerebral arteries and is responsible for physical disability and mortality globally (Katan and Luft 2018).”
Bekele, G., Yitayal, M. M., Belete, Y., Guadie, Y. G., Kassa, T., Assefa, Y. A., Nigatu, S. G., & Eriku, G. A. (2023) · Frontiers in Stroke · doi:10.3389/fstro.2023.1226140 · Cited by 13
“The decrease in death rates globally in recent decades (Katan and Luft, 2018) due to medical advances has resulted in an increase in the number of stroke survivors with varied degrees of functional limitations and disabilities that will last a lifetime.”
Li, J., Shen, S., & Shen, H.-Y. (2023) · Drug development research (Print) · doi:10.1002/ddr.22130 · Cited by 10
“In recent years, the increasing rates of aging population aggravate the lifetime risk of stroke, accompanied with an epidemic rise in the risk of stroke in the young (Katan & Luft, 2018).”
BackgroundFan, J.-S., Wang, M., Chen, N., Sun, B.-C., Zhang, Q.-B., Li, Y., & Huang, M.-J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1204727 · Cited by 11
Cao, C., Wang, T. B., Hu, H., Han, Y. Y., Zhang, X., & Wang, Y. (2024) · BMC Neurology · doi:10.1186/s12883-024-03581-8 · Cited by 10
Cheng, X., Gao, Y., Chen, X., Lu, J., Dai, Q., & Lai, J. (2024) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2024.102703 · Cited by 10
“(Hornby et al., 2019; Katan and Luft, 2018) These problems lead to worsening of their activities of daily living (ADLs), decreased quality of life, and limited participation in family and community activities, which should be considered as important targets of rehabilitation.”
BackgroundNestorone (segesterone acetate) effects on neuroregeneration
Sitruk-Ware, R. L., Sussman, H., Brinton, R. D., Schumacher, M., Singer, P., Kumar, N., Nicola, A. F. D., El‐Etr, M., Guennoun, R., & Borlongan, C. V. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101136 · Cited by 10
FAM19A5 in vascular aging and osteoporosis: Mechanisms and the “calcification paradox”
Zheng, J., He, J., & Li, H. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102361 · Cited by 10
Han, K., Liu, G., Liu, N., Li, J., Li, J., Cui, L., Cheng, M., Long, J., Liao, X., Tang, Z., et al. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240356 · Cited by 10
“Stroke, characterized by cerebrovascular-induced neurological impairment [1], has been described as a significant source of high morbidity, mortality, and disability rates worldwide [2].”
Metadata
- Authors
- Katan, M., & Luft, A.
- Affiliations
- Department of Neurology, Stroke Center, University Hospital of Zurich, Zurich, Switzerland
- University Hospital Zurich (CH)
- Corresponding author
- Luft, Andreas
- ORCID
- Luft, Andreas
- Venue
- Seminars in Neurology
- Publisher
- Georg Thieme Verlag KG
- Published
- 2018-04
- Volume
- 38
- Issue
- 02
- Pages
- 208-211
- ISSN
- 0271-8235 (ISSN-L)
- 1098-9021
- OpenAlex
- W2803306216
- Cited by
- 2,137
- References
- 57
- Citations by year
- 2026: 164 · 2025: 350 · 2024: 361 · 2023: 387 · 2022: 376 · 2021: 276 · 2020: 159 · 2019: 55 · 2018: 7
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Seminars in Neurology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Epidemiology
- Keywords
- stroke, global burden of disease, stroke incidence, stroke mortality, ischemic stroke, hemorrhagic stroke, disability-adjusted life years, population aging, young adults, low- and middle-income countries, ethnic disparities, stroke prevention, neurorehabilitation
- MeSH terms
- Humans, Sex Factors, Global Health, Disease Management, Stroke
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