Cited by 2,137Acute Ischemic Stroke ManagementCardiovascular Health and Risk FactorsGlobal Health and Epidemiology

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Global Burden of Stroke

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Katan, Mira, Luft, Andreas·2018·Seminars in Neurology

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Abstract

Stroke is the second leading cause of death and a major cause of disability worldwide. Its incidence is increasing because the population ages. In addition, more young people are affected by stroke in low- and middle-income countries. Ischemic stroke is more frequent but hemorrhagic stroke is responsible for more deaths and disability-adjusted life-years lost. Incidence and mortality of stroke differ between countries, geographical regions, and ethnic groups. In high-income countries mainly, improvements in prevention, acute treatment, and neurorehabilitation have led to a substantial decrease in the burden of stroke over the past 30 years. This article reviews the epidemiological and clinical data concerning stroke incidence and burden around the globe.

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“32 Neuro-inflammation is a complex yet crucial pathological process following ischemic stroke.”
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Coumarin-Chalcone derivatives as promising antioxidant agents targeting ischemia/reperfusion injury through Nrf2 pathway activation
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Role and Mechanism of Microglia in White Matter Injury Recovery in Ischemic Stroke
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Stroke Survivors Have Almost Three Times Higher Risk of Depression: A Systematic Review and Meta-Analysis
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“Stroke is the main cause of disability and death worldwide (25), and dementia is the second cause of death worldwide among brain diseases (26).”
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The effects of traditional Chinese medicine sensory stimulation combined with transcranial direct current stimulation on deglutition and related complications in stroke patients with dysphagia: a randomized trial
Lu, Y., Zhou, W., Lin, Y., Du, Y., & Zhang, X. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-1055 · Cited by 11
The Association Between Serum Endocan Level and Short-Term Prognosis of Patients With Acute Ischemic Stroke
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Suppression of miR-130a-3p Attenuates Oxygen–Glucose Deprivation/Reoxygenation-Induced Dendritic Spine Loss by Promoting APP
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“Ischemic stroke represents one of the leading causes of death worldwide (Katan and Luft, 2018) and is estimated to be the fourth most common cause of increased disability-adjusted life years by 2030 (Donnan et al.”
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Personalised Approach to Diagnosing and Managing Ischemic Stroke with a Plasma-Soluble Urokinase-Type Plasminogen Activator Receptor
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LEX-BADAT: Language EXperience in Bilinguals With and Without Aphasia DATaset
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“, stroke, increases (Katan and Luft, 2018) leading to language impairment in aging bilingual populations, it can be expected that bilingual people with aphasia (BPWA) will comprise a greater share of caseloads in forthcoming years (Centeno et al.”
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The longitudinal association between movement behavior patterns and the course of participation up to one year after stroke
de Graaf, J. A., Wondergem, R., Kooijmans, E. C. M., Pisters, M. F., Schepers, V. P. M., Veenhof, C., Visser‐Meily, J. M. A., & Post, M. W. M. (2022) · Disability and Rehabilitation · doi:10.1080/09638288.2022.2109071 · Cited by 9
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Luo, J., Chen, D., Qin, B., & Kong, D. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.999426 · Cited by 9
“The rats were randomly divided into four groups as follows: (1) the negative control group: no surgery; (2) the laminarin treatment group: no surgery, but underwent intraperitoneal injection of laminarin (dissolved in normal saline) at 10 mg/kg per day for 7 days; and (3) the MCAO group: the rats were subjected to 2 h…”
BackgroundMethod
New insights into circRNA and its mechanisms in angiogenesis regulation in ischemic stroke: a biomarker and therapeutic target
Cheng, L., Liu, Z., & Xia, J. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07949-2 · Cited by 9
Potential role of Nigella Sativa and its Constituent (Thymoquinone) in Ischemic Stroke
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Integrative analysis of single-cell and bulk RNA sequencing unveils the senescence landscape in ischemic stroke
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Remote Ischaemic Preconditioning Accelerates Brain to Blood Glutamate Efflux via EAATs-mediated Transport
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Trends in hemorrhagic stroke incidence and mortality in a National Stroke Registry of a multi-ethnic Asian population
Lim, M. J. R., Zheng, H., Zhang, Z., Sia, C., Tan, B. Y., Ong, M. E. H., Nga, V. D. W., Yeo, T. T., & Ho, A. F. W. (2023) · European Stroke Journal · doi:10.1177/23969873231202392 · Cited by 9
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Hemorrhage Evaluation and Detector System for Underserved Populations: HEADS-UP
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Boosting Mitochondrial Biogenesis Diminishes Foam Cell Formation in the Post-Stroke Brain
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“Stroke is a leading cause of death and disability worldwide [1].”
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PEMOCS: theory derivation of a concept for PErsonalized MOtor-Cognitive exergame training in chronic Stroke—a methodological paper with an application example
Huber, S. K., Manser, P., & de Bruin, E. D. (2024) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2024.1397949 · Cited by 12
Targeting NLRP3 Inflammasomes: A Trojan Horse Strategy for Intervention in Neurological Disorders
Tork, M. A. B., Fotouhi, S., Roozi, P., & Negah, S. S. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04359-2 · Cited by 9
“For example, cerebrovascular injuries, whether ischemic or hemorrhagic, are a significant global health concern that causes death and several severe disabilities [169].”
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Czinege, Z., Sándor, Á. D., Gyürki, D., Varga, A., Csípő, T., Székely, A. D., Ungvari, Z. I., Banga, P., Sótonyi, P., & Horváth, T. (2024) · GeroScience · doi:10.1007/s11357-024-01390-y · Cited by 9
“Atherosclerotic CAS is a significant risk factor for ischemic stroke, a major cause of death and long-term disability in developed countries [6–8].”
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Chen, J., Li, H., Luo, L., Zhang, Y., Zhang, F., Chen, F., & Chen, M. (2019) · Journal of Healthcare Engineering · doi:10.1155/2019/7463242 · Cited by 9
PECULIARITIES OF NEUROCOGNITIVE STATUS OF PATIENTS IN THE ACUTE ISCHEMIC STROKE PHASE OF DIFFERENT HEMISPHERIC LOCALIZATION
Pushko, O. O., & Lytvynenko, N. V. (2020) · World of Medicine and Biology · doi:10.26724/2079-8334-2020-2-72-99-103 · Cited by 9
Hemoglobin level is associated with severe stroke among stroke patients in Saudi Arabia.
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Cross-cultural adaptation and validation of the Igbo language version of the stroke-specific quality of life 2.0
Odetunde, M. O., Odole, A. C., Odunaiya, N. A., Odetunde, N. A., Okoye, E. C., Mbada, C. E., Umunnah, J. O., & Akinpelu, A. O. (2020) · Pan African Medical Journal · doi:10.11604/pamj.2020.37.111.19557 · Cited by 9
Robotic Orthosis for Upper Limb Rehabilitation
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Ahn, H., Lee, S., Jung, W. J., & Lee, K.-H. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i8.1151 · Cited by 9
Very Early Cognitive Screening and Self-Reported Feeling of Fatigue Three Months After Stroke
Holmberg, J., Jondell, B., Abzhandadze, T., & Sunnerhagen, K. S. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.742105 · Cited by 9
Hospitalization for ischemic stroke was affected more in independent cases than in dependent cases during the COVID-19 pandemic: An interrupted time series analysis
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Incidence, risk factors and microbiological aetiology of urinary tract infections in admitted stroke patients at a teaching hospital in Zimbabwe: A prospective cohort study
Mukapa, N., Mataruse, A., Ngwende, G. W., & Robertson, V. J. (2022) · Infection Prevention in Practice · doi:10.1016/j.infpip.2022.100210 · Cited by 9
“[1,2] In Africa the burden of stroke is high and is still increasing with the increase attributable to population growth and ageing.”
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Dental Pulp Stem Cell Therapy in Ischemic Stroke: A Meta-Analysis of Preclinical Studies
Wang, H., Sun, M., Sun, J., Gong, P., Liu, N., & Wang, M. (2022) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2022.106453 · Cited by 9
Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia
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“INTRODUCTION Stroke is the second leading cause of death and a major cause of severe disability for adults worldwide [1].”
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Co-designing a Program to Improve Post-stroke Sexual Rehabilitation: The Promise of Innovative Methods
Auger, L.-P., Allegue, D. R., Morales, E., Thomas, A., Filiatrault, J., Vachon, B., & Rochette, A. (2022) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2022.777897 · Cited by 9
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BackgroundMethodInfluential
Effects of robot-assisted therapy on upper limb and cognitive function in patients with stroke: study protocol of a randomized controlled study
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Development of portable robotic orthosis and biomechanical validation in people with limited upper limb function after stroke
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An Integrated Strategy of Chemical Fingerprint and Network Pharmacology for the Discovery of Efficacy-Related Q-Markers of Pheretima
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Liposome-based loading enhances the distribution of nicotinamide riboside chloride into the brain and its neuroprotective effects in cerebral ischemic mice
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Authors: Katan, M., & Luft, A.
Affiliations: Department of Neurology, Stroke Center, University Hospital of Zurich, Zurich, Switzerland
University Hospital Zurich (CH)
Corresponding author: Luft, Andreas
ORCID: Luft, Andreas
Venue: Seminars in Neurology
Publisher: Georg Thieme Verlag KG
Published: 2018-04
Volume: 38
Issue: 02
Pages: 208-211
ISSN: 0271-8235 (ISSN-L)
1098-9021
DOI: 10.1055/s-0038-1649503
OpenAlex: W2803306216
Cited by: 2,137
References: 57
Citations by year: 2026: 164 · 2025: 350 · 2024: 361 · 2023: 387 · 2022: 376 · 2021: 276 · 2020: 159 · 2019: 55 · 2018: 7
FWCI: 17.75
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Seminars in Neurology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Topics: Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Epidemiology
Keywords: stroke, global burden of disease, stroke incidence, stroke mortality, ischemic stroke, hemorrhagic stroke, disability-adjusted life years, population aging, young adults, low- and middle-income countries, ethnic disparities, stroke prevention, neurorehabilitation
MeSH terms: Humans, Sex Factors, Global Health, Disease Management, Stroke

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