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Cited by 568

The DOI matches its Crossref record.

An Adipocyte-Derived Plasma Protein, Adiponectin, Adheres to Injured Vascular Walls

Okamoto, Y., Arita, Y., Nishida, M., Muraguchi, M., Ouchi, N., Takahashi, M., Igura, T., Inui, Y., Kihara, S., Nakamura, T., Yamashita, S., Miyagawa, J., Funahashi, T., Matsuzawa, Y.·2000·Hormone and Metabolic Research
DOI 10.1055/s-2007-978586
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Abstract

Adipose tissue secretes a variety of proteins into the bloodstream. We have previously reported a novel cDNA, apM1 (adipose most abundant gene transcript 1), which is specifically and abundantly expressed in adipose tissue [1]. Primary structure analysis predicted that the apM1 gene product possesses significant homology to collagens VIII, X and complement factor C1q, and we named it adiponectin. In the current study, we analyzed characteristics of adiponectin in vitro and in vivo. Adiponectin protein was proved to be secreted into the medium when the cDNA was transfected to COS cells. Anti-adiponectin cross-reactivities were abundantly detected in the human plasma. In solid-phase binding assays, adiponectin specifically bound to collagen types I, III and V, which are present in vascular intima. Immunohistochemical analysis revealed that adiponectin was detected in the walls of the catheter-injured vessels but not in the intact vascular walls. These data suggest that adiponectin is a plasma protein produced by adipose tissue and accumulates in vascular walls when the endothelial barrier is injured.

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Metadata

Authors
Okamoto, Y., Arita, Y., Nishida, M., Muraguchi, M., Ouchi, N., Takahashi, M., Igura, T., Inui, Y., Kihara, S., Nakamura, T., Yamashita, S., Miyagawa, J., Funahashi, T., & Matsuzawa, Y.
Venue
Hormone and Metabolic Research
Publisher
Georg Thieme Verlag KG
Published
2000-02
Volume
32
Issue
02
Pages
47-50
ISSN
  • 0018-5043 (ISSN-L)
  • 1439-4286
DOI
10.1055/s-2007-978586
OpenAlex
W2128422989
Cited by
568
References
0
FWCI
18.29
Type
journal article
Language
en
Open access
closed

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