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Rapid modulation of spine morphology by the 5-HT 2A serotonin receptor through kalirin-7 signaling
Open accessAbstract
The 5-HT 2A serotonin receptor is the most abundant serotonin receptor subtype in the cortex and is predominantly expressed in pyramidal neurons. The 5-HT 2A receptor is a target of several hallucinogens, antipsychotics, anxiolytics, and antidepressants, and it has been associated with several psychiatric disorders, conditions that are also associated with aberrations in dendritic spine morphogenesis. However, the role of 5-HT 2A receptors in regulating dendritic spine morphogenesis in cortical neurons is unknown. Here we show that the 5-HT 2A receptor is present in a subset of spines, in addition to dendritic shafts. It colocalizes with PSD-95 and with multiple PDZ protein-1 (MUPP1) in a subset of dendritic spines of rat cortical pyramidal neurons. MUPP1 is enriched in postsynaptic density (PSD) fractions, is targeted to spines in pyramidal neurons, and enhances the localization of 5-HT 2A receptors to the cell periphery. 5-HT 2A receptor activation by the 5-HT 2 receptor agonist DOI induced a transient increase in dendritic spine size, as well as phosphorylation of p21-activated kinase (PAK) in cultured cortical neurons. PAK is a downstream target of the neuronal Rac guanine nucleotide exchange factor (RacGEF) kalirin-7 that is important for spine remodeling. Kalirin-7 regulates dendritic spine morphogenesis in neurons but its role in neuromodulator signaling has not been investigated. We show that peptide interference that prevents the localization of kalirin-7 to the postsynaptic density disrupts DOI-induced PAK phosphorylation and spine morphogenesis. These results suggest a potential role for serotonin signaling in modulating spine morphology and kalirin-7's function at cortical synapses.
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“The 5-HT 2A R, a common target of psychedelics, is expressed on dendritic shafts and dendritic spines of cortical neurons in both rodents and primates (Jakab and Goldman-Rakic, 1998;Miner et al., 2003;Jones et al., 2009;Weber and Andrade, 2010;Yoshida et al., 2011).”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Jones et al., 2009
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“DOI, one of the more readily accessible psychedelics to researchers, has been shown to increase dendritic growth (Persico et al., 2006;Ohtani et al., 2014;Ly, Greb et al., 2018;Ly et al., 2021), synaptic puncta, spine density (Yoshida et al., 2011;Ly et al., 2018), and spine size (Jones et al., 2009) in cultured cortical neurons.”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Jones et al., 2009
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“Neurotransmitters, including norepinephrine,76, 77, 78 serotonin79, 80, 81 and glutamate,82,83 as well as stress-induced release of neuropeptides26,34,84,85 and steroids,86, 87, 88 can influence synapse number and function.”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [80]
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Cites
González-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.008 · Cited by 925
Balancing Structure and Function at Hippocampal Dendritic Spines
Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916
Pompeiano, M., Palacios, J. M., & Mengod, G. (1994) · Molecular Brain Research · doi:10.1016/0169-328x(94)90223-2 · Cited by 870
Anatomical and Physiological Plasticity of Dendritic Spines
Alvarez, V. A., & Sabatini, B. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094222 · Cited by 629
Jakab, R. L., & Goldman-Rakic, P. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.2.735 · Cited by 536
Penzes, P., Beeser, A., Chernoff, J., Schiller, M. R., Eipper, B. A., Mains, R. E., & Huganir, R. L. (2003) · Neuron · doi:10.1016/s0896-6273(02)01168-6 · Cited by 466
Self-citationCortical 5-HT 2A Receptor Signaling Modulates Anxiety-Like Behaviors in Mice
Weisstaub, N., Zhou, M., Lira, A., Lambe, E. K., González‐Maeso, J., Hornung, J., Sibille, E. L., Underwood, M. D., Itohara, S., Dauer, W. T., et al. (2006) · Science · doi:10.1126/science.1123432 · Cited by 434
Penzes, P., Johnson, R. C., Sattler, R., Zhang, X., Huganir, R. L., Kambampati, V., Mains, R. E., & Eipper, B. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00193-3 · Cited by 378
Self-citationKalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines
Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373
Self-citationParadoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists
Gray, J. A. B., & Roth, B. L. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00623-2 · Cited by 296
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Sala, C., & Segal, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00012.2013 · Cited by 491
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 471
Lesch, K.-P., & Waider, J. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.013 · Cited by 435
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Self-citationHalberstadt, A. L., Chatha, M., Klein, A. K., Wallach, J., & Brandt, S. D. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.107933 · Cited by 278
Barnes, N. M., Ahern, G. P., Bécamel, C., Bockaert, J., Camilleri, M., Chaumont‐Dubel, S., Claeysen, S., Cunningham, K. A., Fone, K. C. F., Gershon, M. D., et al. (2020) · Pharmacological Reviews · doi:10.1124/pr.118.015552 · Cited by 274
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Cane, M., Maco, B., Knott, G., & Holtmaat, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3353-13.2014 · Cited by 216
Raval, N. R., Johansen, A., Donovan, L. L., Ros, N. F., Ozenne, B., Hansen, H. D., & Knudsen, G. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020835 · Cited by 200
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Self-citationRomero, G. G., von Zastrow, M., & Friedman, P. A. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385952-5.00003-8 · Cited by 176
Brouwer, A., & Carhart-Harris, R. L. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120959637 · Cited by 174
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse
Korpi, E. R., den Hollander, B., Farooq, U., Vashchinkina, E., Rajkumar, R., Nutt, D. J., Hyytiä, P., & Dawe, G. S. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010967 · Cited by 148
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Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Bécamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.016 · Cited by 147
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Dakic, V., Minardi Nascimento, J., Costa Sartore, R., Maciel, R. D. M., de Araujo, D. B., Ribeiro, S., Martins-de-Souza, D., & Rehen, S. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-12779-5 · Cited by 134
Insights into Rapid Modulation of Neuroplasticity by Brain Estrogens
Srivastava, D. P., Woolfrey, K. M., & Penzes, P. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005272 · Cited by 146
Self-citationSerotonergic signaling: multiple effectors and pleiotropic effects
Masson, J., Emerit, M. B., Hamon, M., & Darmon, M. C. (2012) · Wiley Interdisciplinary Reviews Membrane Transport and Signalling · doi:10.1002/wmts.50 · Cited by 132
Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity
Olson, D. E. (2022) · Biochemistry · doi:10.1021/acs.biochem.1c00812 · Cited by 146
Bogenschutz, M. P., & Pommy, J. M. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1376 · Cited by 130
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Moxon, K. A., Oliviero, A., Aguilar, J., & Foffani, G. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.06.056 · Cited by 123
Maras, P. M., Molet, J., Chen, Y., Rice, C., Ji, S. G., Solodkin, A., & Baram, T. Z. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.12 · Cited by 118
Meltzer, H. Y., Rajagopal, L., Huang, M., Oyamada, Y., Kwon, S., & Horiguchi, M. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000928 · Cited by 116
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Dunn, H., & Ferguson, S. (2015) · Molecular Pharmacology · doi:10.1124/mol.115.098509 · Cited by 130
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Self-citationBeyond the 5-HT2AReceptor: Classic and Nonclassic Targets in Psychedelic Drug Action
Cameron, L. P., Benetatos, J., Lewis, V., Bonniwell, E. M., Jaster, A. M., Moliner, R., Ċastrén, E., McCorvy, J. D., Palner, M., & Aguilar‐Valles, A. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1384-23.2023 · Cited by 100
Modulatory effects of cannabinoids on brain neurotransmission
Cohen, K., Weizman, A., & Weinstein, A. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14407 · Cited by 98
Bender, D., & Hellerstein, D. J. (2022) · Psychopharmacology · doi:10.1007/s00213-021-06049-6 · Cited by 88
Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82
“…psychedelics to researchers, has been shown to increase dendritic growth (Persico et al., 2006; Ohtani et al., 2014; Ly, Greb et al., 2018; Ly et al., 2021), synaptic puncta, spine density (Yoshida et al., 2011; Ly et al., 2018), and spine size (Jones et al., 2009) in cultured cortical neurons.”
Srivastava, D. P., Woolfrey, K. M., Jones, K. A., Anderson, C. T., Smith, K. R., Russell, T. A., Lee, H., Yasvoina, M. V., Wokosin, D. L., Özdinler, P. H., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001350 · Cited by 85
Self-citationBlizinsky, K. D., Diaz-Castro, B., Forrest, M. P., Schürmann, B., Bach, A. P., Martin-de-Saavedra, M. D., Wang, L., Csernansky, J. G., Duan, J., & Penzes, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607014113 · Cited by 76
Self-citationKozłowska, U., Nichols, C. D., Wiatr, K., & Figiel, M. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15509 · Cited by 86
5-HT2A receptors: Pharmacology and functional selectivity
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Duan, W., Cao, D., Wang, S., & Cheng, J. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00375 · Cited by 81
Gong, Y., & Lippa, C. F. (2010) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317510382893 · Cited by 76
Control of dendritic spine morphological and functional plasticity by small GTPases.
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Muma, N. A., & Mi, Z. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500329r · Cited by 77
Fantegrossi, W. E., Wilson, C. D., & Berquist, M. D. (2018) · Drug Metabolism Reviews · doi:10.1080/03602532.2018.1428343 · Cited by 73
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Berthoux, C., Barre, A., Bockaert, J., Marin, P., & Bécamel, C. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy064 · Cited by 71
Analysis of Dendritic Spine Morphology in Cultured CNS Neurons
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Self-citationPichon, X., Wattiez, A., Bécamel, C., Ehrlich, I., Bockaert, J., Eschalier, A., Marin, P., & Courteix, C. (2010) · Molecular Therapy · doi:10.1038/mt.2010.101 · Cited by 66
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Jain, M. K., Gumpper, R. H., Slocum, S. T., Schmitz, G. P., Madsen, J. S., Tummino, T. A., Suomivuori, C., Huang, X.-P., Shub, L., DiBerto, J. F., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.06.012 · Cited by 74
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Self-citationDukhinova, M., Kuznetsova, I. S., Kopeikina, E., Veniaminova, E. A., Yung, A. W. Y., Veremeyko, T., Levchuk, K., Barteneva, N. S., Wing-Ho, K. K., Yung, W., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.09.009 · Cited by 63
Alba‐Delgado, C., Mountadem, S., Mermet-Joret, N., Monconduit, L., Dallel, R., Artola, A., & Antri, M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1294-18.2018 · Cited by 60
Aznar, S., & Klein, A. B. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8472-0 · Cited by 59
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Jefferson, S. J., Gregg, I., Dibbs, M., Liao, C., Wu, H., Davoudian, P. A., Woodburn, S. C., Wehrle, P. H., Sprouse, J. S., Sherwood, A. M., et al. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01572-w · Cited by 57
Franklin, J. M., & Carrasco, G. A. (2012) · Synapse · doi:10.1002/syn.21626 · Cited by 56
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Roth, B. L., & Gumpper, R. H. (2023) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230172 · Cited by 57
Self-citationSerotonin modulates excitatory synapse maturation in the developing prefrontal cortex
Ogelman, R., Wulschner, L. E. G., Hoelscher, V. M., Hwang, I.-W., Chang, V. N., & Oh, W. C. (2024) · Nature Communications · doi:10.1038/s41467-024-45734-w · Cited by 56
Horsley, R. R., Páleníček, T., Kolin, J., & Valeš, K. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000394 · Cited by 52
Effinger, D. P., Quadir, S. G., Ramage, M. C., Cone, M. G., & Herman, M. A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02414-5 · Cited by 51
Lysergic acid diethylamide: a drug of ‘use’?
Das, S., Barnwal, P., Ramasamy, A., Sen, S., & Mondal, S. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316640440 · Cited by 53
Epac2-mediated dendritic spine remodeling: Implications for disease
Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 49
Self-citationLeung, C., & Wong, Y. (2017) · Molecules · doi:10.3390/molecules22071239 · Cited by 48
KALRN: A central regulator of synaptic function and synaptopathies
Parnell, E., Shapiro, L. P., Voorn, R. A., Forrest, M. P., Jalloul, H. A., Loizzo, D. D., & Penzes, P. (2020) · Gene · doi:10.1016/j.gene.2020.145306 · Cited by 48
Self-citationMartin, H., Bullich, S., Guiard, B. P., & Fioramonti, X. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12928 · Cited by 51
Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease
Srivastava, D. P., & Penzes, P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00077 · Cited by 46
Self-citationKalrnplays key roles within and outside of the nervous system
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Mi, Z., Si, T., Kapadia, K., Li, Q., & Muma, N. A. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.01.034 · Cited by 44
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Self-citationAbnormal kalirin signaling in neuropsychiatric disorders
Remmers, C. L., Sweet, R. A., & Penzes, P. (2013) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2013.12.006 · Cited by 45
Self-citationShahar, O., Botvinnik, A., Shwartz, A., Lerer, E., Golding, P., Buko, A., Hamid, E., Kahn, D., Guralnick, M., Blakolmer, K., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02477-w · Cited by 40
Morgan, C. J. A., McAndrew, A., Stevens, T., Nutt, D., & Lawn, W. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.10.009 · Cited by 42
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Metadata
- Authors
- Jones, K. A., Srivastava, D. P., Allen, J. A., Strachan, R. T., Roth, B. L., & Penzes, P.
- Affiliations
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Case Western Reserve University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2009-11-17
- Volume
- 106
- Issue
- 46
- Pages
- 19575-19580
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC2780750
- OpenAlex
- W2143648030
- Cited by
- 226
- References
- 45
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 14 · 2023: 27 · 2022: 14 · 2021: 21 · 2020: 15 · 2019: 6 · 2018: 11 · 2017: 8 · 2016: 8 · 2015: 11 · 2014: 14 · 2013: 14 · 2012: 14
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- UNC Libraries
- Funders
- Alzheimer's Association
- American Heart Association
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (n01mh32004-8-0-0, U19MH82441)
- National Institute of Mental Health (U19MH082441, U19-MH82441, R01MH061887, R01MH61887, F31MH085362, N01 MH032004, R01MH071316)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD040127)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- 5-HT2A receptor, Kalirin-7, dendritic spine morphogenesis, cortical pyramidal neurons, p21-activated kinase, postsynaptic density, MUPP1, PSD-95, digital object identifiers, serotonin signaling, synaptic plasticity
- MeSH terms
- Animals, Carrier Proteins, Dendrites, Morphogenesis, Neuronal Plasticity, Spine, Synapses, Rats, Sprague-Dawley, Pyramidal Cells, Guanine Nucleotide Exchange Factors, Receptor, Serotonin, 5-HT2A, Intracellular Signaling Peptides and Proteins, Rats
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