Cited by 106Cognitive Abilities and TestingGenetic Associations and EpidemiologyAdvanced Neuroimaging Techniques and Applications

The dynamic role of genetics on cortical patterning during childhood and adolescence

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Schmitt, J. Eric, Neale, Michael C., Fassassi, Bilqis, Perez, Javier, Lenroot, Rhoshel K., Wells, Elizabeth M., Giedd, Jay N.·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: Quantitative genetic studies have established that evolutionarily novel regions of the cerebral cortex have high heritability within human populations. Longitudinal imaging studies have demonstrated that the cerebral cortex is highly dynamic in childhood. In the current study, we examine how genetic effects on cortical thickness change longitudinally over childhood and adolescence using a large genetically informative imaging sample. We find rapid changes in genetic effects in early childhood, with stabilization in late adolescence. The areas with the greatest changes include evolutionarily novel regions. These findings have implications for future molecular genetic studies of imaging endophenotypes and further our sparse understanding of how genes help to shape the brain after birth.

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Crossref · 10.1073/pnas.1311630111

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Authors
Schmitt, J. E., Neale, M. C., Fassassi, B., Perez, J., Lenroot, R. K., Wells, E. M., & Giedd, J. N.
Affiliations
  • Hospital of the University of Pennsylvania (US)
  • Virginia Commonwealth University (US)
  • National Institutes of Health (US)
  • UNSW Sydney (AU)
Venue
Proceedings of the National Academy of Sciences
Published
2014-04-21
Volume
111
Issue
18
Pages
6774-6779
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2089810490
Cited by
103
References
44
Citations by year
2026: 3 · 2025: 4 · 2024: 4 · 2023: 9 · 2022: 3 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 11 · 2015: 15 · 2014: 6 · 2013: 1
FWCI
19.94
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH-20030, T32MH020030)
  • National Institute of Biomedical Imaging and Bioengineering (EB-004311, T32EB004311)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
cortical thickness, heritability, brain development, childhood, adolescence, temporal pole, inferior parietal lobule, frontal cortex, longitudinal MRI, twins and siblings, latent growth curve models
MeSH terms
Adolescent, Cerebral Cortex, Child, Female, Frontal Lobe, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Organ Size, Parietal Lobe, Prospective Studies, Temporal Lobe, Twins, Dizygotic, Twins, Monozygotic, Genetic Variation, Body Patterning, Siblings, Young Adult, Neuroimaging

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