Wireless, intraoral hybrid electronics for real-time quantification of sodium intake toward hypertension management
Open accessAbstract
Significance: We introduce a soft, low-profile, intraoral electronics that offers continuous real-time monitoring of sodium intake via long-range wireless telemetry. The stretchable, hybrid electronic system integrates chip-scale components and microstructured sodium sensors with stretchable interconnects, together in an ultrasoft, breathable, microporous membrane. The quantitative computational and experimental studies of antenna performance optimize the wireless electronics, offering consistent functionality with minimal loss during multimodal deformation. Examples of in vivo study with human subjects demonstrate a highly sensitive, real-time quantification of sodium intake.
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An alternative in vivo oral monitoring device has been developed for sodium intake via long-range wireless telemetry.
“An alternative in vivo oral monitoring device has also been developed for sodium intake via long-range wireless telemetry (Fig. 6d)156.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [156]
This oral sensing platform relies on a user-comfortable system using ultrathin stretchable electronics along with miniaturized sensors.
“This oral sensing platform relies on a user-comfortable system using ultrathin stretchable electronics along with miniaturized sensors.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [156]
The performance of the sodium monitoring device has been demonstrated with human subjects, proving its feasibility for real-time monitoring of sodium consumption, which is desired for managing hypertension.
“The performance of the device has been demonstrated with human subjects, proving its feasibility for real-time monitoring of sodium consumption, which is desired for managing hypertension.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [156]
The toxicity of the sodium monitoring device was evaluated without the chemical sensing layer, and hence practical oral-cavity applications would require further critical assessment along with a biocompatible recognition layer.
“However, the toxicity of the device was evaluated without the chemical sensing layer, and hence practical oral-cavity applications would require further critical assessment along with a biocompatible recognition layer.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [156]
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- Authors
- Lee, Y., Howe, C., Mishra, S., Lee, D. S., Mahmood, M., Piper, M., Kim, Y., Tieu, K., Byun, H.-S., Coffey, J. P., Shayan, M., Chun, Y., Costanzo, R. M., & Yeo, W.-H.
- Affiliations
- George W. Woodruff School of Mechanical Engineering, College of Engineering, Georgia Institute of Technology, Atlanta, GA 30332;
- Virginia Commonwealth University (US)
- Georgia Institute of Technology (US)
- Chonnam National University (KR)
- University of Pittsburgh (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2018-05-07
- Volume
- 115
- Issue
- 21
- Pages
- 5377-5382
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6003521
- OpenAlex
- W2799555070
- Cited by
- 183
- References
- 43
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 19 · 2023: 27 · 2022: 31 · 2021: 25 · 2020: 29 · 2019: 24 · 2018: 3
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Holmes Museum Of Anthropology (Wichita State University) (submittedVersion)
- Funders
- ISTK | Korea Institute of Materials Science (PNK5061)
- Georgia Institute of Technology (Woodruff School of Mechanical Engineering)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Engineering › Biomedical Engineering › Wireless Body Area Networks
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- stretchable electronics, wearable sensors, wireless monitoring, antihypertensive therapy, soft electronics, flexible circuits, food intake measurement, dietary habits
- MeSH terms
- Wearable Electronic Devices, Adult, Electronics, Equipment Design, Humans, Hypertension, Male, Sodium, Dental Prosthesis, Wireless Technology
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