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Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.
Open accessAbstract
The interaction of the mouse c-kit receptor, designated Kit receptor, and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells. Monoclonal antibodies against the extracellular portion of the mouse Kit receptor were established. Five percent to 10% of total bone marrow cells expressed the Kit receptor, and half of them lack the expression of lineage markers. The Kit receptor was expressed on 70-80% of Thy-1.1lo Lin-Sca-1+ cells, which express Thy-1.1 antigen at a low level and constitute approximately 0.05% of adult bone marrow and fetal liver; by previous studies, these cells have been shown to be highly enriched for multipotent hematopoietic stem cells (HSCs) and are the only hematopoietic cell subset with this activity. Spleen colony formation and long-term multilineage reconstitution activities were contained in the Kit+ but not in the Kit- subpopulations of Thy-1lo Lin-Sca-1+ cells from adult bone marrow, suggesting that the Kit receptor is expressed on HSCs from the earliest stage-i.e., pluripotent HSCs. The role of steel factor in the development and self-renewal of HSCs was tested with Sl/Sl homozygote fetuses, which lack genes to encode functional steel factor. They were shown to have 30-40% of the number of HSCs on days 13-15 when compared with normal litermates. However, the absolute number of HSCs increased during fetal development in the Sl/Sl mice. The results suggest that the Kit receptor-steel factor interaction may not be essential for the initiation of hematopoiesis and the self-renewal of (at least) fetal HSCs.
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Citations
Cites
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
Geissler, E. N., Ryan, M. A., & Housman, D. E. (1988) · Cell · doi:10.1016/0092-8674(88)90020-7 · Cited by 1,287
Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L. (1990) · Cell · doi:10.1016/0092-8674(90)90262-d · Cited by 583
Self-citation
Cited by
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I. L., & Grompe, M. (2000) · Nature Medicine · doi:10.1038/81326 · Cited by 2,314
Self-citationIdentification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Kondo, M., Weissman, I. L., & Akashi, K. (1997) · Cell · doi:10.1016/s0092-8674(00)80453-5 · Cited by 2,253
Self-citationCell intrinsic alterations underlie hematopoietic stem cell aging
Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152
Self-citationStem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations
Weissman, I. L., Anderson, D. J., & Gage, F. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.387 · Cited by 948
Self-citationHematopoiesis: a human perspective
Doulatov, S., Notta, F., Laurenti, E., & Dick, J. E. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.01.006 · Cited by 895
In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells
Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3120 · Cited by 858
Adult haematopoietic stem cell niches
Crane, G. M., Jeffery, E., & Morrison, S. J. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.53 · Cited by 712
The purification and characterization of fetal liver hematopoietic stem cells
Morrison, S. J., Hemmati, H. D., Wandycz, A. M., & Weissman, I. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10302 · Cited by 611
Self-citationThymopoiesis independent of common lymphoid progenitors.
Allman, D., Sambandam, A., Kim, S., Miller, J. P., Pagan, A., Well, D., Meraz, A., & Bhandoola, A. (2003) · Nature Immunology · doi:10.1038/ni878 · Cited by 544
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Myeloid Lineage Commitment from the Hematopoietic Stem Cell
Iwasaki, H., & Akashi, K. (2007) · Immunity · doi:10.1016/j.immuni.2007.06.004 · Cited by 394
Hematopoietic Stem Cells Are the Major Source of Multilineage Hematopoiesis in Adult Animals
Sawai, C. M., Babovic, S., Upadhaya, S., Knapp, D. J. H. F., Lavin, Y., Lau, C. M., Goloborodko, A., Feng, J., Fujisaki, J., Ding, L., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.08.007 · Cited by 381
“The HSC activity in the BM of normal adult mice is contained in a small subset of Lineage marker (Lin)− Sca-1+ c-Kit+ (LSK) cells (Ikuta and Weissman, 1992; Morrison and Weissman, 1994) that express high levels of CD150 (Slamf1) and endothelial protein C receptor (EPCR) but low levels of CD135…”
Bowie, M. B., McKnight, K. D., Kent, D. G., McCaffrey, L., Hoodless, P. A., & Eaves, C. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28310 · Cited by 380
STAT3 is required for Flt3L-dependent dendritic cell differentiation
Laouar, Y., Welte, T., Fu, X.-Y., & Flavell, R. A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00332-7 · Cited by 334
Arinobu, Y., Mizuno, S.-I., Chong, Y., Shigematsu, H., Iino, T., Iwasaki, H., Graf, T., Mayfield, R., Chan, S., Kastner, P., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.07.004 · Cited by 309
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
Juntilla, M. M., Patil, V. D., Calamito, M., Joshi, R. P., Birnbaum, M. J., & Koretzky, G. A. (2010) · Blood · doi:10.1182/blood-2009-09-241000 · Cited by 284
Rothenberg, M. E., Nusse, Y., Kalisky, T., Lee, J. J., Dalerba, P., Scheeren, F., Lobo, N., Kulkarni, S., Sim, S., Qian, D., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.006 · Cited by 263
The hematopoietic stem cell niche: from embryo to adult
Gao, X., Xu, C., Asada, N., & Frenette, P. S. (2018) · Development · doi:10.1242/dev.139691 · Cited by 247
New models for analyzing mast cell functions in vivo
Reber, L. L., Marichal, T., & Galli, S. J. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.09.008 · Cited by 171
Blair, A., & Sutherland, H. J. (2000) · Experimental Hematology · doi:10.1016/s0301-472x(00)00155-7 · Cited by 165
Warr, M. R., Pietras, E. M., & Passegué, E. (2011) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.145 · Cited by 112
Approaches for Analyzing the Roles of Mast Cells and Their Proteases In Vivo
Galli, S. J., Tsai, M., Marichal, T., Tchougounova, E., Reber, L. L., & Pejler, G. (2015) · Advances in Immunology · doi:10.1016/bs.ai.2014.11.002 · Cited by 101
Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance
Perry, S. S., Zhao, Y., Nie, L., Cochrane, S. W., Huang, Z., & Sun, X.-H. (2007) · Blood · doi:10.1182/blood-2007-01-069914 · Cited by 100
Bryder, D., Ramsfjell, V., Dybedal, I., Theilgaard-Mönch, K., Högerkorp, C.-M., Adolfsson, J., Borge, O. J., & Jacobsen, S. E. W. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.941 · Cited by 98
MicroRNA-146a disrupts hematopoietic differentiation and survival
Starczynowski, D. T., Kuchenbauer, F., Wegrzyn, J., Rouhi, A., Petriv, O., Hansen, C. L., Humphries, R. K., & Karsan, A. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2010.09.011 · Cited by 84
Murine foetal liver supports limited detectable expansion of life‐long haematopoietic progenitors
Ganuza, M., Hall, T., Myers, J., Nevitt, C., Sánchez-Lanzas, R., Chabot, A., Ding, J., Kooienga, E., Caprio, C., Finkelstein, D., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00999-5 · Cited by 83
Chu, S. H., Heiser, D., Li, L., Kaplan, I., Collector, M., Huso, D., Sharkis, S. J., Civin, C., & Small, D. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.05.027 · Cited by 79
Nygren, J. M., Bryder, D., & Jacobsen, S. E. W. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.201 · Cited by 72
Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells
Bradley, H. L., Hawley, T. S., & Bunting, K. D. (2002) · Blood · doi:10.1182/blood-2002-05-1602 · Cited by 59
Chen, W., Gu, P., Jiang, X., Ruan, H.-B., Li, C., & Gao, X. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.01.041 · Cited by 30
Low c-Kit expression identifies primitive, therapy-resistant CML stem cells
Shah, M., Kumar, H., Qiu, S., Li, H., Harris, M., He, J., Abraham, A., Crossman, D. K., Paterson, A., Welner, R. S., et al. (2023) · JCI Insight · doi:10.1172/jci.insight.157421 · Cited by 11
Metadata
- Authors
- Ikuta, K., & Weissman, I. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-02-15
- Volume
- 89
- Issue
- 4
- Pages
- 1502-1506
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972736348
- Cited by
- 636
- References
- 2
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- green
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