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Cited by 13Urinary Tract Infections ManagementReproductive tract infections researchUrinary Bladder and Prostate Research

Microbiota Ecosystem in Recurrent Cystitis and the Immunological Microenvironment of Urothelium

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Dominoni, Mattia, Scatigno, Annachiara Licia, La Verde, Marco, Bogliolo, Stefano, Melito, Chiara, Gritti, Andrea, Pasquali, Marianna Francesca, Torella, Marco +1 more·2023·Healthcare
DOI 10.3390/healthcare11040525PMC PMC9956625
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Abstract

Urinary tract infections (UTIs) represent one of the most frequent low genital tract diseases in the female population. When UTIs occur with a frequency of at least three times per year or two times in the last six month, we speak of recurrent UTI (rUTI) and up to 70% of women will have rUTI within 1 year. It was previously thought that antibiotic resistance was principally responsible for the recurrence of UTIs, but nowadays new diagnostic technologies have shown the role of microbiota in the pathophysiology of these diseases. Much research has been conducted on the role of gut microbiome in the development of rUTI, while little is known yet about vaginal and urinary microbiome and the possible immunological and microscopical mechanisms through which they trigger symptoms. New discoveries and clinical perspectives are arising, and they all agree that a personalized, multi-modal approach, treating vaginal and urinary dysbiosis, may reduce rUTIs more successfully.

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  1. [1]Stamm W.E. Norrby S.R. Urinary Tract Infections: Disease Panorama and Challenges J. Infect. Dis. 2001 183 (Suppl. 1) S1 S4 10.1086/318850 11171002 · DOI
  2. [2]Cox C.E. Lacy S.S. Hinman F. Jr. The Urethra and its Relationship to Urinary Tract Infection. II. The Urethral Flora of the Female with Recurrent Urinary Infection J. Urol. 1968 99 632 638 10.1016/S0022-5347(17)62762-9 4869868 · DOI
  3. [3]Al-Badr A. Al-Shaikh G. Recurrent Urinary Tract Infections Management in Women: A review Sultan Qaboos Univ. Med. J. 2013 13 359 367 10.12816/0003256 23984019 PMC3749018 · DOI
  4. [4]Renard J. Ballarini S. Mascarenhas T. Zahran M. Quimper E. Choucair J. Iselin C.E. Recurrent Lower Urinary Tract Infections Have a Detrimental Effect on Patient Quality of Life: A Prospective, Observational Study Infect. Dis. Ther. 2014 4 125 135 10.1007/s40121-014-0054-6 25519161 PMC4363217 · DOI
  5. [5]Dason S. Dason J.T. Kapoor A. Guidelines for the diagnosis and management of recurrent urinary tract infection in women Can. Urol. Assoc. J. 2013 5 316 322 10.5489/cuaj.687 PMC3202002 22031610 · DOI
  6. [6]Sabih A. Leslie S.W. Complicated Urinary Tract Infections StatPearls StatPearls Publishing Treasure Island, FL, USA 2022 Available online: https://www-ncbi-nlm-nih-gov.offcampus.lib.washington.edu/books/NBK436013/ (accessed on 12 August 2021) 28613784
  7. [8]Sihra N. Goodman A. Zakri R. Sahai A. Malde S. Nonantibiotic prevention and management of recurrent urinary tract infection Nat. Rev. Urol. 2018 15 750 776 10.1038/s41585-018-0106-x 30361493 · DOI
  8. [9]Boldogh I. Albrecht T. Porter D.D. Persistent Viral Infections Medical Microbiology 4th ed. Baron S. University of Texas Medical Branch at Galveston Galveston, TX, USA 1996 Chapter 46 Available online: https://www.ncbi.nlm.nih.gov/books/NBK8538/ (accessed on 30 January 2023) 21413348
  9. [10]Foxman B. Urinary Tract Infection Syndromes: Occurrence, recurrence, bacteriology, risk factors, and disease burden Infect. Dis. Clin. N. Am. 2014 28 1 13 10.1016/j.idc.2013.09.003 24484571 · DOI
  10. [11]Foxman B. Gillespie B. Koopman J. Zhang L. Palin K. Tallman P. Marsh J.V. Spear S. Sobel J.D. Marty M.J. Risk Factors for Second Urinary Tract Infection among College Women Am. J. Epidemiol. 2000 151 1194 1205 10.1093/oxfordjournals.aje.a010170 10905532 · DOI
  11. [12]Foxman B. Manning S. Tallman P. Bauer R. Zhang L. Koopman J.S. Gillespie B. Sobel J.D. Marrs C.F. Uropathogenic Escherichia coli Are More Likely than Commensal E. coli to Be Shared between Heterosexual Sex Partners Am. J. Epidemiol. 2002 156 1133 1140 10.1093/aje/kwf159 12480658 · DOI
  12. [13]Murray B.E. Rensimer E.R. DuPont H.L. Emergence of high-level trimethoprim resistance in fecal Escherichia coli during oral ad-ministration of trimethoprim or trimethoprim—Sulfamethoxazole N. Engl. J. Med. 1982 306 130 135 10.1056/NEJM198201213060302 7033781 · DOI
  13. [14]Wright S.W. Wrenn K.D. Haynes M.L. Trimethoprim-sulfamethoxazole resistance among urinary coliform isolates J. Gen. Intern. Med. 1999 14 606 609 10.1046/j.1525-1497.1999.10128.x 10571705 PMC1496756 · DOI
  14. [15]Kristiansen J.E. The antimicrobial activity of non-antibiotics. Report from a congress on the antimicrobial effect of drugs other than antibiotics on bacteria, viruses, protozoa, and other organisms APMIS. Suppl. 1992 30 7 14 1295545
  15. [16]Ulett G.C. Schembri M.A. Bacterial pathogenesis: Remodelling recurrent infection Nat. Microbiol. 2016 2 16256 10.1038/nmicrobiol.2016.256 27995931 · DOI
  16. [17]Langford B.J. Brown K.A. Diong C. Marchand-Austin A. Adomako K. Saedi A. Schwartz K.L. Johnstone J. MacFadden D.R. Matukas L.M. The Benefits and Harms of Antibiotic Prophylaxis for Urinary Tract Infection in Older Adults Clin. Infect. Dis. 2021 73 e782 e791 10.1093/cid/ciab116 33595621 · DOI
  17. [18]Gasiorek M. Hsieh M.H. Forster C.S. Utility of DNA Next-Generation Sequencing and Expanded Quantitative Urine Culture in Diagnosis and Management of Chronic or Persistent Lower Urinary Tract Symptoms J. Clin. Microbiol. 2019 58 e00204-19 10.1128/JCM.00204-19 31619534 PMC6935904 · DOI
  18. [19]Thomas-White K. Brady M. Wolfe A.J. Mueller E.R. The Bladder Is Not Sterile: History and Current Discoveries on the Urinary Microbiome Curr. Bladder Dysfunct. Rep. 2016 11 18 24 10.1007/s11884-016-0345-8 27182288 PMC4864995 · DOI
  19. [20]Pohl H.G. Groah S.L. Pérez-Losada M. Ljungberg I. Sprague B.M. Chandal N. Caldovic L. Hsieh M. The Urine Microbiome of Healthy Men and Women Differs by Urine Collection Method Int. Neurourol. J. 2020 24 41 51 10.5213/inj.1938244.122 32252185 PMC7136448 · DOI
  20. [21]Ley R.E. Peterson D.A. Gordon J.I. Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine Cell 2006 124 837 848 10.1016/j.cell.2006.02.017 16497592 · DOI · Paper page
  21. [22]Higgins J. Altman D. Sterne J. Chapter 8: Assessing risk of bias in included studies Cochrane Handbook for Systematic Reviews of Interventions, Version 5.2.0 Higgins J.P.T. Churchill R. Chandler J. Cumpston M.S. John Wiley and Sons Chichester, UK 2017
  22. [23]Schünemann H.J. Higgins J.P. Vist G.E. Glasziou P. Akl E.A. Skoetz N. Guyatt G.H. Cochrane GRADEing Methods Group Cochrane Statistical Methods Group Chapter 14: Completing ‘Summary of findings’ tables and grading the certainty of the evidence Cochrane Handbook for Systematic Reviews of Interventions, Version 6.2 Higgins J.P. Thomas J. Chandler J. Cumpston M. Li T. Page M.J. Welch V.A. John Wiley and Sons Chichester, UK 2021
  23. [24]Czaja C.A. Stamm W.E. Stapleton A.E. Roberts P.L. Hawn T.R. Scholes D. Samadpour M. Hultgren S.J. Hooton T.M. Prospective Cohort Study of Microbial and Inflammatory Events Immediately Preceding Escherichia coli Recurrent Urinary Tract Infection in Women J. Infect. Dis. 2009 200 528 536 10.1086/600385 19586416 PMC3674869 · DOI · Paper page
  24. [25]Ravel J. Gajer P. Abdo Z. Schneider G.M. Koenig S.S.K. McCulle S.L. Karlebach S. Gorle R. Russell J. Tacket C.O. Vaginal microbiome of reproductive-age women Proc. Natl. Acad. Sci. USA 2011 108 (Suppl. S1) 4680 4687 10.1073/pnas.1002611107 20534435 PMC3063603 · DOI · Paper page
  25. [27]Tamarelle J. Thiébaut A. de Barbeyrac B. Bébéar C. Ravel J. Delarocque-Astagneau E. The vaginal microbiota and its association with human papillomavirus, Chlamydia trachomatis, Neisseria gonorrhoeae and Mycoplasma genitalium infections: A systematic review and meta-analysis Clin. Microbiol. Infect. 2019 25 35 47 10.1016/j.cmi.2018.04.019 29729331 PMC7362580 · DOI
  26. [28]Borges S. Silva J. Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health Arch. Gynecol. Obstet. 2013 289 479 489 10.1007/s00404-013-3064-9 24170161 · DOI · Paper page
  27. [29]Tachedjian G. Aldunate M. Bradshaw C.S. Cone R.A. The role of lactic acid production by probiotic Lactobacillus species in vaginal health Res. Microbiol. 2017 168 782 792 10.1016/j.resmic.2017.04.001 28435139 · DOI · Paper page
  28. [30]Lewis A.L. Gilbert N.M. Roles of the vagina and the vaginal microbiota in urinary tract infection: Evidence from clinical correlations and experimental models GMS Infect. Dis. 2020 8 DOC02 10.3205/id000046 32373427 PMC7186798 · DOI · Paper page
  29. [31]Hudson P.L. Hung K.J. Bergerat A. Mitchell C. Effect of Vaginal Lactobacillus Species on Escherichia coli Growth Urogynecology 2020 26 146 151 10.1097/SPV.0000000000000827 31990804 · DOI
  30. [32]Vagios S. Hesham H. Mitchell C. Understanding the potential of lactobacilli in recurrent UTI prevention Microb. Pathog. 2020 148 104544 10.1016/j.micpath.2020.104544 33010368 · DOI · Paper page
  31. [33]Pfau A. Sacks T. The Bacterial Flora of the Vaginal Vestibule, Urethra and Vagina in Premenopausal Women with Recurrent Urinary Tract Infections J. Urol. 1981 126 630 634 10.1016/S0022-5347(17)54661-3 7029007 · DOI
  32. [34]Gupta K. Stapleton A. Hooton T.M. Roberts P.L. Fennell C.L. Stamm W.E. Inverse Association of H2O2-Producing Lactobacilli and Vaginal Escherichia coli Colonization in Women with Recurrent Urinary Tract Infections J. Infect. Dis. 1998 178 446 450 10.1086/515635 9697725 · DOI
  33. [35]Hooton T.M. Fihn S.D. Johnson C. Roberts P.L. Stamm W.E. Association between bacterial vaginosis and acute cystitis in women using diaphragms Arch. Intern. Med. 1989 149 1932 1936 10.1001/archinte.1989.00390090014003 2673116 · DOI
  34. [37]Harmanli O.H. Cheng G.Y. Nyirjesy P. Chatwani A. Gaughan J.P. Urinary Tract Infections in Women with Bacterial Vaginosis Obstet. Gynecol. 2000 95 710 712 10.1097/00006250-200005000-00015 10775734 · DOI · Paper page
  35. [38]Stapleton A.E. Au-Yeung M. Hooton T.M. Fredricks D.N. Roberts P.L. Czaja C.A. Yarova-Yarovaya Y. Fiedler T. Cox M. Stamm W.E. Randomized, Placebo-Controlled Phase 2 Trial of a Lactobacillus crispatus Probiotic Given Intravaginally for Prevention of Recurrent Urinary Tract Infection Clin. Infect. Dis. 2011 52 1212 1217 10.1093/cid/cir183 21498386 PMC3079401 · DOI · Paper page
  36. [39]Amatya R. Bhattarai S. Mandal P.K. Tuladhar H. Karki B.M.S. Urinary tract infection in vaginitis: A condition often overlooked Nepal. Med. Coll. J. 2013 15 65 67 24592798
  37. [40]Navas-Nacher E.L. Dardick F. Venegas M.F. Anderson B.E. Schaeffer A.J. Duncan J.L. Relatedness of Escherichia coli Colonizing Women Longitudinally Mol. Urol. 2001 5 31 36 10.1089/109153601750124285 11689149 · DOI · Paper page
  38. [41]Muder R.R. Brennen C. Rihs J.D. Wagener M.M. Obman A. Stout J.E. Yu V.L. Isolation of Staphylococcus aureus from the Urinary Tract: Association of Isolation with Symptomatic Urinary Tract Infection and Subsequent Staphylococcal Bacteremia Clin. Infect. Dis. 2006 42 46 50 10.1086/498518 16323090 · DOI
  39. [42]Baraboutis I.G. Tsagalou E.P. Lepinski J.L. Papakonstantinou I. Papastamopoulos V. Skoutelis A.T. Johnson S. Primary Staphylococcus aureus urinary tract infection: The role of undetected hematogenous seeding of the urinary tract Eur. J. Clin. Microbiol. Infect. Dis. 2010 29 1095 1101 10.1007/s10096-010-0967-2 20703891 · DOI
  40. [43]Gilbert N.M. O’Brien V.P. Hultgren S. Macones G. Lewis W.G. Lewis A.L. Urinary Tract Infection as a Preventable Cause of Pregnancy Complications: Opportunities, Challenges, and a Global Call to Action Glob. Adv. Health Med. 2013 2 59 69 10.7453/gahmj.2013.061 24416696 PMC3833562 · DOI
  41. [44]Kline K.A. Lewis A.L. Gram-Positive Uropathogens, Polymicrobial Urinary Tract Infection, and the Emerging Microbiota of the Urinary Tract Microbiol. Spectr. 2016 4 UTI-0012-2012 10.1128/microbiolspec.UTI-0012-2012 27227294 PMC4888879 · DOI
  42. [45]Allsworth J.E. Lewis V.A. Peipert J.F. Viral Sexually Transmitted Infections and Bacterial Vaginosis: 2001–2004 National Health and Nutrition Examination Survey Data Sex. Transm. Dis. 2008 35 791 796 10.1097/OLQ.0b013e3181788301 18607314 · DOI
  43. [46]Klein S. Nurjadi D. Horner S. Heeg K. Zimmermann S. Burckhardt I. Significant increase in cultivation of Gardnerella vaginalis, Alloscardovia omnicolens, Actinotignum schaalii, and Actinomyces spp. in urine samples with total laboratory automation Eur. J. Clin. Microbiol. Infect. Dis. 2018 37 1305 1311 10.1007/s10096-018-3250-6 29651616 PMC6015101 · DOI
  44. [47]Sumati A. Saritha N. Association of urinary tract infection in women with bacterial vaginosis J. Glob. Infect. Dis. 2009 1 151 152 10.4103/0974-777X.56254 20300409 PMC2840952 · DOI
  45. [48]Gilbert N.M. O’Brien V.P. Lewis A.L. Transient microbiota exposures activate dormant Escherichia coli infection in the bladder and drive severe outcomes of recurrent disease PLoS Pathog. 2017 13 e1006238 10.1371/journal.ppat.1006238 28358889 PMC5373645 · DOI
  46. [49]Donders G.G. Vereecken A. Bosmans E. Dekeersmaecker A. Salembier G. Spitz B. Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: Aerobic vaginitis BJOG Int. J. Obstet. Gynaecol. 2002 109 34 43 10.1111/j.1471-0528.2002.00432.x 11845812 · DOI
  47. [50]Tan C.K. Ulett K.B. Steele M. Benjamin W.H. Jr. Ulett G.C. Prognostic value of semi-quantitative bacteruria counts in the diagnosis of group B streptococcus urinary tract infection: A 4-year retrospective study in adult patients BMC Infect. Dis. 2012 12 273 10.1186/1471-2334-12-273 23101431 PMC3514254 · DOI
  48. [51]Gottschick C. Deng Z.-L. Vital M. Masur C. Abels C. Pieper D.H. Wagner-Döbler I. The urinary microbiota of men and women and its changes in women during bacterial vaginosis and antibiotic treatment Microbiome 2017 5 99 10.1186/s40168-017-0305-3 28807017 PMC5554977 · DOI
  49. [52]Groah S.L. Pérez-Losada M. Caldovic L. Ljungberg I.H. Sprague B.M. Castro-Nallar E. Chandel N.J. Hsieh M.H. Pohl H. Redefining Healthy Urine: A Cross-Sectional Exploratory Metagenomic Study of People with and Without Bladder Dysfunction J. Urol. 2016 196 579 587 10.1016/j.juro.2016.01.088 26807926 · DOI
  50. [53]Forster C.S. Pohl H. Diagnosis of Urinary Tract Infection in the Neuropathic Bladder: Changing the Paradigm to Include the Microbiome Top. Spinal Cord Inj. Rehabil. 2019 25 222 227 10.1310/sci2503-222 31548789 PMC6743744 · DOI
  51. [54]Whiteside S.A. Razvi H. Dave S. Reid G. Burton J.P. The microbiome of the urinary tract—A role beyond infection Nat. Rev. Urol. 2015 12 81 90 10.1038/nrurol.2014.361 25600098 · DOI
  52. [55]Atassi F. Ahn D.L.P.V. Moal V.L.-L. Diverse Expression of Antimicrobial Activities Against Bacterial Vaginosis and Urinary Tract Infection Pathogens by Cervicovaginal Microbiota Strains of Lactobacillus gasseri and Lactobacillus crispatus Front. Microbiol. 2019 10 2900 10.3389/fmicb.2019.02900 31921075 PMC6933176 · DOI · Paper page
  53. [56]De Seta F. Lonnee-Hoffmann R.M. Campisciano G. Comar M. Verstraelen H.M. Vieira-Baptista P. Ventolini G.M. Lev-Sagie A. The Vaginal Microbiome: III. The Vaginal Microbiome in Various Urogenital Disorders J. Low. Genit. Tract Dis. 2022 26 85 92 10.1097/LGT.0000000000000645 34928258 PMC8719503 · DOI
  54. [57]Morand A. Cornu F. Dufour J.-C. Tsimaratos M. Lagier J.-C. Raoult D. Human Bacterial Repertoire of the Urinary Tract: A Potential Paradigm Shift J. Clin. Microbiol. 2019 57 e00675-18 10.1128/JCM.00675-18 30404941 PMC6425171 · DOI
  55. [58]Dubourg G. Morand A. Mekhalif F. Godefroy R. Corthier A. Yacouba A. Diakite A. Cornu F. Cresci M. Brahimi S. Deciphering the Urinary Microbiota Repertoire by Culturomics Reveals Mostly Anaerobic Bacteria from the Gut Front. Microbiol. 2020 11 513305 10.3389/fmicb.2020.513305 33178140 PMC7596177 · DOI
  56. [59]Neugent M.L. Hulyalkar N.V. Nguyen V.H. Zimmern P.E. De Nisco N.J. Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection Mbio 2020 11 e00218-20 10.1128/mBio.00218-20 32345639 PMC7188990 · DOI
  57. [60]Bossa L. Kline K. McDougald D. Lee B.B. Rice S.A. Urinary catheter-associated microbiota change in accordance with treatment and infection status PLoS ONE 2017 12 e0177633 10.1371/journal.pone.0177633 28628622 PMC5476236 · DOI
  58. [61]Burnett L.A. Hochstedler B.R. Weldon K. Wolfe A.J. Brubaker L. Recurrent urinary tract infection: Association of clinical profiles with urobiome composition in women Neurourol. Urodyn. 2021 40 1479 1489 10.1002/nau.24707 34036621 PMC8298270 · DOI
  59. [62]Elliott T. Reed L. Slack R. Bishop M. Bacteriology and ultrastructure of the bladder in patients with urinary tract infections J. Infect. 1985 11 191 199 10.1016/S0163-4453(85)92997-4 3936879 · DOI
  60. [63]Robino L. Scavone P. Araujo L. Algorta G. Zunino P. Pírez M.C. Vignoli R. Intracellular Bacteria in the Pathogenesis of Escherichia coli Urinary Tract Infection in Children Clin. Infect. Dis. 2014 59 e158 e164 10.1093/cid/ciu634 25091303 PMC4650771 · DOI
  61. [65]Liu S.-C. Han X.-M. Shi M. Pang Z.-L. Persistence of uropathogenic Escherichia Coli in the bladders of female patients with sterile urine after antibiotic therapies J. Huazhong Univ. Sci. Technol. 2016 36 710 715 10.1007/s11596-016-1649-9 27752899 · DOI
  62. [66]De Nisco N.J. Neugent M. Mull J. Chen L. Kuprasertkul A. de Souza Santos M. Palmer K.L. Zimmern P. Orth K. Direct detection of tissue-resident bacteria and chronic inflammation in the bladder wall of postmenopausal women with recurrent urinary tract infection J. Mol. Biol. 2019 431 4368 4379 10.1016/j.jmb.2019.04.008 31002774 PMC6801050 · DOI
  63. [67]Ejrnaes K. Sandvang D. Lundgren B. Ferry S. Holm S. Monsen T. Lundholm R. Frimodt-Moller N. Pulsed-Field Gel Electrophoresis Typing of Escherichia coli Strains from Samples Collected before and after Pivmecillinam or Placebo Treatment of Uncomplicated Community-Acquired Urinary Tract Infection in Women J. Clin. Microbiol. 2006 44 1776 1781 10.1128/JCM.44.5.1776-1781.2006 16672406 PMC1479185 · DOI
  64. [68]Luo Y. Ma Y. Zhao Q. Wang L. Guo L. Ye L. Zhang Y. Yang J. Similarity and Divergence of Phylogenies, Antimicrobial Susceptibilities, and Virulence Factor Profiles of Escherichia coli Isolates Causing Recurrent Urinary Tract Infections That Persist or Result from Reinfection J. Clin. Microbiol. 2012 50 4002 4007 10.1128/JCM.02086-12 23035197 PMC3502954 · DOI
  65. [69]Skjøt-Rasmussen L. Olsen S. Jakobsen L. Ejrnæs K. Scheutz F. Lundgren B. Frimodt-Møller N. Hammerum A. Escherichia coli clonal group A causing bacteraemia of urinary tract origin Clin. Microbiol. Infect. 2013 19 656 661 10.1111/j.1469-0691.2012.03961.x 22784317 · DOI
  66. [70]Kõljalg S. Truusalu K. Stsepetova J. Pai K. Vainumäe I. Sepp E. Mikelsaar M. The Escherichia coli phylogenetic group B2 with integrons prevails in childhood recurrent urinary tract infections Apmis 2014 122 452 458 10.1111/apm.12167 24033434 · DOI
  67. [71]Yoo J.-J. Song J.S. Bin Kim W. Yun J. Shin H.B. Jang M.-A. Ryu C.B. Kim S.S. Chung J.C. Kuk J.C. Gardnerella vaginalis in Recurrent Urinary Tract Infection Is Associated with Dysbiosis of the Bladder Microbiome J. Clin. Med. 2022 11 2295 10.3390/jcm11092295 35566419 PMC9100223 · DOI
  68. [72]Stapleton A.E. The Vaginal Microbiota and Urinary Tract Infection Microbiol. Spectr. 2016 4 79 86 10.1128/microbiolspec.UTI-0025-2016 PMC5746606 28087949 · DOI
  69. [73]Raz R. Urinary Tract Infection in Postmenopausal Women Korean J. Urol. 2011 52 801 808 10.4111/kju.2011.52.12.801 22216390 PMC3246510 · DOI
  70. [74]Muhleisen A.L. Herbst-Kralovetz M.M. Menopause and the vaginal microbiome Maturitas 2016 91 42 50 10.1016/j.maturitas.2016.05.015 27451320 · DOI
  71. [75]Mitchell C.M. Waetjen L.E. Genitourinary changes with aging Obstet. Gynecol. Clin. N. Am. 2018 45 737 750 10.1016/j.ogc.2018.07.010 30401554 · DOI
  72. [76]Bhide A. Tailor V. Khullar V. Interstitial cystitis/bladder pain syndrome and recurrent urinary tract infection and the potential role of the urinary microbiome Post Reprod. Health 2020 26 87 90 10.1177/2053369120936426 32627695 PMC7521016 · DOI
  73. [77]Jung C. Brubaker L. The etiology and management of recurrent urinary tract infections in postmenopausal women Climacteric 2019 22 242 249 10.1080/13697137.2018.1551871 30624087 PMC6629580 · DOI · Paper page
  74. [78]Hugenholtz F. van der Veer C. Terpstra M.L. Borgdorff H. van Houdt R. Bruisten S. Geerlings S.E. van de Wijgert J.H.H.M. Urine and vaginal microbiota compositions of postmenopausal and premenopausal women differ regardless of recurrent urinary tract infection and renal transplant status Sci. Rep. 2022 12 2698 10.1038/s41598-022-06646-1 35177690 PMC8854725 · DOI
  75. [79]Vaughan M.H. Mao J. Karstens L.A. Ma L. Amundsen C.L. Schmader K.E. Siddiqui N.Y. The Urinary Microbiome in Postmenopausal Women with Recurrent Urinary Tract Infections J. Urol. 2021 206 1222 1231 10.1097/JU.0000000000001940 34181466 PMC8497440 · DOI
  76. [80]Curtiss N. Balachandran A. Krska L. Peppiatt-Wildman C. Wildman S. Duckett J. Age, menopausal status and the bladder microbiome Eur. J. Obstet. Gynecol. Reprod. Biol. 2018 228 126 129 10.1016/j.ejogrb.2018.06.011 29936400 · DOI
  77. [81]Biagi E. Candela M. Fairweather-Tait S. Franceschi C. Brigidi P. Ageing of the human metaorganism: The microbial counterpart Age 2011 34 247 267 10.1007/s11357-011-9217-5 21347607 PMC3260362 · DOI
  78. [82]Yoo J.-J. Shin H.B. Song J.S. Kim M. Yun J. Kim Z. Lee Y.M. Lee S.W. Lee K.W. Kim W.b. Urinary Microbiome Characteristics in Female Patients with Acute Uncomplicated Cystitis and Recurrent Cystitis J. Clin. Med. 2021 10 1097 10.3390/jcm10051097 33807946 PMC7961880 · DOI
  79. [83]Ansaldi Y. Weber B.M.d.T. Urinary tract infections in pregnancy Clin. Microbiol. Infect. 2022 10.1016/j.cmi.2022.08.015 36031053 · DOI
  80. [86]Dominguez-Bello M.G. Gestational shaping of the maternal vaginal microbiome Nat. Med. 2019 25 882 883 10.1038/s41591-019-0483-6 31142848 · DOI
  81. [88]Eschenbach D.A. Patton D.L. Meier A. Thwin S.S. Aura J. Stapleton A. Hooton T.M. Effects of oral contraceptive pill use on vaginal flora and vaginal epithelium Contraception 2000 62 107 112 10.1016/S0010-7824(00)00155-4 11124356 · DOI
  82. [89]Gupta K. Hillier S.L. Hooton T.M. Roberts P.L. Stamm W.E. Effects of Contraceptive Method on the Vaginal Microbial Flora: A Prospective Evaluation J. Infect. Dis. 2000 181 595 601 10.1086/315267 10669343 · DOI
  83. [90]Hooton T.M. Hillier S. Johnson C. Roberts P.L. Stamm W.E. Escherichia coli Bacteriuria and Contraceptive Method JAMA 1991 265 64 69 10.1001/jama.1991.03460010064032 1859519 · DOI
  84. [91]Hooton T.M. Scholes D. Roberts P.L. Stapleton A. Stergachis A. Stamm W.E. A prospective cohort study of the association between UTI and contraceptive method Abstr. Intersci. Conf. Antimicrob. Agents Chemother. 1994 34 134
  85. [92]Hooton T.M. Fennell C.L. Clark A.M. Stamm W.E. Nonoxynol-9: Differential Antibacterial Activity and Enhancement of Bacterial Adherence to Vaginal Epithelial Cells J. Infect. Dis. 1991 164 1216 1219 10.1093/infdis/164.6.1216 1659602 · DOI
  86. [93]Achilles S.L. Hillier S.L. The complexity of contraceptives: Understanding their impact on genital immune cells and vaginal microbiota AIDS 2013 27 (Suppl 1) S5 S15 10.1097/QAD.0000000000000058 24088684 PMC4012023 · DOI
  87. [94]Raz R. Stamm W.E. A Controlled Trial of Intravaginal Estriol in Postmenopausal Women with Recurrent Urinary Tract Infections N. Engl. J. Med. 1993 329 753 756 10.1056/NEJM199309093291102 8350884 · DOI
  88. [95]Stapleton A. Latham R.H. Johnson C. Stamm W.E. Postcoital antimicrobial prophylaxis for recurrent urinary tract infection. A randomized, double-blind, placebo-controlled trial JAMA 1990 264 703 706 10.1001/jama.1990.03450060049027 2197450 · DOI
  89. [96]Stamatiou C. Bovis C. Panagopoulos P. Petrakos G. Economou A. Lycoudt A. Sex-induced cystitis--patient burden and other epidemiological features Clin. Exp. Obstet. Gynecol. 2005 32 180 182 16433159
  90. [97]Hooton T.M. Scholes D. Hughes J.P. Winter C. Roberts P.L. Stapleton A.E. Stergachis A. Stamm W.E. A Prospective Study of Risk Factors for Symptomatic Urinary Tract Infection in Young Women N. Engl. J. Med. 1996 335 468 474 10.1056/NEJM199608153350703 8672152 · DOI
  91. [98]Scholes D. Hooton T.M. Roberts P.L. Stapleton A. Gupta K. Stamm W.E. Risk Factors for Recurrent Urinary Tract Infection in Young Women J. Infect. Dis. 2000 182 1177 1182 10.1086/315827 10979915 · DOI
  92. [99]Shreiner A.B. Kao J.Y. Young V.B. The gut microbiome in health and in disease Curr. Opin. Gastroenterol. 2015 31 69 75 10.1097/MOG.0000000000000139 25394236 PMC4290017 · DOI
  93. [100]Cumpanas A.A. Bratu O.G. Bardan R. Ferician O.C. Cumpanas A.D. Horhat F.G. Licker M. Pricop C. Cretu O.M. Urinary Microbiota—Are We Ready for Prime Time? A Literature Review of Study Methods’ Critical Steps in Avoiding Contamination and Minimizing Biased Results Diagnostics 2020 10 343 10.3390/diagnostics10060343 32471022 PMC7345871 · DOI
  94. [101]Meštrović T. Matijašić M. Perić M. Čipčić Paljetak H. Barešić A. Verbanac D. The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside Diagnostics 2021 11 7 10.3390/diagnostics11010007 33375202 PMC7822161 · DOI
  95. [102]Wolfe A.J. Brubaker L. Urobiome updates: Advances in urinary microbiome research Nat. Rev. Urol. 2019 16 73 74 10.1038/s41585-018-0127-5 30510275 PMC6628711 · DOI
  96. [103]Lewis D.A. Brown R. Williams J. White P. Jacobson S.K. Marchesi J.R. Drake M.J. The human urinary microbiome; bacterial DNA in voided urine of asymptomatic adults Front. Cell. Infect. Microbiol. 2013 3 41 10.3389/fcimb.2013.00041 23967406 PMC3744036 · DOI
  97. [104]Finucane T.E. ‘Urinary tract infection’ and the microbiome Am. J. Med. 2017 130 e97 e98 10.1016/j.amjmed.2016.08.018 27593612 · DOI
  98. [105]Ackerman A.L. Chai T.C. The Bladder is Not Sterile: An Update on the Urinary Microbiome Curr. Bladder Dysfunct. Rep. 2019 14 331 341 10.1007/s11884-019-00543-6 32612735 PMC7328282 · DOI
  99. [106]Amabebe E. Anumba D.O.C. Female Gut and Genital Tract Microbiota-Induced Crosstalk and Differential Effects of Short-Chain Fatty Acids on Immune Sequelae Front. Immunol. 2020 11 2184 10.3389/fimmu.2020.02184 33013918 PMC7511578 · DOI
  100. [107]Brubaker L. Wolfe A.J. The new world of the urinary microbiota in women Am. J. Obstet. Gynecol. 2015 213 644 649 10.1016/j.ajog.2015.05.032 26003055 PMC4876712 · DOI
  101. [108]Wolfe A.J. Toh E. Shibata N. Rong R. Kenton K. FitzGerald M. Mueller E.R. Schreckenberger P. Dong Q. Nelson D.E. Evidence of Uncultivated Bacteria in the Adult Female Bladder J. Clin. Microbiol. 2012 50 1376 1383 10.1128/JCM.05852-11 22278835 PMC3318548 · DOI
  102. [109]Hilt E.E. McKinley K. Pearce M.M. Rosenfeld A.B. Zilliox M.J. Mueller E.R. Brubaker L. Gai X. Wolfe A.J. Schreckenberger P.C. Urine Is Not Sterile: Use of Enhanced Urine Culture Techniques to Detect Resident Bacterial Flora in the Adult Female Bladder J. Clin. Microbiol. 2014 52 871 876 10.1128/JCM.02876-13 24371246 PMC3957746 · DOI
  103. [110]Price T.K. Dune T. Hilt E.E. Thomas-White K.J. Kliethermes S. Brincat C. Brubaker L. Wolfe A.J. Mueller E.R. Schreckenberger P.C. The Clinical Urine Culture: Enhanced Techniques Improve Detection of Clinically Relevant Microorganisms J. Clin. Microbiol. 2016 54 1216 1222 10.1128/JCM.00044-16 26962083 PMC4844725 · DOI
  104. [111]Pearce M.M. Hilt E.E. Rosenfeld A.B. Zilliox M.J. Thomas-White K. Fok C. Kliethermes S. Schreckenberger P.C. Brubaker L. Gai X. The Female Urinary Microbiome: A Comparison of Women with and without Urgency Urinary Incontinence Mbio 2014 5 e01283-14 10.1128/mBio.01283-14 25006228 PMC4161260 · DOI
  105. [112]Khasriya R. Sathiananthamoorthy S. Ismail S. Kelsey M. Wilson M. Rohn J.L. Malone-Lee J. Spectrum of Bacterial Colonization Associated with Urothelial Cells from Patients with Chronic Lower Urinary Tract Symptoms J. Clin. Microbiol. 2013 51 2054 2062 10.1128/JCM.03314-12 23596238 PMC3697662 · DOI
  106. [113]McDonald M. Kameh D. Johnson M.E. Johansen T.E.B. Albala D. Mouraviev V. A Head-to-Head Comparative Phase II Study of Standard Urine Culture and Sensitivity Versus DNA Next-generation Sequencing Testing for Urinary Tract Infections Rev. Urol. 2017 19 213 220 10.3909/riu0780 29472825 PMC5811878 · DOI
  107. [114]Ishihara T. Watanabe N. Inoue S. Aoki H. Tsuji T. Yamamoto B. Yanagi H. Oki M. Kryukov K. Nakagawa S. Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection Drug Discov. Ther. 2020 14 42 49 10.5582/ddt.2020.01000 32101813 · DOI
  108. [115]Bennett J.E. Dolin R. Blaser M.J. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases Elsevier Health Sciences Philadelphia, PA, USA 2014 Volume 2
  109. [116]Hooton T.M. Recurrent urinary tract infection in women Int. J. Antimicrob. Agents 2001 17 259 268 10.1016/S0924-8579(00)00350-2 11295405 · DOI
  110. [117]Brannon J.R. Dunigan T.L. Beebout C.J. Ross T. Wiebe M.A. Reynolds W.S. Hadjifrangiskou M. Invasion of vaginal epithelial cells by uropathogenic Escherichia coli Nat. Commun. 2020 11 2803 10.1038/s41467-020-16627-5 32499566 PMC7272400 · DOI
  111. [118]Rosen D.A. Pinkner J.S. Jones J.M. Walker J.N. Clegg S. Hultgren S.J. Utilization of an Intracellular Bacterial Community Pathway in Klebsiella pneumoniae Urinary Tract Infection and the Effects of FimK on Type 1 Pilus Expression Infect. Immun. 2008 76 3337 3345 10.1128/IAI.00090-08 18411285 PMC2446714 · DOI
  112. [119]Robino L. Scavone P. Araujo L. Algorta G. Zunino P. Vignoli R. Detection of intracellular bacterial communities in a child with Escherichia coli recurrent urinary tract infections Pathog. Dis. 2013 68 78 81 10.1111/2049-632X.12047 23733378 · DOI
  113. [120]Schilling J.D. Lorenz R.G. Hultgren S.J. Effect of Trimethoprim-Sulfamethoxazole on Recurrent Bacteriuria and Bacterial Persistence in Mice Infected with Uropathogenic Escherichia coli Infect. Immun. 2002 70 7042 7049 10.1128/IAI.70.12.7042-7049.2002 12438384 PMC132990 · DOI
  114. [121]Mysorekar I.U. Hultgren S.J. Mechanisms of uropathogenic Escherichia coli persistence and eradication from the urinary tract Proc. Natl. Acad. Sci. USA 2006 103 14170 14175 10.1073/pnas.0602136103 16968784 PMC1564066 · DOI
  115. [122]Kim A. Ahn J.H. Choi W.S. Park H.K. Kim S. Paick S.H. Kim H.G. What is the Cause of Recurrent Urinary Tract Infection? Contemporary Microscopic Concepts of Pathophysiology Int. Neurourol. J. 2021 25 192 201 10.5213/inj.2040472.236 34044483 PMC8497731 · DOI · Paper page
  116. [123]Simpson B.W. May J.M. Sherman D.J. Kahne D. Ruiz N. Lipopolysaccharide transport to the cell surface: Biosynthesis and extraction from the inner membrane Philos. Trans. R. Soc. Lond. B Biol. Sci. 2015 370 20150029 10.1098/rstb.2015.0029 26370941 PMC4632605 · DOI
  117. [124]Zhang G. Meredith T.C. Kahne D. On the essentiality of lipopolysaccharide to Gram-negative bacteria Curr. Opin. Microbiol. 2013 16 779 785 10.1016/j.mib.2013.09.007 24148302 PMC3974409 · DOI
  118. [125]Hunstad D.A. Justice S.S. Hung C.S. Lauer S.R. Hultgren S.J. Suppression of Bladder Epithelial Cytokine Responses by Uropathogenic Escherichia coli Infect. Immun. 2005 73 3999 4006 10.1128/IAI.73.7.3999-4006.2005 15972487 PMC1168571 · DOI
  119. [126]Yang Y. Wang H. Kouadir M. Song H. Shi F. Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors Cell Death Dis. 2019 10 128 10.1038/s41419-019-1413-8 30755589 PMC6372664 · DOI
  120. [127]Hughes F.M. Jr. Vivar N.P. Kennis J.G. Pratt-Thomas J.D. Lowe D.W. Shaner B.E. Nietert P.J. Spruill L.S. Purves J.T. Inflammasomes are important mediators of cyclo¬phosphamide-induced bladder inflammation Am. J. Physiol. Ren. Physiol. 2014 306 F299 F308 10.1152/ajprenal.00297.2013 PMC4073918 24285499 · DOI
  121. [128]Jaillon S. Moalli F. Ragnarsdottir B. Bonavita E. Puthia M. Riva F. Barbati E. Nebuloni M. Krajinovic L.C. Markotic A. The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection Immunity 2014 40 621 632 10.1016/j.immuni.2014.02.015 24745336 · DOI · Paper page
  122. [129]Bishop B.L. Duncan M.J. Song J. Li G. Zaas D. Abraham S.N. Cyclic AMP–regulated exocytosis of Escherichia coli from infected bladder epithelial cells Nat. Med. 2007 13 625 630 10.1038/nm1572 17417648 · DOI
  123. [130]O’Brien V.P. Lewis A.L. Gilbert N.M. Bladder Exposure to Gardnerella Activates Host Pathways Necessary for Escherichia coli Recurrent UTI Front. Cell. Infect. Microbiol. 2021 11 788229 10.3389/fcimb.2021.788229 34938672 PMC8685330 · DOI
  124. [131]Yoon K. Lee S.-O. Cho S.-D. Kim K. Khan S. Safe S. Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors Carcinog. 2011 32 836 842 10.1093/carcin/bgr040 PMC3106434 21362629 · DOI
  125. [132]Gao H. Chen Z. Fu Y. Yang X. Weng R. Wang R. Lu J. Pan M. Jin K. McElroy C. Nur77 exacerbates PC12 cellular injury in vitro by aggravating mitochondrial impairment and endoplasmic reticulum stress Sci. Rep. 2016 6 34403 10.1038/srep34403 27679973 PMC5041156 · DOI
  126. [133]Rajpal A. Cho Y.A. Yelent B. Koza-Taylor P.H. Li D. Chen E. Whang M. Kang C. Turi T.G. Winoto A. Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor EMBO J. 2003 22 6526 6536 10.1093/emboj/cdg620 14657025 PMC291815 · DOI
  127. [134]Herring J.A. Elison W.S. Tessem J.S. Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues Cells 2019 8 1373 10.3390/cells8111373 31683815 PMC6912296 · DOI
  128. [136]Liebmann M. Hucke S. Koch K. Eschborn M. Ghelman J. Chasan A.I. Glander S. Schädlich M. Kuhlencord M. Daber N.M. Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity Proc. Natl. Acad. Sci. USA 2018 115 E8017 E8026 10.1073/pnas.1721049115 30072431 PMC6112725 · DOI
  129. [137]Hanna R.N. Carlin L.M. Hubbeling H.G. Nackiewicz D. Green A.M. Punt J.A. Geissmann F. Hedrick C.C. The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes Nat. Immunol. 2011 12 778 785 10.1038/ni.2063 21725321 PMC3324395 · DOI · Paper page
  130. [138]O’Brien V.P. Joens M.S. Lewis A.L. Gilbert N.M. Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice J. Vis. Exp. 2020 166 e61967 10.3791/61967 PMC8034409 33346201 · DOI
  131. [139]Kirjavainen P.V. Pautler S. Baroja M.L. Anukam K. Crowley K. Carter K. Reid G. Abnormal Immunological Profile and Vaginal Microbiota in Women Prone to Urinary Tract Infections Clin. Vaccine Immunol. 2009 16 29 36 10.1128/CVI.00323-08 19020112 PMC2620669 · DOI
  132. [140]Neugent M.L. Kumar A. Hulyalkar N.V. Lutz K.C. Nguyen V.H. Fuentes J.L. Zhang C. Nguyen A. Sharon B.M. Kuprasertkul A. Recurrent urinary tract infection and estrogen shape the taxonomic ecology and function of the postmenopausal urogenital microbiome Cell Rep. Med. 2022 3 100753 10.1016/j.xcrm.2022.100753 36182683 PMC9588997 · DOI
  133. [141]Akgul T. Karakan T. The role of probiotics in women with recurrent urinary tract infections Turk. J. Urol. 2018 44 377 383 10.5152/tud.2018.48742 30487041 PMC6134985 · DOI
  134. [142]Boswell-Ruys C.L. Toh S.-L. Lee B.S.B. Simpson J.M. Clezy K.R. Probiotics for preventing urinary tract infection in people with neuropathic bladder Cochrane Database Syst. Rev. 2017 9 010723 10.1002/14651858.cd010723 PMC6483743 28884476 · DOI
  135. [143]Goneau L.W. Yeoh N.S. MacDonald K.W. Cadieux P.A. Burton J.P. Razvi H. Reid G. Selective Target Inactivation Rather than Global Metabolic Dormancy Causes Antibiotic Tolerance in Uropathogens Antimicrob. Agents Chemother. 2014 58 2089 2097 10.1128/AAC.02552-13 24449771 PMC4023725 · DOI
  136. [144]Uehara S. Monden K. Nomoto K. Seno Y. Kariyama R. Kumon H. A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection Int. J. Antimicrob. Agents 2006 28 (Suppl. 1) 30 34 10.1016/j.ijantimicag.2006.05.008 16859900 · DOI · Paper page
  137. [145]Sadahira T. Wada K. Araki M. Mitsuhata R. Yamamoto M. Maruyama Y. Iwata T. Watanabe M. Watanabe T. Kariyama R. Efficacy of Lactobacillus vaginal suppositories for the prevention of recurrent cystitis: A phase II clinical trial Int. J. Urol. 2021 28 1026 1031 10.1111/iju.14636 34258813 · DOI · Paper page
  138. [146]Reid G. Charbonneau D. Erb J. Kochanowski B. Beuerman D. Poehner R. Bruce A.W. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: Randomized, placebo-controlled trial in 64 healthy women FEMS Immunol. Med. Microbiol. 2003 35 131 134 10.1016/S0928-8244(02)00465-0 12628548 · DOI · Paper page
  139. [147]Garofalo L. Nakama C. Hanes D. Zwickey H. Whole-Person, Urobiome-Centric Therapy for Uncomplicated Urinary Tract Infection Antibiotics 2022 11 218 10.3390/antibiotics11020218 35203820 PMC8868435 · DOI · Paper page
  140. [148]Heinemann C. Reid G. Vaginal microbial diversity among postmenopausal women with and without hormone replacement therapy Can. J. Microbiol. 2005 51 777 781 10.1139/w05-070 16391657 · DOI
  141. [149]Raz R. Hormone Replacement Therapy or Prophylaxis in Postmenopausal Women with Recurrent Urinary Tract Infection J. Infect. Dis. 2001 183 S74 S76 10.1086/318842 11171020 · DOI
  142. [150]Cauci S. Driussi S. De Santo D. Penacchioni P. Iannicelli T. Lanzafame P. De Seta F. Quadrifoglio F. de Aloysio D. Guaschino S. Prevalence of Bacterial Vaginosis and Vaginal Flora Changes in Peri- and Postmenopausal Women J. Clin. Microbiol. 2002 40 2147 2152 10.1128/JCM.40.6.2147-2152.2002 12037079 PMC130764 · DOI
  143. [151]Eriksen B.C. A randomized, open, parallel-group study on the preventive effect of an estradiol-releasing vaginal ring (Estring) on recurrent urinary tract infections in postmenopausal women Am. J. Obstet. Gynecol. 1999 180 1072 1079 10.1016/S0002-9378(99)70597-1 10329858 · DOI · Paper page
  144. [152]Krause M. Wheeler T.L. 2nd Snyder T.E. Richter H.E. Local Effects of Vaginally Administered Estrogen Therapy: A Review J. Pelvic Med. Surg. 2009 15 105 114 10.1097/SPV.0b013e3181ab4804 22229022 PMC3252029 · DOI
  145. [153]Mehta J. Utkarsh K. Fuloria S. Singh T. Sekar M. Salaria D. Rolta R. Begum M.Y. Gan S.H. Rani N.N.I.M. Antibacterial Potential of Bacopa monnieri (L.) Wettst. and Its Bioactive Molecules against Uropathogens—An In Silico Study to Identify Potential Lead Molecule(s) for the Development of New Drugs to Treat Urinary Tract Infections Molecules 2022 27 4971 10.3390/molecules27154971 35956923 PMC9370325 · DOI

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Authors
Dominoni, M., Scatigno, A. L., La Verde, M., Bogliolo, S., Melito, C., Gritti, A., Pasquali, M. F., Torella, M., & Gardella, B.
Affiliations
  • University of Pavia (IT)
  • Department of Woman, Child and General and Specialized Surgery, Obstetrics and Gynecology Unit, University of Campania “Luigi Vanvitelli”, 81100 Naples, Italy
  • Department of Obstetrics and Gynecological Oncology, P.O del Tigullio” Hospital-ASL4, Metropolitan Area of Genoa, 16034 Genoa, Italy
  • University of Campania "Luigi Vanvitelli" (IT)
  • Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, 27100 Pavia, Italy
Corresponding author
Scatigno, Annachiara Licia
ORCID
Venue
Healthcare
Publisher
MDPI AG
Published
2023-02-10
Volume
11
Issue
4
Pages
525
ISSN
2227-9032 (ISSN-L)
DOI
10.3390/healthcare11040525
PMC
PMC9956625
OpenAlex
W4319962175
Cited by
13
References
6
Citations by year
2026: 3 · 2025: 2 · 2024: 5 · 2023: 3
FWCI
0.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Healthcare (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Funders
  • Italian ministry of health
  • IRCCS Fondazione Policlinico San Matteo, Pavia, Italy
Topics
  • Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
  • Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
  • Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords
recurrent cystitis, recurrent urinary tract infection, vaginal microbiota, urinary microbiome, gut microbiota, dysbiosis, urothelium, immune microenvironment, women's health, personalized treatment

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