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Cited by 62Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal Infections and Studies

The many faces of Candida auris: Phenotypic and strain variation in an emerging pathogen

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Santana, Darian J., Zhao, Guolei, O’Meara, Teresa R.·2024·PLOS Pathogens
DOI 10.1371/journal.ppat.1012011PMC PMC10906884
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Abstract

Candida auris is an emerging fungal pathogen with unusual evolutionary history—there are multiple distinct phylogeographic clades showing a near simultaneous transition from a currently unknown reservoir to nosocomial pathogen. Each of these clades has experienced different selective pressures over time, likely resulting in selection for genotypes with differential fitness or phenotypic consequences when introduced to new environments. We also observe diversification within clades, providing additional opportunities for phenotypic differences. These differences can have large impacts on pathogenic potential, drug resistance profile, evolutionary trajectory, and transmissibility. In recent years, there have been significant advances in our understanding of strain-specific behavior in other microbes, including bacterial and fungal pathogens, and we have an opportunity to take this strain variation into account when describing aspects of C . auris biology. Here, we critically review the literature to gain insight into differences at both the strain and clade levels in C . auris , focusing on phenotypes associated with clinical disease or transmission. Our goal is to integrate clinical and epidemiological perspectives with molecular perspectives in a way that would be valuable for both audiences. Identifying differences between strains and understanding which phenotypes are strain specific will be crucial for understanding this emerging pathogen, and an important caveat when describing the analysis of a singular isolate.

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  • Biofilms are often associated with increased persistence on environmental surfaces and colonization on host skin.

    “Since biofilms are often associated with increased persistence on the environmental surfaces and colonization on host skin4,5,11,49, this mutation could contribute to the prevalence and rapid transmission of C. auris.”

    From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [5]

  • The WOR2 mutation could contribute to the prevalence and rapid transmission of C. auris.

    “Since biofilms are often associated with increased persistence on the environmental surfaces and colonization on host skin4,5,11,49, this mutation could contribute to the prevalence and rapid transmission of C. auris.”

    From The Wor2 phenotypic switching regulator controls biofilm formation in Candida auris (2026) · cites this paper as [5]

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Cited by

Sorted by citations

Authors
Santana, D. J., Zhao, G., & O’Meara, T. R.
Affiliations
University of Michigan (US)
Corresponding author
O’Meara, Teresa R.
ORCID
Venue
PLOS Pathogens
Publisher
Public Library of Science (PLoS)
Published
2024-03-01
Volume
20
Issue
3
Pages
e1012011
ISSN
  • 1553-7366 (ISSN-L)
  • 1553-7374
DOI
10.1371/journal.ppat.1012011
PMC
PMC10906884
OpenAlex
W4392361286
Cited by
62
References
22
Citations by year
2026: 22 · 2025: 25 · 2024: 15
FWCI
5.15
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS Pathogens (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Institute of Allergy and Infectious Diseases (R21AI169186, F31AI169823, T32AI007413)
  • National Institute of General Medical Sciences (R35GM147894)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
  • Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords
Candida auris, emerging fungal pathogens, strain differences, phenotypic variability, nosocomial infections, drug resistance, pathogenicity, transmissibility, fungal evolution, clinical isolates
MeSH terms
Candida auris, Biological Evolution, Genotype, Hospitals, Phenotype

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