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Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency
Open accessAbstract
The objective of this study was to assess the effects of oral testosterone supplementation therapy on glucose homeostasis, obesity and sexual function in middle-aged men with type 2 diabetes and mild androgen deficiency. Forty-eight middle-aged men, with type 2 diabetes, (visceral) obesity and symptoms of androgen deficiency, were included in this open-label study. Twenty-four subjects received testosterone undecanoate (TU; 120 mg daily, for 3 months); 24 subjects received no treatment. Body composition was analyzed by bio-impedance. Parameters of metabolic control were determined. Symptoms of androgen deficiency and erectile dysfunction were scored by self-administered questionnaires. TU had a positive effect on (visceral) obesity: statistically significant reduction in body weight (2.66%), waist-hip ratio (-3.96%) and body fat (-5.65%); negligible changes were found in the control group. TU significantly improved metabolic control: decrease in blood glucose values and mean glycated hemoglobin (HbA1c) (from 10.4 to 8.6%). TU treatment significantly improved symptoms of androgen deficiency (including erectile dysfunction), with virtually no change in the control group. There were no adverse effects on blood pressure or hematological, biochemical and lipid parameters, and no adverse events. Oral TU treatment of type 2 diabetic men with androgen deficiency improves glucose homeostasis and body composition (decrease in visceral obesity), and improves symptoms of androgen deficiency (including erectile dysfunction). In these men, the benefit of testosterone supplementation therapy exceeds the correction of symptoms of androgen deficiency and also includes glucose homeostasis and metabolic control.
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In the citing paper
“Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3–12 months.”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [31]
In the citing paper
“and a decrease in the waist hip ratio after 3 months (31, 36) or after 6 months and 30 weeks respectively (17).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [31]
In the citing paper
“A decline in HbA1c was observed after 3 months (31, 36, 43) with further decrease after 12 months (43).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [31]
In the citing paper
“Several studies indicate that upon testosterone administration, serum glucose is reduced after 3 months in men with impaired glucose tolerance (31, 36, 43).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [31]
In the citing paper
“A decrease in fatigue and listlessness was found after 1 month (31) or 6 weeks (68).”
From Onset of effects of testosterone treatment and time span until maximum effects are achieved (2011) · cites this paper as [31]
In the citing paper
“Several studies on carotid artery atherosclerosis have demonstrated an inverse relationship between level of T and degree of atherogenesis [8,10].”
In the citing paper
“Two studies in type 2 diabetic men have shown an improvement in glycemic control (26,27) with testosterone replacement therapy”
From Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes (2007) · cites this paper as [27]
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Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Haffner, S. M., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807233390404 · Cited by 7,000
Impotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
Stamler, J., Vaccaro, O., Neaton, J. D., Wentworth, D., & The Multiple Risk Factor Intervention Trial Research Group (1993) · Diabetes Care · doi:10.2337/diacare.16.2.434 · Cited by 4,063
Rosen, R., Cappelleri, J. C., Smith, M., Lipsky, J., & Peña, B. (1999) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900472 · Cited by 3,095
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.149.7.1514 · Cited by 1,672
(1999) · doi:10.1016/s0090-4295(99)00099-0 · Cited by 1,051
Kaplan, N. M. (1989) · Archives of Internal Medicine · doi:10.1001/archinte.1989.00390070054005 · Cited by 842
The effects of testosterone treatment on body composition and metabolism in middle-aged obese men.
Mårin, P., Holmäng, S., Jönsson, L., Sjöström, L., Kvist, H., Holm, G., Lindstedt, G., & Björntorp, P. A. (1992) · PubMed · Cited by 553
Androgen Treatment of Abdominally Obese Men
Mårin, P., Holmtäng, S., Gustafsson, C., Jönsson, ‡., Kvist, ‡., Elander, A., Eldh, J., Sjöström, L., Holm, G., & Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00618.x · Cited by 345
Research works printed but not linked: 6
- Carlin BW., Metab Clin Exp, 19
- Popivanov P, Medicographia
- Mårin P, 1992, Eur J Med, 1, 329
- Mårin P, 1992, Int J Obes Relat Metab Disord, 16, 991
- Rebuffe-Scrive M, 1991, Int J Obes, 15, 791
- Lund BC, 1999, Pharmaco- therapy, 19, 961
Cited by
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Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Ding, E. L., Song, Y., Malik, V. S., & Liu, S. (2006) · JAMA · doi:10.1001/jama.295.11.1288 · Cited by 1,354
Kapoor, D., Goodwin, E., Channer, K. S., & Jones, T. H. (2006) · European Journal of Endocrinology · doi:10.1530/eje.1.02166 · Cited by 791
Calof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728
Adverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Fernández-Balsells, M. M., Murad, M. H., Lane, M., Lampropulos, J. F., Albuquerque, F., Mullan, R. J., Agrwal, N., Elamin, M. B., Gallegos-Orozco, J. F., Wang, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2575 · Cited by 713
Isidori, A. M., Giannetta, E., Greco, E. A., Gianfrilli, D., Bonifacio, V., Isidori, A., Lenzi, A., & Fabbri, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02339.x · Cited by 695
Testosterone: a metabolic hormone in health and disease
Kelly, D. M., & Jones, T. H. (2013) · Journal of Endocrinology · doi:10.1530/joe-12-0455 · Cited by 612
Causes, consequences, and treatment of metabolically unhealthy fat distribution
Stefan, N. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30110-8 · Cited by 566
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
Direct effects of sex steroid hormones on adipose tissues and obesity
Mayes, J., & Watson, G. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00152.x · Cited by 509
Effects of testosterone on sexual function in men: results of a meta‐analysis
Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02350.x · Cited by 492
Kelly, D. M., & Jones, T. H. (2015) · Obesity Reviews · doi:10.1111/obr.12282 · Cited by 487
Clinical and Biochemical Assessment of Hypogonadism in Men With Type 2 Diabetes
Kapoor, D., Aldred, H., Clark, S., Channer, K. S., & Jones, T. H. (2007) · Diabetes Care · doi:10.2337/dc06-1426 · Cited by 493
Relationship Between Testosterone Levels, Insulin Sensitivity, and Mitochondrial Function in Men
Pitteloud, N., Mootha, V. K., Dwyer, A. A., Hardin, M., Lee, H., Eriksson, K.-F., Tripathy, D., Yialamas, M., Groop, L., Elahi, D., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1636 · Cited by 472
Obesity and androgens: facts and perspectives
Pasquali, R. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.10.054 · Cited by 469
Low testosterone levels are common and associated with insulin resistance in men with diabetes
Grossmann, M., Thomas, M. C., Panagiotopoulos, S., Sharpe, K., MacIsaac, R. J., Clarke, S., Zajac, J. D., & Jerums, G. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2177 · Cited by 468
Type 2 diabetes mellitus and testosterone: a meta-analysis study: Type 2 diabetes and testosterone
Corona, G., Monami, M., Rastrelli, G., Aversa, A., Sforza, A., Lenzi, A., Forti, G., Mannucci, E., & Maggi, M. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01117.x · Cited by 370
Testosterone deficiency, insulin resistance and the metabolic syndrome
Zitzmann, M. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.212 · Cited by 359
Kalinchenko, S. Y., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J., Giltay, E. J., & Saad, F. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03845.x · Cited by 348
Brand, J. S., van der Tweel, I., Grobbee, D. E., Emmelot-Vonk, M. H., & van der Schouw, Y. T. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyq158 · Cited by 334
Androgens, insulin resistance and vascular disease in men
Kapoor, D., Malkin, C. J., Channer, K. S., & Jones, T. H. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02299.x · Cited by 317
Androgens and body fat distribution
Blouin, K., Boivin, A., & Tchernof, A. (2007) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2007.09.001 · Cited by 321
The Metabolic Syndrome and Male Infertility
Kasturi, S. S., Tannir, J. R., & Brannigan, R. E. (2008) · Journal of Andrology · doi:10.2164/jandrol.107.003731 · Cited by 306
Frank, A. P., Santos, R. D. S., Palmer, B. F., & Clegg, D. J. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r086975 · Cited by 335
Lowered testosterone in male obesity: Mechanisms, morbidity and management
Grossmann, M., Tang Fui, M., & Dupuis, P. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122365 · Cited by 293
Testosterone and insulin resistance in the metabolic syndrome and T2DM in men
Rao, P. M., Kelly, D. M., & Jones, T. H. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.122 · Cited by 292
The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunction
Traish, A. M., Guay, A. T., Feeley, R. J., & Saad, F. (2008) · Journal of Andrology · doi:10.2164/jandrol.108.005215 · Cited by 284
The Dark Side of Testosterone Deficiency: II. Type 2 Diabetes and Insulin Resistance
Traish, A. M., Saad, F., & Guay, A. (2009) · Journal of Andrology · doi:10.2164/jandrol.108.005751 · Cited by 266
Onset of effects of testosterone treatment and time span until maximum effects are achieved
Saad, F., Aversa, A., Isidori, A. M., Zafalon, L., Zitzmann, M., & Gooren, L. (2011) · European Journal of Endocrinology · doi:10.1530/eje-11-0221 · Cited by 232
HYPOGONADISM AND METABOLIC SYNDROME: IMPLICATIONS FOR TESTOSTERONE THERAPY
Makhsida, N., Shah, J. B., YAN, G., Fisch, H., & Shabsigh, R. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000169490.78443.59 · Cited by 228
Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddp522 · Cited by 217
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2008.00951.x · Cited by 223
Endocrine Aspects of Male Sexual Dysfunctions
Buvat, J., Maggi, M., Gooren, L., Guay, A. T., Kaufman, J., Morgentaler, A., Schulman, C., Tan, H. M., Torres, L. O., Yassin, A., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01780.x · Cited by 221
Corona, G., Giagulli, V. A., Maseroli, E., Vignozzi, L., Aversa, A., Zitzmann, M., Saad, F., Mannucci, E., & Maggi, M. (2016) · European Journal of Endocrinology · doi:10.1530/eje-15-0262 · Cited by 217
Testosterone Therapy and Cardiovascular Risk: Advances and Controversies
Morgentaler, A., Miner, M. M., Caliber, M., Guay, A. T., Khera, M., & Traish, A. M. (2014) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2014.10.011 · Cited by 213
Testosterone for the aging male; current evidence and recommended practice
Jones, H. (2008) · Clinical Interventions in Aging · doi:10.2147/cia.s190 · Cited by 204
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Gagliano‐Jucá, T., & Basaria, S. S. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0211-4 · Cited by 200
Testosterone deficiency: a risk factor for cardiovascular disease?
Jones, T. H. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.03.002 · Cited by 195
Tsertsvadze, A., Fink, H. A., Yazdi, F., MacDonald, R. H., Bella, A. J., Ansari, M., Garritty, C., Soares‐Weiser, K., Daniel, R., Sampson, M., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-9-200911030-00150 · Cited by 194
Traish, A. M., Haider, A., Doros, G. D., & Saad, F. (2013) · International Journal of Clinical Practice · doi:10.1111/ijcp.12319 · Cited by 188
Boloña, E. R., Uraga, M. V., Haddad, R. M., Tracz, M. J., Sideras, K., Kennedy, C. C., Caples, S. M., Erwin, P. J., & Montori, V. M. (2007) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)60963-4 · Cited by 184
Corona, G., Rastrelli, G., & Maggi, M. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.05.002 · Cited by 177
Androgen deficiency, diabetes, and the metabolic syndrome in men
Kalyani, R. R., & Dobs, A. S. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32814db856 · Cited by 173
Filippi, S., Vignozzi, L., Morelli, A., Chavalmane, A. K., Sarchielli, E., Fibbi, B., Saad, F., Sandner, P., Ruggiano, P., Vannelli, G. B., et al. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01467.x · Cited by 166
Molecular mechanisms associated with diabetic endothelial–erectile dysfunction
Castela, Â., & Costa, C. (2016) · Nature Reviews Urology · doi:10.1038/nrurol.2016.23 · Cited by 161
Testosterone in men with advanced liver disease: Abnormalities and implications
Sinclair, M. J., Grossmann, M., Gow, P. J., & Angus, P. (2014) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12695 · Cited by 163
The effects of testosterone on risk factors for, and the mediators of, the atherosclerotic process
Jones, T. H., & Saad, F. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.04.016 · Cited by 153
Saad, F., Aversa, A., M. Isidori, A., & J. Gooren, L. (2012) · Current Diabetes Reviews · doi:10.2174/157339912799424573 · Cited by 148
Androgen metabolism in adipose tissue: Recent advances
Blouin, K., Veilleux, A., Luu-The, V., & Tchernof, A. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.10.035 · Cited by 147
The paradox of low BNP levels in obesity
Clerico, A., Giannoni, A., Vittorini, S., & Emdin, M. (2011) · Heart Failure Reviews · doi:10.1007/s10741-011-9249-z · Cited by 147
Zhang, H., Liu, Y., Wang, L., Li, Z., Zhang, H., Wu, J., Rahman, N. A., Guo, Y., Li, D., Li, N., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m028969 · Cited by 143
Giltay, E. J., Tishova, Y. A., Mskhalaya, G. J., Gooren, L. J. G., Saad, F., & Kalinchenko, S. Y. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.01859.x · Cited by 140
Contribution of age and declining androgen levels to features of the metabolic syndrome in men
Blouin, K., Després, J., Couillard, C., Tremblay, A., Prud’homme, D., Bouchard, C., & Tchernof, A. (2005) · Metabolism · doi:10.1016/j.metabol.2005.03.006 · Cited by 134
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Metabolic syndrome and urologic diseases.
Gorbachinsky, I., Akpınar, H., & Assimos, D. G. (2010) · Europe PMC (PubMed Central) · Cited by 132
Bisphenol S Induces Adipogenesis in Primary Human Preadipocytes From Female Donors
Boucher, J. G., Ahmed, S., & Atlas, E. (2016) · Endocrinology · doi:10.1210/en.2015-1872 · Cited by 133
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Alemany, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911952 · Cited by 150
Blouin, K., Nadeau, M., Perreault, M., Veilleux, A., Drolet, R., Marceau, P., Mailloux, J. R., Luu‐The, V., & Tchernof, A. (2009) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2009.03645.x · Cited by 131
Traish, A. M., Haider, A., Haider, K. S., Doros, G., & Saad, F. (2017) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248417691136 · Cited by 130
Vikan, T., Schirmer, H., Njølstad, I., & Svartberg, J. (2010) · European Journal of Endocrinology · doi:10.1530/eje-09-0943 · Cited by 151
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Groti, K., Žuran, I., Antonič, B., Foršnarič, L., & Pfeifer, M. (2018) · The Aging Male · doi:10.1080/13685538.2018.1468429 · Cited by 117
Corona, G., Mannucci, E., Petrone, L., Balercia, G., Paggi, F., Fisher, A. D., Lotti, F., Chiarini, V., Fedele, D., Forti, G., et al. (2007) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2007.00529.x · Cited by 116
Wang, K., Cai, X., Tian, Y., Wu, T., Cao, C., & Li, H. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122346 · Cited by 113
Why Is Androgen Replacement in Males Controversial?
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Testosterone and Atherosclerosis in Aging Men
Jones, R. D., Nettleship, J. E., Kapoor, D., Jones, H. T., & Channer, K. S. (2005) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200505030-00001 · Cited by 112
Giagulli, V. A., Carbone, M. D., Ramunni, M. I., Licchelli, B., De Pergola, G., Sabbà, C., Guastamacchia, E., & Triggiani, V. (2015) · Andrology · doi:10.1111/andr.12099 · Cited by 109
Testosterone and type 2 diabetes
Grossmann, M., Gianatti, E. J., & Zajac, J. D. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32833919cf · Cited by 108
Behre, H. M., Tammela, T. L. J., Arver, S., Tolrà, J. R., Bonifacio, V., Lamche, M., Kelly, J., Hiemeyer, F. J., for the European Testogel® Study Team, Giltay, E. J., et al. (2012) · The Aging Male · doi:10.3109/13685538.2012.699562 · Cited by 107
Corona, G., Forti, G., & Maggi, M. (2008) · The Aging Male · doi:10.1080/13685530802468497 · Cited by 107
Lunenfeld, B., Saad, F., & Hoesl, C. E. (2005) · The Aging Male · doi:10.1080/13685530500163416 · Cited by 108
The triad of erectile dysfunction, hypogonadism and the metabolic syndrome
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Onasanya, O., Iyer, G. S., Lucas, E. J., Lin, D. H., Singh, S., & Alexander, G. C. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30215-7 · Cited by 104
Haider, A., Yassin, A. A., Doros, G. D., & Saad, F. (2014) · International Journal of Endocrinology · doi:10.1155/2014/683515 · Cited by 101
Diabetes mellitus is associated with subnormal serum levels of free testosterone in men
Rhoden, E. L., Ribeiro, E. P., Teloken, C., & Souto, C. A. V. (2005) · BJU International · doi:10.1111/j.1464-410x.2005.05728.x · Cited by 100
Kelly, D. M., Nettleship, J. E., Akhtar, S., Muraleedharan, V., Sellers, D. J., Brooke, J. C., McLaren, D. S., Channer, K. S., & Jones, T. H. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.06.007 · Cited by 98
Corona, G., Mannucci, E., Forti, G., & Maggi, M. (2009) · International Journal of Andrology · doi:10.1111/j.1365-2605.2009.00965.x · Cited by 96
Willemse, P.-P. M., Burggraaf, J., Hamdy, N. A. T., Weijl, N. I., VOSSEN, C. Y., van Wulften, L., Tol, A. Q. M. J. V. S.-V., Rosendaal, F. R., & Osanto, S. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.226 · Cited by 93
Aversa, A., Bruzziches, R., Francomano, D., Spera, G., & Lenzi, A. (2010) · Journal of Endocrinological Investigation · doi:10.1007/bf03350341 · Cited by 92
Effects of testosterone on Type 2 diabetes and components of the metabolic syndrome
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Androgen inactivation and steroid-converting enzyme expression in abdominal adipose tissue in men
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Androgens and the Regulation of Adiposity and Body Fat Distribution in Humans
Tchernof, A., Brochu, D., Maltais‐Payette, I., Mansour, M. F., Marchand, G. B., Carreau, A., & Kapeluto, J. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170009 · Cited by 113
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Metadata
- Authors
- Boyanov, M. A., Boneva, Z., & Christov, V. G.
- Affiliations
- Alexandrovska Hospital (BG)
- Ministry of Interior (BG)
- ORCID
- Boyanov, M. A.
- Venue
- The Aging Male
- Publisher
- Informa UK Limited
- Published
- 2003-01
- Volume
- 6
- Issue
- 1
- Pages
- 1-7
- ISSN
- 1368-5538 (ISSN-L)
- 1473-0790
- OpenAlex
- W2134451964
- Cited by
- 381
- References
- 32
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 25 · 2021: 11 · 2020: 13 · 2019: 8 · 2018: 16 · 2017: 16 · 2016: 13 · 2015: 21 · 2014: 20 · 2013: 29 · 2012: 19
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Aging Male (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- testosterone supplementation, testosterone undecanoate, type 2 diabetes, androgen deficiency, visceral obesity, glucose homeostasis, HbA1c, erectile dysfunction, body composition, waist-to-hip ratio, middle-aged men
- MeSH terms
- Androgens, Blood Glucose, Body Composition, Diabetes Mellitus, Type 2, Homeostasis, Humans, Erectile Dysfunction, Libido, Male, Middle Aged, Obesity, Testosterone, Hormone Replacement Therapy
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