CoChat
Sign Up
Cited by 22

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

WDR91 specifies the endosomal retrieval subdomain for retromer-dependent recycling

Liu, Nan, Liu, Kai, Yang, Chonglin·2022·Journal of Cell Biology
DOI 10.1083/jcb.202203013PMC PMC9531996
Open this paper in CoChat — free account

Abstract

Retromer-dependent endosomal recycling of membrane receptors requires Rab7, sorting nexin (SNX)-retromer, and factors that regulate endosomal actin organization. It is not fully understood how these factors cooperate to form endosomal subdomains for cargo retrieval and recycling. Here, we report that WDR91, a Rab7 effector, is the key factor that specifies the endosomal retrieval subdomain. Loss of WDR91 causes defective recycling of both intracellular and cell surface receptors. WDR91 interacts with SNXs through their PX domain, and with VPS35, thus promoting their interaction with Rab7. WDR91 also interacts with the WASH subunit FAM21. In WDR91-deficient cells, Rab7, SNX-retromer, and FAM21 fail to localize to endosomal subdomains, and endosomal actin organization is impaired. Re-expression of WDR91 enables Rab7, SNX-retromer, and FAM21 to concentrate at WDR91-specific endosomal subdomains, where retromer-mediated membrane tubulation and release occur. Thus, WDR91 coordinates Rab7 with SNX-retromer and WASH to establish the endosomal retrieval subdomains required for retromer-mediated endosomal recycling.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1083/jcb.202203013

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • These foci represent previously described retrieval sub-domains from where cargo-enriched transport carriers exit the endosome.

    “These foci therefore represent the previously described retrieval sub-domains from where cargo-enriched transport carriers exit the endosome for transport to their destination9,34,35,39,41,49.”

    From Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway (2024) · cites this paper as [49]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 55

  1. Arighi, 2004, Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor, J. Cell Biol., 165, 123, 10.1083/jcb.200312055 · DOI · Paper page
  2. Ashby, 2004, Removal of AMPA receptors (AMPARs) from synapses is preceded by transient endocytosis of extrasynaptic AMPARs, J. Neurosci., 24, 5172, 10.1523/JNEUROSCI.1042-04.2004 · DOI · Paper page
  3. Bonifacino, 2006, Retrograde transport from endosomes to the trans-Golgi network, Nat. Rev. Mol. Cell Biol., 7, 568, 10.1038/nrm1985 · DOI
  4. Burda, 2002, Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase, J. Cell Sci., 115, 3889, 10.1242/jcs.00090 · DOI
  5. Cantalupo, 2001, Rab-interacting lysosomal protein (RILP): The Rab7 effector required for transport to lysosomes, EMBO J., 20, 683, 10.1093/emboj/20.4.683 · DOI · Paper page
  6. Carlton, 2005, Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport, J. Cell Sci., 118, 4527, 10.1242/jcs.02568 · DOI
  7. Chandra, 2019, Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities, Nat. Commun., 10, 1528, 10.1038/s41467-019-09355-y · DOI
  8. Cozier, 2002, The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation, J. Biol. Chem., 277, 48730, 10.1074/jbc.M206986200 · DOI · Paper page
  9. Cullen, 2011, Sorting nexins provide diversity for retromer-dependent trafficking events, Nat. Cell Biol., 14, 29, 10.1038/ncb2374 · DOI · Paper page
  10. Cullen, 2018, To degrade or not to degrade: Mechanisms and significance of endocytic recycling, Nat. Rev. Mol. Cell Biol., 19, 679, 10.1038/s41580-018-0053-7 · DOI · Paper page
  11. Derivery, 2009, The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex, Dev. Cell, 17, 712, 10.1016/j.devcel.2009.09.010 · DOI · Paper page
  12. Giridharan, 2022, Lipid kinases VPS34 and PIKfyve coordinate a phosphoinositide cascade to regulate retriever-mediated recycling on endosomes, Elife, 11, 10.7554/eLife.69709 · DOI · Paper page
  13. Gokool, 2007, Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex, Biochem. J., 408, 287, 10.1042/BJ20070555 · DOI
  14. Gomez, 2009, A FAM21-containing WASH complex regulates retromer-dependent sorting, Dev. Cell, 17, 699, 10.1016/j.devcel.2009.09.009 · DOI · Paper page
  15. Harbour, 2012, Recruitment of the endosomal WASH complex is mediated by the extended “tail” of Fam21 binding to the retromer protein Vps35, Biochem. J., 442, 209, 10.1042/BJ20111761 · DOI · Paper page
  16. Harrison, 2014, A mechanism for retromer endosomal coat complex assembly with cargo, Proc. Natl. Acad. Sci. USA, 111, 267, 10.1073/pnas.1316482111 · DOI
  17. Harterink, 2011, A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion, Nat. Cell Biol., 13, 914, 10.1038/ncb2281 · DOI · Paper page
  18. Huotari, 2011, Endosome maturation, EMBO J., 30, 3481, 10.1038/emboj.2011.286 · DOI
  19. Jia, 2012, Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer, Mol. Biol. Cell, 23, 2352, 10.1091/mbc.E11-12-1059 · DOI · Paper page
  20. Jia, 2016, Structural and mechanistic insights into regulation of the retromer coat by TBC1d5, Nat. Commun., 7, 13305, 10.1038/ncomms13305 · DOI · Paper page
  21. Jimenez-Orgaz, 2018, Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy, EMBO J., 37, 235, 10.15252/embj.201797128 · DOI · Paper page
  22. Kendall, 2020, Mammalian retromer is an adaptable scaffold for cargo sorting from endosomes, Structure, 28, 393, 10.1016/j.str.2020.01.009 · DOI
  23. Kovtun, 2018, Structure of the membrane-assembled retromer coat determined by cryo-electron tomography, Nature, 561, 561, 10.1038/s41586-018-0526-z · DOI · Paper page
  24. Kvainickas, 2019, Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling, J. Cell Biol., 218, 3019, 10.1083/jcb.201812110 · DOI · Paper page
  25. Lauffer, 2010, SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane, J. Cell Biol., 190, 565, 10.1083/jcb.201004060 · DOI · Paper page
  26. Lee, 2016, FAM21 directs SNX27-retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus, Nat. Commun., 7, 10939, 10.1038/ncomms10939 · DOI · Paper page
  27. Leneva, 2021, Architecture and mechanism of metazoan retromer:SNX3 tubular coat assembly, Sci. Adv., 7, 10.1126/sciadv.abf8598 · DOI · Paper page
  28. Lin, 2007, PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization, J. Neurosci., 27, 13903, 10.1523/JNEUROSCI.1750-07.2007 · DOI
  29. Liu, 2016, Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion, J. Cell Biol., 212, 181, 10.1083/jcb.201506081 · DOI
  30. Liu, 2017, WDR91 is a Rab7 effector required for neuronal development, J. Cell Biol., 216, 3307, 10.1083/jcb.201705151 · DOI
  31. Lunn, 2007, A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction, Nat. Neurosci., 10, 1249, 10.1038/nn1953 · DOI · Paper page
  32. McEwan, 2015, PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins, Mol. Cell, 57, 39, 10.1016/j.molcel.2014.11.006 · DOI · Paper page
  33. McEwan, 2015, PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection, Cell Host Microbe, 17, 58, 10.1016/j.chom.2014.11.011 · DOI
  34. McGough, 2014, Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling, J. Cell Sci., 127, 4940, 10.1242/jcs.156299 · DOI · Paper page
  35. Nakada-Tsukui, 2005, A retromerlike complex is a novel Rab7 effector that is involved in the transport of the virulence factor cysteine protease in the enteric protozoan parasite Entamoeba histolytica, Mol. Biol. Cell, 16, 5294, 10.1091/mbc.e05-04-0283 · DOI
  36. Norris, 2020, Endosomal microdomains: Formation and function, Curr. Opin. Cell Biol., 65, 86, 10.1016/j.ceb.2020.02.018 · DOI
  37. Norwood, 2011, Assembly and solution structure of the core retromer protein complex, Traffic, 12, 56, 10.1111/j.1600-0854.2010.01124.x · DOI · Paper page
  38. Pankiv, 2010, FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport, J. Cell Biol., 188, 253, 10.1083/jcb.200907015 · DOI
  39. Puthenveedu, 2010, Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains, Cell, 143, 761, 10.1016/j.cell.2010.10.003 · DOI · Paper page
  40. Rapiteanu, 2016, A genetic screen identifies a critical role for the WDR81-WDR91 complex in the trafficking and degradation of tetherin, Traffic, 17, 940, 10.1111/tra.12409 · DOI
  41. Rink, 2005, Rab conversion as a mechanism of progression from early to late endosomes, Cell, 122, 735, 10.1016/j.cell.2005.06.043 · DOI
  42. Rojas, 2008, Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7, J. Cell Biol., 183, 513, 10.1083/jcb.200804048 · DOI · Paper page
  43. Seaman, 2004, Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer, J. Cell Biol., 165, 111, 10.1083/jcb.200312034 · DOI · Paper page
  44. Seaman, 2009, Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5, J. Cell Sci., 122, 2371, 10.1242/jcs.048686 · DOI · Paper page
  45. Seaman, 1998, A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast, J. Cell Biol., 142, 665, 10.1083/jcb.142.3.665 · DOI · Paper page
  46. Simonetti, 2019, Actin-dependent endosomal receptor recycling, Curr. Opin. Cell Biol., 56, 22, 10.1016/j.ceb.2018.08.006 · DOI · Paper page
  47. Simonetti, 2019, Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins, Nat. Cell Biol., 21, 1219, 10.1038/s41556-019-0393-3 · DOI · Paper page
  48. Steinberg, 2013, A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport, Nat. Cell Biol., 15, 461, 10.1038/ncb2721 · DOI · Paper page
  49. Teasdale, 2012, Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: Structures, functions and roles in disease, Biochem. J., 441, 39, 10.1042/BJ20111226 · DOI · Paper page
  50. Temkin, 2011, SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors, Nat. Cell Biol., 13, 715, 10.1038/ncb2252 · DOI · Paper page
  51. van Weering, 2012, SNX-BAR-mediated endosome tubulation is co-ordinated with endosome maturation, Traffic, 13, 94, 10.1111/j.1600-0854.2011.01297.x · DOI
  52. Xing, 2021, The Rab7 effector WDR91 promotes autophagy-lysosome degradation in neurons by regulating lysosome fusion, J. Cell Biol., 220, 10.1083/jcb.202007061 · DOI
  53. Xu, 2001, SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P, Nat. Cell Biol., 3, 658, 10.1038/35083051 · DOI
  54. Yong, 2020, Mechanism of cargo recognition by retromer-linked SNX-BAR proteins, PLoS Biol., 18, 10.1371/journal.pbio.3000631 · DOI · Paper page
  55. Zhong, 2002, Endosomal localization and function of sorting nexin 1, Proc. Natl. Acad. Sci. USA, 99, 6767, 10.1073/pnas.092142699 · DOI

Cited by

Sorted by citations

Metadata

Authors
Liu, N., Liu, K., & Yang, C.
Venue
Journal of Cell Biology
Publisher
Rockefeller University Press
Published
2022-10-03
Volume
221
Issue
12
ISSN
  • 0021-9525
  • 1540-8140
DOI
10.1083/jcb.202203013
PMC
PMC9531996
Cited by
22
References
4
Language
en
Licence
Funders
  • National Basic Research Program of China (2017YFA0503403)
  • National Science Foundation of China (31730053, 91954204, 31900500)
  • Yunnan Province Science and Technology Department (202001BB050077)
  • Program of Yunnan Province Leading Talents in Science and Technology

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review