Cited by 83Gut microbiota and healthNutritional Studies and DietOral microbiology and periodontitis research

Association of dietary patterns with the gut microbiota in older, community-dwelling men

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Shikany, James M, Demmer, Ryan T, Johnson, Abigail J, Fino, Nora F, Meyer, Katie, Ensrud, Kristine E, Lane, Nancy E, Orwoll, Eric S +3 more·2019·The American Journal of Clinical Nutrition

Abstract

Background While the gut microbiota is relatively stable through adulthood, its composition is influenced by various host and environmental factors, including changes in health, gastrointestinal processes (e.g., transit time, gastric acidity), medication use, and diet. The association of habitual diet, in the form of a posteriori-derived dietary patterns, and microbiota composition has not been adequately studied, particularly in older men.Objective The objective was to investigate the association of dietary patterns with the composition and diversity of the gut bacterial microbiota in community-dwelling, older men.Methods This cross-sectional study included 517 men who were participants in the Osteoporotic Fractures in Men (MrOS) Study (≥65 y of age at baseline in 2000-2002) and who provided a stool sample and completed an FFQ at MrOS Visit 4 in 2014-2016. Dietary patterns were derived by factor analysis. 16S ribosomal RNA target gene sequencing was performed and taxonomy assignments were derived using the Greengenes database. Linear regression and permutational multivariate analysis of variance (PERMANOVA) considered variations in alpha and beta diversity by dietary pattern, and a model that implements a 0-inflated Gaussian distribution of mean group abundance for each taxa (metagenomeSeq) assessed taxonomic variations by dietary pattern.Results In multivariable-adjusted models, greater adherence to the Western pattern was positively associated with families Mogibacteriaceae and Veillonellaceae and genera Alistipes, Anaerotruncus, CC-115, Collinsella, Coprobacillus, Desulfovibrio, Dorea, Eubacterium, and Ruminococcus, while greater adherence to the prudent pattern was positively associated with order Streptophyta, family Victivallaceae, and genera Cetobacterium, Clostridium, Faecalibacterium, Lachnospira, Paraprevotella, and Veillonella. The relative abundance of the dominant gut bacterial phyla, Bacteroidetes and Firmicutes, did not differ between participants with greater adherence to the Western pattern, compared with those with greater adherence to the prudent pattern. Dietary patterns were not associated with measures of alpha diversity, but beta diversity measures were significantly associated with both Western and prudent patterns.Conclusions We observed significant associations between dietary patterns and measures of gut microbial composition in this sample of community-dwelling, older men.

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Crossref · 10.1093/ajcn/nqz174

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  • Adherence to a Western dietary pattern or a prudent pattern was associated with measures of beta-diversity, but not alpha-diversity, in 517 older men.

    “Adherence to a Western dietary pattern or a “prudent” pattern (based on high factor loadings of fruits, vegetables, nuts, fish, chicken and turkey without skin) on the gut microbiota of 517 older men were found to be associated with measures of beta-diversity, but not alpha-diversity [80].”

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Authors
Shikany, J. M., Demmer, R. T., Johnson, A. J., Fino, N. F., Meyer, K., Ensrud, K. E., Lane, N. E., Orwoll, E. S., Kado, D. M., Zmuda, J. M., & Langsetmo, L.
Affiliations
  • University of Alabama at Birmingham (US)
  • University of Minnesota (US)
  • Oregon Health & Science University (US)
  • University of North Carolina at Chapel Hill (US)
  • Minneapolis VA Medical Center (US)
  • University of California, Davis (US)
  • University of California San Diego (US)
  • University of Pittsburgh (US)
Corresponding author
Shikany, James M
Venue
The American Journal of Clinical Nutrition
Publisher
Elsevier BV
Published
2019-10
Volume
110
Issue
4
Pages
1003-1014
ISSN
0002-9165 (ISSN-L)
OpenAlex
W2970237495
Cited by
83
References
58
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 33 · 2020: 14 · 2019: 1
FWCI
5.13
Type
journal article
Language
en
Open access
Locations
  • American Journal of Clinical Nutrition (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, UL1 TR000128)
  • National Institute on Aging
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • National Center for Advancing Translational Sciences
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
dietary habits, gut microbiota, older men, Western diet, prudent diet, microbial diversity, beta diversity, community-dwelling older adults, Bacteroidetes, Firmicutes, Faecalibacterium, Clostridium, Desulfovibrio, Veillonella, Osteoporotic Fractures in Men Study
MeSH terms
Gastrointestinal Microbiome, Aged, Aged, 80 and over, Cross-Sectional Studies, Diet, Humans, Male, Independent Living

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