Cited by 259Physical Activity and HealthDiabetes, Cardiovascular Risks, and LipoproteinsObesity, Physical Activity, Diet

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Physical Activity, Obesity, and the Incidence of Type 2 Diabetes in a High-Risk Population

Kriska, A. M.·2003·American Journal of Epidemiology

DOI 10.1093/aje/kwg191

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Abstract

This study, examining the longitudinal relation among physical activity, body mass index, and development of type 2 diabetes in a high-risk population, is unique because diabetes was determined by oral glucose tolerance testing rather than by self-report. A physical activity questionnaire assessing past year leisure and occupational activity was administered to 1,728 nondiabetic Pima individuals aged 15-59 years as part of a series of clinic examinations in the Gila River Indian Community from 1987 to 2000. During an average follow-up period of 6 years, 346 subjects developed diabetes. Using time-dependent Cox proportional hazards modeling adjusting for age, the authors found that total activity was related to diabetes incidence in women and men (p < 0.05 in women only). After additional adjustment for body mass index, the relation between activity and diabetes incidence was weakened in both men and women. When the age-adjusted diabetes incidence rates were examined by levels of activity stratified by tertile of body mass index, the diabetes incidence rate remained lower in more active than in less active men and women from all body mass index groups, with the exception of the middle body mass index tertile in men (p < 0.05 in women only). These results suggest that the adoption and maintenance of a physically active lifestyle can play a significant role in preventing type 2 diabetes.

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Authors: Kriska, A. M.
Affiliations: University of Pittsburgh (US)
Corresponding author: Kriska, A. M.
ORCID: Kriska, A. M.
Venue: American Journal of Epidemiology
Publisher: Oxford University Press (OUP)
Published: 2003-10-01
Volume: 158
Issue: 7
Pages: 669-675
ISSN: 0002-9262 (ISSN-L)
DOI: 10.1093/aje/kwg191
OpenAlex: W1988315017
Cited by: 259
References: 19
Citations by year: 2026: 1 · 2025: 2 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 12 · 2016: 12 · 2015: 18 · 2014: 11 · 2013: 22 · 2012: 15
FWCI: 7.85
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Epidemiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01dk043394-08)
National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK43394-06A1)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
Keywords: type 2 diabetes, physical activity, obesity, body mass index, diabetes incidence, Pima Indians, Gila River Indian Community, diabetes prevention, oral glucose tolerance test, occupational physical activity, leisure-time physical activity, sex differences
MeSH terms: Adolescent, Adult, Arizona, Diabetes Mellitus, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Indians, North American, Life Style, Longitudinal Studies, Male, Middle Aged, Motor Activity, Obesity, Occupations, Risk Factors, Sex Factors, Body Mass Index, Incidence, Statistics, Nonparametric

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Physical Activity, Obesity, and the Incidence of Type 2 Diabetes in a High-Risk Population

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