Changes of Cortico-striatal Effective Connectivity during Visuomotor Learning
Open accessAbstract
It has been suggested that the cortico-striatal system might play a crucial role in learning behavioural plans of action. We have tested this hypothesis by studying the dynamics of functional coupling among the neural elements of cortico-striatal circuitry. Human cerebral activity was measured with functional magnetic resonance imaging (fMRI) during the learning of an associative visuomotor task. Structural equation modelling of regional fMRI time-series was used to characterize learning-related changes in effective connectivity. We report that learning to associate visual instructions with motor responses significantly altered cortico-striatal functional couplings. Specific learning-related increases of effective connectivity were found in temporo-striatal and fronto-striatal circuits. Connectivity among portions of the frontal cortex decreased as a function of learning. Temporo-frontal and parieto-frontal couplings were not altered during learning. We infer that novel visuomotor associations are established through the enhancement of specific cortico-striatal circuits, rather than through the alteration of direct temporo-frontal or parieto-frontal connectivity.
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Depending on the task, neuroimaging studies have reported a general decrease in cortical activity, increases in cortical activity, or a more complex redistribution where activity increases in some areas and decreases in others during practice.
“Depending on the task, some studies have reported a general decrease in cortical activity [52–55], a few have reported increases [56–59], and some have reported a more complex redistribution where activity increases in some areas and decreases in others [60–62].”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [55]
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- Authors
- Toni, I.
- Affiliations
- Donders Centre for Cognitive Neuroimaging (NL)
- Corresponding author
- Toni, I.
- ORCID
- Toni, I.
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-10-01
- Volume
- 12
- Issue
- 10
- Pages
- 1040-1047
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W2168028357
- Cited by
- 163
- References
- 73
- Citations by year
- 2025: 5 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 6 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 12
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- JuSER (Forschungszentrum Jülich) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- visuomotor learning, associative learning, frontostriatal circuits, frontal cortex, functional coupling, striatum
- MeSH terms
- Cerebral Cortex, Corpus Striatum, Humans, Learning, Magnetic Resonance Imaging, Neural Pathways, Photic Stimulation, Psychomotor Performance, Linear Models
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