How good is the macaque monkey model of the human brain?
Open accessAbstract
Macaque monkeys are widely used in order to understand the mechanisms of the human brain. But humans have capacities not found in monkeys, and their brains differ in important ways, for example in the proportions of different regions and in microstructure. However, this does not mean that we must abandon the monkey model, only that wherever possible, we should test whether generalizations can be made. One strategy is to use fMRI to visualize activations in humans, and compare these with activations in monkeys. Where the results are the same, we can then use information from single unit recording in those areas to suggest the mechanisms by which those areas perform their functions in the human brain.
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There are differences between human and non-human primate brain neurophysiology that might be crucial to the function of a cortical visual prosthesis.
“Although much information can be acquired from non-human primates, there are differences between human and non-human primate brain neurophysiology that might be crucial to the function of a cortical visual prosthesis [19,20].”
From Eye movements and the perceived location of phosphenes generated by intracranial primary visual cortex stimulation in the blind (2021) · cites this paper as [19]
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- Authors
- Passingham, R.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Passingham, Richard
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 19
- Issue
- 1
- Pages
- 6-11
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC2706975
- OpenAlex
- W2057112864
- Cited by
- 181
- References
- 59
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 7 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 15 · 2019: 30 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 5 · 2013: 7 · 2012: 5
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Neurobiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- human brain, comparative neuroanatomy, brain microstructure, single-unit recording
- MeSH terms
- Animals, Brain, Cognition, Humans, Language, Macaca, Magnetic Resonance Imaging, Models, Animal
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