Consequences of Magnocellular Dysfunction on Processing Attended Information in Schizophrenia
Open accessAbstract
Schizophrenia is associated with perceptual and cognitive dysfunction including impairments in visual attention. These impairments may be related to deficits in early stages of sensory/perceptual processing, particularly within the magnocellular/dorsal visual pathway. In the present study, subjects viewed high and low spatial frequency (SF) gratings designed to test functioning of the parvocellular/magnocellular pathways, respectively. Schizophrenia patients and healthy controls attended to either the low SF (magnocellularly biased) or high SF (parvocellularly biased) gratings. Functional magnetic resonance imaging (fMRI) and recordings of event-related potentials (ERPs) were carried out during task performance. Patients were impaired at detecting low-frequency targets. ERP amplitudes to low-frequency gratings were diminished, both for the early sensory-evoked components and for the attend minus unattend difference component (the selection negativity), which is regarded as a neural index of feature-selective attention. Similarly, fMRI revealed that activity in extrastriate visual cortex was reduced in patients during attention to low, but not high, SF. In contrast, activity in frontal and parietal areas, previously implicated in the control of attention, did not differ between patients and controls. These findings suggest that impaired sensory processing of magnocellularly biased stimuli lead to impairments in the effective processing of attended stimuli, even when the attention control systems themselves are intact.
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Loss of framing function leads to impaired ability to engage in tasks that require sustained attention to visual information.
“or to engage in tasks that require sustained attention to visual information (91, 100).”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [91]
Neurophysiological studies have demonstrated impaired generation of the visual P1 potential to stimuli biased toward the magnocellular visual system.
“Neurophysiological studies have demonstrated impaired generation of the visual P1 potential to stimuli biased toward the magnocellular visual system (65, 89–91)”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [91]
Impaired activation has been observed to low spatial frequency stimulation, along with visual behavioral deficits.
“Nevertheless, impaired activation have been observed to low spatial frequency stimulation (91, 92), along with visual behavioral deficits.”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [91]
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AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058 · see citing works
The neural mechanisms of top-down attentional control
Hopfinger, J. B., Buonocore, M. H., & Mangun, G. R. (2000) · Nature Neuroscience · doi:10.1038/72999 · Cited by 1,876 · see citing works
Psychophysical evidence for separate channels for the perception of form, color, movement, and depth
Livingstone, M. S., & Hubel, D. H. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-11-03416.1987 · Cited by 1,758 · see citing works
Parasuraman, R., & DAVIES, D. R. (1984) · Academic Press eBooks · Cited by 1,555 · see citing works
Event-related brain potentials in the study of visual selective attention
Hillyard, S. A., & Anllo-Vento, L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.781 · Cited by 1,525 · cited 4× · see citing works
“The SN is proposed to index neuronal activity within ventral extrastriate areas specialized for the processing of the attended feature dimension (Harter and Aine 1984; Hillyard and Anllo-Vento 1998).”
BackgroundResultInfluentialSelf-citationCorbetta, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.831 · Cited by 995 · see citing works
Neural Systems for Visual Orienting and Their Relationships to Spatial Working Memory
Corbetta, M., Kincade, J. M., & Shulman, G. L. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902317362029 · Cited by 698 · see citing works
Endogeneous brain potentials associated with selective auditory attention
Hansen, J. C., & Hillyard, S. A. (1980) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(80)90222-9 · Cited by 669 · see citing works
Self-citationAstafiev, S. V., Shulman, G. L., Stanley, C. M., Snyder, A. Z., Van Essen, D. C., & Corbetta, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-11-04689.2003 · Cited by 640 · see citing works
The Quick Test (QT): Provisional Manual,
Ammons, R. B., & Ammons, C. H. (1962) · Psychological Reports · doi:10.1177/003329416201100106 · Cited by 580 · see citing works
When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia
Javitt, D. C. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153502 · Cited by 503 · see citing works
Self-citationFunctional anatomy of macaque striate cortex. III. Color
Tootell, R. B. H., Silverman, M. S., Hamilton, S., Valois, R. L. D., & Switkes, E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01569.1988 · Cited by 472 · see citing works
Kiesel, A., Miller, J. O., Jolicœur, P., & Brisson, B. (2007) · Psychophysiology · doi:10.1111/j.1469-8986.2007.00618.x · Cited by 427 · see citing works
Discrimination at threshold: Labelled detectors in human vision
Watson, A. B., & Robson, J. G. (1981) · Vision Research · doi:10.1016/0042-6989(81)90014-6 · Cited by 423 · see citing works
Early-stage visual processing and cortical amplification deficits in schizophrenia
Butler, P. D., Zemon, V., Schechter, I., Saperstein, A. M., Hoptman, M. J., Lim, K. O., Revheim, N., Silipo, G., & Javitt, D. C. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.495 · Cited by 362 · see citing works
Self-citationMenéndez, R. G. D. P., Andino, S. L. G., Lantz, G., Michel, C. M., & Landis, T. (2001) · Brain Topography · doi:10.1023/a:1012944913650 · Cited by 347 · see citing works
Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia
Doniger, G. M., Foxe, J. J., Murray, M. M., Higgins, B. A., & Javitt, D. C. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.11.1011 · Cited by 345 · see citing works
Self-citationSensory Processing in Schizophrenia: Neither Simple nor Intact
Javitt, D. C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp110 · Cited by 328 · see citing works
Self-citationAnllo‐Vento, L., & Hillyard, S. A. (1996) · Perception & Psychophysics · doi:10.3758/bf03211875 · Cited by 324 · see citing works
Self-citationThe Construct of Attention in Schizophrenia
Luck, S. J., & Gold, J. M. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.014 · Cited by 302 · see citing works
Subcortical visual dysfunction in schizophrenia drives secondary cortical impairments
Butler, P. D., Martinez, A., Foxe, J. J., Kim, D., Zemon, V., Silipo, G., Mahoney, J., Shpaner, M., Jalbrzikowski, M., & Javitt, D. C. (2007) · Brain · doi:10.1093/brain/awl233 · Cited by 292 · see citing works
Self-citationCortical Mechanisms of Feature-based Attentional Control
Liu, T. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg080 · Cited by 287 · see citing works
Functional anatomy of macaque striate cortex. V. Spatial frequency
Tootell, R. B. H., Silverman, M. S., Hamilton, S., Switkes, E., & Valois, R. L. D. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01610.1988 · Cited by 244 · see citing works
Electric source imaging of human brain functions
Michel, C. M., Thut, G., Morand, S. M., Khateb, A., Pegna, A. J., de Peralta, R. G., Gonzalez, S., Seeck, M., & Landis, T. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00086-8 · Cited by 244 · see citing works
Spatial Frequency and Selective Attention to Local and Global Information
Shulman, G. L., & Wilson, J. (1987) · Perception · doi:10.1068/p160089 · Cited by 240 · see citing works
ERPs in schizophrenia: Effects of antipsychotic medication
Ford, J. M., White, P. M., Csernansky, J. G., Faustman, W. O., Roth, W. T., & Pfefferbaum, A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91221-1 · Cited by 227 · see citing works
The Role of Spatial-Frequency Channels in the Perception of Local and Global Structure
Shulman, G. L., Sullivan, M. A., Gish, K., et al. (1986) · Perception · doi:10.1068/p150259 · Cited by 214 · see citing works
Sensory Contributions to Impaired Prosodic Processing in Schizophrenia
Leitman, D. I., Foxe, J. J., Butler, P. D., Saperstein, A., Revheim, N., & Javitt, D. C. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.034 · Cited by 206 · see citing works
Self-citationMartı́nez, A., Hillyard, S. A., Dias, E. C., Hagler, D. J., Butler, P. D., Guilfoyle, D. N., Jalbrzikowski, M., Silipo, G. S., & Javitt, D. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1852-08.2008 · Cited by 205 · see citing works
Self-citationGlobal precedence in attention and decision.
Miller, J. O. (1981) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/0096-1523.7.6.1161 · Cited by 191 · see citing works
Slaghuis, W. A. (1998) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.107.1.49 · Cited by 168 · see citing works
Slaghuis, W. A. (1998) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.107.1.49 · Cited by 168 · see citing works
Schechter, I., Butler, P. D., Zemon, V. M., Revheim, N., Saperstein, A. M., Jalbrzikowski, M., Pasternak, R., Silipo, G., & Javitt, D. C. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.06.013 · Cited by 151 · see citing works
Self-citationSensory Contributions to Impaired Emotion Processing in Schizophrenia
Butler, P. D., Abeles, I. Y., Weiskopf, N. G., Tambini, A., Jalbrzikowski, M., Legatt, M. E., Zemon, V. M., Loughead, J., Gur, R. C., & Javitt, D. C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp109 · Cited by 149 · see citing works
Self-citationMagnocellular contributions to impaired motion processing in schizophrenia
Kim, D., Wylie, G., Pasternak, R., Butler, P. D., & Javitt, D. C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2005.10.008 · Cited by 146 · see citing works
Self-citationEarly Sensory Contributions to Contextual Encoding Deficits in Schizophrenia
Dias, E. C., Butler, P. D., Hoptman, M. J., & Javitt, D. C. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.17 · Cited by 139 · see citing works
Self-citationSehatpour, P., Dias, E. C., Butler, P. D., Revheim, N., Guilfoyle, D. N., Foxe, J. J., & Javitt, D. C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.85 · Cited by 134 · see citing works
Self-citationInformation-processing abnormalities: Trait- and state-dependent components
Saccuzzo, D. P., & Braff, D. L. (1986) · Schizophrenia Bulletin · doi:10.1093/schbul/12.3.447 · Cited by 132 · see citing works
Reading impairment and visual processing deficits in schizophrenia
Revheim, N., Butler, P. D., Schechter, I., Jalbrzikowski, M., Silipo, G., & Javitt, D. C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.06.022 · Cited by 117 · see citing works
Self-citationMartı́nez, A., Russo, F. D., Anllo‐Vento, L., & Hillyard, S. A. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00660-5 · Cited by 115 · see citing works
Self-citationImpaired top–down control of visual search in schizophrenia
Gold, J. M., Fuller, R. L. M., Robinson, B. M., Braun, E. L., & Luck, S. J. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.04.023 · Cited by 114 · see citing works
Spatial frequency uncertainty effects in the detection of sinusoidal gratings
DAVIS, E. T., & Graham, N. (1981) · Vision Research · doi:10.1016/0042-6989(81)90079-1 · Cited by 106 · see citing works
Foxe, J. J., Strugstad, E. C., Sehatpour, P., Molholm, S., Pasieka, W., Schroeder, C. E., & McCourt, M. E. (2008) · Brain Topography · doi:10.1007/s10548-008-0063-4 · Cited by 106 · see citing works
Seeing the World Dimly: The Impact of Early Visual Deficits on Visual Experience in Schizophrenia
Kantrowitz, J. T., Butler, P. D., Schecter, I., Silipo, G. S., & Javitt, D. C. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp100 · Cited by 97 · see citing works
Self-citationImpaired control of visual attention in schizophrenia.
Fuller, R. L. M., Luck, S. J., Braun, E. L., Robinson, B. M., McMahon, R. P., & Gold, J. M. (2006) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.115.2.266 · Cited by 86 · see citing works
Butler, P. D., Harkavy‐Friedman, J., AMADOR, X. F., & Gorman, J. M. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(96)00007-8 · Cited by 81 · see citing works
Self-citationERP signs of early selective attention effects to check size
Zani, A., & Proverbio, A. M. (1995) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(95)00078-d · Cited by 77 · see citing works
Human Attentional Networks: A Connectionist Model
Wang, H., & Fan, J. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.10.1678 · Cited by 71 · see citing works
Slaghuis, W. L., & Bakker, V. J. (1995) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.104.1.41 · Cited by 68 · see citing works
Selective attention to spatial frequency: an ERP and source localization analysis
Baas, J. M. P., Kenemans, J. L., & Mangun, G. R. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00269-9 · Cited by 57 · see citing works
Slaghuis, W. L., & Bakker, V. J. (1995) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.104.1.41 · Cited by 51 · see citing works
Disruption of Neural Systems of Visual Attention in Schizophrenia
Potts, G. F., O’Donnell, B. F., Hirayasu, Y., & McCarley, R. W. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.5.418 · Cited by 49 · see citing works
Feature processing and attention in the human visual system: an overview
Heslenfeld, D. J., Kenemans, J. L., Kok, A., & Molenaar, P. C. M. (1997) · Biological Psychology · doi:10.1016/s0301-0511(96)05228-3 · Cited by 49 · see citing works
Perceptual organization by proximity and similarity in schizophrenia
Kurylo, D. D., Pasternak, R., Silipo, G., Javitt, D. C., & Butler, P. D. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.07.001 · Cited by 46 · see citing works
Coleman, M. J., Cestnick, L., Krastoshevsky, O., Krause, V., Huang, Z., Mendell, N. R., & Levy, D. L. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp090 · Cited by 43 · see citing works
Effects of perceptual context on event‐related brain potentials during auditory spatial attention
Arnott, S. R., & Alain, C. (2002) · Psychophysiology · doi:10.1111/1469-8986.3950625 · Cited by 33 · see citing works
Disruption of auditory and visual attention in schizophrenia
Wood, S. M., Potts, G. F., Martin, L. E., et al. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.04.014 · Cited by 18 · see citing works
KEMALI, D., Galderisi, S., Maj, M., et al. (1991) · International Journal of Psychophysiology · doi:10.1016/0167-8760(91)90032-s · Cited by 13 · see citing works
Bush (1998) · doi:10.1002/(sici)1097-0193(1998)6:4
Flagged first, then by citations
Research works printed but not linked: 2
- First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV axis I disorders—patient edition. New York: New York State Psychiatric Institute; 1997. [Google Scholar]
- Graham N, Kramer P, Haber N. Attending to spatial frequency and spatial position of near-threshold visual patterns. In: Posner MI, Marin OSM, editors. Attention and performance. Hillsdale (NJ): Erlbaum; 1985. pp. 269–284. [Google Scholar]
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Self-citationJavitt, D. C., Zukin, S. R., Heresco-Levy, U., & Umbricht, D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs069 · Cited by 322 · see citing works
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Self-citation
- Authors
- Martinez, A., Hillyard, S. A., Bickel, S., Dias, E. C., Butler, P. D., & Javitt, D. C.
- Affiliations
- University of California San Diego (US)
- Nathan Kline Institute for Psychiatric Research (US)
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-08-11
- Volume
- 22
- Issue
- 6
- Pages
- 1282-1293
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- PMC
- PMC3357176
- OpenAlex
- W2115450690
- Cited by
- 94
- References
- 60
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 13 · 2019: 3 · 2018: 7 · 2017: 6 · 2016: 4 · 2015: 11 · 2014: 9 · 2013: 14 · 2012: 7
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Cerebral Cortex (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R37MH049334, P50MH086385, R24MH082790, R01MH049334)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- schizophrenia, parvocellular pathway, visual attention, spatial frequency, event-related potentials, extrastriate cortex, dorsal visual pathway, sensory processing deficits
- MeSH terms
- Adult, Evoked Potentials, Visual, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Photic Stimulation, Psychomotor Performance, Schizophrenia, Visual Cortex, Visual Pathways
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